Beruflich Dokumente
Kultur Dokumente
Objective
To identify potential toxic and carcinogenic effects
associated with chronic exposure to modulated cell
phone radiofrequency radiation (RFR) and to
characterize dose-response relationships in animals
Critical Study Design Criteria
Study Design
Subchronic
Rats: 3, 6, 9 W/kg
Chronic
Reverberation Chambers
Chamber Interior
Conducted in young and old rats and mice, and pregnant rats
Rat Studies
Subchronic studies
At weaning (PND-21), litter size reduced to 2 male and 2 female pups and
exposure continued for 28 more days (PND 49)
Pregnancy/littering data
Body weight (dam gestation, litter weights, dam lactation, individual pup)
Body temperature (gestation, lactation, individual pups)
Organ weights (pups)
Special gene expression analysis for brain and liver
0 W/kg
3 W/kg
6 W/kg
9 W/kg
Dams Littering
20
19
18
20
11.9 1.8
11.6 2.3
12.7 1.5
12.2 2.3
Mean #
6.1 1.9
5.9 1.7
6.7 2.2
5.8 2.5
Mean #
5.8 1.9
5.7 1.6
6.0 1.9
6.4 2.3
77.2 11.7
76.3 14.6
80.0 8.8
72.2 13.1
40.8 12.8
39.8 10.9
41.8 14.7
34.8 15.0
36.4 11.6
36.6 9.8
37.6 11.3
37.4 13.0
0 W/kg
3 W/kg
6 W/kg
9 W/kg
Dams Littering
20
17
17
16
11.9 1.8
11.6 1.3
10.8 4.4
11.6 2.0
Mean #
6.1 1.9
5.7 1.8
5.0 2.8
6.4 1.9
Mean #
5.8 1.9
5.9 2.2
5.8 3.0
5.2 2.3
77.2 11.7
77.1 8.8
68.2 26.4
40.8 12.8
38.4 11.7
32.2 17.5
39.3 10.7
36.4 11.6
38.2 14.1
38.2 15.6
34.4 7.9
69.4 11.7
CDMA
Decrease may
reflect
non-pregnants
Pregnant Dams
(on PND1)
20
17
17
16
CDMA
Body weights were lower in 6 and 9 W/kg male and female pups at PND4
SAR-dependent decrease
Indication of a potential recovery by PND 21
Body weights were lower in 6 and 9 W/kg male and female pups at PND4
SAR-dependent decrease
Indication of a potential recovery by PND 21
CDMA Modulation
Gestation
Lactation
>1C
CDMA Modulation
Body Weights
o
Body Temperature
Acknowledgements
Chicago, Il
Boulder, CO
Zurich, Switzerland