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Brief communication
and Gynecology,
Christian Medical College Hospital,
Vellore, India
Biochemistry,
Christian Medical College Hospital,
Vellore, India
zinc; Leukocyte
zinc
sorption spectrophotometer
and expressed as
&lo0 ml, kg/g Hb and ng/mg dry weight, respectively. The statistical analysis was performed using
Students r-test and Pearson correlation coefficient.
Analysis of the results revealed that the plasma
zinc levels were significantly lower in pregnant
women during the 3 trimesters compared to the
non-pregnant controls (Table 1). The levels in II
and III trimesters were significantly lower than in
I trimester. Most studies by other authors have
revealed the same observation. This decrease in
plasma zinc levels in pregnancy is the effect of
hemodilution and low albumin levels.
However the erythrocyte and leukocyte zinc levels were similar in pregnant women in all 3
trimesters and non-pregnant women, indicating
that there is no zinc deficiency in normal
pregnancy.
There was no significant correlation between
plasma zinc levels and erythrocyte or leukocyte
zinc in the pregnant and non-pregnant women.
But there was a significant positive correlation be-
SOO20-7292(96)0275
I-8
176
S.S. George
Table I
Zinc levels in pregnant
CI al. / Inrerna~ionnl
and non-pregnant
Zn indices
Mean f SE.
Journal
of Gynecology
& Obsrerrics
55 (19%)
175- I76
women
Non-pregnant
n = 25
Pregnant
n = 14
Trimester
Trimester
II
Trimester
III
Plasma pgilO0 ml
RBC rg/g Hb
WBC ngmg (dry weight)
91.3 f 1.7
46.8 f 0.4
60.4 f 0.5
SO.36 f 4.2
45.28 f 1.8
60.86 f 2.6
67.71 f 2.3
44.51 f 2
56.71 f 2.7
69.19 f 2.9
48.21 f 2.4
57.93 f 2.9
Correlation
coefficient
Plasma, RBC
Plasma, WBC
RBC, WBC
0.25
0.28
0.58"'
0.2
0.28
0.59'
0.36
0.45
0.57*
0.08
0.18
0.17
***f
< 0.056.
tween erythrocyte and leukocyte zinc in the nonpregnant state and during pregnancy except in the
third trimester. This indicates that plasma zinc is
not a reliable index of zinc status in pregnancy.
Erythrocyte and leukocyte measurements give a
fair assessment of the zinc status and preferably
both of these indices should be measured.
Erythrocyte zinc measurement is technically
simpler, less time consuming and less expensive
and has the least variation among the three indices. Therefore, erythrocyte zinc appears to be a
reliable and cost effective index of maternal zinc
status.
References
111
PI
131