Beruflich Dokumente
Kultur Dokumente
Review Article
Siemens Healthcare, CT PLM-E PA, Siemensstr. 1, D- 91301 Forchheim, Germany and bDepartment of Diagnostic
Radiology, Eberhard-Karls-Universitat, Tubingen, Germany
KEYWORDS:
Cardiac CT;
Dual-source CT;
Multidetector row CT;
Spatial resolution;
Temporal resolution;
Volume coverage
Abstract. In this article, we review the current status and discuss potential further improvements and
limitations of system parameters relevant for cardiac CT, in particular spatial resolution, temporal
resolution, and volume coverage.
2009 Society of Cardiovascular Computed Tomography. All rights reserved.
at low to moderate heart rates.17 Despite all promising advances, limitations due to motion artifacts in patients with
higher heart rates, limited spatial resolution for the visualization of stents and calcified coronary arteries, and long
breathhold times up to 40 seconds remained for 4-slice cardiac CT.7,8 Introduced in 2001, 16-slice CT systems with
submillimeter collimation (16 ! 0.5 mm, 16 ! 0.625 mm,
16 ! 0.75 mm) and gantry rotation times down to 0.375
seconds provided improved spatial and temporal resolution,
whereas examination times were considerably reduced to
approximately 1518 seconds.9 CT angiography (CTA) of
the coronary arteries benefited from the increased performance of 16-slice technology.1014 Available since 2004,
64-slice CT systems that provided simultaneous acquisition
of 64 slices with 0.5-mm, 0.6-mm, or 0.625-mm collimated
slice width at gantry rotation times down to 0.33 seconds
were a further advance in integrating coronary CTA into
routine clinical algorithms. The wider coverage with thinner slices has shortened the scan time to 612 seconds,
which is an adequate breathhold time even for patients
with limited ability to cooperate. Although image quality
at higher heart rates and robustness of the method in clinical routine are significantly improved with 64-slice CT
1934-5925/$ -see front matter 2009 Society of Cardiovascular Computed Tomography. All rights reserved.
doi:10.1016/j.jcct.2009.04.004
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Spatial resolution
The in-plane spatial resolution of a CT system is limited
by the number of active detector channels in a detector row
and by their aperture, ie, the width of each individual
detector channel. With 700900 detector channels covering
a scan field of view (SFOV) of usually 500 mm, the inplane sampling distance, ie, the distance between 2 detector
channels, is 0.560.71 mm in the isocenter of the scanner.
Modern CT scanners use techniques such as quarter detector offset or in-plane flying focal spot to double the number
of samples acquired across the SFOV. The quarter detector
offset, ie, a stationary shift of the entire detector by a quarter of the in-plane sampling distance relative to the isocenter, relies on complementary samples acquired half a
rotation earlier or later to provide interleaved samples.
The in-plane flying focal spot doubles the number of samples by dynamically shifting the focal spot position on the
anode plate from one reading to the next, such that subsequent readings interleave. The resulting sampling distance
of 0.280.36 mm obtained with both techniques defines
the theoretical limit of in-plane spatial resolution. In practice, it cannot be fully exploited in routine clinical modes
if excessive image noise and streak artifacts at high contrast
structures shall be avoided. Typically, an in-plane resolution of approximately 0.5 mm is not exceeded for low-contrast imaging with the use of standard body convolution
kernels; this is also the typical in-plane resolution in
ECG-synchronized images of the heart.
Whereas in-plane spatial resolution did not significantly
change from 4-slice CT to 64-slice CT, through-plane
(z-axis) resolution considerably improved since thinner
collimated slices became available for routine use: the
4-slice systems allowed to cover the heart with 1- to 1.25mm collimated slice width in an ECG-gated examination.
The 64-slice systems provide 0.5- to 0.625-mm collimated
slice width for routine cardiac scans. A flying-focal spot in
the z-direction can be applied to improve through-plane
resolution by better approaching the theoretical resolution
limit,23 comparable to the improvement of in-plane resolution by an in-plane flying-focal spot. The z-flying focal spot
technique has meanwhile been implemented in CT scanners
from 2 different vendors.
The progress in through-plane resolution from approximately 1 mm with 4-slice CT to less than 0.4 mm with 64slice CT can best be shown with a z-resolution phantom,
which consists of a Lucite plate with rows of cylindrical
holes with different diameters aligned in the z-axis direction (Fig. 1). The patient examples in Figure 2 show typical
coronary CT angiograms with 4-slice and 64-slice CT scanners. The improvement of detail visualization is obvious. In
sum, cardiac imaging with state-of-the-art CT systems providing simultaneous acquisition of at least 64 slices can be
performed at isotropic spatial resolution down to
0.4 ! 0.4 ! 0.4 mm3, if detail visualization of calcified
coronary arteries or stents is required.
In routine coronary CT angiography, the resolution is
typically reduced to 0.5 ! 0.5 ! 0.5 mm3 by smoother
convolution kernels and somewhat wider reconstructed slices, to obtain smoother images with less image noise. This
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Figure 2 Patient examples depicting similar clinical situations (a stent in the proximal left anterior descending [LAD] artery) to compare
the clinical performance of ECG-gated cardiac CT with a 4-slice CT system (4 ! 1 mm collimation, 0.5-second rotation time) and a
64-slice CT system (32 ! 0.6 mm collimation with z-flying focal spot, 0.33-second rotation time). Because of the significantly improved
spatial and temporal resolutions with the 64-slice system, the in-stent lumen can be evaluated (4-slice case courtesy of Hopital de Coracao,
Sao Paulo, Brazil; 64-slice case courtesy of Peking Union Medical Center (PUMC), Beijing, China).
