Elazer Edelman Curriculum Vitae (Updated 10-2015) - 0

CURRICULUM VITAE
Date prepared: October 30, 2015
Name:
Elazer R. Edelman
Office Address:
Harvard-MIT, Biomedical Engineering Center

77 Massachusetts Ave., Bldg. E25-438
Cambridge, MA 02139
617-253-1569
Home Address:
30 Warren Street, Brookline MA 02445
E-mail:
ere@mit.edu
Place of Birth:
New York, New York
Fax:
617-253-2514
Education:
1978
S.B.
1978
S.B.
1979
S.M.
1983
1984
M.D.
Ph.D.
Massachusetts Institute of Technology

(Electrical Engineering and Computer
Science)
(Life Sciences: Applied Biology)
(Bioelectrical Engineering)
Harvard Medical School
(Medical Engineering and Medical Physics)
Postdoctoral Training:
Internship and Residency:
1984-1987
First, Second and Third Year Resident Physician

Brigham and Women's Hospital, Boston, MA
Clinical and Research Fellowships:

1984-1987
1987-1989
1987-1989
Clinical Fellow in Medicine, Harvard Medical School, Boston, MA

Research Fellow in Medicine, Harvard Medical School, Boston, MA
Research/Clinical Fellow in Medicine, Harvard Medical School,
Boston, MA
Licensure and Certification:

1985
1987
Diplomate, National Board of Medical Examiners

Diplomate, American Board of Internal Medicine
Elazer R. Edelman
1987
1991
1992
1998
Massachusetts License Registration

Diplomate, American College of Cardiology
Fellow, American College of Cardiology
Fellow, Council on Arteriosclerosis, Thrombosis and Vascular Biology,
American Heart Association
Faculty Academic Appointments:

1989-1991
1991-1995
1993-1996
Instructor in Medicine, Harvard Medical School, Boston, MA

Assistant Professor of Medicine, Harvard Medical School, Boston, MA
Hermann von Helmholtz Assistant Professor, Harvard-M.I.T. Division of
Health Sciences and Technology, MIT, Cambridge, MA
1994
Senior Fellow, Program in Advanced Biological Sciences, Harvard
Medical School, Boston, MA
1995-2005
Associate Professor of Medicine, Harvard Medical School, Boston, MA
1996-1997
Thomas D. and Virginia W. Cabot Associate Professor of Health Sciences
and Technology, Massachusetts Institute of Technology, Cambridge, MA
1997-2000
Associate Professor with tenure, Massachusetts Institute of Technology,
Cambridge, MA
2000-Present Thomas D. and Virginia W. Cabot Professor of Health Sciences and
Technology, Massachusetts Institute of Technology, Cambridge, MA
2005-Present Professor of Medicine, Harvard Medical School, Boston, MA
Hospital or Affiliated Institution Appointments:

1989-2006
Associate Physician, Brigham and Women's Hospital, Boston, MA
2006-Present Senior Physician, Brigham and Womens Hospital, Boston, MA
2006-2007
Director, ECI Laboratory, Brigham and Womens Hospital, Boston, MA
Other Professional Positions and Major Visiting Appointments:
1974-1979
1985-1989
Engineering Associate, MITRE Corporation, Bedford, MA

Visiting Scientist, Departments of Applied Biology and Chemical
Engineering, Massachusetts Institute of Technology, Cambridge, MA
1985-1989
Associate in Engineering, Center for Biomedical Engineering,
Massachusetts General Hospital, Boston, MA
2005-Present Visiting Professor, Norwegian University of Science and Technology,
Department of Biology
2007-Present Member, Scientific Advisory Committee, MIT-Spain Collaborative
Research Program
Hospital and Health Care Organization Service Responsibilities:
1989-Present Attending Physician, Samuel Levine Coronary Care Unit
1989-Present Reader electrocardiograms
1989-Present Attending Physician, Cardiothoracic Surgical Service
2
Elazer R. Edelman
Major Administrative Assignments:

1993-Present Director, Harvard-MIT Biomedical Engineering Center
1998-Present Chair, Harvard Medical School, Faculty and Fellows Internal Grant Program
2013-present Director, MIT Clinical Research Center
Major Committee Assignments:
National and Regional:
Year
Name of Committee
Role
Institution
1984-Present
Controlled Release Society
1991-Present
1991-Present
American College of
Cardiology
1994
Outcomes Based Clinical

Research Committee
Society for Biomaterials
1997-2009
ASTM-F4 Committee
Co-Chairman on
Interventional Devices
2005
NHLBI-Specialized Center for

Clinically Oriented Research
External Advisory Committee
The Childrens Hospital of

Philadelphia
2008
External Review Committee,

Weldon School of Biomedical
Engineering
Purdue University
2008-2010
Planning Committee Cancer,

Stem Cell Biology and
Transplantation Interest
Group(IG 13)
Institute of Medicine of the

National Academies
2011-2014
Science Board of the Food and

Drug Administration
Food and Drug

Administration
2011
ORISE (Oak Ridge Institute for

Science and Education)
Fellowship
Food and Drug

Administration Entrepreneur-in-Residence
Member Strategic Team

2014-present
Fritz J. and Dolores H. Russ

Prize Committee
National Academy of
Engineering
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Elazer R. Edelman
Academic:
Year
Name of Committee
Role
1974-1979
Committee on Educational Policy
Dept. of Electrical Engineering,

M.I.T.
1979-1985,
1991-1993
Committee on Curriculum
Harvard-M.I.T. Division of
Health Sciences and Technology
1984
Committee on Skills, New

Pathway Program
1992-present
Board of Advisors
1993
Joint Faculty Committee
Harvard-M.I.T.
1993-1994,
1998-1999,
Search Committee
1993-1997
Curriculum Committee
M.I.T. Program in Biomedical

Engineering
1995-2007
Admissions Committee
Harvard-M.I.T. Medical
Engineering/Medical Physics
Program
1995-1999
Executive Board (Dept.)
M.I.T., Center for Biomedical

Engineering
1997-2000
Lemelson Prize Selection

Committee (Inst.)
M.I.T.
1997
Executive Committee
Center for Innovation and

Minimally Invasive Technology
1997
Committee on the Formation of

the Division of Bioengineering
and Environmental Health
School of Engineering
1997-present
Faculty Fellowship, Faculty of

Medicine Committee
1997-2000
HST/DEAS Bioengineering
Committee
Harvard University
1998-2010
Committee on Biological
Sciences (UCBS)
Harvard University
Institution
Elazer R. Edelman
Year
Name of Committee
Role
1999-present
Faculty Committee
1999-2010
Board of Directors
M.I.T. Hillel Foundation
2000-2005
HMS Faculty Fellowship

Subcommittee
2000
Advanced Biomedical Sciences

Program Committee
2000-2005
The Schepens Eye Research

Institute Scientific Advisory
Board
2003
Ad Hoc Faculty Search

Committee: Biomedical
Engineering
Harvard University
2005-present
MD Admissions Committee
Harvard-MIT Division of Health

Sciences and Technology
2005, 2011
Admissions Committee
Massachusetts Institute of
Technology
2005-present
Committee On Assessment of
Biohazards
Technology
2005-present
Committee on Animal Care
Technology
2006-present
HMS Faculty Fellowship
2006
Ad Hoc Faculty Search

Committee: Childrens Hospital
2006-present
Howard Hughes Medical Institute Program Massachusetts Institute of

Director Technology
Graduate Education In Medical
Science
2007 - 2008
Clinical and Translational Science

Centers, Scientific Incubator
Subcommittee
2007 - 2008
Harvard University
Bioengineering Planning Group
Harvard University
Chair
Institution

Elazer R. Edelman
Year
Name of Committee
Role
Institution
2007 2008

Executive Planning Tools and
Technologies subcommittee
CoChair
2008
Faculty Search Committee
Harvard University School of

Engineering and Applied
Sciences
2008
Search Committee for Director of

the Vascular Biology Program
Childrens Hospital Boston,

2009-present
Committee on the Use of Humans

as Experimental Subjects
Technology
2009-2012
SEAS/Wyss Senior Faculty

Search Committee in Engineered
Biomaterials
Harvard University
2012-present
MEMP Board of Advisors
MIT
2013-present
Chair, FDA Outreach Committee
MIT
2013-present
Presidents Initiative on
Innovation
MIT
2013-present
IMES Faculty Search Committee
MIT
Study Section:
1993
1994
1994-present
1996
1998-2002
1999-2002
1999-2003
2002
2004
2004
2006
Swiss National Science Foundation

National Institutes of Health - Technology and Applied Sciences
Israel Science Foundation
National Institutes of Health - Cardiovascular-A
American Heart Association - Cardiovascular Physiology & Pathophysiology
Massachusetts Affiliate, American Heart Association
American Heart Association Affiliate Consortia Northeast 1 Research
Peer Review Group
National Institutes of Health Chairman, Bioengineering Research Partnership
Review
National Institutes of HealthReviewer, Bioengineering Science and
Technology 50
CVS J 50Reviewer and Chairman, Cardiovascular Tissue Engineering
Bioengineering Research Partnership Study Section
National Institutes of HealthReviewer, International and Cooperative
Projects-1 Council
Elazer R. Edelman
2012
National Institutes of HealthReviewer, Gene and Drug Delivery (GDD) Study

section
2013
National Institutes of HealthReviewer, Gene and Drug Delivery (GDD) Study
section, February
2013
American Heart Association--Bioengineering BSc2 Study section, April
2013
National Institutes of HealthSpecial Emphasis Panel, coded ZRG1 SBIBX(02), June
2013-present National Institutes of HealthSurgical Sciences, Biomedical Imaging and
Bioengineering IRG (SBIB)
Professional Societies:
American Association of Physicians
American College of Cardiology
American Institute for Medical and Biological Engineering
American Society of Clinical Investigators
American Society of Mechanical Engineers
Association of University Cardiologists
Controlled Release Society
Institute of Medicine
National Academy of Engineering
Society for Biomaterials
Community Service Related to Professional Work:
Editorial Boards:
2009-present
2006-Present
2011-present
1991-present
1990-Present
1988-Present
2000-present
2003-present
2010-present
1988-Present
2010-present
1996-Present
1989-Present
2014-present
2006-Present
1994-Present
2010-present
2002-present
1994-Present
Acta Biomaterialia
Acute Cardiac Care Journal
Advanced Materials
Am Heart Journal
American Journal of Cardiology
American Journal of Medicine
American Journal of Physiology
American Society of Nephology
Angiogenesis
Annals of Biomedical Engineering:
Annals of Epidemiology
Arteriosclerosis, Thrombosis and Vascular Biology
Biomaterials
Biomaterials Research
Biomedical Materials
Biophysical Journal
Cancer Research
Cardiovascular Pathology
Cardiovascular Radiation Medicine
7
Ad Hoc Reviewer
Editorial Board
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Editorial Board
Associate Editor
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Elazer R. Edelman
1999-Present
2002-present
1996-Present
1993-Present
1998-Present
1989-Present
2009-present
2000-present
1995-Present
2000-present
2010-present
2010-present
2010-present
2007-present
1999-Present
2009-present
2007-present
1989-present
2013-present
1989-Present
2000-present
1987-Present
2004-Present
2004-Present
1988-Present
2003-present
1989-present
2009-present
1996-Present
2008-present
2009-present
1999-Present
2000-present
1993-Present
2009-present
1990-Present
1999-Present
1985-present
2010
1990-Present
Cardiovascular Radiation Medicine

Cardiovascular Revascularization Medicine
Catheterization and Cardiovascular Diagnosis
Chest
Circulation
Circulation Research
Circulation, Intervention
CRT
Drug Delivery
Elsevier
emedicine.com
Eurointervention
European Journal Of Cancer
Experimental cell Research
Frontiers in Interventional Cardiology
heart.org
IOS Press
Journal of American College of Cardiology

Journal of American Medical Association
Journal of Biomechanics
Journal of Biomedical Materials Research
Journal of Cardiac Failure
Journal of Clinical Investigation
Journal of Controlled Release
Journal of Histochemistry and Cytochemistry
Journal of Pharmaceutical Sciences
Journal of Royal Society Interface
Journal of the American College of Cardiology
Journal of Theoretical Biology
Journal of thrombosis and hemostasis
Journal of Vascular Research
Journal of Vascular Surgery
Macromolecules
Medical Engineering & Physics
Nature
New England Journal of Medicine
Pharmacologic Research
PLOS-ONE
Proceedings of the National Academy of Sciences
Regenerative Engineering and Translational
2015-present
Medicine
1996-Present REMEDICA
2004-Present SABioscience
8
Editorial Board
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Editorial Board
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Editorial Board
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Editorial Board
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Editorial Board
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Editorial Board
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Ad Hoc Reviewer
Editorial Board
Editorial Board
Ad Hoc Reviewer
Elazer R. Edelman
1990-Present Science
2009-2011 Science Translational Medicine
2011-present Science Translational Medicine
2000-present Seminars in Immunology
1990-Present The Lancet
2013-Present Launching the MIT Innovation Initiative
Ad Hoc Reviewer
Senior advisor
Chief Scientific
Advisor
Ad Hoc Reviewer
Ad Hoc Reviewer
Faculty Advisory
Committee
Awards and Honors:

1973-1974
Harvard Book Prize
Telluride Scholarship - semifinalist
Citation of the Secretary of the Commonwealth of Massachusetts for
Excellence in State Funded Research
1978
M.I.T. Undergraduate Research Opportunities Program Citation Research
Excellence
1979
Sigma Xi
1980-1981
Kleberg Foundation Scholar in Health Sciences and Technology
1982-1983
Soma Weiss Award, Harvard Medical School
1983
Cum laude graduate, Harvard Medical School
1984-1985
Surdna Fellowship Award, M.I.T.
1989
Inaugural Address, 350th anniversary the University of Helsinki
1989-1991
Grant-in-Aid, American Heart Association
1989-1994
Physician-Scientist Award, National Institutes of Health
1990
Syntex Scholar Finalist
Visiting Professor, Dept. of Vascular Surgery, Northwestern Medical School
1991
Katz Award, American Heart Association, Finalist
1992
Marcus Award, American Heart Association
1993-1996
Hermann von Helmholtz Chair, MIT
1993-1995
Johnson and Johnson Foundation Grant
1993-1996
Whitaker Foundation Young Investigator Grant in Biomedical Engineering
1994
Cardinal and Gray Lecturer, MIT
1994-1997
Whitaker Foundation Special Opportunity Award in Biomedical Engineering
1994-2002
Perivascular Drug Delivery, NIH-NIGMS (grant # 1R01-GM49039-06)
1994-1999
Burroughs Welcome Award in Experimental Therapeutics
Development of the MIT Quantitative MICR
1995
Academic Research Infrastructure Grant, NSF, (grant # NSF BIR-9512316)
1996-1997
Thomas D. & Virginia W. Cabot Chair, MIT
1997
Tenure, MIT
John F. and Virginia B. Taplin Award
Tau Beta Pi Leonardo Da Vinci Lecturer
1998
Honorary Member, Israel Society of Interventional Cardiology
Visiting Professor, Thomas Jefferson University Hospital
1999-2002
Diabetes Mellitus and Vascular Repair, AHA: Established Investigator
Award, (grant # AHA9940449U)
1999
Simon Dack Visiting Professor, Mount Sinai School of Medicine
9
Elazer R. Edelman
1999-2004
2000
2000
2001
2001
2002
2005
2005
2006
2006
2007
2007-2008
2008
2008
2008
2009
2009
2010
2011
2011
2011
2011
2011
2011
2011
Visiting Professor, Mount Sinai School of Medicine

Visiting Professor, University of Pennsylvania, Institute of Medicine
Biology of Tissue Engineered Endothelial Implants
NIH/NIGMS (grant # NIH 1R01HL60407-01A1)
First Place, V.I.R. Category, National Society for Histotechnology Poster
Session Special Recognition Award
Thomas A. McMahon Mentoring Award, Harvard University / Massachusetts
Institute of Technology Division of Health Sciences and Technology
Fellow, American Institute for Medical and Biological Engineering
Member, American Society for Clinical Investigation
Hermann Lecturer and Visiting Professor, Dept. of Medicine, University of
Texas, Galveston
Scholar, Academy at Harvard Medical School
Visiting Professor, Norwegian University of Science and Technology,
Department of Biology-Molecular/Cellular
Distinguished Speakers in Bioengineering, University of Toronto, Institute of
Biomaterials and Biomedical Engineering.
American Society for Testing and Materials (ASTM) Joseph S. Barr Award
Fellow, Institute of Medicine, National Academies of Science
Feigenbaum/Levine Lecture, Beth Israel Deaconess Hospital
A. Clifford Barger Excellence in Mentoring Award
Hellenic Atherosclerosis Association 4th Scientific Conference Manuscript
Recognition Award, Thessaloniki, Greece (Circulation 2008 117:993-1002)
European Society of Cardiology Young Investigator Award (Y Chatzizisis et
al, Circulation 2008 117:993-1002)
Ioannis Vlyssidis Award, Academy of Athens (Circulation 2008 117:9931002)
Jeffrey M. Hoeg Arteriosclerosis, Thrombosis and Vascular Biology Award
for Basic Science and Clinical Research
European Society of Cardiology Young Investigator-Working Group Award (Y
Chatzizisis et al Circulation 2011 123:621-30)
Officers Cross of the Civil Merit from the Spanish Government
European Atherosclerosis Society Award for Best Paper in Clinical Research
(Circulation 2011 123(6):621-630)
Atherosclerosis Society of Northern Greece Award for Best Abstract of nonHellenic origin (Koskinas KC et al. Book of Abstracts p. 36)
Nominee, Harvard Medical School Donald OHara Faculty Prize for
Excellence in Teaching (Years I & II)
Plenary Lecture, American Society of Mechanical Engineering Annual
meeting
Deans Distinguished Lecture, The Fu Foundation School of Engineering and
Applied Science, Columbia University, New York, New York
Lewis Katz Visiting Professorship in Cardiovascular Research, Columbia
University
European Society of Cardiology Young Investigator Award (M. Papafaklis et
al European Heart Journal 2011 Abstract Supplement 32:156)
10
Elazer R. Edelman
2011
2012
Visiting Professor, Yale University

Hollingsworth Distinguished Lecturer, University of Texas at Austin,
Department of Biomedical Engineering, Cockrell School
Fellow, National Academy of Engineering
Fellow, American Association of Physicians
Fellow, Association of University Cardiologists
Keynote Address, Society for Biomaterials, 2013 Annual Meeting &
Exposition, Boston, MA
Keynote Address, 11th International Congress on Medical Librarianship, the
7th International conference of Animal Health Information Specialists and the
6th International Clinical Librarian Conference
Clemson Award for Basic Research, The Society For Biomaterials
Fellow, American Academy of Arts and Sciences
Lifetime Achievement Award, International Conference on Innovation
Fellow, National Academy of Inventors
Deans Distinguished Lecture, Weill-Cornell Medical School
Massimo Calabresi Lecturer, Yale University
2012
2012
2012
2013
2013
2014
2015
Research, Teaching, and Clinical Contributions:

A.
Narrative report
Prof. Edelman holds tenured faculty appointments in the Department of Medicine at Harvard
Medical School, and in the Division of Health Sciences and Technology at the Massachusetts
Institute of Technology. He is the director of the Harvard-MIT Biomedical Engineering Center
and of MITs Clinical Research Center, and the current occupant of the Thomas D. and Virginia
W. Cabot Chair at MIT.
Elazer R. Edelman received Bachelors and Masters degrees in Electrical Engineering from
the Massachusetts Institute of Technology, an M.D. degree with distinction from Harvard Medical
School, and then his Ph.D. in Medical Engineering and Medical Physics from the HarvardMassachusetts Institute of Technology Division of Health Sciences and Technology. His doctoral
thesis concentrated on the definition and characterization of polymeric controlled drug release
systems. After receiving his degrees he completed an internship and residency in Internal Medicine
and fellowship in Cardiovascular Medicine, all at the Brigham and Women's Hospital in Boston.
He is a fellow of the American College of Cardiology and currently serves as one of the Core
Attending Physicians in the acute coronary care unit at the Brigham and Women's Hospital.
Prof. Edelmans research interests combine his scientific and medical training. His work
integrates multiple disciplines including polymer based controlled and modulated drug delivery;
growth factor biology and biochemistry; tissue engineering; biomaterials-tissue interactions and
the vascular response to injury. He uses elements of continuum mechanics, digital signal
processing and polymeric controlled release technology to examine the cellular and molecular
mechanisms that produce accelerated atherosclerosis and transform stable coronary artery disease
to unstable coronary syndromes. With this as a foundation the Edelman laboratory set the way for
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Elazer R. Edelman
the development and optimization of most of the clinically approved bare metal and drug-eluting
endovascular stents. His work on angiogenesis includes basic studies of endothelial cell and
vascular biology, computational modeling of vessel formation, and creation and use of controlled
angiogenic factor release devices in clinical trials. His most recent publications have focused on
how tissue engineered cells might be used for the local delivery of growth factors and growth
inhibitors in the study of the vascular homeostasis and repair, cancer invasiveness and metastases
and the homology between endothelial paracrine and angiocrine regulation in cancer and vascular
diseases.
He has mentored more than 300 graduate students and postdoctoral fellows. Among Dr.
Edelmans most important accomplishments are marrying his wife Cheryl, and surviving the
increasingly adventurous childhood and young adulthood of his three boys, Alex, A.J. and Austin,
which includes coaching their Bantam hockey team.
Dr. Edelman's research program falls in a variety of general categories:
POLYMER-BASED CONTROLLED AND MODULATED DRUG DELIVERY
Standard means of drug administration are unacceptable for the newer classes of drugs and
many experimental compounds. Polymer-based controlled drug delivery is used to obtain
sustained and modulatable drug delivery. There is a particular focus on the design and development
of such systems, mathematical modeling of transport from these systems and the in vivo use of
these devices in understanding their impact and potential use in a variety of disease states.
VASCULAR BIOLOGY, GLYCOBIOLOGY, and GROWTH FACTOR BIOCHEMISTRY
The endogenous analog of local drug delivery involves natural signaling within tissues and
between cells. Accordingly the Edelman laboratory has for some many years defined cell-cell
interactions, and especially the forces that determine and drive autocrine, paracrine and endocrine
growth control. Polypeptide growth factors and their associated proteoglycan binding proteins
have been shown to play a primary role in the physiology of normal cells and tissues. In addition,
it has become increasingly appreciated that these factors may play a significant role in the
pathophysiology of many diseases. Natural storage, binding, stabilization and release of these
factors are being examined in hopes of understanding growth factor biology and how different
diseases are affected by these growth mediators.
From this perspective the Edelman laboratory has defined the nature of endothelial cell control
of vascular smooth muscle cells and monocyte-endothelial interaction with special attention to the
local regulation of angiogenic growth factors and associated proteoglycans.
TISSUE ENGINEERING
The findings in vascular biology stimulated studies at defining tissue physiology on the one
hand and in harnessing these insights to create synthetic constructs that possess bioregulatory
function. Tissue engineering of vascular cells allows both for a controlled means of examining
complex issues in tissue repair and as potential novel therapeutic modalities. Dr. Edelman uses the
science of tissue engineering to examine whether mechanical structure must be completely
recapitulated to regain full biochemical function of an injured blood vessel. In particular, he and
his colleagues investigate the linkage between the mechanical and biochemical aspects of
endothelial cell function. They have already shown that the endothelial cells need not reside at the
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Elazer R. Edelman
luminal interface for the endothelium to impose its biochemical control on the artery. In this regard
they have continued to use the complex architecture of the blood vessel wall, the controlled
vascular injury induced by implantation of endovascular devices and their knowledge of cell and
molecular vascular biology to examine autocrine and paracrine growth control. Of the most
intriguing findings are that the form and nature of the supporting extracellular matrix native and
synthetic allows endothelial cells to not only become immune tolerated but also
immunomodulatory. Preclinical findings have now been validated in five phase I and II clinical
trials where tissue engineered allogenic endothelial cells have staved off vasoproliferative disease
without engendering an immune response.
Most recently Edelman and his students have extended the angiocrine view of cancer control.
They have shown now how endothelial state governs cancer invasiveness and metastases just as it
does control of vascular repair. The have defined a spectrum of endothelial states quiescent cells
which offer structural support, reparative cells which inhibit cancer growth and metastases just as
they control smooth muscle cell proliferation and intimal hyperplasia, and dysfunctional
endothelial cells which promote these processes. Working with colleagues at the Brigham and
Womens Hospital benchtop and animal experiments have been validated in clinical specimens.
BIOMATERIALS - TISSUE INTERACTIONS
Increasingly mechanical interventions and composite devices are being used to deal with
complex disease. Using innovations in material science the Edelman laboratory has defined a set
of materials with tissue specific adhesion, regulated cohesion and the highest form of contextual
biocompatibility. Polymer based drug delivery systems, image analysis, molecular and cell
biology, and histo- and immunocytochemistry are used to more fully appreciate the role of locally
expressed growth mediators in the pathobiology of the tissue repair. Bench top work with isolated
cells in culture or cells grown on synthetic materials is verified in models of disease of increasing
complexity, including a range from small rodents to large animals.
DEVICE BIOLOGY
Edelman and his students have used their findings and resources in vascular biology and
immunology, materials science and pharmacology to define the cardiovascular reactivity to
implanted devices. Indeed, their basic work paved the way for modern endovascular stents and
their drug-eluting counterparts and more recently endovascular valve-stents. Edelmans work
served as the basis for regulatory guidelines and standards in this field.
TEACHING and CLINICAL WORK
Prof. Edelman is involved in a wide range of teaching programs at the Massachusetts Institute
of Technology, Harvard Medical School, Harvard University and the Brigham and Womens
Hospital. He directs HST090, Cardiovascular Pathophysiology, a 15 unit required course for all
medical and graduate students in the Harvard-MIT Division of Health Sciences and Technology.
This course uses a mechanistic focus and leverages quantitative sciences to explain fundamental
physiology and applied pathology of the heart and vascular system. Instruction emphasizes
hemodynamics, electrophysiology, gross pathology and clinical correlates of cardiovascular
function in health and a variety of disease states. Special attention is given to congenital, valvular,
myocardial, and arteriosclerotic coronary heart disease. The case method is emphasized in tutorial
sessions. There is extensive use of computers in accessing data bases and in quantitative modeling
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Elazer R. Edelman
of the circulation. Prof. Edelman also serves for 6-8 weeks per year as the teaching attending in
the Levine Cardiac Unit, the cardiovascular intensive care unit of the Brigham and Womens
Hospital. This ten bed unit provides clinical care for the most acutely ill patients with
cardiovascular diseases in the hospital including advanced heart failure, cardiogenic shock,
complicated myocardial infractions, refractory electrophysiologic disorders and complex
congenital heart disease in the adult. Dr. Edelman directs the care of these patients and the clinical
teaching of seven house officers, clinical fellows in cardiovascular medicine and nurses and
pharmacists. The latter involves education in the basic biology and physiology of disease, the
practical means of caring for intensive and acutely ill patients and the technical and procedural
aspects of such care including placement of central lines, pulmonary artery catheters, temporary
pacemakers, and intraortic balloon devices, pericardial and pleurocentesis, and ventilator
management.
Prof. Edelman is also Program Director of the MIT Graduate Education in Medical Sciences
(GEMS) sponsored by HHMI, intended to provide graduate students at MIT with deep exposure
to clinical sciences and applied biology. He routinely lectures as well in a range of MIT and
Harvard Courses.
B. Funding Information:
Past:
1989
Advanced Cardiovascular Systems
PI
Vascular Response to Endovascular

Stents
1989-1991
American Heart Association:

Massachusetts Affiliate Grant-in-Aid
PI
Vascular Response of Injury:

Controlled Adventitial Heparin
Delivery
1989-1994
National Institutes of Health: Physician PI

Scientist Program Award
Vascular Response of Injury: The

Effects of the Controlled Release of
Anti-proliferative Agents and
Oxygen Free-Radical Scavengers
1992-1994
Glycomed, Inc.
PI
Adventitial control of vascular injury
1993-1995
Zynaxis, Inc.
PI
Cell Biology of Linker Compounds
1993-1995
Johnson and Johnson Foundation Grant PI
1993-1996
Whitaker Foundation Grant in

Biomedical Engineering
PI
14
Controlled release of growth factors
Elazer R. Edelman
1994-1999
Burroughs Welcome Fund
PI
Experimental Therapeutics Scholar

Award
1995-1998
Whitaker Foundation Special

Opportunities Grant
PI
Center for Biomedical Engineering

Teaching Facility
1994-2002
R01, National Institutes of Health

(grant # NIH 5R01-GM49039)
PI
Perivascular Drug Delivery
1995-1998
NSF Infrastructure Development Grant PI
Quantitative Microscopy and

Imaging Networks
1997-1998
Whitaker Foundation Grant in

PI
Tissue engineered endothelial

implants
1997-1998
Taplin Development Award
PI
Harvard/M.I.T. Biomedical
Engineering Center
1997-1999
Center for Innovative and Minimally

Invasive Technologies
PI
Smart Catheter
1999-2001
National Science Foundation
PI
1999-2003
PI
2001-2005
DuPont-MIT Alliance Grant
Co-PI A Biological Wireless Link
2001-2003
SCIOS/Nova
PI
2003-2004
Johnson and Johnson/MIT
PI
FKBP Binding Kinetics
1999-2003

(grant # NIH 1R01HL60407-01A1)
PI
Biology of Tissue Engineered

Endothelial Implants
2003-2006
PI
Tissue and Cellular

Pharmacodynamics of Vascular
Growth
(grant # NIH HL67246
Established Investigator Award
Modulation of Kinase Signaling
2008-2009
Center for Integration of Medicine and PI

Innovative Technology
High Throughput Flow System for

the Generation of Thrombotic
Fingerprints
2006-2009
DuPont-MIT Alliance Grant
Bioadhesive Sealants
PI
15
Elazer R. Edelman
2007 2009
MIT Deshpande Center for Integration

of Medicine and Innovative
Technology
PI
Pericardial Inotropic Drug Delivery
2009-2011
R01 Supplement, National Institute of

Health (grant # NIH R01HL049039)
PI
Vascular Drug Delivery
2010
Center for Integration of Medicine &

Innovative Technology
PI
Tissue Engineering Therapies for

Inhalation Injury
2010-2011
Deshpande Center for Technological

Innovation
PI
Tissue Specific Adhesive Materials
2010-2011
Harvard Catalyst Pilot Grant
PI
Injectable Matrix Embedded

Endothelial Cells for Vascular
Therapy
2011- 2012
Medtronic Inc,
PI
Implications of Valve Frame

Fracture
2011-2013
Atrium Medical Corp
PI
Studying the Mechanistic Basis for

Novel Drug Eluting Stents,
2013-2014
Bonus Cellora
collab Harnessing the biology of resident

orator adult cardiac stem cells to establish
myocardial regeneration protocols
without the need of cell
transplantation
2012-2015
Bioiberica S.A.
Colla Effect of Chondroitin Sulfate

borat Treatment on Inflammatory
or
Response Associated with
Balce Atherosclerotic Lesions
llsCamp
s (PI)
Current:
ACTIVE
16
Elazer R. Edelman
02/01/201106/30/2016
Atrium Medical Corporation
PI
Mechanistic Basis for

Novel Drug Eluting
Stents
07/01/201205/31/2016
NIH R01GM049039-18
PI
Vascular Drug
Delivery
02/01/20131/31/2016
Sanofi
PI
Understanding
Dynamic Behavior of
Degradable Materials
in Disease States:
Development of
Tunable Smart
Materials
08/01/201312/31/2016
Minnesota Mining &

Manufacturing Co. (3M)
PI
Development of
Smart and Tunable
Topical Adhesive
09/15/201312/31/2016
NOF Corporation
PI
Characterization of
Peg-Based Hydrogels
06/01/2015 Medtronic Inc

04/13/2016
PI
09/01/2014 Deshphande MIT

12/31/2015
Calcium Risk Score

for Predicting Severe
Adverse Events in
TAVR
PI
Queen Mary, University of

05/01/2014 London
4/30/2016
PI
Drug-eluting platform
device to locally treat
pancreatic cancer
04/19/15
09/15/2015
PI
Edwards Life Sciences LLC
17
Hydrogelnanoparticles patches
as prophylactic
scaffold agents for in
vivo local gene/drug
delivery in colorectal
cancer tumors
Improving the
diagnosis and therapy
of structural heart
disease
Elazer R. Edelman
11/14/2014 Massachusetts General Hospital

11/30/2018
07-08-2015 Center for Integration of Medicine

07/07/2016
& amp; Innovative Technology
05/01/2015 Harvard Medical School

10/31/2015
PENDING
10/01/201409/30/2016
PI
PI
PI
NIRF-OFDI of
inflammation in
atheroma progression
and stent
complications
Optimizing tissue
engineering therapies
for airway injury in
the battlefield
Clinical Translation
Science Award
(CTSA) MIT-CCR
NIH
collaborator
VCA
Tolerance
Partnership:
First
Standardized
Multicenter
Upper
Extremity
4/01/201403/31/2019
NIH-R01
Collaborator
Farrouc Jaffer
(PI)
NIRF-OFDI of
Inflammation in
Atheroma Progression
and Stent
Complications
07/01/201406/30/2019
NIH-R01
PI
01/01/2016
Vascular Response
and Clinical Outcome
in Endovascular
Therapies
American Heart
Association
PI
Quantification and
systematic
differentiation of
impact of paravalvular
leaks following
12/31/2017
PI
18
Elazer R. Edelman
06/01/2015
Abiomed
PI
transcatheter aortic
valve replacement
07/01/2015
06/30/2018
Brigham & Womens

Hospital
PI
Determination of
Organ Function via
Integrated Device
Parameters
09/01/2015
08/31/2020
Mayo Clinic Rochester
PI
Pilot Study on
feasibility of lower
extremity
transplantation
01/15/2016
C.
Regulatory genechemokine networks

in the formation of
hemodialysis AVF
stenosis
Report of Current Research Activities:
Bench:
1. Paracrine and autocrine mechanisms of growth control
2. Vascular injury and repair
3. Cell-cell communication within the blood vessel wall
4. Transformation of stable atherosclerotic processes to unstable syndromes
5. Application of biomedical engineering and physics to cell and molecular biology
6. Biology and biochemistry of growth factors
7. Transvascular transport of therapeutic compounds and endogenous growth mediators
Clinical:
D.
Report of Teaching:
1.
a.
Local contributions
Medical School courses
Harvard-MIT Division of Health Sciences and Technology, Harvard Medical
School, Boston
HST-050
Quantitative Physiology
1979
Tutor
25 Medical students
96 hours/year
HST-010
Anatomy
19
Elazer R. Edelman
1980-present
Lecturer
40 Medical and Graduate students
4 hours/year
HST-090
1980, 1982
1991-1998
1999-present
Cardiovascular Pathophysiology
Tutor
Core faculty member
Director
60 hours/year
HST-150
1989-1995
Pharmacology
Founding and core faculty member
60 hours/year
HST-240
1989-present
Physician-Scientist Preceptorship
Founding faculty and course director
required graduation 1 month elective
HST-521
2005-present
Biomaterials and Tissue Engineering in Medical Devices

and Artificial Organs
Lecturer
HST-582
2003-present
Biomedical Signal & Image Processing

Lecturer
HST-500
2007
Frontiers in (Bio) Medical Engineering and Physics

Lecturer
Harvard Medical School, Boston

Metabolism and Function of Human Organ Systems
1988-present
Lecturer
125 Medical Students
4 hours/year
Third Year Harvard Medical Student Rotation in Internal Medicine
1989-present
12 Medical Students
4 hours/year
Clinician-Scientist PreceptorshipMIT & HMS Teaching Hospitals
2006-present
Graduate Students
20
Elazer R. Edelman
b.
1976
21.737
English Literature
1977
6.082
Acoustics
1978-1989
6.023J
Quantitative Physiology: Organs and

Systems
1984
1984
20.035
HST-590
Pharmacoengineering
1995-1999
3.081
Materials Science Laboratory
Graduate medical courses

1989-1992
Introductory Course for First Year Cardiology Fellows,

Brigham and Womens Hospital, Boston
Organizer and Lecturer
20 cardiology fellows, and faculty members
25 hours per year
c.
Local invited teaching presentations
d.
Continuing medical education courses
e.
1989-2000
Cardiovascular Pathophysiology for Engineers and

Scientists
Harvard-MIT Division of Health Sciences and Technology,
Cambridge, summer professional program
Lecturer
100 engineers and biomedical technology professionals
1985-2005
Intensive Review of Internal Medicine

Department of Internal Medicine, Brigham and Womens
Hospital, Boston
Lecturer and case review
600 internists (Lecturer)
1985-2005
Intensive Review of Cardiovascular Medicine

Cardiovascular Division, Brigham and Womens Hospital,
Boston
Lecturer and case review
250 cardiologists/internists (Lecturer)
30 cardiologists/internists (Electrocardiograms)
Advisory and supervisory responsibilities in clinical and laboratory settings
21
Elazer R. Edelman
f.
g.
1989-Present
Brigham and Womens Hospital, Boston

Coronary Care Unit and Cardiology consult service attending
2-3 days/week
1995-Present
Postdoctoral research supervisor

4-6 cardiology fellows/year
6-12 post-doctoral fellows/year
6-10 graduate students/year
4-6 medical students/year
4-8 undergraduate students/year
Teaching leadership role

1995-Present
Director, Biomedical Engineering Center, Harvard-MIT Division

of Health Sciences and Technology
1997-2001
Executive Committee, Center for Innovation and Minimally

Invasive Technology, Partners in Health, Brigham and Womens
and Massachusetts General Hospitals
1995-present
Director, HST090, Cardiovascular Pathophysiology
2005-present
Director, MIT Graduate Program of Excellence in Medical

