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1318
ORIGINAL RESEARCH
Corresponding author: Dr. R. D. Gaikwad, Professor, Department of Physiology, Santhiram Medical College and
General Hospital, NH-18, Nandyal, Kurnool(Dist), Andhra
Pradesh, India.
Source of Support: Nil
Conflict of Interest: None
INTRODUCTION
WHO reports that about 5 million people die each year across
the globe due to cigarette smoking.1 In United States, 440000
premature deaths are attributed to cigarette smoking.2 The
Gaikwad et al.
Physiological Variables
Mean age (years)SD
Sex (%)
Mean BMI (kg/m2)
Exercise (no. of times/month)
Heart Rate (beats/min)
Blood Pressure (mmHg)
*NS: Not significant.
Subjects
Male
SBP
DBP
Smoking Volunteers
20.72.8
54.9%
23.44.1
0.330.40
81.69.3
119.810.8
75.18.6
Non-Smoking Volunteers
21.01.4
45.1%
22.113.7
0.240.30
79.49.8
116.113.8
70.711.4
P value
NS
NS
> 0.05
> 0.05
> 0.05
> 0.05
< 0.05
Mean
Mean
Mean
Exercise
PEFR
Eosinophil
RateSD
(l/min)
Count
(no. of
(cells/mm3)
times per
month)
Male
Smoker
0.430.42
550.9
236.3
Non-smoker
0.300.35
547.8
113.0
Table-3: Mean exercise rate and the association with mean
PEFR and eosinophil count
1.2
1
0.8
0.6
0.4
0.2
0
-0.2 0
Gaikwad et al.
1.2
1
0.8
0.6
0.4
0.2
0
r = 0.359
p < 0.05
100
200
300
400
500
600 700
PEFR (L/min)
Figure-1: Graph showing the rate of exercise in a month and its
association with PEFR
r = -0.04
p > 0.05
Eosinophil count
(cells/mm^3)
900
800
700
600
500
400
300
200
100
0
r =-0.06
p > 0.05
100
200
300
400
500
600 700
PEFR (L/min)
Figure-3: Graph shows absolute eosinophil count against PEFR in
smoking and non-smoking volunteers
eosinophil count and the PEFR. But there was a slight negative correlation coefficient (r = - 0.06) observed, indicating
there were a small number of individuals that showed low
PEFR at increased absolute eosinophil count.
DISCUSSION
Smoking causes decrease in lung function,11-15 butonlya minority of smokers develops severe respiratoryimpairment.16
Reasons for this difference in susceptibility are not fully
understood. Blood eosinophilcount is elevated in nonatopic
smokers compared to nonsmokers.17,18 A simple test to measure how quickly air can be forced out from the lungs is peak
expiratory flow rate. Narrowing of the airways reduces the
ability to move air in and out of the lungs, which lowers the
PEFR.19 The present study evaluated the effect of smoking
on absolute eosinophil count and PEFR, the relationship between absolute eosinophil count and PEFR in male smokers
and non- smokers.
Our study noted that the smoker subjects showed a high mean
PEFR compared to non-smoking subjects. This was not consistent with the expected finding of lower PEFR in smokers
Gaikwad et al.
15.
We sincerely thank all subjects who gave consent and participated in this study.
16.
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