Beruflich Dokumente
Kultur Dokumente
http://www.youtube.com/watch?v=KkVzli4jcmI&NR=1
http://www.youtube.com/watch?v=NMeBZlbs2dU
http://www.youtube.com/watch?v=tMMrTRnFdI4&feature=related
Secreted molecules
Steroid hormones
Neurotransmitters
Eicosanoids
Aspirin
Eicosanoids
Common structure:
N-terminal extracellular
ligand-binding domain
A single trans-membrane
-helix
A cytosolic C-terminal domain
with kinase activity
10
11
Protein-tyrosine phosphatases
12
13
Cyclic-AMP
14
Protein Kinase A
15
16
17
Calcium
18
19
20
21
Rho, Rac, and Cdc42 are members of the Rho subfamily of small GTPbinding proteins controlling cell mobility, cell adhesion, and
cytokinesis.
22
23
24
25
Some secreted
polypeptides signal
apoptosis by activating
receptors that directly
induce cell death. These
molecules belong to the
Tumor necrosis factor
(TNF) family. Best
characterized member:
Fas.
26
27