Sciences (GEMS), Howard Hughes Medical Institute
Names of advisees and trainees

Dates
Name
Current Status
1980-1982
Wayne Rubenstein, M.D.
Neurologist, Park Ridge, IL
1981-1984
John Taylor, M.D.
Practicing Physician
1985-1989
Anthony Fiorino, M.D., Ph.D.
EMF Portfolio Manager, Biotechnology

Pequot Capital Management
1986-1988
Robert Silbergleit, M.D.
Assistant Professor, Dept. of Emergency

Medicine, University of Michigan
1989-1992
Jonathan Stiber, M.D.
Cardiologist Duke University Medical Center
1990-1992
Oliver Chen, M.D.
Physician-Scientist
1990-1993
Matthew Nugent, Ph.D.
Professor, Biochemistry and Ophthalmology,

Boston University School of Medicine
22
Elazer R. Edelman
Dates
Name
Current Status
1990-1994
Campbell Rogers, M.D.
Chief Technology Officer, Johnson &

Johnson-Cordis Corp.
Associate Professor, Harvard Medical School
1991-1992
Afshin Farzenefar, M.D.
Physician-Scientist, United Kingdom
1991-1995
Anthony Patire
Engineer, MIT
1992-1993
Joshua Milner, M.D.
Laboratory of Immunology, NIAID, NIH,

Bethesda, MD
1992-1994
Aruna Nathan, Ph.D.
Scientist, Johnson & Johnson
1993-1995
Greg Zaharchuk, Ph.D.
Radiology Fellow, University of CaliforniaSan Francisco
1993-1997
Iveta Dinbergs, Ph.D.
Assistant Professor, Middlesex Community

College
1993-1997
Edward Koo, Ph.D.
Scientific Director, Cardiovascular System

Program, GeneLogics
1994-1996
Larry Brown, Sc.D.
Senior Vice President, Research and

Development, EPIC
1994-1996
Martin Sirois, Ph.D.
Associate Professor, Montreal Heart Institute
1994-1997
Richard Han, M.D.
Cardiologist, Private Practice
1995-2000
David Ettenson, Ph.D.
Senior Scientist, Angiotech Pharmaceuticals.
1995-2005
Adam Groothuis, Ph.D.
Vice-President, Mitralign
1995-1998
Sohah Iqbal, M.D.
Interventional Cardiologist, New York

University Medical Center
1995-1997
Michael Kjelsberg, M.D.
Cardiologist, Mt. Auburn Hospital;

Instructor in Medicine, Harvard Medical
School
1995-1997
David Tseng, Ph.D.
Senior Research and Development Engineer,

Medtronic AVE, Inc.
1995-1997
James Squire, Ph.D.
Assistant Professor, Electrical Engineering at
23
Elazer R. Edelman
Dates
Name
Current Status
Virginia Military Institute
1995-1998
Frederick Welt, M.D.
Director, ECI Lab, Brigham and Womens

Hospital;
Lecturer, Tufts University Medical School
1996-1999
Anthony English, M.D.
Assistant Professor, Biomedical Engineering,

University of Tennessee
1996-2001
Joseph Garasic, M.D.
Attending Physician, Cardiology

Massachusetts General Hospital;
School
1996-1997
James Januzzi, Jr., M.D.
Attending Physician, Cardiology,

Associate Professor in Medicine, Harvard
Medical School
1996-1997
Stephanie Nonas, M.D.
Fellow, John Hopkins, Division of Pulmonary

and Critical Care
1996-1997
Helen Nugent, Ph.D.
Senior Director, Product Development,

Pervasis Therapeutics Inc.
1996-1997
Toussaint Smith, M.D.
Cardiologist
1996-1999
Thanh-Nga Tran, Ph.D.
Clinical Fellow, Dermatology, Massachusetts

General Hospital
1996-1998
Wade Wan, Ph.D.
Graduate Student, M.I.T
1996-2002
David Wu, M.D., Ph.D.
Resident in Pathology, Brigham and Womens

Hospital
1996-2000
Chun Yu, Ph.D.
Senior Scientist, Medtronic

Author and Poet
1997-2000
Douglas Drachman, M.D.
Attending Physician, Cardiology

School
1997-1999
Omar Elmalak, Ph.D.
Projects Manager, Bio-Rest, Ltd.
24
Elazer R. Edelman
Dates
Name
Current Status
1996-2004
1997-2003
2010-
Chao-Wei Hwang, M.D., Ph.D. Assistant Professor, Johns Hopkins

University, Cardiovascular Division
.
Kumaran Kolandaivelu, M.D. Instructor, Harvard Medical School, Brigham
Ph.D.
and Womens Hospital,
1997-1999
Insup Noh, Ph.D.
Professor, Seoul National University of

Technology
1997-2001
John Paolini, M.D., Ph.D.
Director, Clinical Cardiovascular Research,

Merck & Co.
1998-1999
Chris Creel, M.D.
Radiologist, Private Practice Michigan
1998-
Amy Lee, M.D.
Neurology Residency, University of

California-San Francisco
1998-2000
Audrey Marshall, M.D.
Attending Physician, Pediatric Cardiology,

Boston Childrens Hospital;
Instructor, Harvard Medical School
1998-2000
Sahil Parikh, M.D.
Assistant Professor of Medicine, Case

Western Reserve School of Medicine
Director, Experimental Interventional
Cardiology Laboratory
Harrington-McLaughlin Heart and Vascular
Institute
University Hospitals Case Medical Center
1998-1999
Venkatesh Raman, M.D.
Cardiology Fellow, Georgetown University
1998-1999
Cindy Richmond
Field Scientist, Massachusetts Fish and

Wildlife
1998-2003
Yoram Richter, Ph.D.
Vice President of Research and Development,

Biorest Ltd.
1998-2005
Vishal Saxena
Scientist, Orgill Lab, Brigham and Womens

Hospital; Kohane Lab, Boston Childrens
Hospital
1998-2000
Raymond Szeto
Attorney
1998-2000
T. Cooper Woods, Ph.D.
Professor, Ochsner Hospital Department of

Experimental Pharmacology and
25
Elazer R. Edelman
Dates
Name
Current Status
Therapeutics, LSU Health Sciences Center
1998-2000
Jane Yoo
Graduate Student, M.I.T.
1999-2009
Brinda Balakrishnan, M.D.,

Ph.D.
House Officer, Beth Israel-Deaconess

Program
1999-present
Mercedes Balcells, Ph.D.
1999-2001
Fardad Hashemi
Research Scientist, M.I.T.

Professor, IQS
Graduate Student, M.I.T., Internal
1999-2008
Kha Le
Senior Research Scientist, Millennium Corp.,

Cambridge, MA
1999- present Mark Lovich, Ph.D.
Attending Physician, Caritas Medical Center;

Assistant Professor, Tufts University Medical
School
1999-2001
Rosanne Rouf, M.D.
Cardiology Fellow, Johns Hopkins University
1999-2003
Mathew Walker, Ph.D.
Senior Research Scientist, Dept. of

Pharmacology, Merck Research Laboratories
2000-2003
Haim Danenberg, M.D.
Professor, Hadassah Hospital, Hebrew

University
2000-2003
Wen-hua Fan, Ph.D.
Senior Scientist, Sci-Tech, Inc.
2000-2001
Marta Fernandez-Suarez, Ph.D. Research Fellow, Center for Engineering in

Medicine, Massachusetts General Hospital;
Visiting Scientist, Harvard School of Public
Health
2000-2005
Andrew Levin, Ph.D.
2000-2006
Alisa Morss, Ph.D.
2000-2003
Colin Tso, M.D.
Senior Research Fellow, Heart Research

Institute, Cardiologist, Sydney, Australia
2000-2007
Neda Vukmirovic, Ph.D.
Project Manager Regenerative Products,

Institut Straumann AG, Zurich, Switzerland
2000-200
Peter I-Kung Wu, Ph.D.
Stanford University Medical School student
Principal, Tang Capital Management Co., San

Diego, CA
Professor, Drexel University
26
Elazer R. Edelman
Dates
Name
Current Status
2001-2006
2006 -2010
Aaron Baker, Ph.D.
Asst. Professor, Dept. of Biomedical

Engineering, University of Texas, Austin
2001-2005
Michael Feldstein, M.D.
2001-2002
Jack Morshedzadeh, M.D.
Orthopedic Surgery Resident-University of

California San Francisco (UCSF)
Cardiology Fellow, University of Utah
2001-2004
Collin Stultz, M.D., Ph.D.
2001-2002
Ana Sala Roca
2001-2002
Blanca San Miguel Riva, Ph.D. Molecular Scientist, Lab 21, Cambridge,
England
2004-2005
2007-2008
Rajesh Swaminathan, MD
Assistant Professor, Cornell-New York

Presbyterian Hospital
2002-2003
Brad Carafino, MD
Orthopedic Surgical Resident, Yale
2002-2004
Chen Wen Huang
Graduate Student, M.I.T.
2002-2003
Maria Sotomayor
MBA candidate, International Graduate

School of Management (IESE), Barcelona
2002-2003
Maria Vasquez
Scientist
2002-2008
Rami Tzafriri, Ph.D.
Concord Biomedical Sciences and Emerging

Technologies (CBSET), Lexington, MA.
2002-2007
Shai Schubert, Ph.D.
CEO, Moma Therapeutics
2003-2004
Vu Quan, M.D.
Visiting Scholar
2003-2009
Sylaja Murikipudi
Research Scientist, Smart Cells Inc., Beverly,

MA
2003-2004
Ramon Salsas
Ph.D. Candidate, MIT -Computational and

Systems Biology (CSBi)
2003-2004
Blanca Molins
Ph.D. Candidate, Institut Catala de Ciencies
2003-2006
Michael Jonas, M.D.
Senior Interventional Cardiologist,

Catheterization Laboratory, Sheba Medical
Center, Tel Aviv
27
Professor, IMES & Electrical Engineering,

MIT
Ph.D. Candidate, ETH-Zurich
Elazer R. Edelman
Dates
Name
Current Status
2003-2006
Heiko Methe, M.D., Ph.D.
Assoc. Prof. and Cardiologist, University

Hospital Grosshadern, Munich
2004-2005
Maria del Carmen Alegret
Project Engineer, CPQ Ingenieros
2004
Ariadna Paz
Scientist, Generalitat de Catalunya
2004-2005
Maria Tarragona
Ph.D. candidate, University of Barcelona
2004-2010
Li Yuan Mi, Ph.D.
Post-doctoral Associate
2004-2005
Mamorou Nanasoto, M.D.
Visiting Scientist
2007
Davis Arifin
Graduate Student, National University of

Singapore
2004-2010
Tarek Shazly
Asst. Professor, Mechanical Engineering,

University of South Carolina
2005
Janne Ostvang
Assistant Professor, Norwegian University of

Science and Technology
2004-2006
David Elihu
Junior Associate, Ropes and Gray LLP, New

York, New York
2005-2007
Javier Echenique, M.S.
Clinical Specialist, Medtronic, Inc., New

York, New York
2005-2008
Hector Mobine
Scientist, Amgen Corp., Thousand Oaks, CA
2005-2009
Brett Zani, Ph.D.
Project Manager, Concord Biomedical

Sciences and Emerging Technologies,
(CBSET, Inc.) Lexington, MA
2005
Irina Alexander
Ph.D. Candidate, ETH-Zurich
2005-2009
Natalie Artzi, Ph.D.
2009- present
2006-2007
Neal Kantak, M.D.
Postdoctoral Associate
Research Scientist, M.I.T.
Assistant Professor, Harvard Medical School
Resident, Internal Medicine
2006-2007
Nelson Moussazadeh, M.D.
Resident, Neurosurgery
2007-2008
Pavan Cheruvu, M.D.
Resident
28
Elazer R. Edelman
Dates
Name
Current Status
2006-2010
Joseph Franses, Ph.D.
HMS student
2005- 2006
Marina Santacana
2005- 2007
Alex Benarroch
Technical Assistant, Morchem S.A.C.,

Barcelona, Spain
Ph.D. Candidate, University of Barcelona
2006
Hector Perea
Ph.D. Candidate, Institute for Medical

Technology, Technical University, Munich
2005-2008
Shmulik Hess, Ph.D.
CEO, Active P
2006-2007
Roy Beigel, M.D.
Resident, Internal Medicine, Tel-Hashomer

Hospital, Chaim Sheba Medical Center,
Ramat Gan, Israel.
2006-2007
Cristina Crespo Roman
Project Manager, Miguel y Costas, S.A.,

Barcelona, Spain
2006-2007
Carla Olive Vinas
Business Analyst, Arthur D. Little, Barcelona,

Spain
2006-2011
Vijaya Kolachalama, Ph.D.
Scientist, Charles Stark Draper Laboratories
2007-2008
Cristina Puron Garcia-Tellez
Visiting Scholar
2007-2008
Juan Monter Solans
Project Manager, Sistemas de Filtrado y

Tratamiento de Fluidos, S.A. (STF FILTROS)
2007
Jordi Torres Mallol
McKenzie Consulting
2007-2010
Luismar Marques Porto, Ph.D. Visiting Scientist
2007-2008
Fieta Boehning
Graduate student at RWTH Aachen

University, Aachen, Germany
2008
Motta Golomb
Medical student, Hebrew University,

Jerusalem
2008
Andriana Nikolova
Resident, Massachusetts General Hospital
2008-
Kay Furman
Graduate Student, MIT Internal
2008-
Laura Indolfi, Ph.D.
29
Elazer R. Edelman
Dates
Name
Current Status
2008
William Hwang
2008-2011
Vipul Chitalia, M.D., Ph.D.
Postdoctoral Fellow
2008-2009
Adriana Bon Ramos
Graduate Student, University of Portland,

Oregon
2008-2009
Jason Wu
2008
Jose Antonio Bea Cascarosa,

Ph.D.
Eytan Abraham, Ph.D.
Cardiology Resident, University of Michigan

Medical System, Ann Arbor, MI
Professor, University of Zaragoza, Spain
2008-2010
2009-2013
Jordi Martorell
2014- present
2009
Agua Sobrino
R&D Project Manager, Pluristem

Therapeutics Inc.
Graduate Student, IQS MIT
Visiting Scientist
Visiting Scholar
2009-2010
Dr. Laith Rabadi, M.D.
Visiting Scientist
2009-present
Alexis Turjman
2009
Miquel Duran
Visiting Scholar
2009
Remi Jolibois-Quinot
Visiting Scholar
2009
Alex Nichols
2009-2010
Sagi Shitreet
Visiting Scholar
2009-present
Natalia Drosu
Graduate Student
2009-2011
Nuria Oliva
2011- present
2010
Helena Mateu
Visiting Scholar
Visiting Scholar
2010-2013
Elisabet Rosas
Visiting Scholar
2010
Benjamin Oller
Visiting Scholar
2010-2013
Maria Carcole
Visiting Scholar
2010
Alfredo Palmes
Visiting Scholar
2010
Matthew Canver
M.D., Ph.D. student
30
Elazer R. Edelman
Dates
Name
Current Status
2010-2012
Ayumi Miyakawa, Ph.D.
Assistant Professor, InCor, Brazil
2010-2012
Juliana Dreyfuss, Ph.D.
Assistant Professor, Molecular Biology,

Federal University of Sao Paulo, Sao Paulo,
Brazil (UNIFESP)
2011
Leticia Fernandez Carballo
Visiting Scholar
2011
Begona Canovas Bilbao
Visiting Scholar
2011
Maor Hadar
Visiting Scholar
2011
Ela Levy
Visiting Scholar
2011
Vladik Yushvaev
Visiting Scholar
2011- present Ramon Partida, MD
2011-2012
Jay Wang
Harvard Medical School Student
2011-2012
Alina Freiman
Visiting Scholar
2011-2012
Zohar Shatsberg
Visiting Scholar
2011-2012
Moshe Beck
Visiting Scholar
2011-2012
Vinicius Bassanese
Visiting Scholar
2011-2012
Marc Mier Cervantes
Visiting Scholar
2011-2014
King, Carin
Undergraduate
2011- present St-Pierre, Melissa
Research staff
2012-2014
Caroline O'Brien, PhD
Research Associate
2012
Gabriel Cunha, PhD
Research Associate
2012
Shirley Galbiati
Student
2012-2013
Regina Kelmansky
Graduate Student
2012- 2014
Rita Beckerman
Graduate Student
2012- 2014
Iris Sheu
Undergraduate
31
Elazer R. Edelman
Dates
Name
Current Status
2012-2013
Maryam Zekavat
Undergraduate
2012- present Brett Boval
Graduate Student
2012- present Jonathan Brown
Research Staff
2012-present
Luccie Wo
HST MD PhD
2012-present
Mie Kunio
MEMP Graduate Student
2012-present
Ben Leiden
Research Staff
2011-2013
Michael Papafaklis, MD
Research Associate
2013-present
Claire Conway, PhD
Research Associate
2013- present Pedro Melgar, PhD
Research Associate
2013-present
Augusto Celso de Araujo

Lopes Junior, MD
Research Associate
2013-present
Shimon Unterman, PhD
Research Associate
2013-present
Sara Strecker, PhD
Research Associate
2013-present
Lyndon Charles, PhD
Research Associate
2013-present
Hyun Seok Song, PhD
Research Associate
2013-present
Eric Yi, Phd
Research Associate
2013-present
Brian Bergmark, MD
Research Affiliate
2013-present
Or Gadish
MEMP Graduate Student Student
2013-2014
Denis Kramarenko
UnderGraduate Student
2013-2014
Maria Pont
Graduate Student
2013-2014
Sivan Selikter
2013-2014
Fernando Garcia Polite
Graduate Student
2013-2014
Ferran Guedea Ripoll
Graduate Student
32
Elazer R. Edelman
Dates
Name
Current Status
2014-present
Joao Diogo Osorio de Castro

Conde
Research Associate
2014 - present Zahra Keshavarz-Motamed
Research Associate
2014 - present Farhad Rikhtegar Nezami
Research Associate
2014-present
Adar Oren
2014-present
Dmitry Pivovarchik
2014-present
Mariana Atilano
Graduate Student
2014-present
Mario Lopez Moya
Graduate Student
2014-present
Paula Del Rey Puech
Graduate Student
2014-present
Samantha Stone
2014-present
Efrat Marcus Goffer
2014-present
Antonios P. Antoniadis
Research Affiliate
2014-present
Ioannis Andreou
Research Affiliate
2014-present
Brian Chang
Graduate Student
2014-present
Aditya Kalluri
Graduate Student
2014-present
Kenta Nakamura
Research Associate
2014
David Ede
2014-present
Peijiang Wang
Graduate Student
2014
Sina Salehi
Sarnoff Fellow
2014-present
Daniel Lee
Medical Student
Theses Supervised:
Kinetic Profiles of Macromolecular Release from Polymer Matrices, Wayne Rubenstein,
Bachelors Thesis in the Department of Electrical Engineering and Computer Science,
Massachusetts Institute of Technology, June, 1982
33
Elazer R. Edelman
Dynamics of Macromolecular Release from Magnetically Modulated Polymer Matrices,

John Taylor, Bachelors Thesis in the Department of Biology, Massachusetts Institute of
Technology, May, 1984.
Controlled Release of Drugs from Surgical Suture, Aeseun Loh, Bachelors Thesis in the
Department of Materials Science and Engineering, Massachusetts Institute of Technology,
June, 1987.
Quantitative Image Analysis of Coronary Artery Disease, Robert Silbergleit, Bachelors
Thesis in the Department of Applied Biological Sciences, Massachusetts Institute of
Technology, May, 1988.
Determinants of Perivascular and Myocardial Neovascularization, Jonathan Stiber,
Bachelors Thesis in the Department of Mechanical Engineering, Massachusetts Institute of
Technology, June, 1992.
Perivascular Heparin Delivery Using Biodegradable Polymers, Marie Katada, Bachelors
Thesis in the Department of Mechanical Engineering, Massachusetts Institute of
Technology, May, 1994
Mechanics and dynamics of endovascular implants, James Squire, Masters Thesis in the
Department of Electrical Engineering and Computer Science, Massachusetts Institute of
Technology, February, 1997.
Mathematical Determinants of Transvascular Transport of Macromolecules, Mark Lovich,
Doctoral Thesis in the Harvard-MIT Division of Health Sciences and Technology,
Massachusetts Institute of Technology, June, 1997.
Quantification of the Distribution of Macromolecules in Vascular Tissue, Wade K. Wan,
Masters Thesis in the Department of Electrical Engineering and Computer Science,
Massachusetts Institute of Technology, February, 1998.
Quantification of Myocardial Macromolecular Transport, Jeff Hsing, Masters Thesis,
A Better Guess for a Downhill Simplex Method, Raymond Li, Masters Thesis,
Massachusetts Institute of Technology, June 2000.
In vivo determination of arterial resistance to heparin transport using a two-compartment
model, Stephanie Nonas, M.D. Thesis in the Harvard-MIT Division of Health Sciences and
Technology, Massachusetts Institute of Technology, June 2000.
Distant hemodynamic impact of local geometric alterations in the arterial tree, Yoram
Richter, Masters Thesis in the Harvard-MIT Division of Health Sciences and Technology,
34
Elazer R. Edelman
A finite element of study of different arteries, Vishal Saxena, Masters Thesis in the HarvardMIT Division of Health Sciences and Technology, Massachusetts Institute of Technology,
June, 2000.
Dynamics of Endovascular Stent Expansion, James Squire, Doctoral Thesis in the HarvardMIT Division of Health Sciences and Technology, Massachusetts Institute of Technology,
July, 2000.
Evaluation of Thrombotic Potential and Parameters of Intracoronary Prosthesis, Kumaran
Kolandaivelu, Masters Thesis in the Harvard-MIT Division of Health Sciences and
Technology, Massachusetts Institute of Technology, October 2000.
The Ultra Structural Basis for Macromolecular Transport in Vascular Tissue, Chao-Wei
Hwang, Masters Thesis in the Harvard-MIT Division of Health Sciences and Technology,
Massachusetts Institute of Technology, December, 2000.
A Novel Device for Subjecting Cells to Pulsatile Flow in Vitro: Frequency Response of
Various Cell Types, Marta Fernndez-Suarez, Masters Thesis in the Chemical Engineering
Department, Institut Quimic de Sarria, Ramon Llull University, Barcelona, Spain, January
2001.
A Cellular Pacemaker Using Eel Giant Smooth Muscle Cells and Cardiomyocites, Rosanne
Rouf, Sarnoff Fellow, Duke University, 2001.
Evaluation of Thrombotic Potential and Parameters of Intracoronary Prosthesis, Kumaran
Kolandaivelu, Doctoral Thesis in the Harvard-MIT Division of Health Sciences and
Technology, Massachusetts Institute of Technology, May, 2001.
Safety and Effectiveness of Carotid Angioplasty and Stenting Compared to Endarterectomy
for the Treatment of Carotid Atherosclerotic Disease, Brian J. Wagner, Masters Thesis in
the Field of History of Science, Harvard Extension School, Harvard University, June 2001.
Microengineering Surface based on Chemical Vapor Deposition (CVD) coating, Teresa
Rodn, Masters Thesis in the Chemical Engineering Department, Institut Quimic de Sarria,
Ramon Llull University, Barcelona, Spain, July 2001.
Effects of cellular and tissue pharmacologies on growth factor efficacy, David Wu, Doctoral
Thesis in the Harvard-MIT Division of Health Sciences and Technology, Massachusetts
Institute of Technology, August, 2001.
Local Pharmacokinetics of Stent-Based Drug Delivery, Chao-Wei Hwang, Doctoral Thesis
in the Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute
of Technology, April, 2002.
35
Elazer R. Edelman
A FRET-based and Molecular Dynamics Study of Phosphate-induced Conformational

Changes in Oligopeptides, Andrew D. Levin, Masters Thesis in the Harvard-MIT Division
of Health Sciences and Technology, Massachusetts Institute of Technology, May, 2002.
Extracellular Matrix And Mechanical Load Dependent Modulation of Endothelial
Intercellular Communication and Response to Growth Factor Delivery, Aaron B. Baker,
Masters Thesis in the Harvard-MIT Division of Health Sciences and Technology,
Massachusetts Institute of Technology, May, 2002.
Pharmacokinetics of Local Growth Factor Delivery in Myocardial Tissue, Kha N. Le,
Influence of Frequency on Endothelial Cells Subjected to Pulsatile Flow in Vitro: Biological
responses, Miguel San Miguel, Masters Thesis in Chemical Engineering Department,
Institut Quimic de Sarria, Ramon Llull University, Barcelona, Spain, December 2002.
Distant Hemodynamic Impact of Local Geometric Alterations in the Arterial Tree, Yoram
Richter, Doctoral Thesis in the Harvard-MIT Division of Health Sciences and Technology,
Massachusetts Institute of Technology, May 2003.
Role of the Cell-To-Cell Communication in Dictating the Pharmacodynamics Response to
Growth Factor Simulation, Ana Sala, Masters Thesis in the Chemical Engineering
Department, Institut Quimic de Sarria, Ramon Llull University, Barcelona, Spain, May
2003.
Endothelial Cell Response to Flow Frequency Conditions, Maria Vazquez, Masters Thesis
in the Chemical Engineering Department, Institut Quimic de Sarria, Ramon Llull
University, Barcelona, Spain, July 2003.
CRP Stimulates Vascular Endothelial Cells, Maria Sotomayor, Masters Thesis in the
Chemical Engineering Department, Institut Quimic de Sarria, Ramon Llull University,
Barcelona, Spain, July 2003.
Self-Assembling Peptide Scaffolds as Extracellular Matrix Analogs: Application in Tissue
Engineering, Elsa Genove, Masters Thesis in the Chemistry Department, Institut Quimic de
Sarria, Ramon Llull University, Barcelona, Spain, July 2003.
Effect of Flow Frequency on Cell Proliferation and on Cell Adhesion Molecule Expression,
Blanca Molins, Masters Thesis in the Chemical Engineering Department, Institut Quimic
de Sarria, Ramon Llull University, Barcelona, Spain, September 2004.
Optimization of the Fed-Bath Fermentation of an Antibody Fragment-producing Pichia
Pastoris Culture, Merce Dalmau, Masters Thesis in the Chemical Engineering Department,
Institut Quimic de Sarria, Ramon Llull University, Barcelona, Spain, September 2004.
36
Elazer R. Edelman
Molecular Basis of Collagen Stability and its Relationship to Collagen Diseases, Roman
Salsas, Masters Thesis in the Chemistry Department, Institut Quimic de Sarria, Ramon Llull
University, Barcelona, Spain, December 2004.
The Development of an In Vitro OnePass, HighThroughput Model of Flow Dependent
Thrombosis, Javier Jacobo Echenique, Bachelors Thesis in the Department of Mechanical
Engineering , Massachusetts Institute of Technology, June, 2005.
Specific and General Binding in Arterial Drug Delivery, Andrew D. Levine, Doctoral
Institute of Technology, June, 2005.
Biphasic Polymer Nanocolloids, Sonsoles Olano, Masters Thesis in the Chemical
Engineering Department, Institut Quimic de Sarria, Ramon Llull University, Barcelona,
Spain, July 2005.
Growth Factor Regulation of Endothelial Receptor Expression and Gap Junctional
Communication, Maria Tarragona, Masters Thesis in the Chemical Engineering
Department, Institut Quimic de Sarria, Ramon Llull University, Barcelona, Spain,
September 2005.
Flow Pattern Influence on Immunoregulatory Molecules Expression by Endothelial Cells,
Maria del Carmen, Alegret Masters Thesis in the Chemical Engineering Department,
Design and Characterization of Metal Nanoparticles Aggregates to Control and Study
Integrin Clustering, Jordi Canals, Masters Thesis in Chemical Engineering Department,
Regulation of Specific Connexins Differentally Alters Gap Junction Permeability and
Endothelial Cell Function, David Elihu, Masters Thesis in the Harvard-MIT Division of
Health Sciences and Technology, Massachusetts Institute of Technology, June 2006.
The Role of Heparan Sulfate Proteoglycans and Heparanase In The Control Of Vascular
Remodeling, Aaron B. Baker, Doctoral Thesis in the Harvard-MIT Division of Health
Sciences and Technology, Massachusetts Institute of Technology, June 2006.
Endothelial Cells And Basement Membrane: A CO-Regulatory Unit For Fibroblast Growth
Factor-2 In Hyperglycemic Stress, Alisa S. Morss, Doctoral Thesis in the Harvard-MIT
Division of Health Sciences and Technology, Massachusetts Institute of Technology, June
2006.
Functionalized Poly-p-xylylines for Atom Transfer Radical Polymerization (ATRP),
Gemma Galvn, Masters Thesis in the Chemistry Department, Institut Quimic de Sarria,
37
Elazer R. Edelman
Differential Regulation of mTOR Pathway in Co-Cultured Endothelial and Smooth Muscle

Cells Under Flow, Marina Santacana, Masters Thesis in the Chemical Engineering
September 2006.
Mechanistic Insights into Monocyte Induced Endothelial Cell Proliferation, Alejandro
Benarroch, Masters Thesis in the Chemical Engineering Department, Institut Quimic de
Sarria, Ramon Llull University, Barcelona, Spain, September 2006.
Site-Specific Protein Labeling in Live Cells Application to the Detection of Endogenous
Protein-Protein Interactions, Laura Martnez, Masters Thesis in the Chemistry Department,
Institut Quimic de Sarria, Ramon Llull University, Barcelona, Spain, October 2006.
An Investigation of the Production of Collagen-Like Polymer During Continuous Culture
of Recombinant Escherichia Coli, Alba Snchez, Masters Thesis in the Chemical
Spain, October 2006.
Thrombotic Fingerprints for the Enhanced Prediction of Thrombosis, Javier Jacobo
Echenique, Masters Thesis in the Department of Mechanical Engineering , Massachusetts
Quantitative Analysis and Modeling of Microembolic Phenomena, Michael Feldstein,
Property Determinants of Dextran: Polyethylene Glycol Adhesive Sealants, Tarek Shazly,
Masters Thesis in the Department of Materials Sciences, Massachusetts Institute of
Technology, June 2007.
Computational Modeling of Local Intravascular Drug Delivery, Brinda Balakrishnan,
Drug Deposition and Distribution in Health and Atherosclerotic Arteries and in Models of
Atherosclerosis Following Bulk or Stent-Based Drug Delivery, Neda Vukmirovic, Doctoral
Dewetting droplets onto CVD surfaces, Marc Alum , Masters Thesis in the Chemical
Spain, December 2007.
The Role of Flow in Vascular Recovery After Stenting, Carla Olive, Masters Thesis in the
Barcelona, Spain, January 2008.
38
Elazer R. Edelman
Effect of Specific Growth Rate on Plasmid Loss in an E. Coli Culture Used to Produce
Collagen Like Polymer, Claudia Soldevila, Masters Thesis in the Chemical Engineering
Department, Institut Quimic de Sarria, Ramon Llull University, Barcelona, Spain, March
2008.
Development of PEG: Dextran Hydrogels as Candidate Substrates for Drug Delivery,
Cristina Crespo, Masters Thesis in the Chemical Engineering Department, Institut Quimic
de Sarria, Ramon Llull University, Barcelona, Spain, March 2008.
Effects of Mechanical Loading on Drug Transport in Muscle Tissue, Peter I-Kung Wu,
Production and Quantification of Monoclonal Antibodies, Eduard Pereda, Masters Thesis
in the Chemical Engineering Department, Institut Quimic de Sarria, Ramon Llull
University, Barcelona, Spain, November 2008.
Click Chemistry for Biomolecule Immobilization, Agusti Panads, Masters Thesis in the
Barcelona, Spain, December 2008.
Evaluation of Monocyte-Endothelial Interactions (MEI) Under Inflammatory Conditions
and Anti-Proliferative Drugs, Juan Monter, Masters Thesis in the Chemical Engineering
December 2008.
Pheochromocytoma-Induced Cardiomyopathy as a Model of Synergistic Effects of
Multifactorial Tumor Secretions, Hector Mobine, Doctoral Thesis in the Department of
Biological Engineering, Massachusetts Institute of Technology, December 2008.
Local Pharmacokinetics and Pharmacodynamics of Angiogenic Growth factors in
Myocardial Tissue, Kha N. Le, Doctoral Thesis in the Harvard-MIT Division of Health
Sciences and Technology, Massachusetts Institute of Technology, February 2009.
Development of a Drug Eluting, Biodegradable Sealant Based On Peg: Dextran Hydrogel,
Cristina Purn, Masters Thesis in the Chemical Engineering Department, Institut Quimic de
Sarria, Ramon Llull University, Barcelona, Spain, March 2009.
Tissue-Material Interactions: Bioadhesion and Tissue Response, Tarek Shazly, Doctoral
thesis in the Department of Materials Science and Engineering, Massachusetts Institute of
Technology, August 2009.
The Effect of Scaffold Physical Properties on Endothelial Cell Function, Sylaja Murikipudi,
Doctoral thesis in the Harvard-MIT Division of Health Sciences and Technology,
Massachusetts Institute of Technology, November 2009.
39
Elazer R. Edelman
The Optimization of Firm R&D Decision Making: The Case of Medical Device Outsourcing
into India and Singapore, Adam Groothuis, Doctoral Thesis in International Business in
Southern New Hampshire University 2010
Abnormal Spectroscopic Properties of 9-amino-2,7,12,17-tetraphenylporphycene, Miguel
Duran, Masters Thesis in the Chemistry Department, Institut Quimic de Sarria, Ramon Llull
University, Barcelona, Spain, February 2010.
In Silico and In Vitro Study of Physical and Biological Effects of Stenting Complex
Vascular Environments, Jordi Martorell, Masters Thesis in the Chemical Engineering
Department, Institut Quimic de Sarria, Ramon Llull University, Barcelona, Spain, April
2010.
Regulatory Roles of Endothelial Cells in Cancer, Joseph W. Franses, Doctoral thesis in the
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of
Technology, June 2011.
In Silico and In Vitro Modeling of the Blood-Brain Barrier to Study the Alzheimers
Disease, Helena Mateu, Masters Thesis in the Chemical Engineering Department, Institut
Quimic de Sarria, Ramon Llull University, Barcelona, Spain, June 2011.
Quantifying the Nanomachinery at the Nanoparticle-Biomolecule Interface, Helena De
Puig, Masters Thesis in the Mechanical Engineering Department, Institut Quimic de Sarria,
Characterization of a GSK3b Heterozygote Knockout Mouse Line as Model of Partial and
Selective GSK3b Inhibition in the Study of Alzheimers Disease, Begona Canovas, Masters
Thesis in the BioEngineering Department, Institut Quimic de Sarria, Ramon Llull
University, Barcelona, Spain, September 2011.
Why Some Individuals Are Able to Tolerate Alzheimers Pathology Without Resulting in
Structural Damage or Impaired Cognition?, Leticia Fernandez, Masters Thesis in the
BioEngineering Department, Institut Quimic de Sarria, Ramon Llull University, Barcelona,
Spain. October 2011.
Automatic Generation of a Capillary Network Structure for Obtaining a Computational
Model of the Blood Brain Barrier, Fernando Garcia Polite, Masters Thesis in the Chemical
Spain, December 2012.
Mechanisms and Implications of Fracture in Cardiovascular Stents, Kay Dee Everett,
Doctoral thesis in The School of Engineering and Applied Sciences, Harvard University,
Cambridge, Massachusetts, 2013
40
Elazer R. Edelman
A New Personalized Arterial Model to Understand Biological Response to Flow Through

Computational and In Vitro Techniques, Pablo Santoma, Masters Thesis in the Chemical
Spain, May 2013.
Targeting Photodynamic Therapy to Microvascular Endothelial Cells, Elisabet Rosas,
Masters Thesis in the Chemical Engineering Department, Institut Quimic de Sarria, Ramon
Llull University, Barcelona, Spain, July 2013.
Correlation between cardiovascular disease biomarkers and biochemical and physical
milieu in complex vascular environments, Jordi Martorell Lopez, Doctoral Thesis in
Barcelona, Spain. October 2013.
Effect of Shear stress and Coculture with Astrocyte on Blood Brain Barrier Microvascular
Endothelial Cells Phenotype, Sina Salehi, Sarnoff Fellow at Vanderbilt University, August
2014.
A methodology for designing a supply chain solutions program targeting healthcare
providers, Suman Machinani, Masters of Business Thesis in MIT Leaders for Global
Operations, Sloan School of Management and School of Engineering, 2015.
Diseo de un soporte polimrico para reemplazar tejidos vasculares, Marina Sanchez,
Masters Thesis in the Chemical Engineering Department, Institut Quimic de Sarria, Ramon
Llull University, Barcelona, Spain, May 2015.
Impact of Cellular Component and Their Interaction in the BBB Phenotype, Paula Del Rey
Puech, Masters Thesis in the BioEngineering Department, Institut Quimic de Sarria, Ramon
Llull University, Barcelona, Spain, expected July 2015.
Surface Modification of Pericardium for Enhanced Biocompatibility of Bioprosthetic Aortic
Valves, Mario Lopez Maya, Masters Thesis in the BioEngineering Department, Institut
Quimic de Sarria, Ramon Llull University, Barcelona, Spain, expected July 2015.
THESIS READER
Powers, Mark, Substratum control of hepatocyte aggregate morphology, Doctoral Thesis
in the MIT Department of Chemical Engineering, Massachusetts Institute of Technology,
October 1996.
Caroline Douglass OBrien, Continuum fluid dynamics in Endovascular Stents, Doctoral
Thesis in the MIT Department of Chemical Engineering, Massachusetts Institute of
Technology, 2012
41
Elazer R. Edelman
Grace Teo, Stem cell transmigration though endothelial cells, Doctoral thesis in the
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of
Technology, 2013
Alexandra Elisa German, Paxillin-dependent control of tumor angiogenesis, Doctoral
thesis in the Harvard-MIT Division of Health Sciences and Technology, Massachusetts
Institute of Technology, 2013
Alexander Bagley, Doctoral thesis in the Harvard-MIT Division of Health Sciences and
Technology, Optically Active Nanomaterials for Diagnostic and Therapeutic
Applications in Ovarian Cancer
Kevin Lin, Nanoparticle Systems that Exploit Host Biology for Diagnosis and Treatment
of Disease, Doctoral Thesis in the Department of Chemical Engineering at Massachusetts
Institute of Technology, 2013
Jordi Martell, Correlation between cardiovascular disease biomarkers and biochemical
and physical milieu in complex vascular environments Doctoral Thesis in the Department
of Chemical Engineering at Institute Quemic de Saria, 2013
2.
Regional, National, or International Contributions

a.
Invited Presentations
1987
Polymer-based controlled delivery: Its role in angiogenic processes Beth

