Subject: DSP/Image Processing/Machine Learning/Computer

Vision/Embedded/Electrical Engineer Job Position Application

My name is Chien-Chun Yang. I am writing to apply for an Engineer position
in your company.
With a M.S. degree from the University of Rochester and studying in both
Electrical Engineering and Biomedical Engineering as well as emphasizing in DSP,
Machine Learning, Medical Imaging and Medical Image Analysis, I would like to
interview for this Engineer position. This opportunity allows me to apply and
develop my theoretical knowledge, research and working experiences in a practical
setting, and I believe I will be a strong asset to your team to solve variety of
problems in a challenge and fast pace environment.
Through my academic background and history, I have been focusing my
studies on DSP, Digital Logic Design, Digital Image Processing, Machine Learning,
Feature Extraction/Analysis, Pattern Recognition and Computer Vision.
I had experiences with DSP involving varieties of filter design, hardware
simulation with Texas Instrument DSP chip at bit-exact level, one year experience
with FPGA involving Bandpass filter design with hardware co-simulation, and digital
logic design using FPGA with Verilog to interface with digital ICs such as RS-232,
PS/2, VGA, DVI and Ethernet. Besides, I have gained knowledge in electronic circuits
through hands-on projects and experiments such as ECG amplifier, Audiometer,
circuits for Biosignal/Vital Signs measurement. One project collaborated with my
classmate, Modular Design of Thermal Cautery Surgical Equipment, won the 1st
prize of Regional IEEE BME student paper contest in 2009.
Through my undergraduate studies, I have had knowledge and experiences
with DSP and electrical engineering design using Microcontroller, TI DSP chip and
MultiSim. In my previous work in Industrial Technology Research Institute, my
partner and I worked together to design and build a prototype working console
station for industrial automation machine, which uses motion control chips to
control multi-axes servo motors. We also designed Human Machine Interface using
LabVIEW and C/C++ in order to achieve real-time Automation Machine control and
monitoring. At the same time, I studied industrial communication protocols that
includes RS-232, RS-485 and EtherCAT.
In addition, I am specialized in Digital Image Processing, feature analysis,
pattern recognition and Machine Vision/Learning techniques in Medical Image
application setting, which were gained through my studies and researches in
Rochester Center for Brain Imaging and Department of Imaging Sciences in
University of Rochester Medical Center; in order to support medical image research
and to improve the Computer-Aided Diagnosis system. I have had three years
practical experience in analyzing breast MRI, bone CT and breast cancer micro-CT
images with publications in conferences and journal. Besides the MRI and CT, I also
had hands-on projects experience with acoustic ultrasound and ultrasound images,
which are Using Microbubble-Aided Focus Ultrasound to Disrupt the Blood-Brain
Barrier in Assisting Drug Delivery for Alzheimer Treatment and Use Local
Frequency Estimation of Ultrasound Shear Wave to Detect Stiff Region (phantom).

In addition to the mentioned research experiences, while working in Professor

Axel Wismueller's Computational Radiology Lab, I gained tremendous knowledge,
developed strong research abilities and interpersonal communication as well as
teamwork skills with my professor and lab mates to solve real life clinical problems.
After graduating from the University of Rochester, I joined Intersection
Medical Inc. as an Electrical Engineer. My major duty is to work with senior
engineers and research scientists to research and develop medical device. My tasks
include but are not limited to the following.
In hardware and electrical part, I assist hardware engineer to design and
verify analog filters (Passive, Active, LPF and HPF) and Multi-Stage/Multi-rate Digital
Filters (LPF, BPF, CIC, Half-Band, Moving Average and DC Removal Filters) for our
device. In the meantime, I am responsible for testing and verifying the designed
medical device, the associated electronic circuitry, signal integrity and the GUI;
including write up and maintain detail-oriented testing procedures and protocols.
In software and algorithms development part, under minimal supervision
from research scientists, I am responsible for simulating tetrapolar in-phase/inquadrature sine correlator for bioimpedance measurement, RC Network Circuit and
constructing bioimpedance/bioelectrical resistivity mathematical model using
Wenner-Schlumberger array techniques and perform biosignal analysis.
In addition, I worked closely with research scientists to develop algorithms to
solve challenge ill-posed inverse problems from measured biosignals in order to
quantify/reconstruct the resistivity profile inside human body. The process involves
tremendous data mining, high dimensional feature extraction/selection/analysis
from subjects pathology data and raw human biosignal.
The knowledge and techniques I use but are not limited to are: 3D
interpolation, regression, fix-effect and mix-effect mathematical modeling, k-means
clustering, SVD, PCA, Lasso, Ridge and Elastic Net regularization, SVM, logistic
regression, linear & non-linear constrained optimization to solve ill-posed inverse
problem. The whole process of mathematical modeling, regression analysis, feature
extraction/analysis and machine learning all serve the same ultimate goal, which is
to build a diagnosis model from the acquired bioimpedance signals in order to assist
physicians clinical/diagnostic interpretation.
Besides the hardware testing, verification and algorithm development, I also
assist FDA specialist to setup the medical device testing protocols, Safety Protocol
Compliance (IEC 60601-1 and IEC-60601-2 for Medical Electrical Equipment
regulation), Quality Collaboration by Design (QCBD) to ensure the quality, safety
and the smoothness of the R&D phase.
To sum, my interdisciplinary academic background in both Electrical and
Biomedical Engineering provides me skill sets that include Verilog for Xilinx FPGA,
C/C++/C# programming, MATLAB, LabVIEW, DSP, Image Processing, feature
extraction/analysis and machine learning algorithm development, which makes me
an exemplary candidate for this position.

My resume summarizes the experiences and projects that qualify me for this
position, and I can start working immediately. I hope to hear from you soon
regarding next steps in this process. Thank you very much for your time and
consideration.

P.S. Reference/Recommendation letters are available upon request.

Sincerely,
Chien-Chun Yang
University of Rochester M.S. Biomedical/Electrical Engineering
Email: chien.yang1984@gmail.com Phone: 562-338-6525