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Chromosomes
and their genes
are made of a
molecule
called DNA.
Nucleotides
The nucleotides
are made up of a
nitrogenous
base, a pentose
sugar and a
phosphate group.
Phosphate
group
Phosphate
group
Sugar
Pentose
Sugar
Nitrogenous
base
Nitrogenous
base
nucleotide
+ H2 O
Condensation
Poly-nucleotide
Hydrogen bonding
weak
Hydrogen
bonds link the
bases.
4 bases A, T, G and C
A=T
GC
2 types of bond:
Protein synthesis
B2 1.23 Stages of
protein synthesis,
including
transcription and
translation
B2 1.24 Proteins
specific number and
sequence of amino
acids
Note: CODONS are the triplets of base letters that code for
amino acids: DNA and mRNA have CODONS!
Codon
Codon
Codon
Codon
Codon
Corresponding Amino
Acid
Phenylalanine (Phe)
Glutamine (Glu)
Cysteine (Cys)
Histidine (His)
Asparagine (Asn)
Leucine (Leu)
Valine (Val)
mRNA CODONS
What is Transcription?
What is Translation?
Mutations
Mutation = change in the base sequence of DNA
Change in base
of DNA
Change in base of
mRNA
Change in protein
structure
Change in
mRNA Condon
Change in protein
function
2. Deletion
3. Addition
1. Substitution
1. Substetution
3. Adddition
Substitution mutation
1. Substitution
2. Deletion
Deletion mutation
An addition of a base
[where an extra base is
included in to the genetic
sequence].
Additions
have a very similar effect
to a deletion.
Addition mutation
3. Addition