Israel Hospital, Boston, MA, Cardiovascular Grand Rounds, Invited
Lecture.
1988
Neovascularization of Atherosclerotic Plaque Beth Israel Hospital, Boston,

MA, Cardiovascular Grant Rounds, (April 1988), Invited Lecture.
Neovascularization of Atherosclerotic Plaque, Brigham & Women's
Hospital, Boston, MA, Cardiovascular Grand Rounds, (May 1988), Invited
Lecture.
Neovascularization of the coronary arterial wall, Brigham & Women's
Hospital, Harvard Medical School, The Multidisciplinary Program in
Cardiovascular Disease Vascular Medicine Series, Boston, MA, Invited
Lecture.
Polymer-based controlled delivery: Its role in basic science research
Ministry of Trade and Technology, Danish Council on Technology,
Copenhagen, Denmark, Invited Lecture.
42
Elazer R. Edelman
1989
Polymer-based controlled delivery: Its role in the study of growth factor

biology, Inaugural Address, Biopharmaceutics Program, 350th Anniversary
of the Founding of the University of Helsinki, University of Helsinki,
Helsinki , Finland, Visiting Professorship.
1991
Local therapy of atherosclerosis, Cardiovascular Grand Rounds, Beth Israel

Hospital, Boston, MA, Invited Lecture.
1991
Peri-adventitial control of neointimal proliferation, Northwestern

University, Department of Vascular Surgery, Evanston, Illinois, Visiting
Professorship.
1991
bFGF regulation of smooth muscle cell proliferation and angiogenesis is

linked in the perivascular space of injured blood vessels, The Blood Vessel
Club, Atlanta, GA, Invited Lecture.
1991
Molecular aspects of growth and inflammatory mechanisms in vascular

cells, FASEB, Atlanta, GA, Invited Lecture.
1992
Restenosis: Local action of heparin and heparin binding growth factors,

Grand Rounds, University of Cincinnati, Cardiovascular Division,
Cincinnati, OH, Visiting Professorship.
Longwood Area Vascular Biology Series, Boston, MA, Invited Lecture.
Grand Rounds, Yale University, Cardiovascular Division, New Haven, CT,
Invited Lecture.
Restenosis Summit, Cleveland, OH, Invited Lecture.
1994
Endothelial control of smooth muscle cell proliferation, Northwestern

University Medical School. Cardiovascular Division, Feinberg Institute,
Evanston, IL, Visiting Professorship.
1995
Prevention and treatment of restenosis: Lessons learned from endogenous

forms of vascular repair, Restenosis Summit VII, Cleveland, OH, Invited
Lecture.
Issues in the Responsible Conduct of Research, Massachusetts Institute of
Technology, Boston, MA, Invited Lecture.
1996
Longwood Area Vascular Biology Series, Invited Lecture.
1996
Cardiovascular Research Seminar, Boston VA Medical Center, Boston

University School of Medicine, Boston, MA, Seminar.
1996
Perivascular and Endovascular Drug Delivery Concepts and The Biology

of Endovascular Implants, Transcatheter Cardiovascular Therapeutics
Symposium, 8th Annual Symposium, Cardiology Research Foundation &
43
Elazer R. Edelman
Washington Hospital Center, Washington, DC, February 28-March 3,

Invited Lecture.
1996
Antisense Strategies for Controlling the Vascular Response to Injury,

Research Initiatives in Vascular Disease, Bethesda, MD, Invited Lecture.
1996
Balloons to stents: Reduction and restenosis with evolving interventional

technology, The Physician's Meeting, Chicago, IL, Invited Lecture.
1996
Endogenous mediators of restenosis, Columbia University, Cardiology

Grand Rounds, New York, NY, Visiting Professorship.
1996
Exploring Medical Career Options, National Youth Leadership Forum on

Medicine, Cambridge, MA, Seminar.
1996
Balloons and stents: Local drug delivery potential, Johnson & Johnson's
Annual Symposium on Drug Delivery Technology, Chicago, IL, Invited
Lecture.
1996
Physician's Meeting Seminar

Vascular Biology, Vascular Medicine and Vascular Interventions: Balloons
and Stents, New Jersey Society of Interventional Cardiology, Passaic, NJ,
Invited Lecture.
1997
Cardiovascular Research Seminar Series, St. Elizabeth's Medical Center,

Boston, MA, Invited Lecture.
1997
Tissue engineered vascular endothelial cell implants for the delivery of

vasoactive compounds, Eighth International Symposium on Recent
Advances in Drug Delivery, Salt Lake City, Utah, Invited Lecture.
1997
Pathology of restenosis, Interventional Cardiology, Twelfth Annual

Demonstrations Course, Snowmass, CO, Invited Lecture.
1997
Grand Rounds, The New York Hospital-Cornell Medical Center, New

York, Invited Lecture.
1997
Medical Breakthroughs from M.I.T.: Sampling Current Research,

Catherine N. Stratton Lectures on Aging Successfully, M.I.T Invited
Lecture.
1997
Restenosis and Growth Factors: Model of Paracrine Growth Control

Seminars in Vascular Biology, Harvard Medical School, Seminar.
1997
Controlled Release of Heparin, Antisense Oligonucleotides, and Cytokines

for Restenosis, Controlled Release Society, Stockholm, Sweden, Invited
Lecture.
44
Elazer R. Edelman
1997
Biology and Pathology of Endovascular Implants, 2nd International Meeting

on Interventional Cardiology, Jerusalem, Israel, Invited Lecture.
1997
Controversies in the Biology of Restenosis, 2nd International Meeting on

Interventional Cardiology, Jerusalem, Israel, Invited Lecture.
1997
Materials and Cells in Cardiovascular Healing, Gordon Research

Conference on Biomaterials: Biocompatibility and Tissue Engineering,
Holderness, NH, Invited Lecture.
1997
Evolution of Thought in Coronary Artery Disease, Cadillac Trial

Meeting/Guidant Corp., July 27-29, San Francisco, CA, Invited Lecture.
1997
High Risk Coronary Angioplasty, The Cardiovascular Nursing &

Technologist Symposium, Transcatheter Cardiovascular Therapeutics IX,
September 24, Washington, DC, Invited Lecture.
1997
Tissue Engineering Concepts (cells + composite modalities) to Achieve

Therapeutic Effects, Local Cardiovascular Drug Delivery, Transcatheter
Cardiovascular Therapeutics IX, September 24, Washington, DC, Invited
Lecture.
1997
Nir-ly There: Technology Assessment and New Product Review, Nir-ly

There: Evolution of an Advanced Stent Technology, Transcatheter
Lecture.
1997
Nir-ly There: Vessel Requirements, Product Development, Clinical

Verification The NIR Future, Nir-ly There: Evolution of an Advanced
Stent Technology, Transcatheter Cardiovascular Therapeutics IX,
September 24, Washington, DC, Invited Lecture.
1997
Future Roles and Impact of Biological Coatings in Interventional Vascular

Therapy and Future Coating Technologies, Biological Coatings for
Interventional Devices: Setting A New Standard for Success, Transcatheter
Lecture.
1997
Developing Improved Engineering and Animal Study Guidelines for Stents

in the Future and Stents and the FDA Streamlining the Pathway for
Regulatory Approval of Stents in the Future: A Fireside Chat with the FDA,
Transcatheter Cardiovascular Therapeutics IX, September 25, Washington,
DC, Invited Lecture.
1997
The Impact of Stent Design on Pathobiologic Responses and The Role of

Stents and the Impact of Multilink in Coronary Intervention, The Advanced
Multilink Intracoronary Stent: Harmonizing Design and Function,
45
Elazer R. Edelman
1997
When to Integrate Molecular Biology and Advanced Quantitative

Techniques, Advanced Workshop on Experimental Animal Models,
1997
Future Needs and Developments in Antisense Technology, National Heart,

Lung, and Blood Institute, National Institutes of Health, September 25-26,
Bethesda, Maryland, Invited Lecture.
1997
Stent Design Pathobiologic Responses, Advanced Stent Workshop:

Practical Tips and Tricks (including hands-on industry presentations of the
new stents), Transcatheter Cardiovascular Therapeutics IX, September 28,
Washington, DC, Invited Lecture.
1997
Barriers in Drug Delivery, Conference on Formulations and Drug Delivery

II, American Chemical Society/Controlled Release Society, Inc., October
5-8, La Jolla, California, Invited Lecture.
1997
Polyampholytic Hydrogen Phase Transitions at High Ionic Strengths,

Materials Research Society, Invited Lecture.
1997
Equilibrium and Non-Equilibrium Polyelectrolyte Hydrogen Phase

Transitions, Materials Research Society, Invited Lecture.
1997
Tissue Engineering in Restenosis, American Association of Pharmaceutical

Scientists, November 4, Boston, Mass, Invited Lecture.
Stent and artery geometry determine intimal thickening independent of deep
arterial injury, 70th Scientific Sessions, American Heart Association,
November 9-12, Invited Lecture.
Blockage of the Leukocyte integrin Mac-1 Reduces Experimental
Restenosis, 70th Scientific Sessions, American Heart Association,
November 9-12, Invited Lecture.
Heparin-coated stents eliminate mural thrombus deposition for days
without affecting restenosis, 70th Scientific Sessions, American Heart
Association, November 9-12, Invited Lecture.
1997
Vascular endothelial growth factor effect on vascular permeability is

mediated by synthesis of platelet-activating factor, 70th Scientific Sessions,
American Heart Association, November 9-12, Orlando, FL, Invited
Lecture.
1997
Effects of stent geometry, balloon compliance, and deployment pressure on

balloon-artery interactions during stent placement: A finite element model,
American Heart Association 70th Scientific Sessions, November 9-12,
Orlando, FL, Invited Lecture.
46
Elazer R. Edelman
1997
Controlled Drug Delivery and Vascular Disease, The 4th US-Japan

Symposium on Drug Delivery Systems, December 14-19, Kauai, HI,
Invited Lecture.
1997
Research Seminar, Guidant Inc, Santa Clara, CA, Seminar.
1998
Pathology of Local Vascular Implants, 15th Annual International

Symposium on Interventional Cardiology, January 21-25, Miami Beach,
FL, Invited Lecture.
1998
Frontier Therapy for Vascular Proliferative Diseases, 15th Annual

International Symposium on Interventional Cardiology, January 21-25,
Miami Beach, FL, Invited Lecture.
1998
Local Cardiovascular Drug Delivery, 15th Annual International

Symposium on Interventional Cardiology, January 21-25, Miami Beach,
FL, Invited Lecture.
1998
Stent-Based Drug Delivery, 4th Local Drug Delivery Meeting and

Cardiovascular Course on Radiation and Molecular Strategies, February 2628, Hotel Noga Hilton, Geneva, Switzerland, Invited Lecture.
1998
Expanded polytetrafluoroethylene stent graft encapsulation reduces intimal

thickening regardless of stent design, 47th Annual Scientific Session,
American College of Cardiology, March 29-April 1, Atlanta, GA, Invited
Lecture.
1998
Local Perivascular Basic Fibroblast Growth Factor (bFGF) Treatment in

Patients with Ischemic Heart Disease, 47th Annual Scientific Session,
American College of Cardiology, March 29-April 1, Atlanta, GA, Invited
Lecture.
1998
The Endothelium in Vascular Disease, Cardiology & Cardio-thoracic

Surgery, Third International Symposium, June 8-9, Jerusalem, Israel,
Invited Lecture.
1998
Development of Scientifically-based Cardiovascular Therapies, Thomas

Jefferson University Hospital/Cardiovascular Research Center, July 17,
Philadelphia, PA, Invited Lecture.
1998
Intensive Review of Internal Medicine. Brigham & Womens Hospital and

Harvard Medical School, August 9-16, Cambridge, MA, Invited Lecture.
1998
Vascular Visions: Acute Myocardial Infarction and Cardiogenic Shock:

Salvaging Myocardium, Stabilizing Rhythm, and Prolonging Life.
Cardiology Research Foundation, September 15-17, Washington, D.C,
Invited Lecture.
47
Elazer R. Edelman
1998
Molecular Cardiology and Local Cardiovascular Drug Delivery I,

Washington Convention Center, October 6, Washington, D.C, Invited
Lecture.
1998
Molecular Cardiology and Local Cardiovascular Drug Delivery II,

Washington Convention Center, October 7, Washington, D.C, Invited
Lecture.
1998
Coronary Stents I: Stent Designs, Controversies in Stenting, and The NIR

Stent: An Advanced Platform for the Future. Interactive FDA Working
Session, October 8, Washington Convention Center, Washington, D.C,
Invited Lecture.
1998
Understanding The Biomaterials, Biomechanics, and Pathobiologic

Responses of Coronary Stents: Revising U.S. Regulatory Standards ,
Plenary Session #7 Endovascular Prosthetic Devices I. (Stents). October,
9, Washington Convention Center, Washington, D.C, Plenary
Presentation.
1998
Vascular Biology and Biomedical Engineering, Center for Engineering in

Medicine, Shriners Hospital for Children, October 21, Boston, MA, Invited
Lecture.
1998
The Vascular Biology of Interventional Cardiology over the last 400 years,
Mt. Sinai Hospital, October 21, New York, NY, Invited Lecture.
1998
The Future of the Clinician-Scientist, Mt. Sinai Hospital, October 21, New
York, NY, Invited Lecture.
1999
Tissue engineering and vascular disease, Mt. Sinai School of Medicine,

July 14, New York, NY, Invited Lecture.
Controlled release of growth factors: Biology, pharmacokinetics and
clinical applications, Alkermes, Inc., August 3, Invited Lecture.
1999
Drug Delivery: Innovations in Therapeutic Targeting, Massachusetts

Biotechnology Council, October 18, Invited Lecture.
1999
Tissue Engineering and Vascular Disease, Institute for Medicine and

Engineering, University of Pennsylvania, December 7, Visiting
Professorship.
1999
Controlled release from endovascular implants, 5th Japan Symposium on

Drug Delivery Systems, December 12-17, Maui, Hawaii, Invited Lecture.
2000
Molecular Intervention in Cardiovascular Disease and Stent-based Drug

Delivery, 12th Annual International Symposium on Endovascular Therapy,
ISET 2000, January 23-27, Miami Beach, FL, Invited Lecture.
48
Elazer R. Edelman
2000
Frontiers in Cardiovascular Biology, Harvard School of Public Health,

Laboratory of Cardiovascular Biology-Center for the prevention of
Cardiovascular Disease, February 11, Boston, MA, Seminar.
2000
Vascular Tissue Engineering: Structure vs. Function, The Biology of

Vascular Interventions Minimally Invasive Approaches to Vascular
Disease, February 17-18, Bethesda, MD, Invited Lecture.
2000
Tissue Engineering & Vascular Disease, Cardiovascular Research Seminar

1999-2000, February 23, St. Elizabeths Medical Center, Boston, MA,
Invited Lecture.
2000
Scaffolds for Perivascular Endothelial Cell Implantation, Tissue

Engineering, Biomemetics and Medical Implant Science: Second Annual
Grantees Meeting, National Institute of Health, March 2, 2000, Bethesda,
MD, Invited Lecture.
2000
Scaffolds for perivascular endothelial cell transplantation, VIIth Biannual

Meeting of the International Society for Applied Cardiovascular Biology,
March, 9-11, Tucson, AZ, Invited Lecture.
2000
4th Biannual International Symposium on Cardiology and Cardio-Thoracic

Surgery, July 3-4, Jerusalem, Israel, Invited Lecture.
2000
Local treatment and biomaterials, XIth International Vascular Biology

Meeting, September, 5-9, Geneva, Switzerland, Invited Lecture.
2000
Debate: Gold Stents Represent a New Standard for Visibility,

Performance and Clinical Outcomes, The 12th Annual Symposium,
Washington Convention Center, October 19, Washington, DC, Invited
Lecture.
2000
Coronary Stents I: Differentiating Stent Design and Performance,

Transcatheter Cardiovascular Therapeutics, The Twelfth Annual
Symposium, Washington Convention Center, October 19, Washington,
2000
Implications of Stent Design: Key Findings from Multi-Link Tetre Animal

Studies, Controversies in Coronary Stenting, Transcatheter Cardiovascular
Therapeutics, The Twelfth Annual Symposium, Washington Convention
Center, October 19, Washington, DC, Invited Lecture.
2000
Molecular Cardiology for the 'Clinician': Concepts, Semantics, and

Clinical Applications -- Hope or Hype?, Plenary Session #3:
Atherosclerosis and Molecular Cardiology, Transcatheter Cardiovascular
Therapeutics, The Twelfth Annual Symposium, Washington Convention
Center, October 19, Washington, DC, Invited Lecture.
49
Elazer R. Edelman
Stent Design Dictates Thrombosis and Restenosis: New Insight Into the
Performance of Standard Stainless Steel Stents from Computer Modeling
2001
Evaluating Stent Performance and Biocompatibility in Bench and Animal

Models, CIMIT Forum, Massachusetts General Hospital, January 9,
Boston, MA.
2001
BioTechnology and Entrepreneurship: Visions of the Future, MIT-Science

and Engineering Business Club, January 19, Cambridge, MA.
2001
Does Stent Design Really Matter?, Cardiovascular Radiation Therapy

V/Restenosis Forum, February 7, Washington, DC.
2001
Tissue Engineering: Living Stent II, Cardiovascular Radiation Therapy

V/Restenosis Forum, February 7, Washington, DC.
2001
Stent Design and Drug Delivery, Cardiology of Georgia, P.C., March 15,
Atlanta, GA.
2001
Cardiology Grand Rounds, Columbia University, May 15, New York, NY
2001
Vascular Biology, Vascular Medicine, and Vascular Biotechnology,

Division of Cardiology, University of Texas Medical Branch at Galveston,
May 24, Galveston, TX.
2001
Endovascular Stents: Model Systems for Vascular Biology Research,

Division of Cardiology, University of Texas Medical Branch at Galveston,
May 24, Galveston, TX.
2001
Do We Understand Restenosis? Which Pathways Should Be Interrupted?

Transcatheter Cardiovascular Therapeutics 2001, September 11,
Washington, DC.
2001
Importance of Release Kinetics and Depth of Penetration, Transcatheter

Cardiovascular Therapeutics 2001, September 11, Washington, DC.
2001
The Burgeoning Field of Clinical Tissue Engineering: From Stem Cell

Implants to Vascular and Myocardial Remodeling, Transcatheter
Cardiovascular Therapeutics 2001, September 12, Washington, DC.
2001
Tissue Engineering - Present Status and Future Expectations,

Transcatheter Cardiovascular Therapeutics 2001, September 12,
Washington, DC.
2002
Stent Based Drug Delivery, 14th Annual International Symposium on

Endovascular Therapy, ISET 2002, January 20-24, Miami Beach, FL,
Invited Lecture.
50
Elazer R. Edelman
2002
What is Tissue Engineering and How Can it be Applied?, 14th Annual

International Symposium on Endovascular Therapy, ISET 2002, January
20-24, Miami Beach, FL, Invited Lecture.
2002
Polymers on Stents: Biocompatibility, Release Kinetics, and Depth of

Penetration, Cardiovascular Radiation Therapy VI/Restenosis Forum II,
February 6-8, Washington, DC.
2002
Joint Interventional Meeting, JIM 2002, February 7-9, Rome, Italy.
2002
Cyphers, the Key Difference, Cordis Symposium, May 22-24, 2002,

France, Paris.
2002
Vascular Biology, Tissue Engineering and Vascular Repair, Morris

Karnovsky Symposium, June 10, 2002, Cambridge, MA, Invited Lecture.
2002
The Drug-Eluting Stent Revolution: Multi-Component Design Elements of

a Breakthrough Technology, Transcatheter Cardiovascular Therapeutics
2002, September 24, 2002, Washington, DC, Invited Lecture.
2002
Live Case Transmissions, Transcatheter Cardiovascular Therapeutics

2002, September 24, 2002, Washington, DC, Discussant.
2002
Moderated Panel and Audience Q & A: Drug-Eluting Stents, 2ranscatheter

Cardiovascular Therapeutics 2002, September 25, 2002, Washington, DC,
Discussant.
2002
The Molecular Cardiology Symposium: Angiogenesis, Cell Therapy, and

Local Drug Delivery, Transcatheter Cardiovascular Therapeutics 2002,
September 27, 2002, Washington, DC, Event Moderator.
2002
The Burgeoning Field of Tissue-EngineeringFrom Cell Therapy

approaches to Vascular and Myocardial Remodeling to Organogenesis,
Transcatheter Cardiovascular Therapeutics 2002, September 27, 2002,
2002
The Drug-Eluting Stent Summit, Transcatheter Cardiovascular

Therapeutics 2002, September 27, 2002, Washington, DC, Section
Moderator.
2002
The drug carrier vehicle1) Polymer vs. Phosphorylcholine vs. Direct

Adherence; 2) Impact of Bioerodability and Vascular Reactivity,
Transcatheter Cardiovascular Therapeutics 2002, September 27, 2002,
2002
Drug Release KineticsFactors Governing Dose and Tissue Penetration

From Polymer and Non Polymer Based Systems, Transcatheter
Invited Lecture.
51
Elazer R. Edelman
2002
Basic Science and Desirable Components of a Drug Eluting Stent,

Roundtable Discussion and Audience Q & A, Transcatheter
Discussant.
2003
Understanding the Concept of Drug-Eluting Stents, January 19, 2003,

International Symposium on Endovascular Theory, Miami, FL.
2003
Hot Topics in Interventional Cardiology, January 19, 2003, International

Symposium on Endovascular Theory, Miami, FL, Panelist.
2003
Controversies in Endovascular Medicine, January 20, 2003, International

Symposium on Endovascular Theory, Miami, FL, Moderator.
2003
What do Vascular Specialists Need to Know about Drug Eluting Stents,

January 20, 2003, International Symposium on Endovascular Theory,
Miami, FL.
2003
Issues Regarding Stent Design Drug-Related System, April 1 2003,

American College of Cardiology Meeting 2003, Chicago, IL.
2003
Inhibitor Macrophage Infusion, May 23, 2003, EuroPCR, Paris, France
2003
A novel systemic anti-inflammatory strategy to reduce restenosis:

Liposomal bisphonates and macrophage depletion, September 16 2003
Transcatheter Cardiovascular Therapeutics, Washington, DC.
2003
Drug-eluting stents: A case study of the first successful biotechnology

platform- pitfalls, lessons and insights, September 17 2003 Transcatheter
Cardiovascular Therapeutics, Washington, DC.
2003
A basic primer on the essentials of drug-carrier systems- polymers, PC

coatings, and direct bonding methods- similarities, differences and other
innovative solutions, September 18 2003 Transcatheter Cardiovascular
Therapeutics, Washington, DC.
2003
Pharmaceutical Patent Forum, SG Cowen Securities Corporation, October

7 2003, 6th Annual Pharmaceutical Therapeutic Categories Review
Conference, New York, NY.
2003
Drug-Eluting Stents: Technical Update, December 8 2003, 5th

International Meeting on Interventional Cardiology, Tel Aviv, Israel.
2004
Understanding the Concept of Drug Eluting Stents: The Impact of Stent

Design, January 25 2004, International Symposium on Endovascular
Theory, Miami, FL.
2004
Crossfire: Topical debates in Endovascular Therapy, January 26 2004,

52
Elazer R. Edelman
2004
Live Case Demonstrations, January 26 2004, International Symposium on

Endovascular Theory, Miami, FL.
2004
Carotid Artery Therapy, January 26 2004, International Symposium on

Endovascular Theory, Miami, FL.
2004
Engineering Solutions for Restenosis, January 26 2004, International

Symposium on Endovascular Theory, Miami, FL.
2004
Mechanisms of DES Failures, May 7, 2004, Drug Eluting Stents In-Dept

Symposium, Washington, DC.
2004
Bioabsorbable Polymers, May 7, 2004, Drug Eluting Stents In-Dept

Symposium, Washington, DC.
2004
Mechanistic insights into Sirolimus activity and distribution after stent

delivery, May 24, 2004, PCR, Paris, France. Plenary Session.
2004
The Brave New World: Drug Eluting Stents and Other Revolutions,
August 12, 2004, Life Sciences Conference, Jerusalem, Israel.
2004
Innovations in Experimental Medicine: Impact on Drug-Eluting Stents and

Other Antirestenosis Therapies, September 27, 2004, Transcatheter
Cardiovascular Therapeutics, Washington, DC.
Understanding the Concept of Drug Eluting Stents: The Impact of Stent
Design, International Symposium on Endovascular Theory, January 25
2004, Miami, FL, Invited Lecture.
Session II- Crossfire: Topical debates in Endovascular Therapy,
International Symposium on Endovascular Theory, January 26 2004,
Miami, FL, Moderator.
Live Case Demonstrations, International Symposium on Endovascular
Theory, January 26 2004, Miami, FL, Panelist.
Topic I- Carotid Artery Therapy, International Symposium on
Endovascular Theory, January 26 2004, Miami, FL, Moderator.
Engineering Solutions for Restenosis, International Symposium on
Endovascular Theory, January 26 2004, Miami, FL, Invited Lecture.
Stent Design and Geometry, A.G. Edwards 3rd Annual Panel and Interactive
Discussion on Emerging Medical Technology, February 24, 2004, NY, NY,
Keynote Speaker.
2005
The Basics of Restenosis and DES, January 16 2005, International

Symposium on Endovascular Theory, Miami, FL.
53
Elazer R. Edelman
The Trials and Tribulations of Drug Eluting Stents, January 16 2005,

Stent Based Drug Delivery: Conception, Clinical Use and Remaining
Challenges, January 27 2005, St. Elizabeths Hospital, Tufts University.
Tissue Engineering: Examples from the Cardiovascular System, February
7, 2005, Pathology Grand Rounds, Brigham and Womens Hospital,
Boston, MA.
Drug Eluting Stents: Mechanisms and Myths, February 21 2005, 12th
International Symposium on Recent Advances in Drug Delivery Systems,
Salt Lake City, UT.
Drug Eluting Stents: Conception, Implementation and Current
Challenges, April 13 2005, Minnesotas Medical Device Community
Forum: Design of Medical Devices, Minneapolis, MN.
Current Trends and Lab Issues regarding Drug Eluting Stent Technology,
February 24, 2005, Morgan Stanley 8th Annual Interventional Cardiology,
Conference, New York, NY.
Drug Eluting Stents: Conception, Implementation and Current Challenges,
Design of Medical Devices Conference and Presidents Interdisciplinary
Conference on Medical Devices, April 13-15, 2005, Minneapolis, MN,
Invited Lecture.
Innovations in Cardiovascular Tissue Engineering, National Academy of
Engineering and MIT School of Engineering Symposium on Stimulating
Invention and Innovation, May 17, 2005, Cambridge, MA, Panelist.
Biomedical Applications of Expandable Microspheres,
Symposium, May 19, 2005, Wilmington, DL, Panelist.
DuPont
Stent-Based Drug Delivery, Controlled Release Society Annual Meeting,

June 18-22, 2005, Miami, FL, Invited Lecture.
Vascular Repair, Inside and Out, Devices, Drugs and Cells, Gordon
Research Conference on Biomaterials: Biocompatibility/ Tissue
Engineering, July 31-August 5, 2005, Plymouth, NH, Invited Lecture.
The Evolution of Medical Sciences in Judaism, MIT Hillel Faculty Lunch
Speakers Series, September 23, 2005, Invited Lecture.
Advances in Polymer and Drug Development, American Heart Association
Annual Meeting, Dallas, Texas, November 14, 2005, Invited Lecture.
54
Elazer R. Edelman
Cardiovascular Tissue Engineering: Lessons from Devices and Vascular

Biology, Cardiovascular Grand Rounds, Dartmouth-Hitchcock Medical
Center, Hanover, New Hampshire, December 2005. Invited Lecture.
2006
Drug Eluting Stents In-Depth, Cardiovascular Revascularization Therapies

2006 Conference, Cardiovascular Research Institute, Washington Hospital
Center, Washington, DC, Moderator.
New Insights into the Biology of DES, Cardiovascular Revascularization
Therapies 2006 Conference, Cardiovascular Research Institute,
Tissue Regeneration and Translational Research, Massachusetts Medical
Device Industry Council, Massachusetts Medical Society, Waltham, MA,
May, 2006, Invited Panelist.
Tissue Engineering of Endothelial Cells and the Immune Response, World
Transplant Congress, Washington, DC, Invited Lecture.
2007
Stents, Drug Elution and Tissue Engineering: Technology in Evolution,

Cardiology Grand Rounds, Cardiovascular Research Institute, Washington
Hospital Center, Washington, DC, May 1, 2007. Invited Lecture.
Animal Studies, Harvard Clinical Research Institute-Cardiomed Device
Consultants Seminar: Medical Device Development Workshop: A Case
Study Approach, Boston, MA, May 16, 2007. Invited Lecture.
Cardiovascular Tissue Engineering and Biotechnologies, Re-Engineering
of the Cardiovascular Stem Cell Biology, Harvard Stem Cell Institutes
Strategic Development in Biological Innovation, Cambridge, MA,. April
30, 2007, Invited Lecture.
The Right Approaches for Animal Models and Pre-clinical Studies to Gain
the Required Data to Allow Clinical Studies, ICI 2007 Innovations in
Cardiovascular Interventions, Tel Aviv, Israel, December 4, 2007, Invited
Lecture.
2008
Drug Transport in Artery Walls, FDA/NSF/NIH Workshop on Computer

Methods in Cardiovascular Device Design & Evaluation, Bethesda, MD,
March 18, 2008, Invited Lecture
Challenges of Academic-Industry Collaboration in the Modern Era, 3rd
Annual Medical Device Regulatory, Reimbursement and Compliance
55
Elazer R. Edelman
Congress, Harvard University, Cambridge, MA, March 27, 2008, Invited

Lecture.
Vascular Biology, Endovascular Stents, and Tissue Engineering: Robert
Koch and The Dread Pirate Robert, 25th Reunion Symposium, Harvard
Medical School, Boston MA, June 5, 2008, Invited Lecture.
Stents as a Case-Study of Experimental Interventional Medicine,
Transcatheter Cardiovascular Therapeutics 20th Annual Symposium; 2008
Washington, DC, October 12-17, Plenary Lecture.
Biodegradable Polymers, Healing Drugs and Disappearing Stents: Where
Is the Future? Scientific Sessions 2008, American Heart Association
Annual Meeting, New Orleans, LA, November 11,Invited Lecture.
2009
Endothelial Engineering Concept to Clinic, Cardiovascular Grand

Rounds, Massachusetts General Hospital, Boston, MA, March 4, 2009.
Invited Lecture.
Keynote Speaker, 4th International Symposium on Biomechanics in
Vascular Biology and Cardiovascular Disease, Rotterdam, The
Netherlands, April 16-17, 2009.
Endothelial Regulation of Vascular Homeostasis: Intersection of Vascular
and Immune Biology Inside and Out, Jeffrey M. Hoeg Arteriosclerosis,
Thrombosis and Vascular Biology Award for Basic Science and Clinical
Research Lecture. American Heart Association Arteriosclerosis,
Thrombosis and Vascular Biology Annual Conference, April 29-May 1,
2009, Washington, DC.
Climate for Innovation in Massachusetts, Medical Technology Leadership
Forum, May 7-8, 2009, Boston, MA, Invited Lecture.
Center for Scientific Review Special Emphasis Panel: American Recovery
Reinvestment Act Grand Opportunity (GO) Grant Applications, August 6,
2009, Bethesda, MD.
Part 1: A Basic Science Tour de Force: Perivascular Tissue Engineered
Allogeneic Endothelial Cells: Vascular Repair After Intervention:
Preclincial and Clinical Results, Transcatheter Cardiovascular
Therapeutics 21st Annual Conference, September 21-25, 2009, San
Francisco, CA, Invited Lecture.
Polymer Bioabsorption Fundamentals and Differences Among DES
Systems, Transcatheter Cardiovascular Therapeutics 21st Annual
Conference, September 21-25, 2009, San Francisco, CA, Invited Lecture.
56
Elazer R. Edelman
Session III- Polymer-Free DES Platforms, Transcatheter Cardiovascular

Therapeutics 21st Annual Conference, September 21-25, 2009, San
Francisco, CA, Moderator.
2010
Vascular Biology, Vascular Tissue Engineering and Novel Vascular

Therapeutics, Translational and Molecular Imaging Institute Seminar
Series, Mount Sinai School of Medicine, May 21, 2010, New York, New
York. Invited Lecture.
Tissue Engineering for the Injured Lung, Harvard Lung Conference &
CIMIT:Center for Integration of Medicine & Innovative Technology,
Inhalation Technology Workshop, Harvard Medical School, October 6-7,
2010, Boston MA. Invited Lecture.
Early, Innovative Resuscitation and Bleeding Control after Injury,
CIMIT:Center for Integration of Medicine & Innovative Technology
Forum-Trauma and Critical Care, Pre-Hospital Resuscitation Workshop,
Massachusetts General Hospital, Boston, MA. Invited Lecture
The Impact of Vascular Biology & Computational Models on Device
Innovation in Cardiovascular Medicine (Case Examples), Transcatheter
Cardiovascular Therapeutics 22st Annual Conference, September 21-25,
2010, Washington, DC. Invited Lecture.
2011
Tissue-Specific Adhesive Materials, IDEASTREAM Deshpande Center

Symposium 2011, April 15, 2011, Massachusetts Institute of Technology,
Cambridge, MA. Invited Lecture.
Bench to Bedside: Marriage of Engineering and Biological Sciences:
Forget the Future, What have we learned from the past, Deans
Distinguished Lecture, April 21, 2011, The Fu Foundation School of
Engineering and Applied Science, Columbia University, New York, New
York. Invited Lecture
A Report from the Edelman Lab, Harvard-MIT Biomedical Engineering
Center, Massachusetts Medical Device Industry Council, 15th Annual
Conference, May 3, 2011, UMass Boston Campus Center, Boston, MA.
Plenary Speaker
Bioengineering, Vascular Biology and Emerging Cardiovascular
Therapeutics, American Society of Mechanical Engineering (ASME) 2011
Summer Bioengineering Conference, June 23, 2011, Farmington, PA.
Plenary Speaker
57
Elazer R. Edelman
ISCTE-IUL / MIT-Portugal Venture Competition, September 22, 2011,

Lisbon, Portugal. Keynote Speaker
Tissue Engineering: Linking Vascular & Cancer Biology, Brigham &
Womens Hospital, Biomedical Research Institute Regenerative
Therapeutics Research Center Inaugural Symposium, September 26, 2011.
Invited Lecture
Engineering Endothelial Cells The Paradigmatic Paracrine Cell
Regulators, Society for Laboratory Automation and Screening: Global
Symposia Series Screening Stem Cells11, September 27, 2011,
Sheraton Boston, Boston, MA. Invited Lecture.
Potential Improvements in the US Regulatory System Hope for the
Future? MD4 Utah Summit 2011, October 25, 2011
What Vascular Biology can Teach us About Cancer Biology, Columbia
University, Katz Prize Lecture in Cardiovascular Research, October 27,
2011
VBT-CVM Seminar: Endothelial Angiocrine Regulation Convergence
of Vascular & Cancer Biology, Yale University, October 31, 2011
Cardiovascular Medicine Grand Rounds: The Polymer Coating in Stent
Biology Culprit or Savior, Yale University, November 1, 2011
Whats Gone RIGHT! Innovation Is Still the Cornerstone of Less Invasive
Interventional Therapy, TransCatheter Therapeutic Conference, November
7, 2011 San Francisco
Durable Polymers Can Be a Positive Attribute of a Stent!, TransCatheter
Therapeutic Conference, November 8, 2011 San Francisco
Lecture Title: Do Polymers on Stents Add Risk or Safety? New
Experimental Insights, TransCatheter Therapeutic Conference, November
8, 2011 San Francisco
Drug Coated Balloons Validation Strategies: Bench Testing, In Vivo PK,
and Beyond,TransCatheter Therapeutic Conference, November 8, 2011
San Francisco
Emerging Technologies, 14th annual MIT Venture Capital Conference,
Nov 18, 2011, Boston Marriott Cambridge
2012
Tissue Engineering: Unraveling the Mysteries of Cardiovascular and

Cancer Biology, Hollingsworth Lecture, University of Texas at Austin,
January 26, 2012
58
Elazer R. Edelman
Factors in Stent Thrombogenicity and Stent-Based Drug Deposition,

