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Occipital Neuralgia
By S T E V E N B A R N A , M . D .
B.S.
AND
MGH
1811
MASSACHUSETTS
GENERAL
HOSPITAL
M ALI H A H ASH M I ,
Headache accounts for nearly 20 million outpatient visits per year in the United States and
is one of the most common complaints brought to doctors. Nearly 95% of the population
will experience a headache at some point in their life. While the parenchyma of the brain is
insen- sate, the scalp, head muscles, periosteum, dura, and blood vessels are all painsensitive; thus, there are many possible causes of head and face pain. Occipital
neuralgia is a headache syndrome that may be either primary or secondary.
Primary headaches have no clear structural or disease-related cause, (eg, migraine, tension,
and cluster headaches). Primary headaches constitute the etiology of >90% of head and
1
facial pain and occipital neuralgia is often confused with other primary headache syndromes,
includ- ing migraine and cluster headaches.
Secondary headaches have an underlying disease process that may include tumor, trauma,
infection, systemic disease, or hemorrhage.
ETIOLOGY
Patients with occipital neuralgia may be divided into those with structural causes and
those with idiopathic causes. Structural causes include:
trauma to the greater and/or lesser occipital nerves
compression of the greater and/or lesser occipital nerves or C2 and/or C3 nerve roots by
degenerative cervical spine changes
cervical disc disease
tumors affecting the C2 and C3 nerve roots.
The greater occipital nerve receives sensory fibers from the C2 nerve root and the lesser
occipital nerve receives fibers from the C2 and C3 nerve roots. The third occipital nerve (least
occipital nerve) stems from the medial sensory branch of the posterior division of the C3
nerve
MG H PA I N CEN TE R
Jane C. Ballantyne, M.D.
Chief, Division of Pain Medicine
Editor, Pain Management Rounds
Salahadin Abdi, M.D., Ph.D.
Director, MGH Pain Center
Martin Acquadro, M.D., D.M.D.
Director of Cancer Pain Service
Steve Barna, M.D.
Medical Director, MGH Pain Clinic
Gary Brenner, M.D., Ph.D.
Director, Pain Medicine Fellowship
Lucy Chen, M.D.
Katharine Fleischmann, M.D.
Director, Acute Pain Service
Jatinder Gill, M.D.
Karla Hayes, M.D.
Eugenia-Daniela Hord, M.D.
Ronald Kulich, Ph.D.
Jianren Mao, M.D., Ph.D.
Director, Pain Research Group
Seyed Ali Mostoufi, M.D.
Anne Louise Oaklander, M.D., Ph.D.
Director, Nerve Injury Unit
Director, Center for Shingles and
Postherpetic Neuralgia
Gary Polykoff, M.D.
Milan Stojanovic, M.D.
Director, Interventional
Pain Management
Nerve blocks consisting of steroids and local anesthetics may also be considered for treatment of
11
occipital neuralgia.
Occipital
block
nerve
Clinical features
Epidemiology
Pathophysiology
Migraine
headache
Neurovascular headache
associated with cranial perivascular
inflammation via the trigeminal
nerve. May be some serotonergic
involvement.
Tension
headache
Cluster
headache
Occipital
neuralgia
RADIOFREQUENCY THERMOCOAGULATION
Surgical implantation of a subcutaneous electrode along the C1-C3 nerve level has been shown
to significantly reduce the pain of occipital neuralgia
in patients who have failed conservative
23
therapies.
In one study of 19 patients, 95% reported
improve- ment in their quality of life and would
24
undergo the procedure again. In another study of
13 patients,
12 reported good-to-excellent pain control at up to
25
6 years of follow-up. The benefit of this procedure
is that it is minimally invasive and there is no
perma- nent destruction of nerves or other vital
structures. Another advantage is that patients can
first undergo a percutaneous trial of temporary lead
placement for several days prior to permanent lead
implantation. Depending on the results of the
temporary percuta- neous trial, patients may or
may not undergo the more invasive permanent
lead implantation. It has been postulated that a
successful temporary percuta- neous lead trial, in
combination with a successful diagnostic occipital
nerve block, may predict a highly effective
permanent occipital ner ve stimulator
implantation.
CONCLUSION
2004;7(2):103-112.
25. Weiner RL, Reed KL. Peripheral neurostimulation for
control
of
intractable
occipital
neuralgia.
Neuromodulation
1999;2(3): 217-221.
Abstracts of Interest
Botulinum neurotoxin for the treatment of
migraine and other primary headache disorders.
B L U M E N F E L D A M , D O D I C K D W, S I L B E R S T E I N S D ,
S A N D IE G O , C A
EINER
EXAS
RL, R
EED
KL ,
ALL AS
, T
OST ON
Neurostimulation methods for control of chronic neuropathic pain have recently gained in popularity. The
reasons for this are multifactorial. As opposed to nerve
ablation, these methods are minimally invasive and
reversible. The improvements in hardware design
simplified implantation techniques and prolonged
equipment longevity. Stimulation trials have become less
invasive, allowing patients to test its effects before final
implantation. Finally, the scientific evidence has
shown good outcomes of neurostimulation methods
for chronic neuropathic pain control. Recent research
efforts have revealed new potential mechanisms of action
of neurostimulation. Whereas its action was widely
Pfizer, Inc.
2004 The MGH Pain Center, Massachusetts General Hospital, which is solely responsible for the contents. The opinions expressed in this publication do not necessarily reflect those of the publisher
or sponsor, but rather are those of the authoring institution based on the available scientific literature. Publisher: SNELL Medical Communication Inc. in cooperation with the MGH Pain
Center, Massachusetts General Hospital. All rights reserved. The administration of any therapies discussed or referred to in Pain Management Rounds should always be consistent with the recognized
prescribing information as required by the FDA. SNELL Medical Communication Inc. is committed to the development of superior Continuing Medical Education.
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