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loop starts again, and it is continued until the deviation between measured and calculated projections is smaller than
a predefined limit. Iterative reconstruction has the potential
to enhance spatial resolution at higher object contrasts and
to reduce image noise in low-contrast areas. It is not unlikely
that the visualization of calcified plaques can be considerably
improved and calcium blooming can be significantly reduced
with the use of such techniques (see Fig. 4). As a drawback,
iterative reconstruction is computationally more demanding
than conventional filtered backprojection reconstruction, and
hardware efforts are currently needed to avoid long image reconstruction times. Furthermore, the noise texture of the images may be different from standard filtered backprojection,
and the users may have to get used to an image impression
that they are currently not familiar with. Nevertheless, iterative reconstruction appears to be the most promising
approach to reduce or even solve the problem of heavily calcified coronary arteries in cardiac CT.
One should keep in mind, however, that any further
increase in spatial resolution in cardiac CT without simultaneous improvement of temporal resolution is doubtful and
will not necessarily result in sharper images. Much of the
blurring and unsharp contours that limit the visualization of
calcified plaques in coronary arteries are caused by object
motion. Clinical experience with the improved temporal
resolution of newer generations of CT systems has shown
that better temporal resolution translates into visually
perceived improvement of image sharpness, although the
actual spatial resolution of the system may not have
changed (Fig. 5).
Temporal Resolution
In ECG-synchronized cardiac MDCT, scan data acquisition and image reconstruction are controlled by the
Figure 3 Small coronary artery phantom with calcified and noncalcified plaques (computer simulation). Constant radiation dose was
applied both for 0.5 mm (left) and 0.35 mm (right) isotropic resolution. Because of the significantly increased image noise at 0.35 mm
isotropic resolution, detail visualization is hampered.
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Figure 4 Detail of a coronary CTA in a patient with significant coronary calcifications. The scan data were acquired on a dual-source CT
system. Standard filtered backprojection reconstruction (top); iterative reconstruction, start image with filtered backprojection, 2 iterations
(bottom). Calcium blooming is significantly reduced.
250 milliseconds with the first generation of 4-slice CT systems3,27 to 135 milliseconds with the latest generation of
64-slice and 128-slice CTs, which improved image quality
at higher heart rates and robustness of the method1517 and
constituted a fundamental step in the ongoing process of
introducing cardiac CT into routine clinical practice.
Nevertheless, further improved temporal resolution
down to 50 milliseconds is desirable to improve image
quality in particular in patients with irregular heart rates28
and to reduce the need for b-blocker medication. The temporal resolution of MDCT scanners can be improved by
dividing the half-scan data segment into N 5 24 subsegments acquired in subsequent cardiac cycles. When using
multisegment reconstruction, the patients heart rate and
the gantry rotation time of the scanner have to be desynchronized to enable improved temporal resolution.
Two requirements have to be met: first, the subsegments
have to fit together in projection space to build up a halfscan interval. As a consequence, the start projections of
subsequent subsegments have to be shifted relative to
each other. Second, all subsegments have to be acquired
in the same relative phase of the patients heart cycle to reduce the exposure time per image. If the patients heart beat
and the rotation of the scanner are completely synchronous,
the 2 requirements are contradictory. In this case, temporal
resolution will not improve with multisegment reconstruction. Depending on the relation of rotation time and patient
heart rate, temporal resolution in an N-segment reconstruction varies between one-half and 1/(2N) times the gantry
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Figure 5 Improved visualization of calcified plaques (reduced blooming artifact) because of improved temporal resolution. A followup examination in a patient with calcified LAD artery is shown both for a conventional 64-slice CT system with 165-millisecond temporal
resolution (top left) and a DSCT system with 83-millisecond temporal resolution (top right). The spatial resolution of both systems is similar (courtesy of Dr S. Achenbach, Erlangen University, Germany). At least part of the blooming artifact is caused by residual coronary
motion. This clinical result is supported by a computer simulation study of a moving coronary artery at identical spatial resolution but different temporal resolution (165 milliseconds, bottom left, versus 83 milliseconds, bottom right).
rotation time. There are sweet spots, heart rates with optimum temporal resolution, and heart rates at which temporal resolution cannot be improved beyond half the gantry
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Volume Coverage
With typical MDCT detector z-coverages of 40 mm and
recently up to 80 mm (the z-direction is the patients longitudinal direction), an ECG-synchronized volume image of the
heart still consists of several image slabs reconstructed from
data acquired in multiple consecutive heart beats (Fig. 6 and
Fig. 7). As a consequence of insufficient temporal resolution
and variations of the heart motion from one cardiac cycle to
the next, in particular in the case of arrhythmia, these image
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Figure 9 Influence of scattered radiation on the contrast-to-noise ratio (CNR) of the images and on cupping artifacts. (Left) Axial image
of a coronary CTA acquired on a CT system with 2-cm detector coverage. (Right) Simulated scattered radiation corresponding to a CT
system with 16-cm detector coverage. Note the decreased CNR.
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Conclusion
We presented various approaches to improve temporal
resolution, spatial resolution, and volume coverage in ECGsynchronized cardiac CT, and we discussed the technical
and practical limitations. Technical progress alone, however, does not necessarily translate into better diagnostic or
prognostic value of cardiac imaging or into improved
patient outcomes. Complementary to the ongoing refinement of imaging techniques clinical studies are required as
a basis for establishing cardiac CT in routine clinical
practice.
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