Cardiovascular Grand Rounds, Beth Israel Deaconess Hospital, January
27, 2012
What Endothelial Biology and Tissue Engineering Have Taught us about
Vascular and Cancer Diseases, Simposi Incor FMUSP Harvard de
Excelencia em Pesquisa Medica May 17, 2012 Sao Paolo Brazil
NIH workshop on imaging in tissue engineering & regenerative medicine
May 31, 2012, Bethesda MD
Cell Based Therapies in Vascular Access Maturation and Preservation,
Fresenius Medical Directors Meeting, Las Vegas NV, June 13, 2012
2012 Smooth Muscle Conference June 24-29, 2012 Snowmass Village,
CO, Chair: Cell to Cell Communication
2012 Smooth Muscle Conference June 24-29, 2012 Snowmass Village,
CO, Cell-cell communication dominates in vascular repair: Coupled
interactions of endothelial cells, smooth muscle cells and monocytes
Sinai Innovations, Innovation: Withering Art or Thriving Science?",
November 13, 2012, Mt Sinai NY
Transcatheter Therapeutic Conference, October 22, 2012, Miami FL,
Associate Director
Is Innovation In The United States On The Road To Recovery? An Interim
Analysis And Critique, Transcatheter Therapeutic Conference, October
22, 2012, Miami FL
DCB - Evaluation Of Drug Transfer, Tissue Pharmacokinetics, And
Vascular Effects, Transcatheter Therapeutic Conference, October 22,
2012, Miami FL
Cell-Based Therapies For Vascular Disease, Transcatheter Therapeutic
Conference, October 22, 2012, Miami FL
Strut Architecture And Polymer Configuration Modulate Device
Outcomes, Transcatheter Therapeutic Conference, October 22, 2012,
Miami FL
2013
Cell-cell Communications Dominates in Tissue Repair: Coupled
Interactions of Endothelial Cells, Smooth Muscle Cells, Monocytes and
59
Elazer R. Edelman
Tissue Cells Implications for Vascular Disease and Cancer Biology,

Association of University Cardiologists Meetings, January 9 -11, 2013
Materials Innovation: Driving the Revolution in Cardiovascular
Interventions, Keynote Address, Society for Biomaterials 2013 Annual
Meeting & Exposition, April 10 13, 2013, Boston, MA
Future of Innovation and Investigation in Science and Technology,
Congressional Committee on Science and Technology, Congress of the
United States, April 16, 2013
The Big Bang in Medicine and Engineering - will the knowledge
explosion actually hurt innovation across disciplines? April 17, TEDMED
2013, Washington DC
Panel Discussion, 2nd Annual Kantoff-Sang Lecture, Regulatory Science:
Perspectives, May 2, 2013, Cambridge, MA
Innovation Grand Rounds; Brigham and Womens Hospital Oct 2013:
Developing Technology in the Modern Era: Industrial-Academic
Collaborations in Creating Cardiovascular Innovations
Keynote Address: Interventional Innovation Then and Now. The
Evolution of Translational Science, Clinical Evidence-Based Medicine.
Transcatheter Cardiovascular Therapeutics, October 28, 2013, San
Francisco, CA
Structural vs. Biologic DES Failure Modes: Experimental Insights.
Transcatheter Cardiovascular Therapeutics, October 28, 2013, San
Francisco, CA
Electrical irrigation alters RF ablation treatment zone geometry and
preserves medical and adventitial tissue while maintaining. Transcatheter
Cardiovascular Therapeutics, October 28, 2013, San Francisco, CA
Computational mthods to assess plaque and intravascular hemodynamics.
George D. Behrakis Cardiovascular Symposium on Vascular Biology,
November 14, 2013, Boston MA
Regulatory Sciences, Harvard Catalyst, The Harvard Clinical and
Translational Science Center, Medical Device Development, November
14, 2013, Cambridge, MA
2014
MMA Roadshow: Managing App Development under FDA Regulation,

March 20, 2014, Cambridge MA
60
Elazer R. Edelman

Translational Science Center, Medical Device Development, April 10,
2014 Cambridge, MA
The unique anatomy of renal artery ostium may limit efficacy of
endovascular radiofrequency ablation, euroPCR, May 21, 2014, Paris
France
Computational methodology for understanding and predicting lesion
geometry in catheter-based renal sympathetic denervation, euroPCR, May
21, 2014, Paris France
Cordis RenLane: Irrigated, helical multi-electrode, euroPCR, May 21,
2014, Paris France
Mechanisms and Myths in Endovascular Stenting, euroPCR, May 21,
2014, Paris France
Thrombosis in Endovascular Implants: Flow, surfaces and milieu
Virchow knew it first. Thrombosis Mini-Symposium, Boston University,
Boston MA, May 29, 2014
DES Gap Analysis 1: Mechanistic Concepts, BioResorbable Vascular
Scaffolds: Transformational Technology for PCI, Boston MA July 25,
2014
Plenary Session IX: Dynamic Dialogues I: Myths and Controversies
Drug-Eluting Stents (Metallic and Bioresorbable). Transcatheter
Cardiovascular Therapeutics, September 14, 2014, Washington DC
Dynamic Dialogues II: Myths and Controversies - Adjunctive
Pharmacology. Transcatheter Cardiovascular Therapeutics, September 15,
2014, Washington DC
Endothelial cell control of vascular and cancer biology. Transcatheter
Cardiovascular Therapeutics, September 15, 2014, Washington DC
Dynamic Dialogues III: Myths and Controversies Endovascular
Therapies. Transcatheter Cardiovascular Therapeutics, September 16,
2014, Washington DC
Early Device Validation Strategies: Changes and Opportunities.
Transcatheter Cardiovascular Therapeutics, September 16, 2014,
Washington DC
61
Elazer R. Edelman
Mechanisms of Renal Denervation, International Conference on

Innovation, Tel Aviv, Israel, December 15, 2014
Renal Denervation: Mechanistic Drivers Explain Disparate Clinical
Findings, International Conference on Innovation, Tel Aviv, Israel,
December 16, 2014
How do we Bridge the Gap in Medical Innovation?, Plenary Lecture,
International Conference on Innovation, Tel Aviv, Israel, December 16,
2014
2015
Endothelial control of Vascular and Cancer Biology, Deans Distinguished

Lecture, Weill-Cornell New York, February 13, 2015
Effects of Orbital Atherectomy Treatment on Drug Absorption in
Calcified Peripheral Arteries, Cardiovascular Research Technologies
2015, Washington DC February 22, 2015
Antiplatelet Therapy and Stent Design: Considerations of Stent Design.\,
Polymer and Drug. Platelet Colloquium, University of Lexington, KY,
April 8, 2015
Endothelial Control of Vascular Disease and Cancer Biology, Department
of Clinical Laboratory and Nutritional Sciences Colloquium University of
Massachusetts Lowell, April 16, 2015
Translational Science Center, Medical Device Development, April 10, 2015
Cambridge, MA
Innovations in Bare Metal, Drug-Eluting, Self-Expanding, and Absorbable
Coronary Stents, Cardiovascular Medicine: Update for the Practitioner,
Boston, MA, May 7, 2015
Innovation in Medicine: We are done or are we only beginning ?, Massimo
Calabresi Lecture, Medical Grand Rounds, Yale University, New Haven
CT, May 14, 2015
Vascular and Cancer Biology Where Specific Etiology clashes with
Tissue Engineering, Cardiology Grand Rounds, Yale University, New
Haven CT, May 15, 2015
Hot line - DES trials and registries, co-chair, Euro-PCR, Paris May 19, 2015
62
Elazer R. Edelman
Primary lesion treatment with orbital atherectomy system enhances

paclitaxel deposition in calcified peripheral arteries, Euro-PCR, Paris May
19, 2015
Redefining bioabsorbable DES with MiStent: drug elution beyond polymer
rpresence- preclinical testing, Euro-PCR, Paris May 20, 2015
Hot line Peripheral interventions, Chair, Euro-PCR, Paris May 20, 2015
Cardiovascular innovation pipeline- TAVI and peripheral interventions, cochair, Euro-PCR, Paris May 20, 2015
Procedural parameters of successful ablation Anything on the horizon,
Euro-PCR, Paris May 21, 2015
Redefining Aortic stenosis Use of Advanced Imaging, Hemodynamics,
Computational Models, and Clinical Data to Revise Triggers Points for
Treatment, Keynote Lecture. TCT-San Francisco, CA, October 11, 2015
Renal Denervation: Do New Anatomical Insights Dictate Procedural
Changes? Lecture TCT-San Francisco, CA, October 11, 2015
Can Todays Metallic Stent Platforms, Delivery Systems, and Durable
Polymers Be Meaningfully Improved? Yes, Made Thinner and More
Flexible, With Optimally Designed Platforms and Enhanced Polymers
There is Still Room for Improvement! Lecture. TCT-San Francisco, CA,
October 12, 2015
Enhanced Circumferential Ablation using a Multi-electrode
Bipolar/Unipolar Over-the-Wire Renal Denervation RF Catheter System
with Closed Loop Sensing Lecture. TCT-San Francisco, CA, October 13,
2015
Emerging Cardiovascular Technologies and Interventional Heart Failure,
Discussant, TCT-San Francisco, CA, October 14, 2015
Bioresorbabale Vascular Scafflods, Part 1, Moderator. TCT-San Francisco,
CA, October 14, 2015
Emerging Understanding of BRS Fundamentals, Lecturer, TCT-San
Francisco, CA, October 14, 2015
b.
Professional and educational leadership role
63
Elazer R. Edelman
3.
Teaching awards received
2000
The 2000 Thomas A. McMahon Mentoring Award, Harvard

University / Massachusetts Institute of Technology Division of
4.
Major curriculum offerings/educational programs developed
1989-1992
Introductory Course for First Year Cardiology Fellows, Brigham and

Womens Hospital, Boston
Organizer and Lecturer
20 cardiology fellows, and faculty members
25 hours per year
HST-150
1989-1996
Pharmacology
founding and core faculty member
60 hours/year
HST-240
1989-present
Physician-Scientist Preceptorship
founding faculty and course director
required graduation 1 month elective
HST-090
1980, 1982
1991-1998
1999-present
Cardiovascular Pathophysiology
tutor
core faculty member
director
E.
Report of Clinical Activities:
1989
Attending Physician, Levine Coronary Care Unit, Brigham and Womens

Hospital, Boston
1.
Core member of the Brigham and Womens Hospital coronary care unit
faculty in addition to general cardiology outpatient and inpatient care.
2.
Clinical activity includes directing the day-to-day care of the most acutely
ill patients in our hospital with ischemic heart disease, unstable angina,
myocardial infarction, respiratory distress, shock, sepsis, sudden death,
congestive heart failure, dysrhythmias etc. I routinely perform diagnostic
right heart catheterization, trans-thoracic echocardiograms, pluerocenteses,
paracenteses, and insertion of temporary pacemakers, pulmonary artery
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Elazer R. Edelman
catheters, central venous catheters, and arterial pressure monitoring

catheters. On an emergent basis I perform pericardiocenteses, tracheal
incubations and insert intra-aortic balloon counterpulsation pumps.
3.
I also serve on a permanent rotating basis at providing formal legacy

interpretations of departmental electrocardiograms
BIBLIOGRAPHY:
Original Articles:
1.
Christopher, PF, Edelman ER. Frequency optimization for low cost satellite
communications, IEEE Transactions on Antennas and Propagation. 1977; 15: 509-511.
2.
Young LR, Litchenberg BK, Arrott AP, Crites TA, Oman CM, Edelman ER. Ocular
torsion on earth and in weightlessness. Ann NY Acad Sci,1981;374:80-92.
3.
Edelman ER, Brown L, Kost J, Taylor J, Langer RS. Modulated release from polymeric
drug delivery systems using oscillating magnetic fields: in vitro and in vivo characteristics.
Trans Am Soc for Artif Intern Organs 1984;30:445-9.
4.
Langer RS, Seigel R, Brown L, Leong K, Kost J, Edelman ER. Controlled release systems:
some recent advances. Polymeric Material Science and Engineering 1984;51:115-118.
5.
McCarthy MJ, Soong DS, Edelman ER. Control of drug release from polymer matrices
impregnated with magnetic beads - a proposed mechanism and model for enhanced release.
Journal of Controlled Release 1984;1:143-147.
6.
Brown L, Edelman ER, Langer RS. Quantitation of simultaneous controlled release of

insulin and somatostatin from implantable polymer matrices. Diabetes 1984;33(suppl.
#1):177a.
7.
Edelman ER, Kost J, Bobeck H, Langer RS. Regulation of drug release from polymer
matrices by oscillating magnetic fields. J Biomed Mater Res 1985;19(1):67-83.
8.
Langer RS, Brown L, Edelman ER. Controlled release and magnetically modulated
release systems for macromolecules. Methods Enzymol 1985;112:399-422.
9.
Langer RS, Seigel R, Brown L, Leong K, Kost J, Edelman ER. Controlled release and
magnetically modulated systems for macromolecular drugs. Ann NY Acad Sci
1985;446:1-13.
10.
Langer RS, Siegel R, Brown L, Leong K, Kost J, Edelman ER. Controlled release: three
mechanisms, Chemtech.1986;16(2):108-10.
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Elazer R. Edelman
11.
Brown L, Munoz C, Siemer L, Edelman ER, Langer RS. Controlled release of insulin
from polymer matrices. Control of diabetes in rats. Diabetes 1986 Jun;35(6):692-7.
12.
Edelman ER, Brown L, Taylor J, Langer RS. In vitro and in vivo kinetics of regulated
drug release from polymer matrices by oscillating magnetic fields. J Biomed Mater Res
1987 Mar;21(3):339-53.
13.
Klagsbrun M, Edelman ER. Biological and biochemical properties of fibroblast growth

factors. Implications for the pathogenesis of atherosclerosis. Arteriosclerosis 1989 MayJun;9(3):269-78.
14.
Muller JE, Tofler GH, Edelman ER. Probable triggers of onset of acute myocardial
infarction. Clin Cardiol 1989 Aug;12(8):473-5.
15.
Friedman PL, Selwyn AP, Edelman ER, Wang PJ. Effect of selective intracoronary
antiarrhythmic drug administration in sustained ventricular tachycardia. Am J Cardiol 1989
Sep;64(8):475-80.
16.
Tofler GH, Stone PH, Maclure M, Edelman ER, Davis VG, Robertson T, Antman EM,
Muller JE. Analysis of possible triggers of acute myocardial infarction (the MILIS study),
Am J Cardiol 1990 Jul;66(1):22-7.
17.
Edelman ER, Smith TW. Role of digitalis in the management of congestive heart failure.
Cardiovascular Perspectives.1990;5(1):6-7.
18.
Edelman ER, Adams DH, Karnovsky MJ. Effect of controlled adventitial heparin delivery
on smooth muscle cell proliferation following endothelial injury. Proc Natl Acad Sci U S
A 1990 May;87(10):3773-7.
19.
Edelman ER, Nugent MA. Controlled release of basic fibroblast growth factor. Drug
News and Perspectives 1991;4(6):352-57.
20.
Edelman ER, Mathiowitz E, Langer RS, Klagsbrun M. Controlled and modulated release
of basic fibroblast growth-factor. Biomaterials 1991 Sep;12(7):619-26.
21.
Edelman ER, Fiorino A, Grodzinsky A, Langer RS. Mechanical deformation of polymer

matrix controlled release devices modulates drug release. J Biomed Mater Res 1992
Dec;26(12):1619-31.
22.
Edelman ER, Stuenkel, CA, Rutherford, JD, Williams, GH. Diabetic ketoacidosis
associated with pheochromocytoma, Clevel Clin J Med 1992 Jul-Aug; 59(4): 423-27
23.
Nugent MA, Edelman ER. Kinetics of basic fibroblast growth factor binding to its receptor
and heparan sulfate proteoglycan: a mechanism for cooperativity. Biochemistry 1992
Sept;31(37):8876-83.
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Elazer R. Edelman
24.
Edelman ER, Nugent MA, Smith LT, Karnovsky MJ. Basic fibroblast growth factor
enhances the coupling of intimal hyperplasia and proliferation of vasa vasorum in injured
rat arteries. J Clin Invest 1992 Feb;89(2):465-73.
25.
Rogers C, Edelman ER. Controlled release of heparin reduces neointimal hyperplasia in

stented rabbit arteries: ramifications for local therapy, J Interv Cardio 1992;5(3):195-202.
26.
Simons M, Edelman ER, DeKeyser JL, Langer RS, Rosenberg RD. Antisense c-myb
oligonucleotides inhibit intimal arterial smooth muscle accumulation in vivo. Nature 1992
Sept;359(6390):67-70.
27.
Nugent MA, Edelman ER. Transforming growth factor 1 stimulates the production of
basic fibroblast growth factor binding proteoglycans in Balb/c3T3 cells. J Biol Chem 1992
Oct;267(29):21256-64.
28.
Edelman ER, Nugent MA, Karnovsky MJ. Perivascular and intravenous administration of
basic fibroblast growth factor: vascular and solid organ deposition. Proc Natl Acad Sci U
S A 1993 Feb;90(4):1513-7.
29.
Donovan MG, Edelman ER. Heparin Binding Growth Factors and Wound Healing.
Medtronic Science and Technology Journal 1993:2-9.
30.
Edelman ER, Pukac LA, Karnovsky MJ. Protamine and protamine-insulins exacerbate the
vascular response to injury. J Clin Invest 1993 May;91(5):2308-13.
31.
Edelman ER, Langer R. Optimization of release from magnetically controlled polymeric

drug release devices. Biomaterials 1993 Jul;14(8):621-6.
32.
Wolfe MW, Edelman ER. Transient systolic dysfunction after relief of cardiac tamponade.
Ann Intern Med 1993 Jul;119(1):42-4.
33.
Rogers C, Karnovsky MJ, Edelman ER. Inhibition of experimental neointimal hyperplasia

and thrombosis depends on the type of vascular injury and the site of drug administration.
Circulation 1993 Sept;88(3):1215-21.
34.
Nugent MA, Karnovsky MJ, Edelman ER. Vascular cell-derived heparan sulfate shows
coupled inhibition of basic fibroblast growth factor binding and mitogenesis in vascular
smooth muscle cells. Circulation Research 1993 Dec;73(6):1051-60.
35.
Harada K, Grossman W, Friedman M, Edelman ER, Prasad PV, Keighley CS, Manning
WJ, Selke FW, Simons M. Basic fibroblast growth factor improves myocardial function in
chronically ischemic porcine hearts. J Clin Invest 1994 Aug;94(2):623-30.
36.
Nathan A, Katada M, Edelman ER. Perivascular heparin delivery using biodegradable

polymers. Polymeric Material Science and Engineering 1994;70:320-21.
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Elazer R. Edelman
37.
Sellke FW, Wang SY, Friedman M, Harada K, Edelman ER, Grossman W, Simons M.
Basic FGF enhances endothelium-dependent relaxation of the collateral-perfused coronary
microcirculation. Am J Physiol 1994 Oct;267(4 Pt 2):H1303-H1311.
38.
Edelman ER, Karnovsky MJ. Contrasting effects of the intermittent and continuous
administration of heparin in experimental restenosis. Circulation 1994 Feb;89(2):770-6.
39.
Rabbani LE, Edelman ER, Ganz P, Selwyn AP, Loscalzo J, Bittl JA. Relation of restenosis
after excimer laser angioplasty to fasting insulin levels. Am J Cardiol 1994 Feb;73(5):32327.
40.
Simons M, Edelman ER, Rosenberg RD. Antisense proliferating cell nuclear antigen
oligonucleotides inhibit intimal hyperplasia in a rat carotid artery injury model. J Clin
Invest 1994 Jun;93(6):2351-6.
41.
Edelman ER, Simons M, Sirois MG, Rosenberg RD. c-myc in vasculoproliferative

disease. Circ Res 1995 Feb;76(2):176-82.
42.
Edelman ER. Perivascular Delivery of Heparin Regulates Myointimal Hyperplasia.

Reactive Polymers 1995;25(2/3):149-56.
43.
Rogers C, Edelman ER. Endovascular stent design dictates experimental restenosis and
thrombosis. Circulation 1995 Jun; 91(12):2995-3001.
44.
Nathan A, Nugent MA, Edelman ER. Tissue engineered perivascular endothelial cell
implants regulate vascular injury. Proc Natl Acad Sci U S A 1995 Aug;92(18):8130-4.
45.
Prausnitz MR, Edelman ER, Gimm JA, Langer R, Weaver JC. Transdermal delivery of
heparin by skin electroporation. Biotechnology(NY) 1995 Nov;13(11):1205-9.
46.
Lovich MA, Edelman ER. Mechanisms of transmural heparin transport in the rat
abdominal aorta after local vascular delivery. Circ Res 1995 Dec; 77(6):1143-50.
47.
Edelman ER, Brown LR, Langer RS. Quantification of insulin release from implantable
polymer-based delivery systems and augmentation of therapeutic effect with simultaneous
release of somatostatin. J Pharm Sci 1996 Dec;85(12):1271-5.
48.
Harada K, Friedman M, Lopez JJ, Wang SY, Li J, Prasad PV, Pearlman JD, Edelman ER,
Sellke FW, Simons M. Vascular Endothelial growth factor administration in chronic
myocardial ischemia. Am J Physiol 1996 May; 270(5 Pt 2):H1791-802.
49.
Lopez JJ, Edelman ER, Stamler A, Morgan JP, Sellke FW, Simons M. Local perivascular
administration of basic fibroblast growth factor: drug delivery and toxicological
evaluation. Drug Metab Dispos1996 Aug;24(8):922-4.
50.
Lovich MA, Edelman ER. Computational simulations of local vascular heparin deposition
and distribution. Am J Physiol 1996 Aug;271(5 Pt 2):H2014-24.
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Elazer R. Edelman
51.
Lovich MA, Edelman ER. Tissue average binding and equilibrium distribution: an
example with heparin in arterial tissues. Biophys J 1996 Mar;70(3):1553-9.
52.
Edelman ER, Sirois MG. Antisense strategies for controlling the vascular response to
injury. J Vasc Surg 1996;24(1):166-69.
53.
Koo EWY, Edelman ER. Cellular Effects of Antisense c-myc Oligodeoxynucleotides Are
Delivery-Dependent. Drug Delivery 1996;3(3):149-54.
54.
Rogers C, Welt FG, Karnovsky MJ, Edelman ER. Monocyte recruitment and neointimal
hyperplasia in rabbits. Coupled inhibitory effects of heparin. Arterioscler Thromb Vasc
Biol 1996 Oct;16(10):1312-8.
55.
Dinbergs ID, Brown L, Edelman ER. Cellular response to transforming growth factor-1
and basic fibroblast growth factor depends on release kinetics and extracellular matrix
interactions. J Biol Chem 1996 Nov; 271(47):29822-9.
56.
Brown LR, Edelman ER, Fischel-Ghodsian F, Langer RS. Characterization of glucosemediated insulin release from implantable polymers. J Pharm Sci 1996 Dec; 85(12):13415.
57.
Rogers C, Parikh S, Seifert P, Edelman ER. Endogenous cell seeding. Remnant

endothelium after stenting enhances vascular repair. Circulation 1996 Dec; 94(11):290914.
58.
English AE, Tanaka T, Edelman ER. Polyelectrolyte hydrogel instabilities in ionic

solution. J Chem Physics 1996; 105(23):10606-13.
59.
Rigotti A, Edelman ER, Seifert P, Iqbal SN, DeMattos RB, Temel RE, Krieger M,
Williams DL. Regulation by adrenocorticotropic hormone of the in vivo expression of
scavenger receptor Class B Type I (SR-BI), a high density lipoprotein receptor in
steroidogenic cells of the murine adrenal gland. J Biol Chem 1996 Dec;217(52):33545-9.
60.
D'Orlans-Juste P, Sirois MG, Edelman ER, Regoli D, Pheng LH, Bkaily G, Lindsey CJ.
DNA antisense strategies in the study of receptors for vasoactive peptides, and of growth
and wound-healing factors. Mol Cell Biochem 1997 Jul;172(1-2):199-211.
61.
Han RO, Ettenson DS, Koo EW, Edelman ER. Heparin/heparan sulfate chelation inhibits
control of vascular repair by tissue-engineered endothelial cells. Am J Physiol 1997 Dec;
273(6 Pt 2):H2586-95.
62.
Lopez JJ, Edelman ER, Stamler A, Hibberd MG, Prasad P, Caputo RP, Carrozza JP,
Douglas PS, Sellke FW, Simons M. Basic fibroblast growth factor in a porcine model of
chronic myocardial ischemia: a comparison of angiographic, echocardiographic and
coronary flow parameters, J Pharmacol Exp Ther1997 Jul;282(1):385-90.
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Elazer R. Edelman
63.
Sirois MG, Edelman ER. VEGF effect on vascular permeability is mediated by synthesis
of platelet-activating factor. Am J Physiol 1997 Jun;272(6Pt2):H2746-56.
64.
Sirois MG, Simons M, Edelman ER. Antisense oligonucleotide inhibition of PDGFR-

receptor subunit expression directs suppression of intimal thickening. Circulation.
1997Feb;95(3):669-76.
65.
Kozarsky KF, Donahee MH, Rigotti A, Iqbal SN, Edelman ER, Krieger M.
Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels.
Nature 1997 May; 387(6631):414-7.
66.
Lovich MA, Brown L, Edelman ER. Drug clearance and arterial uptake after local
perivascular delivery to the rat carotid artery. J Am Coll Cardiol 1997 Jun;29(7):1645-50.
67.
English AE, Tanaka T, Edelman ER. Equilibrium and Non-Equilibrium Phase Transitions
in Copolymer Polyelectrolyte Hydrogels. J Chem Physics 1997;107(5):1645-54.
68.
Sirois MG, Simons M, Kuter DJ, Rosenberg RD, Edelman ER. Rat arterial wall retains
myointimal hyperplastic potential long after arterial injury. Circulation 1997Aug;
96(4):1291-8.
69.
Nugent HM, Edelman ER. Local Drug Delivery and Tissue Engineering Regulate
Vascular Injury. Current Pharmaceutical Design 1997;3(6):529-44.
70.
Sellke FW, Laham RJ, Edelman ER, Pearlman JD, Simons M. Therapeutic angiogenesis
with basic fibroblast growth factor: technique and early results. Ann Thorac Surg 1998
Jun;65(6):1540-4.
71.
Tseng DY, Edelman ER. Effects of amide and amine plasma-treated ePTFE vascular
grafts on endothelial cell lining in an artificial circulatory system. J Biomed Mater Res
1998 Nov;42(2):188-98.
72.
Lopez JJ, Edelman ER, Stamler A, Hibberd MG, Prasad P, Thomas KA, DiSalvo J,
Caputo RP, Carrozza JP, Douglas PS, Sellke FW, Simons M. Angiogenic potential of
perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia. Am J
Physiol 1998 Mar;274(3 Pt 2):H930-6.
73.
Kjelsberg MA, Seifert P, Edelman ER, Rogers C. Design-Dependent Variations in

Coronary Stent Stenosis Measured as Precisely by Angiography as by Histology. J Invasive
Cardiol 1998;10(3):142-50.
74.
Edelman ER, Rogers C. Pathobiologic responses to stenting. Am J Cardiol 1998

Apr;81(7A):4E-6E.
75.
Rogers C, Edelman ER, Simon DI. A mAb to the 2-leukocyte integrin Mac-1
(CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in
rabbits. Proc Natl Acad Sci U S A 1998 Aug;95(17):10134-9.
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Elazer R. Edelman
76.
Yu C, Cunningham M, Rogers C, Dinbergs ID, Edelman ER. The biologic effects of

growth factor-toxin conjugates in models of vascular injury depend on dose, mode of
delivery, and animal species. J Pharm Sci1998 Nov;87(11):1300-4.
77.
English AE, Tanaka T, Edelman ER. Polymer and Solution Ion Shielding in
Polyampholytic Hydrogels. Polymer 1998;39(24):5893-97.
78.
Lovich MA, Philbrook M, Sawyer S, Weselcouch E, Edelman ER. Arterial heparin

deposition: role of diffusion, convection, and extravascular space. Am J Physiol 1998
Dec;275(6 Pt 2):H2236-42.
79.
Raman VK, Edelman ER. Coated stents: local pharmacology. Semin Interv Cardiol 1998
Sep-Dec; 3(3-4);133-7.
80.
Nugent HM, Rogers C, Edelman ER. Endothelial implants inhibit intimal hyperplasia
after porcine angioplasty. Circ Res 1999 Mar;84(4):384-91.
81.
Rogers C, Tseng DY, Squire JC, Edelman ER. Balloon-artery interactions during stent
placement: a finite element analysis approach to pressure, compliance, and stent design as
contributors to vascular injury. Circ Res 1999 Mar;84(4):378-83.
82.
Wan WK, Lovich MA, Hwang CW, Edelman ER. Measurement of drug distribution in
vascular tissue using quantitative fluorescence microscopy. J Pharm Sci 1999
Aug;88(8):822-9.
83.
Lovich MA, Edelman ER. Tissue concentration of heparin, not administered dose,
correlates with the biological response of injured arteries in vivo. Proc Natl Acad Sci U S
A 1999 Sep;96(20):11111-6.
84.
Squire JC, Rogers C, Edelman ER. Measuring arterial strain induced by endovascular
stents. Med Biol Eng Comput 1999 Nov;37(6):692-8.
85.
Laham RJ, Sellke FW, Edelman ER, Pearlman JD, Ware JA, Brown DL, Gold JP, Simons
M. Local perivascular delivery of basic fibroblast growth factor in patients undergoing
coronary bypass surgery: results of a phase I randomized, double-blind, placebo-controlled
trial. Circulation 1999 Nov;100(18):1865-71.
86.
Ettenson DS, Koo EW, Januzzi JL, Edelman ER. Endothelial heparan sulfate is necessary
but not sufficient for control of vascular smooth muscle cell growth. J Cell Physiol 2000
Jul;184(1):93-100.
87.
Ettenson DS, Edelman ER. Local drug delivery: an emerging approach in the treatment
of restenosis. Vasc Med 2000; 5(2):97-102.
88.
Noh I, Lovich MA, Edelman ER. Mechanisms of heparin transport through expanded
poly(tetrafluoroethylene) vascular grafts. J Biomed Mater Res 2000 Jan;49(1):112-9.
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Elazer R. Edelman
89.
Simon DI, Dhen Z, Seifert P, Edelman ER, Ballantyne CM, Rogers C. Decreased
neointimal formation in Mac-1-/- mice reveals a role for inflammation in vascular repair
after angioplasty. J Clin Invest 2000 Feb;105(3):293-300.
90.
Garasic JM, Edelman ER, Squire JC, Seifert P, Williams MS, Rogers C. Stent and artery
geometry determine intimal thickening independent of arterial injury. Circulation 2000
Feb;101(7):812-8.
91.
Creel CJ, Lovich MA, Edelman ER. Arterial paclitaxel distribution and deposition. Circ
Res 2000 Apr;86(8):879-84.
92.
Tavakkolizadeh A, Shen R, Abraham P, Kormi N, Seifert PA, Edelman ER, Jacobs DO,
Zinner MJ, Ashley SW, Whang EE. Glucagon-like peptide 2: a new treatment for
chemotherapy-induced enteritis. J Surg Res 2000;91(1):77-82.
93.
Nugent MA, Nugent HM, Iozzo RV, Sanchack K, Edelman ER. Perlecan is required to
inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated
inhibition of intimal hyperplasia. Proc Natl Acad Sci U S A 2000 Jun;97(12):6722-7.
94.
Edelman ER, Nathan A, Katada M, Gates J, Karnovsky MJ. Perivascular graft heparin
delivery using biodegradable polymer wraps. Biomaterials 2000 Nov;21(22):2279-86.
95.
Elmalak O, Lovich MA, Edelman ER. Correlation of transarterial transport of various

dextrans with their physicochemical properties. Biomaterials 2000 Nov;21(22):2263-72.
96.
Drachman DE, Edelman ER, Seifert P, Groothuis AR, Bornstein DA, Kamath KR, Palasis
M, Yang D, Nott SH, Rogers C. Neointimal thickening after stent delivery of paclitaxel:
change in composition and arrest of growth over six months. J Am Coll Cardiol 2000
Dec;36(7):2325-32.
97.
Welt FG, Edelman ER, Simon DI, Rogers C. Neutrophil, not macrophage, infiltration
precedes neointimal thickening in balloon-injured arteries. Arterioscler Thromb Vasc Biol
2000 Dec;20(12):2553-8.
98.
Parikh SA, Edelman ER. Endothelial cell delivery for cardiovascular therapy. Adv Drug
Deliv Rev 2000 Aug; 42(1-2):139-61.
99.
Edelman ER, Seifert P, Groothuis A, Morss A, Bornstein D, Rogers C. Gold-coated NIR

stents in porcine coronary arteries. Circulation 2001 Jan;103(3):429-34.
100.
Consi TR, Seifert PA, Triantafyllou MS, Edelman ER. The dorsal fin engine of the
seahorse (Hippocampus sp.). J Morphol 2001 Apr;248(1):80-97.
101.
Hwang CW, Wu D, Edelman ER. Physiological transport forces govern drug distribution
for stent-based delivery. Circulation 2001 Jul;104(5):600-05.
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Elazer R. Edelman
102.
Nugent HM, Edelman ER. Endothelial implants provide long-term control of vascular
repair in a porcine model of arterial injury. J Surg Res 2001 Aug;99(2):228-34.
103.
Lovich MA, Creel C, Hong K, Hwang CW, Edelman ER. Carrier proteins
determine local pharmokinetics and arterial distribution of paclitaxel. J Pharm Sci
2001 Sep;90(9):1324-35.
104.
Welt FG, Woods TC, Edelman ER. Oral heparin prevents neointimal hyperplasia
following arterial injury: inhibitory potential depends on type of vascular injury.
Circulation 2001 Dec;104(25):3121-4.
105.
Woods TC, Blystone CR, Yoo J, Edelman ER. Activation of EphB2 and its ligands
promotes vascular smooth muscle cell proliferation. J Biol Chem 2002 Jan;277(3):1924-7.
PMID: 11706028
106.
Hwang CW, Edelman ER. Arterial ultrastructure influences transport of locally delivered
drugs. Circ Res 2002 Apr; 90(7):826-32. PMID: 11964377
107.
Balcells M, Edelman ER. Effect of pre-absorbed proteins on attachment, proliferation,

and function of endothelial cells. J Cell Physiol 2002 May; 191(2):155-61. PMID:
12064458
108.
Lewis EF, Edelman ER. Images in cardiovascular medicine. Acute ST depressions in a

patient with idiopathic hypertrophic subaortic stenosis and normal coronary arteries.
Circulation 2002 Aug; 106(6):757-8. PMID: 12163440
109.
Nugent HM, Groothuis A, Seifert P, Guerrero JL, Nedelman M, Mohanakumar T,

Edelman ER. Perivascular endothelial implants inhibit intimal hyperplasia in model of
arteriovenous fistulae: a safety and efficacy study in the pig. J Vasc Res 2002 NovDec;39(6):524-33. PMID: 12566978
110.
Kolandaivelu K, Edelman ER. Low background, pulsatile, in vitro circuit for modeling
coronary implant thrombosis. J Biomech Eng 2002 Dec;124(6):662-8. PMID: 12596633
111.
Danenberg HD, Welt, FG, Walker III, M, Seifert P, Toegel GS, Edelman, ER. Systemic
inflammation induced by lipopolysaccharide increases neointimal formation after balloon
and stent injury in rabbits. Circulation 2002 Jun;105(24):2917-22. PMID: 12070123
112.
Schwartz RS, Edelman ER, Carter A, Chronos N, Rogers C, Robinson KA, Waksman R,
Weingerger J, Wilensky RL, Jensen DN, Zuckerman BD, Virmani R. Drug-eluting stents
in preclinical studies: recommended evaluation from a consensus group. Circulation 2002
Oct;106(14):1867-73. PMID: 12356643
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Elazer R. Edelman
113.
Stultz CM, Levin AD, Edelman ER. Phosphorylation-induced conformational changes in

a mitogen-activated protein kinase substrate. Implications for tyrosine hydroxylase
activation. J Biol Chem 2002 Dec; 277(49): 47653-61. PMID: 12361946
114.
Hwang CW, Wu D, Edelman ER. Impact of transport and drug properties on the local
pharmacology of drug-eluting stents. Int J Cardiovasc Intervent. 2003; 5(1): 7- 12.PMID:
12623559
115.
Welt FG, Tso C, Edelman ER, Kjelsberg MA, Paolini JF, Seifert P, Rogers C. Leukocyte
recruitment and expression of chemokines following different forms of vascular injury.
Vasc Med 2003; 8(1):1-7. PMID: 12866605
116.
Danenberg HD, Szalai AJ, Swaminathan RV, Peng L, Chen Z, Seifert P, Fay WP, Simon
DI, Edelman ER. Increased thrombosis after arterial injury in human C-reactive proteintransgenic mice. Circulation 2003 Aug; 108(5): 512-5. PMID: 12874178
117.
Danenberg HD, Golomb G, Groothuis A, Gao J, Epstein H, Swaminathan RV, Seifert P,

