Preparation #19

Iso-alcoholic Elixir
Materials:
*glycerin, sucrose, (sorbitol) sweetening
agents
*alcohol excellent solvent for drugs but
has an unpleasant taste (need flavorant)
Substitution for glycerin and alcohol
propylene glycol
Elixirs hydroalcoholic (alcohol + H2O)
oral solutions that are clear, sweetened and
usually flavored to improve their taste.
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Contain less sugar than syrups

Less effective in masking
unpleasant taste of active
ingredients
Can be prepared by:
simple solution with agitation
solutes are dissolved in
solvent
admixture of two or more
liquid ingredients

Advantage: can contain both watersoluble and alcohol-soluble

components (because of
hydroalcholic character)
Glycerine and propylene glycol adjunctive
solvents added to elixirs
*alcohol content of more than 10-12%
renders them self-preserving
* aqueous portion is added to the alcoholic
portion
Non-medicated elixirs used as vehicles,
flavorants
Medicated elixirs used for the indication
of the active ingredient incorporated

Iso-alcholic Elixirs - general vehicles for

pharmaceutical preps. requiring a specified
alcoholic strength
Alligation how volumes of low and high
alcoholic elixirs are determined in order to
attain a certain alcoholic strength
Iso-alcoholic Elixir
Category: Medicated elixir
Synonyms: Iso-Elixir
Description of Final Product: clear,
colorless alcoholic solution
Uses: vehicle, solvent
Label: white label (internal)
Method: Simple solution
Preparation #20
Terpin Hydrate Elixir
Materials:
*Orange Peel tincture flavorant
Benzaldehyde preservative
Glycerine and syrup sweetener
Terpin Hydrate Oral Solution former name
USP specification each 100 ml of terpin
hydrate OS contains nlt 1.53g and nmt than
1.87g of terpin hydrate
Terpin Hydrate Elixir
Category: Medicated Elixir
Synonyms: Elixir Terpin Hydrate, Terpinol
Elixir, Terpin Hydrate Oral Solution
Use: Expectorant
Label: White (internal)
Method: Simple solution with agitation

*talc filtering aid

absorbs excessive amounts of oils
Preparation #21
Compound Orange Spirit
Spirits also known as essences

alcoholic/hydroalcoholic
solutions of aromatic or volatile
material
high alcoholic conc. (usually over
60%) is due to greater solubility of
the volatile ingredient in alcohol
rather than in water
active ingredient contained in spirit
may be solid, liquid, or gas
used as flavoring agent or for its
medicinal value
can be applies externally, inhaled, or
taken internally
diluting the spirit with water before
oral intake reduces its pungent taste
can be prepared by: simple solution
(solutes are dissolved in solvent),
solution by maceration ( leaves are
soaked in alcohol to extract desired
volatile substance) and distillation
(takes advantage of the process of
fermentation: sugar in the raw
material is consumed by the added
yeast resulting to the formation of
alcohol)
USP specification: each 100 ml of
compound orange spirit contains nlt
25 ml and nmt 30 ml of the mixed
oils

Distillation
Fermentation
Brandy fermented grapes

Whisky fermented mash of wholly

germinated malted cereal grain
Compound Orange Spirit
Category: Non-medicated Spirit
Synonyms: Spiritus Auranti Compositus
Description of Final Product: alcoholic
solution with the odor of orange
Use: flavoring agent
Label: white (internal)
Method: simple solution
Remarks: tight and light resistant
Storage cool place
Preparation #22
Peppermint Spirit
Category: medicated spirit
Synonyms: Essence of Peppermint, Spiritus
Menthos Piperitas
Description of Final Product: clear
brilliant green solution with odor and taste
of peppermint
Uses: carminative in flatulence, for nausea
and vomiting
Label: white (internal)
Method: maceration
Remarks: macerate the leaves thoroughly
with water to exhaust the leaves of water
soluble extractives
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Traces of water in apparatus

make the solution turbid