Edelman ER. Liposomal alendronate inhibit systemic innate immunity and reduces instent neointimal hyperplasia in rabbits. Circulation 2003 Dec;108(22):2798-804. PMID:
14610008
118.
Janicki C, Hwang CW, Edelman ER. Dose model for stent-based delivery of a radioactive
compound for the treatment of restenosis in coronary arteries. Med Phys. Oct 2003; 30(10):
2622-8. PMID: 14596298
119.
Stultz CM, Edelman ER. A structural model that explains the effects of hyperglycemia on
collagenolysis. Biophys J 2003 Oct; 85(4):2198-204. PMID: 25735934
120.
Nugent HM, Edelman ER. Tissue engineering therapy for cardiovascular disease. Circ
Res 2003 May;92(10);1068-78. PMID: 12775655
121.
Rogers C, Huynh R, Seifert PA, Chvalier B, Schofer J, Edelman ER, Toegel G, Kuchela
A, Woupio A, Kuntz RE, Macon ND. Embolic protection with filtering or occlusion
balloons during saphenous vein graft stenting retrieves identical volumes and sizes of
particulate debris. Circulation 2004 Apr;109(14):1735-40. PMID: 15066954
122.
Wu D, Edelman ER. Resonance energy transfer for assessing the molecular integrity of
proteins for local delivery. Biotechnol Bioeng 2004 Feb; 85(4):406-12. PMID: 14755558
123.
Sapp JL, Cooper JM, Soejima K, Sorrell T, Lopera G, Satti SD, Koplan BA, Epstein LM,
Edelman ER, Rogers C, Stevenson WG. Deep myocardial ablation lesions can be created
with a retractable needle-tipped catheter. Pacing Clin Electrophysiol 2004;27(5):594-9.
124.
Richter Y, Groothuis A, Seifert P, Edelman ER. Dynamic flow alterations dictate

leukocyte adhesion and response to endovascular interventions. J Clin Invest 2004
Jun;113(11):1607-14. PMID: 15173877
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Elazer R. Edelman
125.
Tzafriri AR, Wu D, Edelman ER. Analysis of compartmental models of ligand-induced

endocytosis. J Theor Biol 2004 Jul; 229(1):127-38. PMID: 15178191
126.
Tzafriri AR, Edelman ER. The total quasi-steady-state approximation is valid for
reversible enzyme kinetics. J Theor Biol 2004 Feb;226(3):303-13.
127.
Levin AD, Vukmirovic N, Hwang CW, Edelman ER. Specific binding to intracellular
proteins determines arterial transport properties for rapamycin and paclitaxel. Proc Natl
Acad Sci U S A 2004 Jun;101(25):9463-7. PMID: 15197278
128.
Kolandaivelu K, Edelman ER. Environmental influences on endovascular stent platelet

reactivity: an in vitro comparison of stainless steel and gold surfaces. J Biomed Mater
Res A 2004 Aug;70(2):186-93. PMID: 15227663
129.
Schwartz RS, Edelman ER, Carter A, Chronos NA, Rogers C, Robinson KA, Waksman
R, Machan L, Weinberger J, Wilensky RL, Goode JL, Hottenstein OD, Zuckerman BD,
Virmani R. Preclinical evaluation of drug-eluting stents for peripheral applications:
recommendations from an expert consensus group. Circulation 2004 Oct;110(16):2498505. PMID: 15492330
130.
Tzafriri AR, Edelman ER. On the validity of the quasi-steady state approximation of
bimolecular reactions in solution. J Theor Biol 2005 Apr; 233(3):343-50. PMID:
15652144
131.
Balcells M, Fernandez Suarez M, Vazquez M, Edelman ER. Cells in fluidic environments

are sensitive to flow frequency. J Cell Physiol. 2005 Jul;204(1): 329-35. PMID: 15700266
132.
Methe H, Brunner S, Wiegand D, Nabauer M, Koglin J, Edelman ER. Enhanced Thelper-1 lymphocyte activation patterns in acute coronary syndromes. J Am Coll Cardiol
2005 Jun; 45(12):1939-45. PMID: 15963390
133.
Balakrishnan B, Tzafriri AR, Seifert P, Groothuis A, Rogers C, Edelman ER. Strut

position, blood flow, and drug deposition: implications for single and overlapping drugeluting stents. Circulation 2005 Jun; 111(22): 2958-65. PMID: 15927969
134.
Hwang CW, Levin AD, Jonas M, Li PH, Edelman ER. Thrombosis modulates arterial
drug distribution for drug-eluting stents. Circulation 2005 Apr; 111(13):1619-26. PMID:
11964377
135.
Jonas M, Edelman ER, Groothuis A, Baker AB, Seifert P, Rogers C. Vascular neointimal
formation and signaling pathway activation in response to stent injury in insulin-resistant
and diabetic animals. Circ Res 2005 Sep; 97(7):725-33. PMID: 16123336
136.
Francesch L, Garreta E, Balcells M, Edelman ER, Borrs S, Fabrication of bioactive

surfaces by plasma polymerization techniques using a novel acrylated-derived monomer.
Plasma Process Polym 2005; 2:605-11.
75
Elazer R. Edelman
137.
Noh I, Edelman ER. Smooth muscle cell ingrowth of a surface-modified ePTFE vascular
graft. Key Engineering Materials 2005, (288-289):367-370.http://www.scientific.net
138.
Levin AD, Jonas M, Hwang CW, Edelman ER. Local and systemic drug competition in
drug-eluting stent tissue deposition properties. J Control Release 2005 Dec;109(1-3):23643. PMID: 16289420
139.
Methe H, Nugent HM, Groothuis A, Seifert P, Sayegh MH, Edelman ER. Matrix
embedding alters the immune response against endothelial cells in vitro and in vivo.
Circulation 2005 Aug; 112(9 Suppl):I89-95. PMID: 16159871
140.
Costa LF, Balcells M, Edelman ER, Nadler LM, Cardoso AA. Proangiogenic stimulation
of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockage of
mTOR and NF-kappaB. Blood 2006 Jan;107(1):285-92. PMID: 16141350
141.
Methe H, Edelman ER. Cell-matrix contact prevents recognition and damage of

endothelial cells in states of heightened immunity. Circulation 2006 Jul; 114(1
Suppl):1233-8. PMID: 16820578
142.
Methe H, Edelman ER. Tissue Engineering of Endothelial Cells and the Immune
Response. Transplant Proc 2006 Dec; 38(10):3293-9.
143.
Methe H, Groothuis A, Sayegh MH, Edelman ER. Matrix adherence of endothelial cells
attenuates immune reactivity: induction of hyporesponsiveness in allo- and xenogeneic
models, Faseb J 2007 May; 21(7):1515-26. PMID: 17264166
144.
Thomas AH, Edelman ER, Stultz CM. Collagen fragments modulate innate immunity.
Exp Biol Med (Maywood) 2007 Mar; 232(3):406-11. PMID: 17327474
145.
Tzafriri AR, Edelman ER. Endosomal receptor kinetics determine the stability of
intracellular growth factor signaling complexes. Biochem J 2007 Mar; 402(3):537-49.
PMID: 17117924
146.
Danenberg HD, Kantak N, Grad E, Swaminathan RV, Lotan C, Edelman ER. C-reactive
protein promotes monocyte-platelet aggregation: an additional link to the inflammatorythrombotic intricacy. Eur J Haematol 2007 Mar; 78(3):246-52. PMID: 17253971
147.
Tzafriri AR, Edelman ER, Quasi-steady-state kinetics at enzyme and substrate

concentrations in excess of the Michaelis-Menten constant. J Theor Biol 2007 Apr; 245(4):
737-48.
148.
Hamik A, Lin Z, Kumar A, Balcells M, Sinha S, Katz J, Feinberg MW, Gerzsten RE,
Edelman ER, Jain MK. Kruppel-like factor 4 regulates endothelial inflammation. J Biol
Chem 2007 May; 282(18): 13769-79. PMID: 17339326
149.
Methe H, Hess S, Edelman ER. Endothelial cell-matrix interactions determine maturation

of dendritic cells. Eur J Immunol 2007 Jun; 37(7):1773-1784. PMID: 17559179
76
Elazer R. Edelman
150.
Methe H, Balcells M, Alegret Mdel C, Santacana M, Molins B, Hamik A, Jain MK,

Edelman ER. Vascular bed origin dictates flow pattern regulation of endothelial adhesion
molecule expression. Am J Physiol Heart Circ Physiol 2007 May; 292(5):H2167-75.
PMID: 17209004
151.
Methe H, Hess S, Edelman ER. Endothelial immunogenicity--a matter of matrix

microarchitecture. Thromb Haemost 2007 Aug; 98(2):278-82.. PMID: 17721607
152.
Morss AS, Edelman ER. Glucose modulates basement membrane fibroblast growth
factor-2 via alterations in endothelial cell permeability. J Biol Chem 2007 May;
282(19):14635-44. PMID: 17327226
153.
Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH. Role of
endothelial shear stress in the natural history of coronary atherosclerosis and vascular
remodeling: molecular, cellular and vascular behavior. J Am Coll Cardiol 2007 Jun;
49(25):2379-93. PMID: 17599600
154.
Grad E, Golomb M, Mor-Yosef I, Koroukhov N, Lotan C, Edelman ER, Danenberg HD.

Transgenic expression of human C-reactive protein suppresses endothelial nitric oxide
synthase expression and bioactivity following vascular injury. Am J Physiol Heart Circ
Physiol 2007 Jul; 293(1): H489-95. PMID: 17369452
155.
Kaluski E, Groothuis A, Klapholz M, Seifert P, Edelman ER. Coronary stenting with Mguard: feasibility and safety porcine trial. J Invasive Cardiol 2007 Aug; 19(8):326-30.
156.
Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Stone PH, Feldman CL. Risk
stratification of individual coronary lesions using local endothelial shear stress: a new
paradigm for managing coronary artery disease. Curr Opin Cardiol 2007 Nov;22(6):55264. PMID: 17921744
157.
Balakrishnan B, Dooley JF, Kopia G, Edelman ER. Intravascular drug release kinetics
dictate arterial drug deposition, retention, and distribution. J Control Release 2007 Nov;
123(2):100-8. PMID: 17868948. PMC2702153
158.
Methe H, Hess S, Edelman ER. Endothelial cell-matrix interactions determine maturation

of dendritic cells. Eur J Immunol 2007 Jul;37(7):1773-84. PMID: 17209004
159.
Nugent HM, Sjin RT, White D, Milton LG, Manson RJ, Lawson JH,Edelman ER.
Adventitial endothelial implants reduce matrix metalloproteinase-2 expression and
increase luminal diameter in porcine arteriovenous grafts. J Vasc Surg 2007 Sept;
46(3):548-556. PMID: 17826244. PMC2702136
160.
Schubert SY, Benarroch A, Ostvang J, Edelman ER. Regulation of endothelial cell

proliferation by primary monocytes. Arterioscler Thromb Vasc Biol 2008 Jan; 28(1)97104. PMID: 17991870
77
Elazer R. Edelman
161.
Chatzizisis YS, Jonas M, Coskun AU, Beigel R, Stone BV, Maynard C, Gerrity RG, Daley
W, Rogers C, Edelman ER, Feldman CL, Stone PH. Prediction of the localization of highrisk coronary atherosclerotic plaques on the basis of low endothelial shear stress: an
intravascular ultrasound and histopathology natural history study. Circulation 2008 Feb;
117(8):993-1002. PMID:18250270
162.
Zani B, Kojima K, Vacanti C, Edelman ER. Tissue-engineered endothelial and epithelial

implants differentially and synergistically regulate airway repair. Proc Natl Acad Sci U S
A 2008 May 13; 105(19):7046-51. PMCID:PMC2383974
163.
Mi LY, Ettenson DS, Edelman ER. Phospholipase C-delta extends intercellular signalling
range and responses to injury-released growth factors in non-excitable cells. Cell Prolif
2008 Aug; 41(4): 671-90. PMCID: PMC2838236
164.
Baker AB, Ettenson DS, Jonas M, Nugent MA, Iozzo RV, Edelman ER. Endothelial cells
provide feedback control for vascular remodeling through mechanosensitive autocrine
TGF-beta signaling pathway. Circ Res 2008 Aug; 103(3); 289-97. PMCID: PMC2766078
165.
Balcells M, Wallins JS, Edelman ER. Amyloid beta toxicity dependent upon endothelial
cell state. Neurosci Lett 2008 Aug; 441(3): 319-22. PMCID: PMC2536632
166.
Morss Clyne AS, Zhu H, Edelman ER. Elevated fibroblast growth factor-2 increases
tumor necrosis factor-alpha induced endothelial cell death in high glucose. J Cell Physiol
2008 Oct; 217(1):86-92. PMCID: PMC2838244
167.
Wu PI, Edelman ER. Structural biomechanics modulate intramuscular distribution of

locally delivered drugs. J Biomech 2008 Sep; 41(13):2884-91. PMCID:PMC2613955
168.
Epstein H, Grad E, Golomb M, Koroukhov N, Edelman ER, Golomb G, Danenberg HD.

Innate immunity has a dual effect on vascular healing: suppression and aggravation of
neointimal formation and remodeling post-endotoxin challenge. Atherosclerosis 2008 Jul;
199(1): 41-6. PMCID:PMC2839234
169.
Balakrishnan B, Dooley J, Kopia G, Edelman ER. Thrombus causes fluctuations in arterial

drug delivery from intravascular stents. J Control Release 2008 Nov; 131(3):173-80.
PMCID: PMC2852622
170.
Shazly TM, Artzi N, Boehning F, Edelman ER. Viscoelastic adhesive mechanics of

aldehyde-mediated soft tissue sealants. Biomaterials 2008 Dec; 29(35):4584-91.
PMCID:PMC2614899
171.
Danenberg H, Grad E, Swaminathan RV, Chen Z, Seifert P, Szalai AJ, Lotan C, Simon DI,
Edelman ER. Neointimal formation is reduced after arterial injury in human crp transgenic
mice. Atherosclerosis 2008 Nov; 201(1):85-91. PMID: 18358478. PMC2857691
172.
Morss Clyne A, Edelman ER. Vascular growth factor binding kinetics to the endothelial
cell basement membrane, with kinetics-based correction for substrate binding.
78
Elazer R. Edelman
Cytotechnology 2009 Jul; 60(1): 33-44. PMCID: PMC3076139

173.
Chatzizisis YS, Jonas M, Beigel R, Coskun AU, Baker AB, Stone BV, Maynard C, Gerrity
RG, Daley W, Edelman ER, Feldman CL, Stone PH. Attenuation of inflammation and
expansive remodeling by Valsartan alone or in combination with Simvastatin in high-risk
coronary atherosclerotic plaques. Atherosclerosis 2009 Apr; 203(2): 387-94. PMID:
18786669 (submitted 10/23/15)
174.
Methe H, Hess S, Edelman ER. The effect of three-dimensional matrix-embedding of

endothelial cells on the humoral and cellular immune response. Seminars in Immunology
2008 Feb; 20:117-122. PMID: 18243732
175.
Kolachalama VB, Tzafriri AR, Arifin DY, Edelman ER. Luminal flow patterns dictate
arterial drug deposition in stent-based delivery. J of Control Release 2009 Jan; 133(1):2430. PMCID:PMC2836846
176.
Baker AB, Groothuis A, Jonas M, Ettenson DS, Shazly T, Zcharia E, Vlodavsky I, Seifert
P, Edelman ER. Heparanase alters arterial structure, mechanics, and repair following
endovascular stenting in mice. Circ Res 2009 Feb; 104(3):380-7. PMCID:PMC2805167.
177.
Tzafriri AR, Levin AD, Edelman ER. Diffusion-limited binding explains binary dose
response for local arterial and tumor drug delivery. Cell Proliferation 2009 Jun; 42(3):348363. PMCID: PMC2852623
178.
Maron BA, Kolandaivelu K, Rhee DK, Bukhman AK, Edelman ER. Echocardiographic
capture of right ventricular wall rupture during inferior wall acute myocardial infarction.
Am J Cardiol 2009 May; 103(10):1478-80. PMID: 19427450
179.
Hess S, Methe H, Kim JO, Edelman ER. NF-kappaB activity in endothelial cells is
modulated by cell substratum interactions and influences chemokine-mediated adhesion of
natural killer cells. Cell Transplant 2009;18(3): 261-73. PMCID: PMC2857529
180.
Mobine HR, Engelmayr GC, Moussazadeh N, Anwar TR, Freed LE, Edelman ER.
Encapsulated pheochromocytoma cells secrete potent noncatecholamine factors. 2009 Jul;
Tissue Eng Part A;15(7):1719-28. PMCID:PMC2792103
181.
Le KN, Hwang CW, Tzafriri AR, Lovich MA, Hayward A, Edelman ER. Vascular
regeneration by local growth factor release is self-limited by microvascular clearance.
Circulation 2009 Jun; 119(22):2928-35. PMCID:PMC2764268
182.
Wu PI, Minisini S, Edelman ER. Intramuscular drug transport under mechanical loading:
resonance between tissue function and uptake. J Control Release 2009 Jun;136(2):99-109.
PMCID: PMC2683910.
182.
Artzi N, Shazly T, Crespo C, Bon Ramos A, Chenault K, Edelman ER. Characterization

of star adhesive sealant based on PEG:dextran hydrogels. Macromolecular Bioscience
2009 Aug; 9(8):754-65. PMID: 19384975
79
Elazer R. Edelman
183.
Mobine HR, Baker AB, Wang L, Wakimoto H, Seidman CE, Seidman JG, Edelman ER.
Pheochromocytoma-induced cardiomyopathy is modulated by the synergistic effects of
cell-secreted factors. Circ Heart Fail 2009 Mar; 2(2):121-8. PMCID:PMC2769512.
184.
Artzi N, Shazly T, Baker A, Bon A, Edelman ER. Aldehyde-Amine Chemistry Enables

Modulated Biosealants with Tissue-Specific Adhesion. Advanced Materials 2009 Sep; 21:
3399-3403, PMCID: PMC3615669
185.
Nugent H, Ng YS, White D, Groothius A, Kanner G, Edelman ER. Delivery site of

perivascular endothelial cell matrices determines control of stenosis in a porcine femoral
tent model. J Vasc Interv Radiol 2009 Dec; 20(12); 1617-24. PMCID:PMC2788031.
186.
Kolachalama V, Levine E, Edelman ER. Luminal flow amplifies stent-based drug

deposition in arterial bifurcations. Public Library of Science 2009 Dec; 4(12):e8105.
PMCID:PMC2781163
187.
Alexander I, Edelman ER, Methe H. Function and mode of regulation of endothelial major
histocompatibility complex class II. Cell Transplant 2009; 18(3):255-9.
PMCID:PMC2845447
188.
Zani BG, Indolfi L, Edelman ER. Tubular bridges for bronchial epithelial cell migration
and communication. Public Library of Science 2010 Jan; 5(1): e8930.
PMCID:PMC2812493
189.
Tzafriri A, Vukmirovic N, Kolachalama V, Astafieva I, Edelman ER. Lesion complexity

determines arterial drug distribution after local drug delivery. Journal of Controlled
Release 2010 Mar;142(3): 332-338. PMCID:PMC2994187
190.
Schubert SY, Benarroch A, Monter-Solans, J, Edelman ER. Monocyte activation state

regulates monocyte-induced endothelial proliferation through Met signaling. Blood 2010
Apr; 115(16):3407-12. PMCID:PMC2858488
191.
Methe H, Nanasato M, Spognardi A, Groothuis A, Edelman ER. Th2 cells are essential
for modulation of vascular repair by allogeneic endothelial cells. Journal of Heart and Lung
Transplantation 2010 Apr; 29(4):479-486. PMCID:PMC2846227
192.
Aronson D, Edelman ER. Revascularization for coronary artery disease in diabetes

mellitus: Angioplasty, stents and coronary artery bypass grafting. Reviews in Endocrine
and Metabolic Disorders 2010 Mar; 11(1):75-86. PMCID:PMC3076727
193.
Brown L, Edelman ER. Optimal control of blood glucose: the diabetic patient or the
machine. Science Translational Medicine 2010 Apr; 2(27): 27ps18. PMID: 20393187.
NIHMSID: 72977 PMCID: PMC4620569
194.
Zani B, Edelman ER. Cellular bridges: routes for intercellular communication and cell
migration. Communicative and Integrative Biology 2010 May-Jun; 3(3): 1-6.
80
Elazer R. Edelman
PMCID:PMC2918759
195.
Koskinas K, Feldman C, Chatzizisis Y, Coskun A, Jonas M, Maynard C, Baker A,

Edelman ER, Stone P. Natural history of experimental coronary atherosclerosis and
vascular remodeling in relation to endothelial shear stress: A serial, in-vivo intravascular
ultrasound study. Circulation 2010 May; 121(19): 2092-101. PMCID:PMC2902864
196.
Balcells M, Martorell J, Olive C, Santacana M, Chitalia V, Cardoso A, Edelman ER.

Smooth Muscle Cells Orchestrate the Endothelial Cell Response to Flow and Injury.
Circulation 2010 May; 121(20): 2192-9. PMCID:PMC2887340
197.
Edelman ER, Joynt K. J waves of Osborn revisited. Journal of American College of

Cardiology 2010 May; 55(20): 2287. PMID: 21715675 (submitted 10/21/15)
198.
Artzi N, Zeiger A, Boehning F, Bon Ramos A, Van Vliet K, Edelman ER. Tuning
adhesion failure strength for tissue specific applications. Acta Biomaterialia 2011 Jan;
7(1) 67-74. PMCID: PMC2967578 (Available on 1/1/2012)
199.
Shazly TM, Baker AB, Naber JR, Bon A, Van Vliet KJ, Edelman ER. Augmentation of
postswelling surgical sealant potential of adhesive hydrogels. Journal of Biomedical
Materials Resources A 2010 Dec; 95(4):1159-69. PMCID: PMC2988649
200.
Baker A, Chatzizisis Y, Beigel R, Jonas M, Stone B, Coskun A, Maynarad C, Rogers C,

Koskinas K, Feldman C, Stone P, Edelman ER. Regulation of Heparanase Expression in
Coronary Artery Disease in Diabetic Hyperlipidemic Swine. Atherosclerosis 2010
Dec;213(2): 436-442. PMCID: PMC3042136
201.
Franses, JW, Baker AB, Chitalia VC, Edelman ER. Stromal Endothelial Cells Directly
Influence Cancer Progression. Science Translational Medicine 2011;(3): 66ra5.
PMCID:PMC3076139
202.
Chatzizisis Y, Baker A, Sukhova G, Koskinas K, Papafaklis M, Beigel R, Jonas M, Coskun

A, Stone B, Maynard C, Shi GP, Libby P, Feldman C, Edelman ER, Stone P. Augumented
Expression and Activity of Extracellular Matrix-Degrading Enzymes in Regions of Low
Endothelial Shear Stress Colocalize with Coronary Atheromata with Thin Fibrous Caps in
Pigs. Circulation 2011 Feb; 123(6):621-630. PMCID: PMC3066078
203.
Schubert S, Benarroch A, Monter-Solans J, Edelman ER. Primary Monocytes Regulate

Endothelial Cell Survival Through Secretion of Angiopoietin-1 and Activation of
Endothelial Tie2. Arteriosclerosis Thrombosis, and Vascular Biology 2011 Apr;
31(4):870-875. PMCID: PMC3104028
204.
Kolandaivelu K, Swaminathan R, Gibson WJ, Kolachalama VB, Nguyen-Ehrenreich KL,

Giddings VL, Coleman L, Wong GK, Edelman ER. Stent Thrombogenicity Early in High
Risk Interventional Settings is Driven by Stent Design and Deployment and Protected by
Polymer-Drug Coatings. Circulation 2011Apr; 123(13): 1400-1409. PMCID:
PMC3131199
81
Elazer R. Edelman
205.
Lovich M, Wei A, Wu P, Maslov M, Edelman ER. Local epicardial inotropic drug

delivery allows targeted pharmacologic intervention with preservation of myocardial
loading conditions. Journal of Pharmaceutical Science 2011 Nov; (100)11:45993-5006.
PMID: 21721001. NIHMSID 731673 (submitted 10/22/15)
206.
Chitalia V, Murikipudi S, Indolfi L, Rabadi L, Valdez R, Franses J, Edelman ER. Matrixembedded endothelial cells are protected from the uremic milieu. Nephrology Dialysis
Transplantation. (2011) doi: 10.1093/ndt/gfr337.
PMID: 17599600. PMCID:
PMC3254162
207.
Artzi N, Oliva N, Puron C, Shitreet S, Artzi S, Ramos A, Groothuis A, Sahagian G, and

Edelman ER. In Vivo and In Vitro Tracking of Erosion in Biodegradable Materials Using
Non-Invasive Fluorescence Imaging, Nature Materials, 10, 704-709, 2011, PMCID:
PMC3160718
208.
Artzi N, Zeiger A, Boehning F, bon Ramos A, Van Vliet K, Edelman ER. Tuning adhesion
failure strength for tissue-specific applications. Acta biomaterialia. 2011;7(1):67-74. Epub
2010/07/14. doi: 10.1016/j.actbio.2010.07.008. PubMed PMID: 20624496; PubMed
Central PMCID: PMC2967578.
209.
Balcells M, Edelman ER. [Models of human vascular disease: is there an animal of la

mancha?]. Revista espanola de cardiologia. 2011;64(9):739-42. Epub 2011/07/15. doi:
10.1016/j.recesp.2011.05.010. PubMed PMID: 21752515. (submitted 10/27/15)
210.
Franses JW, Edelman ER. The evolution of endothelial regulatory paradigms in cancer
biology and vascular repair. Cancer research. 2011;71(24):7339-44. Epub 2011/12/07. doi:
10.1158/0008-5472.CAN-11-1718. PubMed PMID: 22144472; PubMed Central PMCID:
PMC3242853.
211.
Murikipudi S, Methe H, Edelman ER. The effect of substrate modulus on the growth and
function of matrix-embedded endothelial cells. Biomaterials. 2013; 34:677-684, PMCID:
PMC3505450
212.
Oliva N, Shitreet S, Abraham E, Stanley B, Edelman ER, Artzi N. Natural tissue

microenvironmental conditions modulate adhesive material performance. Langmuir : the
ACS journal of surfaces and colloids. 2012; 28:15402-15409. PMID:25632035 (submitted
10/22/15)
213.
Banai S, Jolicoeur EM, Schwartz M, Garceau P, Biner S, Tanguay JF, Cartier R, Verheye
S, White CJ, Edelman E. Tiara: A novel catheter-based mitral valve bioprosthesis: Initial
experiments and short-term pre-clinical results. Journal of the American College of
Cardiology. 2012; 60:1430-1431 (submitted 10/26/15)
214.
Carlyle WC, McClain JB, Tzafriri AR, Bailey L, Zani BG, Markham PM, Stanley JR,
Edelman ER. Enhanced drug delivery capabilities from stents coated with absorbable
polymer and crystalline drug. Journal of controlled release. 2012;162:561-567. PMID:
22800575 (submitted 10/27/15)
82
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215.
Indolfi L, Baker AB, Edelman ER. The role of scaffold microarchitecture in engineering
endothelial cell immunomodulation. Biomaterials. 2012; 33:7019-7027, PMCID:
PMC3615558
216.
Nugent HM, Ng YS, White D, Groothius A, Kanner G, Edelman ER. Ultrasound-guided

percutaneous delivery of tissue-engineered endothelial cells to the adventitia of stented
arteries controls the response to vascular injury in a porcine model. Journal of Vascular
Surgery. 2012; 56:1078-1088, PMCID: PMC3762489
217.
Tzafriri AR, Groothuis A, Price GS, Edelman ER. Stent elution rate determines drug
deposition and receptor-mediated effects. Journal of Controlled Release: 2012;161(3):91826. Epub 2012/05/31. doi: 10.1016/j.jconrel.2012.05.039. PubMed PMID: 22642931,
PMCID: PMC3616625
218.
Edelman ER, LaMarco K. Clinician-investigators as translational bioscientists: Shaping a

seamless identity. Science translational medicine. 2012;4:135fs114. PMID: 22623734.
PMCID: PMC4624334
219.
Martorell J, Santoma P, Molins JJ, Garcia-Granada AA, Bea JA, Edelman ER, et al.
Engineered arterial models to correlate blood flow to tissue biological response. Annals of
the New York Academy of Sciences. 2012;1254:51-6. Epub 2012/05/03. doi:
10.1111/j.1749-6632.2012.06518.x. PubMed PMID: 22548569; PubMed Central PMCID:
PMC3342771.
220.
Baker AB, Gibson WJ, Kolachalama VB, Golomb M, Indolfi L, Spruell C, Zcharia E,
Vlodavsky I, Edelman ER.. Heparanase regulates thrombosis in vascular injury and stentinduced flow disturbance. Journal of the American College of Cardiology.
2012;59(17):1551-60. Epub 2012/04/21. doi: 10.1016/j.jacc.2011.11.057. PubMed PMID:
22516446. PMCID: PMC4191917.
221.
Aronson D, Edelman ER. Role of CABG in the management of obstructive coronary

arterial disease in patients with diabetes mellitus. Current opinion in pharmacology.
2012;12(2):134-41. Epub 2012/02/14. doi: 10.1016/j.coph.2012.01.011. PubMed PMID:
22325857. PMCID: PMC4582944
222.
Jang E, Albadawi H, Watkins MT, Edelman ER, Baker AB. Syndecan-4 proteoliposomes
enhance fibroblast growth factor-2 (FGF-2)-induced proliferation, migration, and
neovascularization of ischemic muscle. Proceedings of the National Academy of Sciences
of the United States of America. 2012;109(5):1679-84. Epub 2012/02/07. doi:
10.1073/pnas.1117885109. PubMed PMID: 22307630; PubMed Central PMCID:
PMC3277125.
223.
Shazly T, Kolachalama VB, Ferdous J, Oberhauser JP, Hossainy S, Edelman ER.

Assessment of material by-product fate from bioresorbable vascular scaffolds. Annals of
biomedical engineering. 2012;40(4):955-65. Epub 2011/11/02. doi: 10.1007/s10439-0110445-8. PubMed PMID: 22042625. PMCID: PMC4616251
83
Elazer R. Edelman
224.
Jolicur ME, Banai S, Henry DT, Schwartz M, Doucet S, White JC, Edelman ER, Verheye
S: A phase II, sham-controlled, double-blinded study testing the safety and efficacy of the
coronary sinus reducer in patients with refractory angina: study protocol for a randomized
controlled trial. Trials.2013, 14:46. DOI: 10.1186/1745-6215-14-46. PMID: 23413981.
PMCID: PMC3599995.
225.
Murikipudi, S., H. Methe, and E.R. Edelman, The effect of substrate modulus on the
growth and function of matrix-embedded endothelial cells. Biomaterials, 2013. 34(3): p.
677-84. PMID: 23102623. PMCID: PMC3505450
226.
Orekhov, A.N., I.A. Sobenin, N.V. Korneev, T.V. Kirichenko, V.A. Myasoedova, A.A.
Melnichenko, M. Balcells, E.R. Edelman, and Y.V. Bobryshev, Anti-atherosclerotic
therapy based on botanicals. Recent Pat Cardiovasc Drug Discov, 2013. 8(1): p. 56-66.
PMID: 23176379. (submitted 10/27/15)
227.
Chitalia, V.C., S. Shivanna, J. Martorell, M. Balcells, I. Bosch, K. Kolandaivelu, and E.R.

Edelman, Uremic serum and solutes increase post-vascular interventional thrombotic risk
through altered stability of smooth muscle cell tissue factor. Circulation, 2013. 127(3): p.
365-76. PMID: 2326489. PMCID: PMC4407990
228.
Banai, S., A. Finkelstein, Y. Almagor, A. Assali, Y. Hasin, U. Rosenschein, P. Apruzzese,

A.J. Lansky, T. Kume, and E.R. Edelman, Targeted anti-inflammatory systemic therapy
for restenosis: the Biorest Liposomal Alendronate with Stenting sTudy (BLAST)-a double
blind, randomized clinical trial. Am Heart J, 2013. 165(2): p. 234-40 e1. PMID: 23351827.
(submitted 10/26/15)
229.
Rosas, E., I. Sobenin, A. Orekhov, E.R. Edelman, and M. Balcells, Importance of

Receptor-Targeted Systems In The Battle Against Atherosclerosis. Curr Pharm Des, 2013.
PMID: 23438961 (submitted 10/27/15)
230.
Franses, J.W., N.C. Drosu, W.J. Gibson, V.C. Chitalia, and E.R. Edelman, Dysfunctional
endothelial cells directly stimulate cancer inflammation and metastasis. Int J Cancer, 2013
Sep 15;133(6):1334-44.
http://www.ncbi.nlm.nih.gov/pubmed/23463345 PMCID:
PMC3707950
231.
O'Brien, C.C., V.B. Kolachalama, T.J. Barber, A. Simmons, and E.R. Edelman, Impact of
flow pulsatility on arterial drug distribution in stent-based therapy. J Control Release, 2013
Jun
10;168(2):115-24.
http://www.ncbi.nlm.nih.gov/pubmed/23541929PMCID:
PMC3697861
232.
Kolachalama, V.B., S.D. Pacetti, J.W. Franses, J.J. Stankus, H.Q. Zhao, T. Shazly, A.
Nikanorov, L.B. Schwartz, A.R. Tzafriri, and E.R. Edelman, Mechanisms of tissue uptake
and retention in zotarolimus-coated balloon therapy. Circulation, 2013 May
21;127(20):2047-55.http://www.ncbi.nlm.nih.gov/pubmed/23584359,PMCID:
PMC3748613
84
Elazer R. Edelman
233.
Koskinask KC, Sukhova G, Baker AB, Papafaklis M; Chatzizisis Y, Coskun A, Quillard

T, Oskinas K, Maynard C, Antonia A, Shi G, Libby P, Edelman ER, Feldman, C, Stone,
P: Thin-capped atheromata with reduced collagen content in pigs develop in coronary
arterial regions exposed to persistently low endothelial shear stress. Arterioscler Throm
Vasc Biol, 2013 Jul;33(7):1494-1504. http://www.ncbi.nlm.nih.gov/pubmed/23640495
PMCID: PMC3954496
234.
Ross E, Santom P, Hernandez B, Duran-Frigola Miquel; Ruiz-Gonzalez R, Llinas MC,

Snchez-Garca D, Nonell S, Edelman ER, Balcells M: Modifications of microvascular EC
surface modulate phototoxicity of a porphycene anti-ICAM-1 immunoconjugate;
therapeutic
implications;
Langmuir,
2013
Aug
6;29(31):9734-43.
http://www.ncbi.nlm.nih.gov/pubmed/23844929, PMCID: PMC3857026
235.
Koskinas KC, Chatzizisis YS, Papafaklis M, Coskun AU, Baker AB, Jarolim P, Antoniadis
A, Edelman ER, Stone P, Feldman C: Synergistic Effect of Local Endothelial Shear Stress
and Systemic Hypercholesterolemia on Coronary Atherosclerotic Plaque Progression and
Composition in Pigs; International Journal of Cardiology, 2013 Nov 30; 169(6):394-401
236.
Maslov MY, Edelman ER, Wei AE, Pezone MJ, Lovich MA. High concentrations of drug
in target tissues following local controlled release are utilized for both drug distribution
and biological effect: an example with epicardial inotropic drug delivery. Journal of
Control
Release;
2013
October
28;
171(2):201-7
in
process.
http://www.ncbi.nlm.nih.gov/pubmed/23872515 PMID: 23872515 (submitted 10/22/15)
237.
Nickmann M, Saemisch M, Wilbert-Lampen U, Nickel T, Edelman ER, Methe H. Cell

matrix contact modifies endothelial major histocompatibility complex class II expression
in high-glucose environment. American Journal Physiol Heart Circ Physiol; 2013
December 1;305(11):H1592-9. http://www.ncbi.nlm.nih.gov/pubmed/24043258.
238.
Koskinas KC, Chatzizisis YS, Papafaklis M, Coskun AU, Baker AB, Jarolim P, Antoniadis
A, Edelman ER, Stone P, Feldman C: Synergistic Effect of Local Endothelial Shear Stress
and Systemic Hypercholesterolemia on Coronary Atherosclerotic Plaque Progression and
Composition in Pigs; International Journal of Cardiology, 2013 Nov 30; 169(6):394-401.
239.
Banai, S., S. Verheye, A. Cheung, M. Schwartz, A. Marko, R. Lane, E.M. Jolicoeur, P.

Garceau, S. Biner, J.F. Tanguay, E.R. Edelman, and C.J. White, Transapical mitral
implantation of the tiara bioprosthesis: pre-clinical results. JACC Cardiovasc Interv, 2014
Feb. 7(2): p. 154-62. http://www.ncbi.nlm.nih.gov/pubmed/24556094 PMID:
24556094(submitted 10/26/15)
240.
Wei AE, Maslov MY, Pezone MJ, Edelman ER, Lovich MA. Use of pressure-volume
conductance catheters in real-time cardiovascular experimentation. Heart, lung &
circulation. 2014. PMCID: PMC4241179
85
Elazer R. Edelman
241.
Sakakura K, Ladich E, Edelman ER, Markham P, Stanley JRL, Keating J, Kolodgie FD,
Virmani R, Joner, M, Methodological Standardization for the Pre-Clinical Evaluation of
Renal Sympathetic Denervation, JACC Cardiovascular Intervention, 2014, 7(10),
http://dx.doi.org/10.1016/j.jcin. 2014. 04.024.
PMID:
25240550. .
PMCID:
PMC4625553
242.
Karanasiou, GS, C Conway, MI Papafaklis, AC Lopes, KA Stefanou, LS Athanasiou, LK

Michalis, ER Edelman, and DI Fotiadis, Finite element analysis of stent implantation in a
three-dimensional reconstructed arterial segment. Conf Proc IEEE Eng Med Biol Soc,
2014. 2014: p. 5623-6. PMID: 25571270
243.
Mariani, J, Jr, C Guedes, P Soares, S Zalc, CM Campos, AC Lopes, AG Spadaro, MA

Perin, AE Filho, CK Takimura, E Ribeiro, R Kalil-Filho, ER Edelman, PW Serruys, and
PA Lemos, Intravascular Ultrasound Guidance to Minimize the Use of Iodine Contrast in
Percutaneous Coronary Intervention: The MOZART (Minimizing cOntrast utiliZation
With IVUS Guidance in coRonary angioplasTy) Randomized Controlled Trial. JACC
Cardiovasc Interv, 2014. 7(11): p. 1287-93. PMID: 25326742. (submitted 10/27/15)
244.
Martorell, J, P Santoma, K Kolandaivelu, VB Kolachalama, P Melgar-Lesmes, JJ Molins,

L Garcia, ER Edelman, and M Balcells, Extent of flow recirculation governs expression
of atherosclerotic and thrombotic biomarkers in arterial bifurcations. Cardiovasc Res,
2014. 103(1): p. 37-46. PMID: 24841070. (submitted 10/26/15)
245.
Maslov, MY, ER Edelman, MJ Pezone, AE Wei, MG Wakim, MR Murray, H Tsukada,

IS Gerogiannis, A Groothuis, and MA Lovich, Myocardial drug distribution generated
from local epicardial application: Potential impact of cardiac capillary perfusion in a swine
model using epinephrine. J Control Release, 2014. 194: p. 257-65. PMCID: PMC4252373
246.
Tzafriri, AR, F Mahfoud, JH Keating, PM Markham, A Spognardi, G Wong, K Fuimaono,

M Bohm, and ER Edelman, Innervation patterns may limit response to endovascular renal
denervation. J Am Coll Cardiol, 2014. 64(11): p. 1079-87.PMCID: PMC4377282
247.
N. Oliva, M. Carcole, M. Beckerman, S. Seliktar, A. Hayward, B. Stanley, N. M. A. Parry,

E. R. Edelman, N. Artzi, Regulation of dendrimer/dextran material performance by altered
tissue microenvironment in inflammation and neoplasia. Sci. Transl. Med. 7, 272ra11
(2015). PMID: 25632035.(submitted 10/21/15)
248.
Chan KE, Edelman ER, Wegner JB, Thadhani RI, Maddux FW, Dabigatran and
rivaroxaban use in atrial fibrillation patients on hemodialysis, Circulation, 2015 Mar
17;131(11):972-9,
DOI:
10.1161/CIRCULATIONAHA.114.014113
PMCID:
PMC4363265
249.
Verheye S, Jolicur EM, Behan MW, Pettersson T, Sainsbury P, Hill J, Vrolix M,

Agostoni P, Engstrom T, Labinaz M, de Silva R, Schwartz M, Meyten N, Uren NG, Doucet
S, Henry TD, White CJ, Edelman ER, Banai S. Efficacy of the Coronary Sinus Reducer
in Patients with Refractory Angina: The COSIRA Randomized, Sham-Controlled, DoubleBlinded Trial (COronary SInus Reducer for Treatment of Refractory Angina), N Engl J
86
Elazer R. Edelman
Med 2015; 372:519-527, DOI: 10.1056/NEJMoa1402556. PMID: 23413981. PMCID:

PMC3599995.
250.
Tzafriri AR, Keating JH, Markham PM, Spognardi A-M, Stanley JRL, Wong G, Zani BG,
Grunewald D, OFallon P, Fuimaono K, Mahfoud F, Edelman ER, Arterial microanatomy
determines the success of renal denervation in controlling hypertension, Science
Translational Medicine, 2015 Apr 29;7(285). PMID: 25925684 PMCID: PMC4624328
251.
Zani BG, Baird R, Stanley JRL, Markham PM, Wilke M, Zeiter S, Beck A, Nehrbass D,
Kopia GA, Edelman ER, Rabiner R. Evaluation of an Intramedullary Bone Stabilization
System Using a Light-Curable Monomer in Sheep, Journal of Biomedical Materials
Research: Part B - Applied Biomaterials , 2015 Mar 12. PMID: 25772144. (submitted
10/26/15)
252.
Kolandaivelu K, O'Brien CC, Shazly T, Edelman ER, Kolachalama VB. Enhancing

physiologic simulations using supervised learning on coarse mesh solutions, J. R. Soc.
Interface 2015, 12: 20141073., http://dx.doi.org/10.1098/rsif.2014.1073.
PMID:
25652458. PMCID: PMC4345474
253.
Stanley JRL, Tzafriri AR, Regan K, LaRochelle A, Wong G, Zani BG, Markham PM,
Bailey L, Spognardi A, Kopia GA, Edelman ER. Particulates from hydrophilic-coated
guiding sheaths embolise to the brain EuroIntervention 2015 Mar 5;10(12) DOI:
10.4244/EIJY15M02_0. PMID: 25735934. (submitted 10/23/15)
254.
Maslov MM, Wei AE, Pezone MJ, Edelman ER, Lovich MA. Vascular Dilation,
Tachycardia, and Increased Inotropy Occur Sequentially with Increasing Epinephrine Dose
Rate, Plasma and Myocardial Concentrations, and cAMP, Heart, Lung and Circulation
2015 DOI: http://dx.doi.org/10.1016/j.hlc.2015.02.012. PMID: 25790776. (submitted
10/22/15)
255.
Shivanna S, Harrold I, Shashar M, Meyer R, Kiang C, Francis J, Zhao Q, Feng H, Edelman

ER, Rahimi N and Vipul C. Chitalia VC. c-Cbl regulates nuclear -catenin and
angiogenesis through its Wnt-mediated phosphorylation J. Biol. Chem. published online
March 17, 2015. PMID: 25784557. PMCID: PMC4432275.
256.
Vijayaratnam P, Barber T, Reizes J, O'Brien CC, Edelman ER. The Impact of Blood
Rheology on Drug Transport in Stented Arteries: Steady Simulations, PLOS-one, PONED-15-03824R1. PMID: 26066041. PMCID: PMC4466567.
257.
Shivanna S, Kolandaivelu K, Shashar M, Belghasim M, Al-Rabadi L, Balcells M, Zhang

A, Weinberg J, Francis J, Pollastri MP, Edelman ER, Sherr DH, and Chitalia VC. The
Aryl Hydrocarbon Receptor is a Critical Regulator of Tissue Factor Stability and an
Antithrombotic Target in Uremia JASN ASN.2014121241; published ahead of print May
27, 2015, doi:10.1681/ASN.2014121241. PMID: 26019318. (submitted 10/27/15)
258.
Conde, J., C. Bao, Y. Tan, D. Cui, E.R. Edelman, H.S. Azevedo, H.J. Byrne, N. Artzi
and F. Tian. Dual targeted immunotherapy via in vivo delivery of biohybrid RNAi87
Elazer R. Edelman
peptide nanoparticles to tumour-associated macrophages and cancer cells. Advanced

Functional Materials, 2015. COVER Featured (submitted 10/23/15)
259.
Melgar-Lesmes P, Edelman ER. Monocyte-endothelial cell interactions in the

regulation of vascular sprouting and liver regeneration in mouse. J Hepatol. 2015 May
25. PMID: 26022689. PMCID: PMC4575901
260.
Artzi N, Tzafriri AR, Faucher KM, Moodie G, Albergo T, Conroy S, Corbeil S, Martako
P, Virmani R, Edelman ER. Sustained Efficacy and Arterial Drug Retention by a Fast
Drug Eluting Cross-Linked Fatty Acid Coronary Stent Coating, Annals of Biomedical Eng.
2015, DOI: 10.1007/s10439-015-1435-z. PMID: 26314990 (submitted 10/21/15)
261.
Everett, K., C. Conway, G. Desany, B. Baker, G. Choi, C. Taylor, and E. Edelman,

Structural Mechanics Predictions Relating to Clinical Coronary Stent Fracture in a 5 Year
Period in FDA MAUDE Database. Ann Biomed Eng, 2015: p. 1-13. 10.1007/s10439-0151476-3
262.
Keshavarz-Motamed Z, Edelman ER, Motamed PK, Garcia J, Dahdah N, Kadem L. The

role of aortic compliance in determination of coarctation severity: lumped parameter
modeling, in vitro study and clinical evaluation. Journal of Biomechanics, Accepted, 2015.
263.
Connor Y, Tekleab S, Nandakumar S, Walls C, Tekleab Y, Husain A, Gadish O, Sabbisetti

V, Kaushik S, Sehrawat S, Kulkarni A, Dvorak H, Edelman ER, Zetter B, Sengupta S.
Physical nanoscale conduits-mediated communication between tumor cells and
endothelium enables a metastatic hijack. Nature Communications, in press, 2015
264.
OBrien CC, Kolandaivelu K, Brown J, Lopes AC, Kunio M, Kolachalama VB,

Edelman ER. Constraining OCT With Knowledge Of Device Design Enables High
Accuracy Hemodynamic Assessment Of Endovascular Implants PLOS ONE.
PONE_D_33021. Accepted with Revision October 2015
265.
OBrien, CC, Lopes AC, Kolandaivelu K. Kunio M, Brown J, Kolachalama, VB,

Conway, C, Bailey L, Makham P, Costa M, Ware J, Edelman ER. Vascular Response
to Experimental Stent Malapposition and Under-Expansion. Annals of Biomedical
Engineering. Accepted with Revision October 2015
Proceedings of Refereed Conferences:

1.
Christopher PF, Edelman ER. Frequency Optimization for Low Cost Satellite
Communications. Antennas and Propagation Society International Symposium; 1977 June
21; Stanford, CA. In: IEEE Transactions on Antennas and Propagation; 25. p. 509-511.
2.
Edelman ER, Oman CM, Schulter P, Cavalerrano A. Video Based Analysis of Ocular
Movement. Second Conference on Oculomotor Physiology; 1981 ; California Institute of
Technology, Pasadena, CA.
88
Elazer R. Edelman
3.
Edelman ER, Bobeck H, Langer RS. Magnetically Controlled Delivery Systems.

Polymers as Biomaterials Symposium, American Chemical Society Meeting; 1983;
Seattle, WA. p. 49-50.
4.
Langer RS, Seigel R, Brown L, Leong K, Kost J, Edelman ER. Controlled Release and
Magnetically Modulated Systems for Macromolecular Drugs. New York Academy of
Sciences; 1984 ; New York, NY.
5.
Edelman ER, Mathiowitz E, Langer RS, Klagsbrun M. Controlled and Modulated Release
of Fibroblast Growth Factor. Controlled Release Society, 16th International Symposium
on the Controlled Release of Bioactive Materials; 1989 August 6-9; Chicago, IL. In:
Proceedings of the International Symposium on Controlled Release of Bioactive Materials;
16. p. 227-228.
6.
Edelman ER, Rogers C, Karnovsky MJ. Local Regulation of Vascular Injury: DrugDevice-Tissue Interactions. Cardiovascular Science and Technology Conference,
Proceedings of the Association for the Advancement of Medical Instrumentation/The
National Heart, Lung, and Blood Institute; 1992 December 12-14; Bethesda, MD. p. 191.
7.
Nugent MA, Chen OS, Edelman ER. Controlled Release of Fibroblast Growth Factor:
Activity in Cell Culture. Material Research Society Symposium Proceedings
1992;252:273-84.
8.
Edelman ER. Local and Molecular Interventions for Accelerated Arterial Proliferative
Diseases. Emerging Strategies in the Management of Coronary Artery Disease: New
England Cardiovascular Society Annual Scientific Sessions; 1994 May 26 p. 1-8.
9.
Edelman ER. Perivascular Drug Delivery. The First Annual International Symposium on
Local Cardiovascular Drug Delivery; 1995 September 28; Cambridge, MA. p. 15.1-15.7.
10.
Seifert PA, Rogers C, Edelman ER. A methacrylate method for histologic and
immunohistochemical staining of intact endovascular stent-implanted vessels. Proceedings
of the National Society of Histotechnology; 1996 p. 18.
11.
Edelman ER. Local Drug Delivery in Angioplasty Restenosis. Eighth International

Symposium on Recent Advances in Drug Delivery Systems; 1997 February; Salt Lake
City, UT. p. 36.
12.
Tseng DY, Rogers C, Squire JC, Edelman ER. Mechanisms of Endothelial Denudation
During Endovascular Stent Deployment. Society for Biomaterials Annual Meeting; 1997
April 30-May 4; New Orleans, LA. p. 38.
13.
Edelman ER. Controlled release and restenosis. Proceedings of the International

Symposium on the Controlled Release of Bioactive Materials; 1997 June 24 p. 195.
14.
Edelman ER. Biology and Pathology of Endovascular Implants. 2nd International

Meeting on Interventional Cardiology; 1997 June 30-July 3; Jerusalem, Israel. p. 26.
89
Elazer R. Edelman
15.
Edelman ER. Stent Synergy. Satellite Symposium on Stenting and Adjunctive

Pharmaceutical Therapy; 1997 July; Eilat, Israel. p. 83.
16.
Edelman ER. Tissue Engineering Concepts (cell + composite modalities) to Achieve

Therapeutic Effects, Local Cardiovascular Drug Delivery. Transcatheter Cardiovascular
Therapeutics Ninth Annual Symposium; 1997 September; Washington, DC. p. 19.
17.
Edelman ER. Conceptual Requirements: Defining the 'Right' Animal Model to Test an
Hypothesis (Case Example: Assessing 'Anti-Restenosis' Therapies), Advanced Workshop
on Experimental Animal Models. Transcatheter Cardiovascular Therapeutics Ninth
Annual Symposium; 1997 September 24-27; Washington, DC. p. 49.
18.
Edelman ER. Developing Improved Engineering and Animal Study Guidelines for Stents
in the Future, Streamlining the Pathway for Regulatory Approval of Stents in the Future:
A Fireside Chat with the FDA. Transcatheter Cardiovascular Therapeutics Ninth Annual
Symposium; 1997 September 24-27; Washington, DC. p. 55.
19.
Edelman ER. The Impact of Stent Design on Pathobiologic Responses, Satellite

Symposium: The Advanced Multilink Intracoronary Stent - Harmonizing Design and
Function. Transcatheter Cardiovascular Therapeutics Ninth Annual Symposium; 1997
September 24-27; Washington, DC. p. 64.
20.
Edelman ER. Pathobiologic Responses. Advanced Stent Workshop, Transcatheter

Cardiovascular Therapeutics Ninth Annual Symposium; 1997 September 24-27;
Washington, DC. p. 68.
21.
Edelman ER. Stent Designs Influence Neointimal Growth Patterns: Evidence from
Experimental Animal Models. Transcatheter Cardiovascular Therapeutics Ninth Annual
22.
Edelman ER. Stent-Induced Pathobiological Responses: Determinants of Early and Late

Clinical Events. Plenary Lecture-Transcatheter Cardiovascular Therapeutics Ninth Annual
23.
Edelman ER. When to Integrate Molecular Biology and Advanced Quantitative

Techniques. Advanced Workshop on Experimental Animal Models, Transcatheter
Cardiovascular Therapeutics Ninth Annual Symposium; 1997 September 24-27;
Washington, DC. p. 49.
24.
Edelman ER. The Linkage of Antisense Pharmacokinetics of Cell Cycle Regulation.

Future Needs and Developments in Antisense Technology; 1997 September 25-26;
Bethesda, MD.
25.
Edelman ER. Critical evaluation of local drug delivery: perivascular drug delivery as a
model. Conference on Formulations and Drug Delivery II; 1997 October 5-8; La Jolla, CA.
90
Elazer R. Edelman
26.
Edelman ER. Tissue Engineering in Restenosis. American Association of Pharmaceutical

Scientists Annual Meeting and Exposition; 1997 November 3; Boston, MA. p. 26.
27.
Edelman ER. Controlled Drug Delivery and Vascular Disease. The 4th US-Japan
Symposium on Drug Delivery Systems; 1997 December 14-19; Kauai, HI. p. 11.
28.
Edelman ER. Frontier Therapy for Vascular Proliferative Diseases. 15th Annual
International Symposium on Interventional Cardiology; 1998 January 21-25; Miami
Beach, FL. p. 9.
29.
Edelman ER. Local Cardiovascular Drug Delivery. 15th Annual International Symposium
on Interventional Cardiology; 1998 January 21-25; Miami Beach, FL. p. 9.
30.
Edelman ER. Pathology of Local Vascular Implants. 15th Annual International

Symposium on Interventional Cardiology; 1998 January 21-25; Miami Beach, FL. p. 8.
31.
Edelman ER. Stent-based delivery: from pharmacokinetics to biological effects. 5th

International LDD&R Local Drug Delivery Meeting and Cardiovascular Course on
Radiation and Molecular Strategies; 1999 January 31-February 2; Geneva, Switzerland. p.
24.
32.
Elmalak O, Edelman ER. Correlation of Transarterial Drug Pharmacokinetics with Their

Physicochemical Properties. Controlled Release Society; 1999 June 21; Boston, MA. In:
Proceedings of the International Symposium on Controlled Release of Bioactive Materials;
26. p. 42-43.
33.
Wu D, Lauffenburger DA, Edelman ER. Cellular Pharmacokinetics Affect the Efficacy

of EVAc Controlled-Release Devices. Controlled Release Society; 1999 June 21; Boston,
MA. In: Proceedings of the International Symposium on Controlled Release of Bioactive
Materials; 26. p. 58-59.
34.
Yu C, Cunningham M, Rogers C, Dinbergs ID, Edelman ER. Controlled-Release of

Growth Factor-Toxin Conjugates in Vascular Injury. Controlled Release Society; 1999
June 21; Boston, MA. In: Proceedings of the International Symposium on Controlled
Release of Bioactive Materials; 26. p. 60-61.
35.
Yu C, Simons M, Edelman ER. Controlled Release of Endothelial Growth Factors for

Local Intervention of Vascular Diseases and Angiogenesis. Controlled Release Society;
1999 June 21; Boston, MA. In: Proceedings of the International Symposium on Controlled
Release of Bioactive Materials; 26. p. 32-33.
36.
Sellke FW, Laham RJ, Ruel M, Post MJ, Ware AJ, Edelman ER, Simons M. Long-Term
Effects of Angiogenic Therapy with bFGF Protein. 81st Annual Meeting of the American
Association for Thoracic Surgery; 2001 May 6-9; San Diego, CA.
37.
Edelman ER, Fourth Annual Boston Angiogenesis Meeting, Boston, MA November 1,

2002, Endothelial Cell Biology and Endothelial Tissue Engineering, November 1, 2002,
91
Elazer R. Edelman
Boston, MA.
38.
Morss AS, Edelman ER, Seifert P, Bornstein D, Rogers C. Biocompatibility comparison

of stainless steel, gold-coated, and heat-treated gold-coated endovascular stents. In:
Proceedings of the Material Resources Society Symposium; 2002.
39.
Lahann, J., Balcells, M., Rodon, T. and R. Langer, Polymer-based microengineered

Surfaces, Annual Meeting of Surfaces in Biomaterials Society, Scottdale, US, 2001.
40.
Lahann, J., Balcells, M., Lu, H., Edelman, E.R., Langer, R. and K. Jensen, Functionalized
parylene coatings for microfluidic applications, TAS, Japan, 2002..
41.
Walker, M., Fan, W.H., Hwang, C.W., Ettenson, D.S., Wu, D., Balcells, M. and E.R.
Edelman, Growth factor early signaling and gene expression are modulated by
intercellular communication, the American Physiological Society Annual Meeting of
Experimental Biology, New Orleans, US, 2002.
42.
Balcells, M., Walker, M., Fernandez, M. and E. R. Edelman, Cells in fluidic environments
are frequency sensitive independent of alterations in shear, the American Physiological
Society Annual Meeting of Experimental Biology, New Orleans, US, 2002.
43.
Balcells, M. and E. R. Edelman, Regulation of endothelial cell adhesion, proliferation,

and function through pre-adsorbed proteins, TESi, Kobe, Japan, 2002.
44.
Vazquez, M., Balcells, M. and E. R. Edelman, Defined flow regimes: a novel perfusion
bioreactor for optimum cell growth, Summer Bioengineering Conference, Key Biscayne,
US, 2003.
45.
Balcells, M., and E. R. Edelman, Controlling endothelial cell biosecretory function

through surface modification, Summer Bioengineering Conference, Key Biscayne, US,
2003.
46.
Genove, E., Chen, C., Balcells, M., Edelman, E.R., Zhang, S. and C. Semino,
Bioengineering functional endothelial cell monolayer cultured on designed peptide
hydrogel scaffold, Summer Bioengineering Conference, Key Biscayne, US, 2003.
47.
Molins, B., Vzquez, M., Balcells, M. and E. R. Edelman, The impact of the
biomechanical environment on endothelial cell proliferation and metabolic activity,
International Vascular Biology Meeting, Toronto, Canada, 2004.
48.
Olive, C., Santacana, M., Cardoso, A., Balcells, M. and E. R. Edelman, Flow differentially
regulates the mTOR pathway in cocultures endothelial and smooth muscle cells,
Arteriosclerosis, Thrombosis and Vascular Biology Annual conference, Chicago, US,
2007.
49.
Balcells, M., Methe, H., Molins, B., Alegret, C. and E. R. Edelman, Not all endothelial
cells are equal under flow: studies on cell adhesion molecule expression, Arteriosclerosis,
92
Elazer R. Edelman
Thrombosis and Vascular Biology Annual conference, Chicago, US, 2007.

50.
Balcells, M., Olive, C., Cardoso, A.A. and E.R. Edelman, In silico and in vitro study of
physical and biological effects of stenting complex vascular environments, 7th
International Symposium on Endovascular Therapeutics, Barcelona, Spain, 2009.
51.
Indolfi L, Ligorio M, Ting D, Ferrone CR, Clark JW, Langer R, Edelman ER. Design of
a Drug Eluting Stent for treatment of pancreatic malignancy. In: Proceedings of the Society
for Biomaterials Annual Meeting, April 2013.
52.
Tzafriri RA, Edelman ER. Understanding the Influence of Stent Design on Arterial Drug
Distribution and Effect through Computational Modeling. In: Proceedings of the Society
53.
Cunha GLA, Freiman A, Indolfi L, Artzi N, Dreyfuss, JL, Edelman ER. CDK Inhibitor
PD 0332991 Selectively Inhibits Lung Adenocarinoma Cells Without Sacrificing Matrix
Embedded Endothelial Cells Ability Regulatory Effect on Tumor Proliferation. In:
Proceedings of the Society for Biomaterials Annual Meeting, April 2013.
54.
Faucher K, Artzi N, Albergo T, Bienkiewicz J, Conroy S, Dale A, Kozlova I, Edelman

ER, Martakos P. Naturally Derived Fatty Acid Biomaterials for Local Drug Delivery. In:
55.
Edelman ER. MATERIALS INNOVATION; Driving the Revolution in Cardiovascular

Interventions. In: Proceedings of the Society for Biomaterials Annual Meeting, April 2013.
56.
Kunio M, O'Brien CC, Lopes AC, Edelman ER. In vivo deformation of stented coronary
vessel centerline with cardiac motion: Implications for angiography-OCT fusion.
Biomedical Imaging (ISBI). 2015 IEEE 12th International Symposium on; 2015 16-19
April 2015.
Reviews, chapters, and editorials:

1.
Langer RS, Edelman ER, Hsieh DST. Magnetically Controlled Polymeric Delivery
Systems. In: Szycher M, editor. Biocompatible Polymers, Metals, and Composites.
Lancaster, PA: Technomic Publishing Company; 1983. p. 585-596.
2.
Langer RS, Brown L, Edelman ER. Controlled Release and Magnetically Modulated
Systems for Macromolecules: Recent Advances. In: Anderson JM, Kim SW, editors.
Recent Advances in Drug Delivery Systems. New York, NY: Plenum Press; 1984. p. 249258.
3.
Brown L, Edelman ER, Siemer L, Langer RS. Controlled-Release Systems for

Macromolecules: Methods and Applications. In: Nervig RM, Gough PM, Kaeberle ML,
Whetstone CA, editors. Advances in Carriers and Adjuvants for Veterinary Biologics.
93
Elazer R. Edelman
Ames, IA: Iowa State University Press; 1986. p. 133-141.

4.
Edelman ER, Linhardt RJ, Bobeck H, Kost J, Rosen HB, Langer RS. Polymer Based Drug
Delivery: Magnetically Modulated and Bioerodible Systems. In: Shalaby SW, Hoffman
AS, Ratner BD, Horbett TA, editors. Polymers as Biomaterials. New York, NY: Plenum
Press; 1986. p. 279-292.
5.
Langer RS, Leong K, Edelman ER, Siegel R, Bawa R. Zero order release, magnetic
control and polypeptide release. In: Mller BW, editor. Controlled Drug Delivery.
Stuttgart: Wissenschaftliche Verlagsgesellschaft mbH; 1986.
6.
Edelman ER, Stuenkel CA, Rutherford JD, Williams GH. Diabetic ketoacidosis is
associated with pheochromocytoma. Cleveland Clinic Journal of Medicine
1992;59(4):423-427.
7.
Karnovsky MJ, Edelman ER. Heparin/Heparan Sulfate Regulation of Vascular Smooth

Muscle Cell Behavior. In: Page C, Black J, editors. Airway and Vascular Remodeling in
Asthma and Cardiovascular Diseases: Implications for Therapeutic Interventions. London,
UK: Academic Press; 1994. p. 45-70.
8.
Nathan A, Edelman ER. Local Interventions for Vasculoproliferative Diseases. In:

Edelman ER, editor. Molecular Interventions and Local Drug Delivery. London, UK: WB
Saunders Company Limited; 1995. p. 29-52.
9.
Parikh SA, Rogers C, Edelman ER. Endovascular Stents: Experimental Data. In: Sigwart
U, editor. Endoluminal Stenting. London, UK: W.B. Saunders Company Ltd; 1996. p. 615.
10.
Rogers C, Edelman ER. Local Drug Delivery and the Modulation of Thrombosis and
Neointimal Hyperplasia After Endovascular Stenting. In: Sigwart U, editor. Endoluminal
Stenting. London, UK: WB Saunders Company Ltd; 1996. p. 114-122.
11.
Simons M, Rosenberg RD, Edelman ER. ...and surreal antisense? Nature Medicine
1996;2(2):131.
12.
Edelman ER, Rogers C. Hoop Dreams: Stents Without Restenosis. Circulation

1996;94(6):1199-1202.
13.
Garasic JM, Rogers C, Edelman ER. Stent design and the biologic response. In: Beyar R,
Keren G, Leon M, Serruys PW, editors. Frontiers in Interventional Cardiology. London,
UK: Martin Dunitz; 1997. p. 95-100.
14.
Welt FGP, Edelman ER. Second International Symposium on Cardiovascular Drug

Delivery. Circulation 1997;95(4):773-776.
15.
Welt FGP, Edelman ER. Cell cycle regulation and control of angioplasty restenosis.
Advanced Drug Delivery Reviews 1997;25(2,3):299-307.
94
Elazer R. Edelman
16.
Edelman ER, Koo EWY. Antisense Oligonucleotide Regulation of the Vascular Response
to Injury. In: Schwinn DA, editor. New Advances in Vascular Biology and Molecular
Cardiovascular Medicine. Baltimore, MD: Williams and Wilkins; 1998. p. 189-208.
17.
English AE, Grosberg A, Edelman ER. Polyampholytes. In: Research Signpost. 1998.
18.
Raman VK, Edelman ER. Coated stents: local pharmacology. Seminar on Interventional
Cardiology 1998;3:133-137.
19.
Edelman ER, Lovich MA. Drug delivery models transported to a new level. Nature
Biotechnology 1998;16:136-137.
20.
Edelman ER. Vessel Size, Antioxidants, and Restenosis: Never Too Small, Not Too Little,
but Often Too Late. Circulation 1998;97(5):416-420.
21.
Drachman DE, Edelman ER, Rogers C. Local Delivery of Antirestenotic Drugs. In:
Rabbani LE, editor. Applications of Antisense Therapies to Restenosis. Boston, MA:
Kluwer Academic Publishers; 1999. p. 153-161.
22.
Hertzog BA, Thanos C, Sandor M, Raman V, Edelman ER. Cardiovascular Drug Delivery
Systems. In: Mathiowitz E, editor. Encyclopedia of Controlled Drug Delivery. New York,
NY: John Wiley & Sons, Inc.; 1999. p. 161-173.
23.
Januzzi JL, Edelman ER. The Pathobiology of Restenosis: A Paradigm from Clinical and
Experimental Studies. In: Rabbani LE, editor. Applications of Antisense Therapies to
Restenosis. Boston, MA: Kluwer Academic Publishers; 1999. p. 21-34.
24.
Libby P, Edelman ER. Restenosis: Involvement of Growth Factors and Cytokines. In:
Topel EJ, editor. Textbook of Interventional Cardiology. Philadelphia, PA: W.B. Saunders
Company; 1999. p. 346-357.
25.
Yu C, English AE, Edelman ER. Growth Factor Delivery Strategies. In: Ware JA, Simons
M, editors. Angiogenesis and Cardiovascular Disease. New York, NY: Oxford University
Press; 1999. p. 238-257.
26.
Edelman ER. Stent-Versus-Stent Equivalency Trials: Are Some Stents More Equal Than
Others? Circulation 1999;100:896-898.
27.
Edelman ER. Vascular Tissue Engineering: Designer Arteries. Circulation Research

1999;85:1115-1117.
28.
English AE, Edelman ER. Polymer Hydrogel Phase Transitions. In: Tanaka T, editor.
Experimental Methods in Polymer Science: Modern Methods in Polymer Research and
Technology. San Deigo, CA: Academic Press; 2000. p. 547-589.
29.
Ettenson DS, Edelman ER. Local drug delivery: an emerging approach in the treatment
of restenosis. Vascular Medicine 2000;5(2):97-102.
95
Elazer R. Edelman
30.
Paolini JF, Edelman ER. Antioxidants and Restenosis: Animal and Clinical Studies. In:
Keaney JF, editor. Oxidative Stress and Vascular Disease. Boston, MA: Kluwer Academic
Press; 2000. p. 349-359.
31.
Parikh SA, Edelman ER. Endothelial cell delivery for cardiovascular therapy. Advanced
Drug Reviews 2000;42(1-2):139-161.
32.
Nugent HM, Parikh SA, Edelman ER. Mesenchymal Cell Culture: Endothelial Cell Tissue
Engineering. In: Methods of Tissue Engineering. Academic Press; 2001. p. 345-357.
33.
Seifert PA, Rogers C, Edelman ER. Histochemical and Immunohistochemical Methods

for Vascular Animal Model Studies. In: Simon DI, Rogers C, editors. Vascular Disease
and Injury: Preclinical Research. Totowa, NJ: Humana Press; 2001. p. 325-338.
34.
Welt FGP, Edelman ER, Rogers C. Mechanical Injury in Normal and Atherosclerotic
Rabbit Iliac Arteries. In: Simon DI, Rogers C, editors. Vascular Disease and Injury:
Preclinical Research. Totowa, NJ: Humana Press; 2001. p. 3-18.
35.
Edelman, ER. On Causes: Hippocrates, Aristotle, Robert Koch and the Dread Pirate
Roberts. Circulation 2001;104(46):2509-2512.
36.
Edelman ER, Leon, Dangas. Appendix 2: Intracardiac Devices and Catheters, Part A:
Endovascular Implants. In: Antman E, editor. Cardiovascular Therapeutics. New York,
NY: W. B. Saunders Company; 2002.
37.
Hwang CW, Wu D, Edelman ER. Impact of transport and drug properties on the local
pharmacology of drug-eluting stents. International Journal of Cardiovascular Interventions
2002;90.
38.
Malhotra R., E.R. Edelman and Lilly, L., Basic Cardiac Structure and Function,
Pathophysiology of Heart Disease: A Collaborative Project of Medical Students and
Faculty, Lippincott Williams and Wilkins, 2003.
39.
Edelman E.R., Danenberg H.D., Rapamycin for cardiac transplant rejection and
vasculopathy: one stone, two birds? Circulation, 108, 6 (2003).
40.
Hwang CW, Edelman ER. Principles of continuum pharmacokinetics in stentbased drug elution. In: Serruys PW, Gershlick AG editors. Handbook of DrugEluting Stents. London, UK: Martin Dunitz Limited. 2005.
41.
Noh I., Edelman ER. Advanced Biomaterials VI (ISBN: 0-87849-967-9), Smooth

Muscle Cell In growth of a Surface-Modified ePTFE Vascular Graft. KEM (Key
Engineering Materials), Vol. 288-289 (ISSN: 1013-9826), Page 367.
42.
Rogers, C, Edelman, ER. Pushing Drug-Eluting Stents Into Uncharted Territory. Simpler
Than You ThinkMore Complex Than You Imagine. Circulation 2006;19(113)22622265.
96
Elazer R. Edelman
43.
Richter Y, Edelman, ER. Cardiology Is Flow. Circulation 2006; 23(113)2679-2682.
44.
Methe H, Hess S, Edelman ER. The effect of three-dimensional matrix-embedding of

endothelial cells on the humoral and cellular immune response. Semin Immunol 2008 Apr;
20(2):117-22.
45.
Koskinas KC, Chatzizisis YS, Baker AB, Edelman ER, Stone PH, Feldman CL. The role
of low endothelial shear stress in the conversion of atherosclerotic lesions from stable to
unstable plaque. Curr Opin Cardiology 2009 Oct; 24(6):581-590.
46.
Falotico R, Parker T, Edelman ER. NevoTM Sirolimus-eluting coronary stent. Cardiac

and Vascular Update, 2009; 2: 7-9.
47.
Desai AS, Chutkow WA, Edelman ER, Economy KE, Dec W, A Crisis in Late Pregnancy
N Engl J Med 2009; 361:2271-2277December 3, 2009DOI: 10.1056/NEJMcps0708258
48.
Edelman ER, Leon MB. The Fiber of Modern Society. Sci Transl Med 2011;
89(3):89cm14.
49.
Balcells M, Edelman, ER. Models of human vascular disease: Is there an animal of La

Mancha? Revista Espanola Cardiologia 2011 Sept; (64)9:739-742.
50.
Franses JW, Edelman ER. The evolution of endothelial regulatory paradigms in cancer
biology and vascular repair. Cancer research. 2011;71(24):7339-44. Epub 2011/12/07. doi:
10.1158/0008-5472.CAN-11-1718. PubMed PMID: 22144472; PubMed Central PMCID:
PMC3242853.
51.
Edelman ER, FitzGerald GA. A rattle bag of science and the art of translation. Science
translational
medicine.
2011;3(104):104ed3.
Epub
2011/10/15.
doi:
10.1126/scitranslmed.3002131. PubMed PMID: 21998406.
52.
Martorell, J., Molins, J.J., Garca-Granada, A., Palms, A., Bea, J.A., Edelman,E.R. and
M. Balcells, Biophysical property assessment of new endovascular devices in artificial
vessel, 8th International Symposium on Endovascular Therapeutics, Barcelona, Spain,
2011.
53.
Martorell, J., Santom, P., Molins, J.J., Garca-Granada, A., Edelman, E.R. and M.
Balcells, "Engineering Physiological Models of Arterial Bifurcations to Expedite
Treatments, Evolving Challenges in Promoting Cardiovascular Health, New York
Academy of Sciences, Barcelona, Spain, 2011.
54.
Joynt KE, Edelman ER. Letter by Joynt and Edelman regarding article, "Iatrogenic giant
Osborn waves". Circulation. 2011;123(12):e390; author reply e1. Epub 2011/03/30. doi:
10.1161/CIRCULATIONAHA.110.006478. PubMed PMID: 21444891.
97
Elazer R. Edelman
54.
Edelman ER, Lamarco K. Clinician-investigators as translational bioscientists: shaping a

seamless identity. Science Translational Medicine. 2012;4(135):135fs14. Epub
2012/05/25. doi: 10.1126/scitranslmed.3004109. PubMed PMID: 22623734.
56.
Tzafriri AR, Edelman ER. Y.H. Bae et al. (eds.), Cancer Targeted Drug Delivery: An
Elusive Dream, DOI 10.1007/978-1-4614-7876-8_21, Springer Science+Business Media
New York 2013
57.
Martorell, J., Santoma, P., Molins, J.J., Garca-Granada, A., Palms, A., Edelman, E.R. and
M. Balcells, What can we learn from endovascular devices prior to implantation?, 9th
International Symposium on Endovascular Therapeutics, Barcelona, Spain, 2013.
58.
Garcia Polite, F., Martorell, J., Edelman, E.R. and M. Balcells, Disrupted wall shear stress
alters autocrine signaling of brain microvascular endothelial cells at the blood-brain
barrier, 16th Symposium on Signal transduction in blood-brain barriers, Dublin, Ireland,
2014.
59.
Kolandaivelu, K., B.B. Leiden, and E.R. Edelman, Predicting response to endovascular
therapies: Dissecting the roles of local lesion complexity, systemic comorbidity, and
clinical uncertainty. J Biomech, 2014 Mar 3; 47(4): p. 908-21.
http://www.ncbi.nlm.nih.gov/pubmed/24495755
60.
Turjman, A.S., F. Turjman, and E.R. Edelman, Role of fluid dynamics and inflammation
in intracranial aneurysm formation. Circulation, 2014 Jan 21; 129 (3): 373-82.
http://www.ncbi.nlm.nih.gov/pubmed/24446407, PMCID:PMC4371596
61.
E. R. Edelman, Endothelial insights: The Florian dialectic. Sci. Transl. Med. 6, 239fs24
(2014).
62.
Mahfoud F, Edelman ER, Bhm, M, Catheter-Based Renal Denervation Is No Simple

Matter Lessons to Be Learned From Our Anatomy? 2014, 64(7): 644-646,
http://dx.doi.org/10.1016/j.jacc.2014.05.037
63.
Aronson D, Edelman ER. Coronary artery disease and diabetes mellitus. Cardiology
clinics. 2014;32:439-455
64.
Fischer, S., C.G. Lian, M. Kueckelhaus, T.B. Strom, E.R. Edelman, R.A. Clark, G.F.
Murphy, A.K. Chandraker, L.V. Riella, S.G. Tullius, and B. Pomahac, Acute Rejection in
Vascularized Composite Allotransplantation" is accepted for publication in the journal
"Current Opinion in Organ Transplantation", 2014. 19(6): p. 531-44.
65.
Andreou, I., A.P. Antoniadis, K. Shishido, M.I. Papafaklis, K.C. Koskinas, Y.S.
Chatzizisis, A.U. Coskun, E.R. Edelman, C.L. Feldman, and P.H. Stone, How Do We
Prevent the Vulnerable Atherosclerotic Plaque From Rupturing? Insights From In Vivo
Assessments of Plaque, Vascular Remodeling, and Local Endothelial Shear Stress. J
Cardiovasc Pharmacol Ther, 2014.
98
Elazer R. Edelman
66.
Conde, J., E.R. Edelman, and N. Artzi, Target-responsive DNA/RNA nanomaterials for
microRNA sensing and inhibition: The jack-of-all-trades in cancer nanotheranostics? Adv
Drug Deliv Rev, 2015. 81C: p. 169-183.
67.
Andreou I, Sun X, Stone PH, Edelman ER*, Feinberg MW*, miRNAs in atherosclerotic
plaque initiation, progression, and rupture, Trends in Mol Medicine, 2015 May;21(5):30718 (* shared senior author) PMCID: PMC4424146
68.
Edelman ER, LaMarco K, William Heberden and reverse translation. Sci. Transl. Med. 7,
287fs20 (2015).
Books:
1.
Edelman ER, editor. Molecular Interventions and Local Drug Delivery. 1st ed. Frontiers
in Cardiology. London, U.K.: W.B. Saunders Company Ltd; 1995.
Theses:
1.
Edelman ER. Video Based Measurement of Rotational Eye Movements [thesis].

Cambridge, MA: Massachusetts Institute of Technology; 1979.
2.
Edelman ER. Regulation of Drug Delivery from Porous Polymer Matrices [thesis].
Cambridge, MA: Massachusetts Institute of Technology; 1984.
99
Elazer R. Edelman
Patents and Patent Application Pending:
100
Elazer R. Edelman
Title
Controlled release systems

containing heparin and growth
factors
Localized oligonucleotide
therapy
2
therapy
3
Lokalisert oligonukleotidterapi
4
Extraluminal regulation of the

growth and repair of tubular
structures in vivo
structures in vivo
structures in vivo
Inhibition of Vascular
Occlusion Following Vascular
Intervention
therapy
Publication
number
Publication
Inventor(s)
date
Edelman Elazer R,
Langer Robert S,
US5100668 (A)
3/31/1992
Klagsburn Michael,
Mathiowitz Edith
Rosenberg Robert D,
Simons Michael,
WO9301286 (A2);
Edelman Elazer,
1/21/1993
WO9301286 (A3)
Langer Robert S,
Dekeyser JeanLuc[Be]
Rosenberg Robert D,
Simons Michael,
Edelman Elazer,
WO9308845 (A1)
5/13/1993
Langer Robert S,
Rosenberg Robert D,
Simons Michael,
Edelman Elazer,
NO934828 (A)
2/24/1994
Langer Robert S,
Edelman Elazer R,
US5455039 (A)
10/3/1995 Adams David H,
Karnovsky Morris J
Edelman Elazer R,
US5527532 (A)
Karnovsky Morris J
Edelman Elazer R,
US5540928 (A)
Karnovsky Morris J
Edelman Elazer,
WO 996038188 A1
12/5/1996 Aruna Nathan,
Nugent Matthew A
Rosenberg Robert D,
Simons Michael,
Edelman Elazer,
US5593974 (A)
1/14/1997
Langer Robert S,
101
Elazer R. Edelman
10
11
12
13
14
Inhibition of vascular smooth

muscle cell proliferation with
implanted matrix containing
vascular endothelial cells
US5766584 (A)
Edelman Elazer R,
6/16/1998 Nathan Aruna,
Nugent Matthew A
therapy for preventing
restenosis
CA2228977 (A1)
Stent slip sensing system and

method
US6091980 (A)
Device for stabilizing a

treatment site and method of
use
WO0062680 (A1)
10/26/2000
Stent expansion and

apposition sensing
US6179858 (B1)
1/30/2001

use
US6231585 (B1)
5/15/2001
Low disturbance pulsatile flow

AU4359201 (A)
system
9/24/2001
Low disturbance pulsatile flow US2001053928

system
(A1)
12/20/2001
5/7/1999
7/18/2000
15
16
17

use
US6338710 (B1)
1/15/2002
Modulation of vascular
healing by inhibition of
leukocyte adhesion and
function
US2002006401
(A1)
Rogers Campbell,
1/17/2002 Edelman Elazer R,
Simon Daniel I
US6492180 (B2);
US2002019055
(A1)
US6764507 (B2);
US2002068969
(A1)
Brown Larry R,
2/14/2002 Edelman Elazer,
Tseng David
Shanley John F,
6/6/2002 Eigler Neal L,
Edelman Elazer R
18
19
20
21
Rosenberg Robert D,
Simons Michael,
Edelman Elazer R,
Sirois Martin G[Ca]
Squire James C,
Rogers Campbell,
Edelman Elazer R
Takahashi Masao;
Edelman Elazer E;
Carpenter Kenneth W
Squire James C,
Rogers Campell,
Edelman Elazer R
Takahashi
Masao[Jp];
Edelman Elazer E,
Carpenter Kenneth
W
Edelman Elazer;
Kolandaivelu
Kumaran
Edelman Elazer,
Kolandaivelu
Kumaran
Takahashi
Masao[Jp];
Edelman Elazer E,
Carpenter Kenneth
W
Non-invasive transdermal
detection of analytes
Expandable medical device
with improved spatial
distribution
102
Elazer R. Edelman
22
23
24
25
therapy for preventing
restenosis
Stent concept for minimization
of deployment related wall
shear and injury
Direct arterial infiltration for
production of vascular
pathology
Method and apparatus for
accurate positioning of a dual
balloon catheter
Method of treating acute
coronary syndromes
26
27
US2002151513
(A1)
10/17/2002
US2003093142
(A1)
5/15/2003
US2003192555
(A1)
10/16/2003
US7066905 (B2);
US2004092870
(A1)
WO2005002545
(A1);
WO2005002545
(A8)
Inhibition of occlusion of
blood vessel after intervening
blood vessel
JP2005254000
Method of treating ischemiareperfusion injury
US2006051407
(A1)
Methods and compositions for

enhancing vascular access
WO2006062909
(A3);
WO2006062909
(A2)
28
29
30
31
Materials and methods for

minimally-invasive
administration of a cellcontaining flowable
composition
Expandable medical device
with improved spatial
distribution
Localized delivery of cardiac
inotropic agents
32
WO2006062871
(A2);
WO2006062871
(A3);
WO2006062871
(A9)
US2006149354
(A1); US7842083
(B2)
WO2006127907
(A2);
WO2006127907
(A3)
103
5/13/2004
Sirois Martin G[Ca];

Edelman Elazer R,
Rosenberg Robert D,
Simons Michael
Edelman Elazer,
Kolandaivelu
Kumaran
Edelman Elazer,
Rogers Campbell,
Welt Frederick G
Squire James C,
Edelman Elazer R,
Teirstein Paul
Edelman Elazer R,
1/13/2005 Golomb Gershon;
Danenberg Haim D
Edelman Elazer R,
9/22/2005 Nathan Aruna,
Nugent Matthew A
Richter Yoram;
Edelman Elazer R,
3/9/2006
Golomb Gershon;
Danenberg Haim D
Nugent Helen Marie,
Edelman Elazer,
6/15/2006 Dalal Anupam,
Bollinger Steve,
Epperly Scott
Nugent Helen Marie,
6/15/2006 Edelman Elazer,
Bollinger Steve
Shanley John F,
7/6/2006 Eigler Neal L,
Edelman Elazer R
11/30/2006
Edelman Elazer,
Lovich Mark
Elazer R. Edelman
Process for embolization using US8062673 (B2);

swellable and deformable
US2007237742
microspheres
(A1)
10/11/2007
Medical treatment applications US2007237741

of swellable and deformable
(A1); US8252339
microspheres
(B2)
10/11/2007
33
34

modulating tissue modeling
WO2008057590
(A2);
WO2008057590
(A3)
5/15/2008

treating and managing wounds
and the effects of trauma
WO2009020650
(A3);
WO2009020650
(A2)
2/12/2009
35
36
37
38
Devices and systems for local

delivery of inotropic agents to
the epicardium
US8562586 (B2);
US2010057039
(A1)
AU2010200882
Expandable medical device for (A1);
delivery of beneficial agent
AU2010200882
(B2)
3/4/2010
4/1/2010
Endovascular devices with

axial perturbations
US2010114302
(A1)
5/6/2010

US2010204783
(A1)
8/12/2010
Methods and devices for

treatment of lumenal systems
US2010228280
(A1)
9/9/2010
39
40
41
104
Figuly Garret D,
Mahajan Surbhi,
Schiffino Rinaldo S,
Feldstein Michael J,
Shazly Tarek M,
Edelman Elazer R
Figuly Garret D,
Mahajan Surbhi,
Schiffino Rinaldo S,
Bhatia Sujata K,
Edelman Elazer R,
Shazly Tarek
Michael, Feldstein
Michael Jordan
Nugent Helen Marie,
Edelman Elazer R,
Tjin Tham Sjin
Robert M
Nugent Helen Marie,
Bollinger Stephen A,
Edelman Elazer R,
Schubert Shai, Ng
Yin Shan, Tjin Tham
Sjin Robert
Lovich Mark,
Edelman Elazer
Edelman Elazer R;
Eigler Neal L; Park
Kinam; Shanley
John F
Tzafriri Abraham,
Kolandaivelu
Kumaran, Edelman
Elazer R
Nugent Helen Marie,
Edelman Elazer,
Dalal Anupam,
Bollinger Stephen
August, Epperly
Scott
Groothuis Adam,
Mcnamara Edward I,
Markham Peter,
Edelman Elazer R
Elazer R. Edelman
42
Endovascular devices/catheter
platforms and methods for
achieving congruency in
sequentially deployed devices
US2010318173
(A1)
12/16/2010
Composiciones y su uso para

aumentar el acceso vascular.
ES2348961 (T3)
12/17/2010
43
Expandable medical advice for EP2263619 (A3);

delivery of beneficial agent
EP2263619 (A2)
12/22/2010
44
45
Endovascular platforms for the

differential targeting of
US2011004293
molecules to vessel wall and
(A1)
vessel lumen
1/6/2011
Method for treating acute

coronary syndrome
JP2011016838 (A)
1/27/2011
Method for imaging

biomaterial erosion in vivo
US2011085712
(A1)
4/14/2011

AU2011211370
(A1);
AU2011211370
(B2)
9/1/2011
US2011313508
(A1)
12/22/2011
46
47
48
49
50
Endovascular platforms for

uniform therapeutic delivery
to local targets
Stent type opening method
and device
JP2012005867 (A);
JP5198637 (B2)

managing cancer cell growth
US2012027858
(A1)
Method of treating acute

myocardial infarction
EP2266536 A3
51
52
105
Kolandaivelu
Kumaran,
Swaminathan Rajesh
V, Gibson William J,
Edelman Elazer R
Nugent Helen;
Edelman Elazer;
Epperly Scott;
Bollinger Steve;
Dalal Anupam
Park Kinam, Shanley
John F, Edelman
Elazer R, Eigler Neal
L
Kolandaivelu
Kumaran, Tzafriri
Abraham,
Kolachalama Vijaya
B, Edelman Elazer R
Edelman Elazer R;
Golomb Gershon;
Danenberg Haim D;
Richter Yoram
Artzi Natalie,
Edelman Elazer R
Marie Nugent Helen;
Elazer Edelman;
Anupam Dalal;
Steve Bollinger;
Scott Epperly
Kolachalama Vijaya,
Levine Evan,
Edelman Elazer
1/12/2012
Franses Joseph W,
Edelman Elazer R,
2/2/2012 Cardoso Angelo
Manuel De Almeida,
Nugent Helen Marie
Danenberg Haim D,
10/17/2012 Golomb Gershon,
Edelman, Elazer R
Elazer R. Edelman
53
Biocompatible adhesive
materials and methods
US8802072 (B2);
US2012263672
(A1)

AU2012238220
(A1);
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(B2)
Mechanical testing system and

method
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altering an immune response
to exogenous and endogenous
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54
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treating and managing
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58
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Simultaneous delivery of
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Edelman Elazer R,
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treating and managing plaque
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9/4/2014 Edelman Elazer;
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Non-print Images:
1.
Cover Massachusetts Institute of Technology 1998-1999 Faculty and Staff Directory.
2.
Cover Massachusetts Institute of Technology 1998-1999 Student Directory.
3.
Cover Circulation. 2001 Jul 31. 104(5): 600-605. Hwang CW, Wu D, Edelman ER.
Physiological transport forces govern drug distribution for stent-based delivery.
4.
Cover Circulation. 2003 Dec 2; 108(22):2798-2804 Danenberg HD, Golomb G, Groothuis

A, Gao J, Epstein H, Swaminathan RV, Seifert P, Edelman ER. Liposomal Alendronate
Inhibits Systemic Innate Immunity and Reduces In-Stent Neointimal Hyperplasia in
Rabbits.
5.
Cover J Control Release 2009 Jan; 133(1):24-30 Kolachalama VB, Tzafriri AR, Arifin
DY, Edelman ER. Luminal flow patterns dictate arterial drug deposition in stent-based
delivery.
Abstracts:
1.
Brown L, Wei C, Hsieh D, Edelman ER, Langer RS. Insulin Polymers: Controlled Release
and Magnetically Modulated Systems. American Institute of Chemical Engineers 1981
Annual Meeting; 1981 November 11; New Orleans, LA. p. T-184.
2.
Brown L, Munoz C, Siemer L, Edelman ER, Kost J, Langer RS. Sustained Insulin Release
from Implantable Polymers. American Diabetes Association 43rd Annual Meeting; 1983
June 12-14; San Antonio, TX. In: Diabetes; 32. p. 35A.
3.
Kost J, Edelman ER, Langer RS. Experimental Approaches to Elucidate the Mechanism
of Magnetically Controlled Delivery of Macromolecules. 10th International Symposium
on Controlled Release of Bioactive Materials; 1983 July 24-27; San Francisco, CA. In:
Controlled Release Society p. 158-163.
4.
Langer RS, Seigel R, Brown L, Leong K, Kost J, Edelman ER. Controlled Release
Systems: Using Oscillating Magnetic Fields: In Vitro and In Vivo Characteristics.
American Chemical Society; 1984 ; Philadelphia, PA.
5.
Kost J, Edelman ER, Brown L, Leong R. Magnetically Modulated Release from

Implantable Devices. Second World Congress on Biomaterials; 1984 April 27-May 1;
Washington, DC.
107
Elazer R. Edelman
6.
Brown L, Edelman ER, Langer RS. Quantization of Simultaneous Controlled Release of

Insulin and Somatostatin from Implantable Polymer Matrices. Diabetes 1984;33(suppl.
#1):177a.
7.
Langer RS, Brown L, Edelman ER, Kost J. Controlled Release and Magnetically
Modulated Release of Polypeptides: Recent Advances. Controlled Release Society; 1985;
Geneva, Switzerland.
8.
Langer RS, Edelman ER, Kost J. The Use of Magnetic Particles. Symposium on Properties
of Polymers and Drug Delivery; 1985 ; Stockholm, Sweden.
9.
Brown L, Edelman ER, Fischel-Ghodsian F, Mathiowitz E, Langer RS. Glucose Mediated

Release from Implantable Polymers. Third International Symposium on Recent Advances
in Drug Delivery Systems; 1987 ; Salt Lake City, Utah.
10.
Edelman ER, Grodzinsky AJ, Langer RS. Magnetically Controlled Polymer Matrix Drug
Delivery Systems: Mechanisms & Dynamics. IEEE/Ninth Annual Conference of the
Engineering in Medicine and Biology Society; 1987; Boston, MA. In: IEEE p. 375-376.
11.
Edelman ER, Brown L, Langer RS. Quantitation of Insulin Release from Implantable
Delivery Systems and Augmentation of Therapeutic Effect with Simultaneous Release of
Somatostatin. International Conference on Pharmaceutical Sciences and Clinical
Pharmacology;1988 May 29-June 3; Jerusalem, Israel. p. 127.
12.
Friedman PL, Selwyn AP, Edelman ER, Rizk H, Guo HS, Wang PJ. Abolition of
Ventricular Tachycardia by Selective Intracoronary Lidocaine Infusion. American Heart
Association, 61st Annual Meeting; 1988 October; Washington, DC. In: Circulation; 78. p.
II-72.
13.
Masi M, Edelman ER, St.John-Sutton MG, Loscalzo J. Transient Patency of the Foramen
Ovale in Young Patients with Stroke of Unclear Etiology. American Heart Association,
61st Annual Meeting; 1988 October; Washington, DC. In: Circulation; 78. p. II-601.
14.
Edelman ER, Adams DH, Karnovsky MJ. Vascular Response to Injury: Effect of
Controlled Adventitial Heparin Delivery on Smooth Muscle Cells. American Heart
Association, 62nd Scientific Sessions; 1989 November 14; New Orleans, LA. In:
Arteriosclerosis 9(5), p. A702.
15.
Brown L, Edelman ER. The Simultaneous Release of Somatostatin and Insulin from
Implantable Polymeric Delivery Systems and Augmentation of Therapeutic Effect.
American Chemical Society; 1990; Boston, MA.
16.
Edelman ER, Adams DH, Karnovsky MJ. Polymer Matrix Based Controlled Adventitial
Delivery of Antiproliferative Agents and Regulation of the Vascular Response to Injury.
American Chemical Society; 1990; Boston, MA.
108
Elazer R. Edelman
17.
Edelman ER. bFGF Regulation of SMC Proliferation and Angiogenesis are Linked in the
Perivascular Space of Injured Blood Vessels. The Blood Vessel Club;1991; Atlanta, GA.
18.
Nugent MA, Edelman ER. TGFb1 Stimulates the Production of bFGF-Binding Heparan
Sulfate Proteoglycans and Potentiates bFGF-Stimulated DNA Synthesis in Balb/c3T3
Cells. New York Academy of Sciences;1991; New York, NY.
19.
Nugent MA, Edelman ER. Differential Bindings of Basic Fibroblast Growth Factor to
Extracellular Matrix and Cell Surface Receptors Results from a Difference in Off Rates
Not On Rates. Federation of American Societies for Experimental Biology; 1991 April 22;
Atlanta, GA. p. A540. In: FASEB Journal 5(4), p.A540 Part 1.
20.
Edelman ER. Perivascular, endovascular and intravascular drug delivery. Second

International Congress - Advanced Drug Research in Heart and Vascular Diseases; 1992;
Paris, France.
21.
Rabbani LE, Bittl JA, Ganz P, Selwyn AP, Edelman ER, Loscalzo J, Libby P. Insulin
Levels Predict Restenosis After Laser Angioplasty: Multivariate Analysis in 100 Patients.
American College of Cardiology, 41st Annual Scientific Session; 1992 April 15; Dallas,
TX. In: Journal of the American College of Cardiology; 19. p.171A.
22.
Edelman ER, Karnovsky MJ. Vascular injury is mediated by a compound reversed by

potamine sulfate. American Heart Association, 65th Scientific Sessions; 1992 November
16-19; New Orleans, LA. In: Circulation; 86(4), p.13 Supplement S.
23.
Rogers C, Karnovsky MJ, Edelman ER. Intravenous and Local Perivascular Heparin
Reduces Endovascular Stent Thrombosis and Intimal Hyperplasia. American Heart
Association, 65th Scientific Sessions; 1992 November17; New Orleans, LA. In:
Circulation; 86(4) p. 227 Supplement S.
24.
Simons M, Edelman ER, DeKeyser J-L, Langer RS, Rosenberg RD. Antisense c-myb
oligonucleotides suppress smooth muscle proliferation in a rat model of restenosis.
American Heart Association, 65th Scientific Sessions; 1992 November 17; New Orleans,
LA. In: Circulation; 86. p. I-227.
25.
Edelman ER. Perivascular, endovascular and intravascular drug delivery. American

Society for Artificial Internal Organs; 1993; New Orleans, LA.
26.
Sellke FW, Harada K, Wang SY, Friedman M, Simons M, Edelman ER, Grossman W.
Basic FGF preserves endothelial function in the microcirculation perfused by collaterals.
Science Conference on the Molecular Cellular Biology of the Vascular Wall, American
Heart Association; 1993.
27.
Edelman ER, Simons M, Rosenberg RD. Messenger-RNA Burden and Duration of Gene
Expression Determine the Vasculo-Proliferative Inhibitory Effects of Antisense
Oligonucleotides. American Heart Association, 66th Scientific Sessions;1993 November
8; Atlanta, GA. In: Circulation 88(4). p. 81, Part 2.
109
Elazer R. Edelman
28.
Harada K, Friedman M, Prasad PV, Manning WJ, Sellke FW, Edelman ER, Simons M,
Grossman W. Basic Fibroblast Growth Factor Improves Myocardial Function in
Chronically Ischemic Porcine Hearts. American Heart Association, 66th Scientific
Sessions; 1993 November 9; Atlanta, GA. In: Circulation 88(4). p. 238, Part 2.
29.
Rogers C, Karnovsky MJ, Edelman ER. Heparin's Inhibition of Monocyte Adhesion to

Experimentally Injured Arteries Matches its Antiproliferative Effects. American Heart
Association, 66th Scientific Sessions; 1993 November 10; Atlanta, GA. In: Circulation;
88(4), p. 370, Part 2.
30.
Sellke FW, Wang Y, Friedman M, Harada K, Simons M, Edelman ER, Grossman W.

Basic FGF Enhances Endothelium-Dependent Relaxation in the Collateral-Dependent
Microcirculation. In: Circulation 1993, 88(4), p. 471, Part 2.
31.
Simons M, Edelman ER, Rosenberg RD. Inhibition of Neointimal Formation by AntiPCNA Oligonucleotides in a Rat Model of Arterial Injury. American Heart Association,
66th Scientific Sessions; 1993 November 10; Atlanta, GA. In: Circulation; 88(4). p.368,
Part 2.
32.
Rogers C, Edelman ER. Stent Design not Lumen Size Dictates Experimental Restenosis
and Thromobosis. American Heart Association, 67th Scientific Sessions; 1994 November
16; Dallas, TX. In: Circulation; 90(4). p. 508, Part 2.
33.
Rogers C, Nugent MA, Lovich MA, Edelman ER. Efficiencies of Local Vascular Delivery
of Heparin and Heparin Binding Growth Factors Differ Depending on Compound, Artery,
and Site of Administration. American Heart Association, 67th Scientific Sessions; 1994
November 16; Dallas, TX. In: Circulation; 90. p. I-508.
34.
Sirois MG, Simons M, Edelman ER, Kuter DJ, Rosenberg RD. Platelet Release of
Platelet-Derived Growth Factor is Required for Intimal Hyperplasia in Rat Vascular Model
Injury. American Heart Association, 67th Scientific Sessions; 1994 November 16; Dallas,
TX. In: Circulation; 90. p. I-511.
35.
Nathan A, Katada M, Edelman ER. Perivascular Heparin Delivery Using Biodegradable

Polymers. In: Abstracts of Papers of the American Chemical Society 207, p. 171-PMSE,
Part 2.
36.
Edelman ER. Accelerated Arteriopathies: Polar Forms of Wound Healing. Annual Fall
Meeting of the Biomedical Engineering Society; 1995; Boston University, Boston, MA.
37.
Edelman ER. Endovascular and Perivascular Drug Delivery. Conference on Formulations

and Drug Delivery, American Chemical Society; 1995; Boston, MA.
38.
Edelman ER. Experimental Observations Effect the Practical Application of Local Drug
Delivery. Transcatheter Cardiovascular Therapeutics VII; 1995; Washington, DC.
110
Elazer R. Edelman
39.
Edelman ER. Issues in the Responsible Conduct of Research. Issues in the Responsible
Conduct of Science; 1995; Massachusetts Institute of Technology, Cambridge, MA.
34.
Edelman ER. Prevention and Treatment of Restenosis: Lessons Learned from

Endogenous Forms of Vascular Repair. Restenosis Summit VII; 1995; Cleveland, OH.
41.
Lopez JJ, Edelman ER, Stambler A, Sellke FW, Morgan JP, Simons M. Local Perivascular
Delivery of bFGF for Chronic Myocardial Ischemia Achieves Low Plasma Levels without
Systemic Toxicity. 68th Scientific Sessions, American Heart Association; 1995 ; Anaheim,
CA.
42.
Edelman ER. Local and Molecular Interventions in Cardiovascular Disease. Unity in

Diversity, 1995 American Association for the Advancement of Science Annual Meeting
and Science Innovation Exposition; 1995 February 20; Atlanta, GA. p. 98.
43.
Edelman ER. Cell-Based Drug Delivery. The First Annual International Symposium on
Local Cardiovascular Drug Delivery; 1995 September 28; Cambridge, MA. p. 9.1-9.6.
44.
Lopez JJ, Stamler A, Edelman ER, Hibberd MG, Caputo RP, Carrozza JP, Prasad PV,
Douglas PS, Sellke FW, Simons M. Local bFGF Treatment Results in Angiographic
Collateral Development, Dose-Related Increase in Coronary Flow and Myocardial
Function in Chronic Myocardial Ischemia. American Heart Association, 68th Scientific
Sessions; 1995 November 13; Anaheim, CA. In: Circulation 92(8), p. 318, Supplement S.
45.
Rogers C, Parikh SA, Edelman ER. A Unified Model of Vascular Repair After
Mechanical Injury. American Heart Association, 68th Scientific Sessions; 1995 November
15; Anaheim, CA. In: Circulation; 92(8), p. 2388, Supplement S.
46.
Edelman ER, Nathan A, Nugent MA. Tissue Engineered Endothelial Cell Implants and
Proliferative Vascular Disease. American Heart Association, 68th Scientific Sessions;
1995 November 16; Anaheim, CA. In: Circulation; 92, p. 3597, Supplement S.
47.
Dinbergs ID, Brown LR, Edelman ER. Cell Response to Growth Factors Depends on the
Mode of Administration. Experimental Biology '96; 1996; Washington, DC. In: FASEB
Journal 10(3), p. 3332.
48.
Edelman ER. Antisense Strategies for Controlling the Vascular Response to Injury.
Research Initiatives in Vascular Disease; 1996 ; Bethesda, MD.
49.
Edelman ER. Balloons to stents: Reduction and restenosis with evolving interventional
technology. The Physician's Meeting; 1996; Chicago, IL.
50.
Edelman ER. Endovascular stent Design Dictates Experiment Restenosis and

Thrombosis. The Society of Interventional Cardiology Annual Meeting; 1996; Eilat, Israel.
51.
Edelman ER. Local drug delivery in stent and through stents. The Stent Summit; 1996 ;
London, United Kingdom.
111
Elazer R. Edelman
52.
Edelman ER. May delivery modality influence effect? Second Thoraxcenter Local Drug
Delivery Meeting; 1996 ; Amsterdam, The Netherlands.
53.
Edelman ER. Perivascular and Endovascular Drug Delivery Concepts. Transcatheter

Cardiovascular Therapeutics VIII; 1996; Washington, DC.
54.
Koo EWY, Edelman ER. Cellular effects of antisense c-myc oligodeoxynucleotides are
delivery-dependent. ASBMB/ASIP/AAI Joint Meeting & ASBMB Satellite Meetings;
1996 ; New Orleans, LA.
55.
Edelman ER. The Biology of Endovascular Implants. Transcatheter Cardiovascular

Therapeutics VIII; 1996 February 28-March 3; Washington, DC.
56.
Stamler A, Lopez JJ, Edelman ER, Simons M, Sellke FW. BFGF-Induced Angiogenesis
as an Alternative Method of Myocardial Revascularization. Mediterranean Association of
Cardiology and Cardiac Surgery, 9th Annual Meeting; 1996 October 20-23; Tel Aviv,
Israel. In: Israel Journal of Medical Sciences; 32. p. 1003.
57.
Squire JC, Rogers C, Edelman ER. Stent Geometry During Inflation Influences Later
Restenosis. American Heart Association, 69th Scientific Sessions; 1996 November 10;
New Orleans, LA. In: Circulation; 94(8). p. 1514, Supplement S.
58.
Kjelsberg MA, Edelman ER, Rogers C. Quantitative Angiography Measures Variable

Coronary Stent Restenosis as Accurately as Histology. American College of Cardiology
46th Annual Scientific Session; 1997 March 16-19; Anaheim, CA.
59.
Tseng DY, Martakos P, Edelman ER. Endothelial Cell Lining on ePTFE Vascular Grafts
in an Artificial Circulatory System. American Chemical Society Spring Meeting, Division
of Biochemical Technology; 1997 April 17; San Francisco, CA. In: Abstracts of Papers of
the American Chemical Society 213, p. 261-BIOT, Part 1.
60.
Edelman ER. Keynote Speaker. Cadillac Investigator/Research Coordinator Meeting;

1997 July 27-29; San Francisco, CA.
61.
Edelman ER. Materials and Cells in Cardiovascular Healing. Gordon Research

Conference in Biomaterials: Biocompatibility and Tissue Engineering; 1997 July 20-25;
Holderness, NH.
62.
Sirois MG, Edelman ER. Vascular Endothelial Growth Factor Effect on Vascular
Permeability is Mediated by Synthesis of Platelet-Activating Factor. American Heart
Association, 70th Scientific Sessions; 1997 November 9; Orlando, FL. In: Circulation
96(8), p.973, Supplement S.
63.
Garasic JM, Squire JC, Edelman ER, Rogers C. Stent and Artery Geometry Determine
Intimal Thickening Independent of Deep Arterial Injury. American Heart Association, 70th
Scientific Sessions; 1997 November 10; Orlando, FL. In: Circulation; 96(8). p. 2255.
Supplement S.
112
Elazer R. Edelman
64.
Tseng DY, Rogers C, Edelman ER. Effects of Stent Geometry, Balloon Compliance and
Deployment Pressure on Balloon-Artery Interactions During Stent Placement: A Finite
Element Analysis Approach. American Heart Association, 70th Scientific Sessions; 1997
November 10; Orlando, FL. In: Circulation; 96(8). p. 2257, Supplement S.
65.
Rogers C, Edelman ER, Simon DI. Blockade of the Leukocyte Integrin Mac-1 Reduces
Experimental Restenosis. American Heart Association, 70th Scientific Sessions; 1997
November 11; Orlando, FL. In: Circulation; 96(8), p. 3727. Supplement S.
66.
Rogers C, Kjelsberg MA, Seifert PA, Edelman ER. Heparin-Coated Stents Eliminate
Mural Thrombus Deposition for Days Without Affecting Restenosis. American Heart
Association, 70th Scientific Sessions;1997 November 11; Orlando, FL. In: Circulation;
96(8). p. 3983 Supplement S.
67.
English AE, Tanaka T, Edelman ER. Equilibrium and Non-Equilibrium Polyelectrolyte

Hydrogel Phase Transitions. Materials Research Society 1997 Fall Meeting; 1997
December 1-5; Boston, MA.
68.
English AE, Tanaka T, Edelman ER. Polyampholytic Hydrogen Phase Transitions at High
Ionic Strengths. Materials Research Society 1997 Fall Meeting; 1997 December 1-5;
Boston, MA. p.304.
69.
Edelman ER. Stent-Based Drug Delivery. 4th Local Drug Delivery Meeting and
Cardiovascular Course on Radiation and Molecular Strategies; 1998 February 26-28; Hotel
Noga Hilton, Geneva, Switzerland.
70.
Laham RJ, Sellke FW, Edelman ER, Pearlman JD, Simons M. Local Perivascular Basic
Fibroblast Growth Factor (bFGF) Treatment in Patients with Ischemic Heart Disease. 47th
Annual Scientific Session of the American College of Cardiology, 1998 April 1; Atlanta,
GA.; Journal of the American College of Cardiology 31(2); p. 394A, Supplement A.
71.
Rogers C, Tseng DY, Gingras PH, Karwoski T, Martakos P, Edelman ER. Expanded
Polytetrafluoroethylene Stent Graft Encapsulation Reduces Intimal Thickening Regardless
of Stent Design. 47th Annual Scientific Sessions of the American College of Cardiology,
1998 April 1; Atlanta, GA. In: Journal of the American College of Cardiology; 31(2), p.
413A-414A Supplement A.
72.
Edelman ER. The Endothelium in Vascular Disease. Cardiology & Cardiothoracic

Surgery, Third International Symposium; 1998 June 8-9; Jerusalem, Israel.
73.
Edelman ER. Development of Scientifically-Based Cardiovascular Therapies.

Cardiovascular Research Center; 1998 July; Jefferson Medical College, Philadelphia, PA.
74.
Seifert PA, Rogers C, Edelman ER. Characteristics and Effects of Methacrylate Resins on
Polyurethane-Coated Stent-Implanted Vessels. National Society for Histotechnology
Symposium/Convention; 1998 September 13-15; Salt Lake City, UT.
113
Elazer R. Edelman
75.
Edelman ER. Vascular Visions: Acute Myocardial Infarction and Cardiogenic Shock:
Salvaging Myocardium, Stabilizing Rhythm, and Prolonging Life. Cardiology Research
Foundation; 1998 September 15-17; Washington, DC.
76.
Rogers C, Seifert PA, Edelman ER. The Neointima Provoked by Human Coronary
Stenting: Contributions of Smooth Muscle and Inflammatory Cells and Extracellular
Matrix in Autopsy Specimens Over Time. American Heart Association, 71st Scientific
Sessions; 1998 November 8; Dallas, TX. In: Circulation; 98(17). p. 182 Supplement S.
77.
Simon DI, Chen Z, Seifert PA, Edelman ER, Ballantyne CM, Rogers C. Markedly
Reduced Neointimal Thickening in Mac-1 (CD11b/CD18)-Deficient Mice After Carotid
Artery Dilation and Endothelial Denudation. 71st Annual Scientific Sessions of the
American Heart Association 1998 November 9; Dallas, TX. In: Circulation; 98(17). p. 238
Supplement S.
78.
Drachman DE, Edelman ER, Kamath KR, Palasis M, Yang D, Nott SH, Rogers C.
Sustained stent-based delivery of paclitaxel arrests neointimal thickening and cell
proliferation. American Heart Association, 71st Scientific Sessions; 1998 November 10;
Dallas, TX. In: Circulation; 98(17). p.740 Supplement S.
79.
Edelman ER, Nugent HM. Scaffolds for Perivascular Endothelial Cell Transplantation.
International Society for Applied Cardiovascular Biology; 2000. In: Cardiovascular
Pathology; 9. p. 190-244.
80.
Edelman ER, Nugent HM, Nugent MA. Tissue Engineered Endothelial Cell
Transplantation. XIth International Vascular Biology Meeting; 2000 September 5-9;
Geneva, Switzerland. p. 389.
81.
Seifert PA, Hesselberg S, Delaney R, Edelman ER. Controlled Temperatures Preserve

Antigenicity in Methacrylate Embedded Tissues. NHS Symposium/Convention; 2000
September 17-19; Milwaukee, WI.
82.
Nugent HM, Nugent MA, Edelman ER. Perivascular Endothelial Cell Transplantation.
3rd International Congress on Coronary Artery Disease -- From Prevention to Intervention;
2000 October 4; Lyon, France.
83.
Rogers C, Groothuis AR, Toegel GS, Stejskal E, Kamath KR, Seifert PA, Hesselberg S,
Delaney R, Edelman ER. Paclitaxel Release from Inert Polymer Material-Coated Stents
Curtails Coronary In-Stent Restenosis in Pigs. Scientific Sessions of the American Heart
Association 2000 November 14; New Orleans, LA. In: Circulation; 102(18). p. 566- 567
Supplement S.
84.
Nugent HM, Groothuis A, Guerrero JL, White D, Nedelman M, Edelman ER.

Transplanted Endothelial Cells Control Repair in Complex Models of Vascular Injury.
American Heart Association, Scientific Sessions, 2001 November 11, Anaheim, CA. In:
Circulation; 104(17). p. 16-17 Supplement S.
114
Elazer R. Edelman
85.
Danenberg HD, Welt FGP, Edelman ER. Nonspecific Stimulation of the Innate Immune
System Increases Neointimal Formation Following Vascular Injury in Rabbits. American
Heart Association, Scientific Sessions 2001, November 13; Anaheim, CA. In: Circulation;
104. p. II-631.
86.
Rogers C, Huynh R, Seifert PA, Edelman ER, Toegel GS, Woupio A, Macon ND. Size
Distribution and Tissue Composition of Particulate Retrieved with Embolic Protection
Filter is Comparable to Particulate Retrieved with Embolic Protection Balloon Following
SVG Interventions. American Heart Association, Scientific Sessions 2001 November 14;
Anaheim, CA. In: Circulation; 104(17). p. 777 Supplement S.
87.
Sapp JL, Cooper JM, Sorrell T, Lopera G, Soejima K, Satti SD, Koplan BA, Epstein LM,
Edelman ER, Rogers C, Stevens WG. Feasibility of a Retractable Needle-Tipped Catheter
for the Creation of Deep Radiofrequency Ablation Lesions. 2001.
88.
Morss AS, Seifert P, Groothuis A, Bornstein D, Edelman ER. Biocompatibility

Comparison of Stainless Steel, Gold Coated, and Heat-Treated Gold Coated Endovascular
Stents. Materials Research Society, Fall 2001 Meeting; 2001 November 27-29; Boston,
MA. p. 232.
89.
Noh I, Oh KS, Edelman ER. Tissue Engineering of the Modified Expanded

Poly(tetrafluoroethelyene) Vascular Graft and Drug Transport Through its Pore Space.
CRC; 2002.
90.
J. Sapp, J. Cooper, K. Soejima, T. Sorrell, G. Lopera, S Satti, B. Koplan, L. Epstein, E.R.

Edelman, C. Rogers, W. Stevenson, W. Tyrrell, Deep Myocardial Ablation Lesions Can
Be Created With A Retractable Needle-Tipped Catheter, American Heart Association
Journal, 2002.
91.
Walker M. Fan WH, Hwang CW, Edelman ER. Growth factor early signaling and gene
expression are modulated by intercellular communication. Experimental Biology; 2002
April 20-24; New Orleans, LA. In: FASEB Journal 16(4), p. A90 Part 1.
92.
Balcells-Camps M, Walker M, Fernandez-Suarez M, Edelman E.R.. Cells in fluidic

environments are frequency sensitive independent of alterations in shear. Experimental
Biology; 2002 April 20-24; New Orleans, LA. In: FASEB J; 16(4), p. A88.
93.
Balcells-Camps M, Edelman ER. Regulation of endothelial cell adhesion, proliferation,

and function through pre-adsorbed proteins. 5th International Meeting of the Tissue
Engineering Society; 2002 December 8-10, Kobe, Japan. In: Tissue Engineering; 6. p.
1118.
115
Elazer R. Edelman
94.
Danenberg, H., Walker M., Seifert, P, E.R. Edelman, Inflammatory Preconditioning by

Lipopolysaccharide Modulates Vascular Repair Following Balloon Injury in Rabbits.
American Heart Association Abstracts From Scientific Sessions 2002 November 17-20,
Chicago, IL. In: Circulation 2002; 106. p.42.
95.
Genove E, Shen C, Balcells M, Edelman ER, Zhang S, Semino C. Bioengineering

Functional Endothelial Cell Monolayer Cultured on Design Peptide Hydrogel Scaffold.
Summer Bioengineering Conference; 2003 June 25-29; Key Biscayne, FL.
96.
Vasquez M, Balcells M, Edelman ER. Defined Flow Regimes: A Novel Perfusion

Bioreactor for Optimum Cell Growth. Summer Bioengineering Conference; 2003 June 2529; Key Biscayne, FL. In: Proceedings; 1. p. 981.
97.
Sotomayor M, Danenberg H, Fan WH, Edelman ER. C-Reactive Protein-Induced Increase

in Cytosolic Free Calcium Involves Both IP3 Mediated Stores and Capacitive Entry.
Summer Bioengineering Conference; 2003 June 25-29; Key Biscayne, FL.
98.
Balcells M, Edelman ER. Controlling Endothelial Cell Biosecretory Function Through

Surface Modification. Summer Bioengineering Conference; 2003 June 25-29; Key
Biscayne, FL. In: Proceedings; 1. p. 527.
99.
Edelman ER. Tissue Engineered Endothelial Cells Inhibit Early Events in the Vascular
Response to Injury to Prevent Restenosis Presentation Time, American College of
Cardiology Meeting, 2004 March.
100.
Edelman ER. A Novel Systemic Anti-Inflammatory Strategy To Reduce Restenosis:

Liposomal Bisphonates and Macrophage Depletion. Transcatheter Cardiovascular
Therapeutics; 2003 September 16, Washington, DC.
101.
Edelman ER. Drug-eluting stents: A case study of the first successful biotechnology
platform- pitfalls, lessons and insights. Transcatheter Cardiovascular Therapeutics; 2003
September 17, Washington, DC.
102.
Edelman ER. A basic primer on the essentials of drug-carrier systems- polymers, PC

coatings, and direct bonding methods- similarities, differences and other innovative
solutions. Transcatheter Cardiovascular Therapeutics; 2003 September 18, Washington,
DC.
103.
Edelman ER. The Drug-Eluting Stent Era: Update and Impact. 5th International Meeting
on International Cardiology: Frontiers in Interventional Cardiology, 2003 December 8; Tel
Aviv, Israel.
104.
Danenberg HD, Szalai AJ, Swaminathan RV, Peng L, Chen Z, Seifert P, Fay WP, Simon
DI, Edelman ER. Increased arterial thrombosis in human C-reactive protein transgenic
mice. 76th annual Scientific Session of the American Heart Association 2003, November
7-12, Orlando, FL. In: Circulation 108(17), p. 159.
116
Elazer R. Edelman
105.
Danenberg HD, Golomb G, Groothuis AR, Gao J, Epstein H, Swaminathan RV, Seifert P,
Edelman ER. Innate immunomodulation via transient depletion of monocytes by
liposomal-alendronate suppresses neointimal formation following balloon and stent injury
in rabbits. 52nd Annual Scientific Session of the American College of Cardiology 2003
March 30 April 2, Chicago, IL. In: Journal of the American College of Cardiology 41(6),
p. 31A-32A.
106.
Welt FG, Edelman ER, Vukmirovic N. Stent release of a rapamycin analogue: Tissue
pharmacokinetics of rapid versus delayed release. 52nd Annual Scientific Session of the
American College of Cardiology 2003, March 30-April 2, Chicago, IL. In: Journal of the
American College of Cardiology 41(6), p. 74A.
107.
Edelman ER. Understanding the Concept of Drug Eluting Stents: The Impact of Stent
Design. International Symposium on Endovascular Therapy, 2004 January 25; Miami, FL.
108.
Edelman ER. Engineering Solutions for Restenosis. International Symposium on

Endovascular Therapy; 2004 January 26; Miami, FL.
109.
Edelman ER. Tissue Engineering. Cardiovascular Revascularization Therapy 2004; 2004

May 6, Washington, DC.
110.
Edelman ER. Biophoshonates to Target Restenosis. Cardiovascular Revascularization

Therapy 2004; 2004 May 6; Washington, DC.
111.
Molins B, Vazquez M, Balcells M, Edelman ER. Endothelial Cell Response to Flow

Frequency. XIIIth International Vascular Biology Meeting, 2004 June 1 5; Toronto,
Canada.
112.
Methe H, Nugent H, Groothuis A, Edelman ER. Matrix Embedding Alters The Immune
Response Against Endothelial Cells In Vitro And In Vivo. 77th Scientific Meeting of the
American Heart Association 2004 November 7-10, New Orleans, LA. In: Circulation
2004; 110(17), p. 508.
113.
Sapp J, Cooper J, Soejima K, Sorrell T, Lopera G, Satti S, Koplan B,Epstein,L, Edelman

ER, Campbell R, Stevenson W. Deep Myocardial Ablation Lesions Can Be Created with
a Retractable Needle-Tipped Catheter. Pacing and Clinical Electrophysiology. 2004,
27(5):594.
114.
Parikh SA, Carofino BC, Lee AC, Edelman ER. Tissue engineered endothelial cells
inhibit early events in the vascular response to injury to prevent restenosis. 54th annual
Scientific Session of the American College of Cardiology 2004 March 07-10, New
Orleans, LA. In: Journal of the American College of Cardiology 43(5), p. 2A.
115.
Methe H, Nugent H, Groothuis A, Edelman ER. Tissue Engineering Attenuates the Th2Driven Immune Response Against Xenogeneic Endothelial Cells. 54th Annual Scientific
Session of the American College of Cardiology 2005, March 6-9; Orlando, FL. In:
Journal of the American College of Cardiology 45(3), p. 406A.
117
Elazer R. Edelman
116.
Methe H, Sayegh M, Edelman ER. Matrix-Embedding Alters Endothelial CellLymphocyte Interactions. XXXV International Congress of Physiological Sciences: 2005
March 31-April 5; San Diego, CA. In: FASEB J; 19(5), p. A1412.
117.
Methe H, Kim J, Edelman ER, Weis M. Statins Decrease TLR4 Expression and
Downstream Signaling via Small-G Proteins and the Phosphoinositide-3-Kinase Pathway.
Experimental Biology 2005/35th International Congress of Physiological Sciences; March
31-April 6; San Diego, CA. In: FASEB J; 19(4). p. A334-A335.
118.
Edelman, ER, Levin, AD, Hwang, CW. Stent-Based Drug Delivery. Controlled Release
Society, 2005, June 18; Miami, FL.
119.
Quan VH, Seifert P, Groothuis AR, Edelman ER. Dual-Action Combination

Chemotherapy Drug Eluting Stent Reduces Restenosis, Plaque mass, and Inflammation in
Injured Hypercholesterolemic Rabbit Iliac Arteries. 54th annual Scientific Session of the
American College of Cardiology 2005, March 6, Orlando, FL. In: Journal of the American
College of Cardiology 45(3), p. 48A.
120.
Jonas M, Edelman ER, Groothuis A, Baker A, Seifert P. Vascular Neointimal Formation

and Signaling Pathway Activation in Response to Stent Injury in Insulin Resistant and
Diabetic Animals. 78th Annual Scientific Session of the American Heart Association, 2005
November 13-16; Dallas, Texas. In: Circulation 112(17), p.U82.
121.
Methe H, Edelman ER. Matrix Embedding Protects Endothelial Cells from Host Immune
Reactions. 78th Annual Scientific Session of the American Heart Association, 2005
November 13-16; Dallas, Texas. In: Circulation; 112(17). p.U391.
122.
Hess S, Methe H, Edelman ER. Matrix Embedding Attenuates Endothelial MHC Class II
Expression Via SOCS3 Upregulation. Annual Meeting of the American Association of
Immunologists 2006 May 12-16; Boston, MA. In: Journal of Immunology 176, p. S240S241.
123.
Edelman, ER. Self-expanding Coronary Stents Entirely Incorporated with an 0.014 Wire:
Late Lumen Gain 90 days after Porcine Coronary Artery Implantation. Transcatheter
Cardiovascular Therapeutics; 2006 October 22-27, Washington, DC. In: American Journal
of Cardiology.
124.
Edelman, ER. Dissociating DES safety and efficacy: Endothelial regrowth and drug effect
after abluminal or circumferential paclitaxel delivery from a bioerodable polymer in
porcine coronaries. Transcatheter Cardiovascular Therapeutics; 2006 October 22-27,
Washington, DC. In: American Journal of Cardiology.
125.
Jonas M, Edelman ER, Baker AB, Spognardi A, Groothuis A, Seifert P, Rogers C.

Differential Response to Vascular Stenting in Control Vs Insulin-Treated Diabetic Pigs:
Analysis of Carotid, Renal and Coronary Bare Metal Stents (BMS) and Coronary Sirolimus
Eluting Stents (SES). 79th Annual Scientific Session of the American Heart Association
2006 November 12-15; Chicago, Illinois. In: Circulation; 114(18). p. 396.
118
Elazer R. Edelman
126.
Schubert S, Benarroch A, Ostvang J, Edelman ER. Monocytes Are Specific Potent

Regulators of Endothelial Cell Proliferation through a Contact Dependent Mechanism
Independent of VEGF Receptor 2. 79th Annual Scientific Session of the American Heart
Association 2006 November 12-15; Chicago, Illinois. In: Circulation; 114(18), p. 69-70.
127.
Methe H, Edelman ER. Three-Dimensional Matrix Embedding of Endothelial Cells

Abates Alloimmunity Via Upregulation of CD4+CD25+Foxp3+ T Regulatory Cells. 27th
Annual Meeting and Scientific Sessions of the International Society for Heart and Lung
Transplantation; 2007 April 25-28, San Francisco, CA. In: Journal of Heart and Lung
Transplantation 26(2), p. S184. Supplement S.
128.
Methe H, Edelman ER. Endothelial Cell-Matrix Interactions Influence Induction of

CD4+CD25+Foxp3+ T Regulatory Cells. 80th annual Scientific Session of the American
Heart Association 2007, November 4-7, Orlando, FL. In: Circulation 116(16), p. 243.
129.
Nugent H, Sjin RTT, White D, Milton L, Manson R, Lawson J, Edelman ER. Perivascular
Endothelial Cells Increase Positive Remodeling by Down Regulation of Matrix
Metalloproteinase (MMP)-2 in Porcine Arteriovenous Grafts. Experimental Biology 2007
American Association of Anatomists; 2007 April 29, Washington DC.
130.
Morss A, Edelman ER. Glucose modulates basement membrane fibroblast growth factor2 via changes in endothelial cell permeability. Experimental Biology 2007Annual Meeting
April 28-May 2, Washington, DC. In: FASEB Journal 21(5): A268.
131.
Jonas M, Chatzizisis Y, Coskun A, Spognardi A, Groothuis A, Gerrity R, Seifert P, Stone

B, Daley W, Feldman C, Edelman ER, Stone P, Rogers C. Combined Valsartan (Vn) and
Simvastatin (Sn) Therapy Decreases Early and Late Manifestations of Vulnerable
Atherosclerostic Plaque in Diabetic Hyperlipidemic Pigs: A Longitudinal Intravascular
Ultrasound (IVUS) and Histology Study. American College of Cardiology 56th Annual
Scientific Session, 2007 March 24-27, New Orleans, Louisiana. In: Journal of the
American College of Cardiology; (49)9, p. 407A.
132.
Chatzizisis Y, Jonas M, Coskun A, Stone B, Seifert P, Gerrity R, Daley W, Edelman ER,

Feldman C, Stone P. Low Endothelial Shear Stress (ESS) Predicts the Development of
High-Risk Coronary Atherosclerotic Plaques: A Correlative IVUS and Histopathology
Natural History Study. American College of Cardiology 56th Annual Scientific Session,
2007 March 24-27, New Orleans, Louisiana. In: Journal of the American College of
Cardiology; (49)9, p. 334A.
133.
Chatzizisis Y, Jonas M, Coskun A, Stone B, Gerrity R, Daley W, Edelman ER, Friedman

C, Stone P. Low Endothelial Shear Stress (ESS) Leads to Expansive Remodeling of
Atherosclerotic Coronary Subsegments: An In-Vivo Follow-up IVUS Study. American
College of Cardiology 56th Annual Scientific Session, 2007 March 24-27, New Orleans,
Louisiana. In: Journal of the American College of Cardiology; (49)9, p.335A.
134.
Chatzizisis Y, Jonas M, Coskun A, Stone B, Seifert P, Gerrity R, Daley W, Edelman ER,

Feldman C, Stone P. Prediction of the Localization of High-Risk Coronary Atherosclerotic
119
Elazer R. Edelman
Plaques Based on Low Endothelial Shear Stress: A serial IVUS and Histopathology
Natural History Study. Annual Conference on Arteriosclerosis, Thrombosis, and Vascular
Biology, 27(6), p. E133.
135.
Chatzizisis Y, Jonas, M, Coskun A, Stone B, Gerrity R, Daley W, Edelman ER, Friedman

C, Stone P. Low Endothelial Shear Stress Promotes The Differentiation of Early
Atherosclerotic Lesions To Thin Cap Fibroatheromas. 80th Annual Scientific Session of
the American Heart Association, 2007, November 4-7, Orlando, FL. In: Circulation
116(16), p. 114.
136.
Jonas M, Chatzizisis Y, Coskun A, Spognardi A, Groothuis A, Gerrity R, Seifert P, Stone

B, Daley W, Feldman C, Edelman ER, Stone P, Rogers C. Role of valsartan (V) alone or
in combination with simvastatin(S) in reducing inflammation of thin cap fibroatheromas.
80th annual Scientific Session of the American Heart Association, 2007 November 4-7,
Orlando, FL. In: Circulation 116(16), p. 2.
137.
Hamik A, Lin Z, Kumar A, Balcells M, Sinha S, Katz J, Gerzsten R, Edelman ER, Jain
M. Kruppel-like factor 4 (KLF4) Regulates Endothelial Inflammation. 56th Annual
Scientific Session of the American College of Cardiology, 2007 March 24-27, New
Orleans, Louisiana. In: Journal of the American College of Cardiology; (49)9, p.421A.
138.
Hamik A, Lin Z, Kumar A, Balcells M, Sinha S, Katz J, Gerzsten R, Edelman ER, Jain
M.Kruppel-like factor 4 Regulates Endothelial Inflammation. Combined Annual Meeting
of the Central Society for Clinical Research/Midwestern Section of the American
Federation for Medical Research 2007, April 12-13. In: Journal of Investigative Medicine
55(2) p. S355-S356.
139.
Balcells M, Methe H, Molins B, Alegret C, Edelman ER. Not All Endothelial Cells Are
Equal Under Flow: Studies on Cell Adhesion Molecule Expression. Annual Conference on
Arteriosclerosis, Thrombosis and Vascular Biology 2007 April 19-21, Chicago, IL. In:
Arteriosclerosis, Thrombosis and Vascular Biology 27(6):E102-E103.
140.
Olive C, Santacana M, Cardoso A, Balcells M, Edelman ER. Flow Differentially

Regulates the mTOR Pathway in Cocultured Endothelial and Smooth Muscle Cells.
Annual Conference on Arteriosclerosis Thrombosis and Vascular Biology 2007 April 10
21, Chicago, IL. In: Arteriosclerosis Thrombosis and Vascular Biology 27(6):E133.
141.
DAntonio P, Burgermeister R, Kopia G, Dooley J, Krever M, Marrey R, Chen S. Hansgen

A, Carroll J, Bailey L, Rousselle S, Edelman ER. The Effect of Porcine Coronary Artery
Motion On Neointimal Response And Stent Fracture After Percutaneous Coronary
Intervention. Transcatheter Cardiovascular Therapeutics Conference, 2007 October 20-25,
Washington, D.C.
142.
Morss A, Jonas M, Edelman ER. Elevated Basement Membrane Fibroblast Growth

Factor-2 Protects Endothelial Cells in High Glucose.American Society of Mechanical
Engineers 2007 Summer Bioengineering Conference, 2007 June 20-24, Denver, Colorado.
In: Arteriosclerosis Thrombosis and Vascular Biology
120
Elazer R. Edelman
143.
Baker AB, Ji A, Edelman ER. Intracellular Translocation and Cytoskeletal Association of

Syndecan-1 in Response to Mechanical Strain. 47th Annual Meeting of the American
Society for Cell Biology, December 1-5, 2007, Washington, DC.
144.
Chatzizisis Y, Beigel R, Baker A, Jonas M, Coskun A, Stone B, Maynard C, Gerrity R,

Edelman E, Feldman C, Stone P. Attenuation of the Expression of Matrix Proteases and
Expansive Remodeling in Coronary Atherosclerotic Plaques by Valsartan (V) Alone or in
Combination with Simvastatin(S). 9th Annual Conference on Arteriosclerosis, Thrombosis,
and Vascular Biology 2008 April 16-18, Atlanta, Georgia. In: Arteriosclerosis,
Thrombosis, and Vascular Biology 28(6) E115-E116.
145.
Chatzizisis Y, Baker A, Beigel R, Jonas M, Coskun A, Stone B, Maynard C, Gerrity R,

Edelman ER, Stone P, Feldman C. Low Endothelial Shear Stress Upregulates
Extracellular Matrix Degrading Enzymes and Promotes the Formation of Thin Cap
Fibroatheromas in the Coronary Arteries. 9th Annual Arteriosclerosis, Thrombosis, and
Vascular Biology Conference 2008, April 16-18, Atlanta, Georgia. In: Arteriosclerosis,
Thrombosis, and Vascular Biology 28(6):E44.
146.
Baker A, Chatzizisis Y, Beigel R, Jonas M, Stone B, Coskun A, Daley W, Maynard C,

Gerrity R, Rogers C, Feldman C, Stone P, Edelman ER. Heparanase Expression in the
Development of Thin Cap Fibroatheromas (TCFAs): Effects of Plaque Stage, Endothelial
Shear Stress and Pharmacologic Interventions. 9th Annual Conference on Arteriosclerosis,
Thrombosis, and Vascular Biology 2008, April 16-18, Atlanta, Georgia. In:
Arteriosclerosis, Thrombosis, and Vascular Biology 28(6):E48.
147.
Methe H, Hess S, Kim JO, Edelman ER. Cell-matrix interactions influence endothelial
MHC class II expression via SOCS1 and 3 upregulation. 28th Annual Meeting of
International-Society- for-Heart-and-Lung-Transplantation 2008. April 9-12, Boston, MA.
In: Journal of Heart and Lung Transplantation 27(2):S210-S210.
148.
Chatzizisis Y, Jonas M, Beigel R, Baker A, Coskun A, Stone B, Maynard C, Edelman ER,

Feldman C, Stone P. Attenuation of inflammation and expansive remodeling by Valsartan
(V) alone or in combination with Simvastatin (S) in coronary thin cap fibroatheromas.
European Society of Cardiology Annual Conference 2008, August 30 September 3,
Munich, Germany.
149.
Chatzizisis Y, Baker A, Beigel M, Jonas M, Coskun A, Stone B, Maynard C, Feldman C,

Stone P, Edelman ER. Low endothelial shear stress determines the formation of coronary
thin cap fibroatheromas through upregulation of extracellular matrix degrading enzymes.
European Heart Journal 2008; Abstract Supplement 128. European Society of Cardiology
Annual Conference 2008, August 30-September 3, Munich, Germany.
150.
Chatzizisis Y, Baker A, Sukhova G, Beigel R, Jonas M, Coskun A, Stone B, Maynard C,

Gerrity R, Shi GP, Libby P, Stone P, Feldman C, Edelman ER. Low endothelial shear
stress(ESS)-mediated elastolytic activity promotes the formation of high risk
atherosclerotic plaques in coronary arteries. 81st Annual Scientific Session of the American
Heart Association 2008, November 8-12, New Orleans, LA. In: Circulation 118(18): S409.
121
Elazer R. Edelman
151.
Le K, Hwang CW, Tzafriri AR, Lovich M, Edelman, ER. Local therapeutic angiogenesis
is limited by microvascular clearance. Scientific Sessions 2008, American Heart
Association Annual Conference, November 9-12, New Orleans, LA. Abstract No.11527.
152.
B.G. Zani, K. Kojima, C.A. Vacanti, and E.R. Edelman. Tissue engineered endothelial
and epithelial implants differentially and synergistically regulate airway repair. Tissue
Engineering and Regenerative Medicine International Society (TERMIS) North American
Meeting, 2008, December 7-12, San Diego, CA.
153.
Y. Chatzizisis, K. Koskinas, M. Jonas, A. Coskun and E.R. Edelman. Differential

atherosclerotic vascular response to local endothelial shear stress based on the severity of
hyperlipidemia. International Symposium on Atherosclerosis, June 14-18, 2009, Boston,
MA.
154.
Y. Chatzizisis, K. Koskinas, M. Jonas, A. Coskun, A. Baker, C. Maynard, E.R. Edelman,

P. Stone and C. Feldman. Differential atherosclerotic vascular response to local endothelial
shear stress based on the severity of hyperlipidemia. Atherosclerosis, Thrombosis and
Vascular Biology Annual Conference, April 29-May 1, 2009, Washington, D.C.
155.
K. Koskinas, Y. Chatzizisis, A. Coskun, M. Jonas, A. Groothuis, E.R. Edelman, C.

Feldman and P. Stone. High-risk coronary plaques develop in a persistently low endothelial
shear stress environment: a long-term, serial, natural history IVUS study. European Society
of Cardiology Congress, August 29 September 2, 2009, Barcelona, Spain.
156.
K. Koskinas, Y. Chatzizisis, A. Coskun, M. Jonas, A. Groothuis, E.R. Edelman, C.

Feldman and P. Stone. In-vivo identification of extreme high-risk coronary plaque based
on assessment of endothelial shear stress and arterial remodeling: an IVUS study. European
Society of Cardiology Congress, August 29 September 2, 2009, Barcelona, Spain.
157.
K. Koskinas, A. Coskun, Y. Chatzizisis M. Jonas, E.R. Edelman, P. Stone and C. Feldman.

Low endothelial shear stress promotes plaque progression in coronary segments free of
plaque and segments with established plaque in the setting of expansive remodeling: a
serial IVUS study. European Society of Cardiology Congress, August 29 September 2,
2009, Barcelona, Spain.
158.
K. Koskinas, A. Coskun, Y. Chatzizisis, M. Jonas, E.R. Edelman, P. Stone and C.

Feldman. Excessive expansive remodeling develops in coronary regions of preceding low
endothelial shear stress and is related to worsening subsequent plaque progression: a serial,
natural history IVUS study. European Society of Cardiology Congress, August 29
September 2, 2009, Barcelona, Spain.
159.
Y. Chatzizisis, A. Baker, G. Sukhova, R. Beigel, M. Jonas, A. Coskun, B. Stone, K.

Koskinas, C. Maynard, G. Ping Shi, P. Libby, C. Feldman, P. Stone and E.R. Edelman.
Augmented expression of extracellular matrix-degrading enzymes by low endothelial shear
stress promotes the formation of coronary atheromata with thin fibrous caps. 4th
International Symposium on Biomechanics in Vascular Biology and Cardiovascular
Disease, April 16-17, 2009, Rotterdam, The Netherlands.
122
Elazer R. Edelman
160.
Y. Chatzizisis, K. Koskinas, M. Jonas, A. Coskun, A. Baker, E.R. Edelman, P. Stone, and

C. Feldman. Synergistic role of local endothelial shear stress with hyperlipidemia in the
formation and progression of atherosclerotic lesions. 4th International Symposium on
Biomechanics in Vascular Biology and Cardiovascular Disease, April 16-17, 2009,
Rotterdam, The Netherlands.
161.
Y. Chatzizisis, K. Koskinas, M. Jonas, A. Coskun, A. Baker, C. Maynard, E.R. Edelman,

P. Stone, C. Feldman. Differential atherosclerotic vascular response to local endothelial
shear stress based on the severity of hyperlipidemia. American Heart Association 10th
Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology, April 29-May
1, 2009, Washington, D.C. In: Arteriosclerosis, Thrombosis and Vascular Biology 29(7):
E118.
162.
A. Groothuis, J. McClain, S. Maki, D. Taylor, P. Markham, E.R. Edelman. Multi-laminate

Rapid-Absorbing Polymer and Crystalline Drug (Sirolimus) Provides Safe Delivery of
Sirolimus in Porcine Coronary Arteries. Transcatheter Cardiovascular Therapeutics 21st
Annual Conference, September 21-25, 2009, San Francisco, CA. In: The American Journal
of Cardiology 104 (Suppl 6A): 184D-185D.
163.
K. Koskinas, A. Baker, Y. Chatzizisis, A. Coskun, M. Papafaklis, M. Jonas, P. Stone, C.

Feldman, ER Edelman. Persistently low endothelial shear stress promotes vascular
smooth muscle cell differentiation and high-risk coronary plaque formation in pigs: A
serial, intravascular ultrasound and histopathology natural history study. Arteriosclerosis,
Thrombosis and Vascular Biology 2010 Scientific Sessions, April 8-10, 2010, San
Francisco, CA
164.
Y. Chatzizisis, A. Baker, S. Sukhova, K. Koskinas, M. Jonas, R. Beigel, A. Coskun, C.

Maynard, G Shi, P. Libby, E.R. Edelman, P. Stone, C. Feldman. Local hemodynamic,
histopathologic and molecular mechanisms responsible for the evolution of atheromata
with thin fibrous caps. Arteriosclerosis, Thrombosis and Vascular Biology 2010 Scientific
Sessions, April 8-10, 2010, San Francisco, CA
165.
M. Papafaklis, K. Koskinas, A. Baker, Y. Chatzizisis, A. Coskun, J. Franses, S. Takahashi,

ER Edelman, P. Stone, C. Feldman. Low endothelial shear stress upregulates atherogenic
and inflammatory genes extremely early in the natural history of coronary artery disease
in diabetic hyperlipidemic juvenile swine. European Society of Cardiology Congress
2011, Young Investigators Awards Session, August 28, 2011.
166.
Spatz, J., Martorell, J., Barry, K.J., Edelman, E.R., Balcells, M. and P. Pajevic, PTH
regulation of SOST and FGF23 in a novel osteocytic cell lines, American Society for
Bone and Mineral Research Annual Meeting , San Diego, US, 2011.
167.
Chitalia, V., Shivanna, S., Martorell, J., Balcells, M., Bosch, I., Kolandaivelu, K. and E.R.
Edelman, Uremia Regulates Tissue Factor Stability and Ubiquitylation and Predisposes
to Stent Thrombosis, American Society of Nephrology Kidney Week, Philadelphia, US,
2011.
123
Elazer R. Edelman
168.
M. Papafaklis, KC Koskinas, GK Sukhova, AB Baker, AP Antoniadis, AU Coskun, JW

Franses, S Takahashi, ER Edelman, PH Stone, CL Feldman. Early drug-induced
inhibition of proatherogenic genes in coronary regions of low endothelial shear stress in
diabetic hyperlipidemic juvenile swine. Poster presentation, Arteriosclerosis, Thrombosis
and Vascular Biology Scientific Sessions, Chicago, USA, April2012 .Arterioscler Thromb
Vasc Biol 2012;32:A347
169.
. KC Koskinas, YS Chatzizisis, MI Papafaklis, AB Baker, AU Coskun, M Jonas, AP

Antoniadis, ER Edelman, CL Feldman, PH Stone. Incremental effect of
hypercholesterolemia on coronary plaque progression and high-risk composition despite
similarly low local endothelial shear stress. Poster presentation, European Society of
Cardiology Congress, Munich, Germany, August 2012. Eur Heart J 2012;33(Abstract
Supplement):273.
170.
AP, Antoniadis, MI, Papafaklis, YS Chatzizisis, GK Sukhova, AB, Baker, AU Coskun, S.

Takahashi, ER Edelman, PH Stone, CL Feldman. Adventitial inflammation is associated
with thin-cap atheromas and expression of matrix-degrading enzymes and occurs in
coronary regions exposed to low endothelial shear stress. Oral presentation, European
Society
of
Cardiology
Congress,
Munich,
Germany,
August
2012.
Eur Heart J 2012;33(Abstract Supplement):944-5
171.
MI, Papafaklis, KC, Koskinas, AP, Antoniadis, AB, Baker, GK Sukhova, AU,Coskun, S
Takahashi, PH Stone, CL Feldman, ER, Edelman. Early inhibitory drug effect on the
expression of pro-inflammatory and pro-oxidant genes in coronary regions of low
endothelial shear stress: an in vivo study in diabetic hyperlipidemic juvenile swine. Poster
presentation, European Society of Cardiology Congress, Munich, Germany,
August2012.Eur Heart J 2012;33(Abstract Supplement):275
172.
S Banai, M Jolicoeur, J-F Tanguay, ER Edelman, S Verheye, TCT-384 The Coronary

Sinus Reducer a Device Based Therapy for Refractory Angina; Interim Safety Results of
the ongoing COSIRA clinical Trial and efficacy results of the CS Reducer Registry J Am
Coll Cardiol. 2012;60(17_S):. doi:10.1016/j.jacc.2012.08.412
173.
A Tzafriri, L Bailey, J Stanley, B Zani, P Markham, W Carlyle, J McClain, ER Edelman,

TCT-570 Stents With Absorbable Tissue-Deployable Coatings Can Distribute Drug More
Uniformly
Between
Struts
J
Am
Coll
Cardiol.
2012;60(17_S):.
doi:10.1016/j.jacc.2012.08.605
174.
L Bailey, A Groothuis, A Zucker, S Buzzi, A Mder, A Ziogas, V Milleret, M Ehrbar, ER

Edelman, TCT-637 A Novel Bioactive and Coating-Free Stent Surface Exhibits a
Reduction in Neointimal Hyperplasia by Decreasing Platelet Aggregation and Promoting
Endothelialization , J Am Coll Cardiol. 2012;60(17_S):. doi:10.1016/j.jacc.2012.08.674
175.
S Banai, M Jolicoeur, J-F Tanguay, S Verheye, C White, ER Edelman, TCT-107 TIARA

- A Novel Catheter-Based Mitral Valve Bio-Prosthesis Short Term Pre-Clinical Results ,J
Am Coll Cardiol. 2012;60(17_S):. doi:10.1016/j.jacc.2012.08.124
124
Elazer R. Edelman
176.
S Banai, E.M Jolicoeur, M Schwartz, P Garceau, S Biner, J-F Tanguay, R Cartier, S

Verheye, C.J. White, E.R. Edelman, Tiara: A Novel Catheter-Based Mitral Valve
Bioprosthesis: Experiments and Short-Term Pre-Clinical Results, J Am Coll Cardiol. 2012;
60(15):1430-1431. doi:10.1016/j.jacc.2012.05.047
177.
Indolfi L, Ligorio M, Ting D, Ferrone CR, Clark JW, Langer R, Edelman ER. Design of
a Drug Eluting Stent for treatment of pancreatic malignancy. In: Proceedings of the Society
178.
Tzafriri RA, Edelman ER. Understanding the Influence of Stent Design on Arterial Drug
Distribution and Effect through Computational Modeling. In: Proceedings of the Society
179.
Cunha GLA, Freiman A, Indolfi L, Artzi N, Dreyfuss, JL, Edelman ER. CDK Inhibitor
PD 0332991 Selectively Inhibits Lung Adenocarinoma Cells Without Sacrificing Matrix
Embedded Endothelial Cells Ability Regulatory Effect on Tumor Proliferation. In:
180.
Faucher K, Artzi N, Albergo T, Bienkiewicz J, Conroy S, Dale A, Kozlova I, Edelman

ER, Martakos P. Naturally Derived Fatty Acid Biomaterials for Local Drug Delivery. In:
181.
Edelman ER, MATERIALS INNOVATION: Driving the Revolution in Cardiovascular

Interventions. In: Proceedings of the Society for Biomaterials Annual Meeting, April 2013.
182.
Oliva-Jorge N, Edelman ER, Artzi N. EGF-Conjugated Dendrimers For Local, Sustained

And Targeted Delivery Of Chemotherapeutic Drugs For Treatment Of Breast Cancer
BMES 2014 Annual Meeting, October 22-25, 2014 San Antonio,
183.
Salehi, S., Garcia-Polite, F., Melgar, P., Garcia-Granada, A.A., OBrien, C., Edelman,
E.R. and M. Balcells, Shear stress and co-culture with astrocytes determine brain
microvascular endothelial cell phenotype, AHA International Stroke Conference,
Nashville, US, 2015.
184.
Garca-Polite, F., Del Rey-Puech, P., Martorell, J., O'Brien, C., Edelman, E. and M.
Balcells, Tight junction expression and efflux activity correlate with shear stress in
microvascular endothelial cells at the Blood-Brain Barrier, Abstract accepted to 10th
International Symposium on Endovascular Therapeutics, Barcelona, Spain, June 2015.
185.
Del Rey, P., Garcia-Polite, F., Lopez, M., Roquer, J., Ois, A., Principe, A., Melgar, P.,
Edelman, E.R. and M. Balcells Impact of cellular components and their interaction in
blood-brain barrier phenotype, Abstract accepted to 17th Symposium on Signal
transduction in blood-brain barriers, Paris, France, July 2015.
186.
Garcia-Polite, F., Del Rey, P., Martorell, J., OBrien, C., ORourke, M., Edelman, E.R.
and M. Balcells, Increasing wall shear stress correlates with tight junction expression and
P-glycoprotein efflux activity in microvascular endothelial cells at the neurovascular unit,
125
Elazer R. Edelman
Abstract accepted to 17th Symposium on Signal transduction in blood-brain barriers, Paris,

France, July 2015.
187.
Melgar, P. Balcells, M. and E.R. Edelman, Implants of matrix-embedded endothelial

cells rescue ischemic tissue and liver engraftment in hepatectomized mice, Abstract
accepted in AASLD The Liver Meeting, San Francisco, US, November 2015.
188.
Tzafriri, A. Zani, B., Stanley, J. Markham, P. Nikanorov, A. Edelman E.R., Lesion

preparation with an orbital atherectomy system enhances paclitaxel deposition in calcified
peripheral arteries, Abstract accepted in the Transcatheter Cardiovascular Therapuetics
Conference, San Francisco, US, October 2015.
189.
Tzafriri, A. Markham, P. Goshgarian, J. Schulz-Jander, D. Tunev, S. Melder, R. Stone, G.

Edelman, ER. Titratable drug delivery from drug filled stents, Abstract accepted in the
Transcatheter Cardiovascular Therapuetics Conference, San Francisco, US, October 2015.
126

Elazer Edelman Curriculum Vitae (Updated 10-2015) - 0

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CURRICULUM VITAE

Date prepared: October 30, 2015

Harvard-MIT, Biomedical Engineering Center

30 Warren Street, Brookline MA 02445

New York, New York

Massachusetts Institute of Technology

First, Second and Third Year Resident Physician

Clinical and Research Fellowships:

Clinical Fellow in Medicine, Harvard Medical School, Boston, MA

Licensure and Certification:

Diplomate, National Board of Medical Examiners

Massachusetts License Registration

Faculty Academic Appointments:

Instructor in Medicine, Harvard Medical School, Boston, MA

Hospital or Affiliated Institution Appointments:

Engineering Associate, MITRE Corporation, Bedford, MA

Major Administrative Assignments:

Controlled Release Society

American Heart Association

Outcomes Based Clinical

Society for Biomaterials

NHLBI-Specialized Center for

The Childrens Hospital of

External Review Committee,

Planning Committee Cancer,

Institute of Medicine of the

Science Board of the Food and

Food and Drug

ORISE (Oak Ridge Institute for

Food and Drug

Member Strategic Team

Fritz J. and Dolores H. Russ

Committee on Educational Policy

Dept. of Electrical Engineering,

Committee on Skills, New

Harvard Medical School

Joint Faculty Committee

M.I.T. Program in Biomedical

Executive Board (Dept.)

M.I.T., Center for Biomedical

Lemelson Prize Selection

Center for Innovation and

Committee on the Formation of

Faculty Fellowship, Faculty of

Harvard Medical School

M.I.T. Hillel Foundation

HMS Faculty Fellowship

Harvard Medical School

Advanced Biomedical Sciences

Harvard Medical School

The Schepens Eye Research

Harvard Medical School

Ad Hoc Faculty Search

Harvard-MIT Division of Health

Committee on Animal Care

HMS Faculty Fellowship

Ad Hoc Faculty Search

Howard Hughes Medical Institute Program Massachusetts Institute of

Clinical and Translational Science

Harvard Medical School

Harvard Medical School

Harvard Medical School

Harvard Medical School