Sie sind auf Seite 1von 33

7.

LITERATURA
1. Aabiaka C, Al-Awadi F, Al-Sayer H, Gulshan S, Behbehani A, Farghally M (2002)
Activites of erythrocyte antioxidant enzymes in cancer patients. J Clin Lab Anal
16:167-171.
2. Adachi T, Wang J, Wang XL Age-related change of plasma extracellular-superoxide
dismutase. Clin Chim Acta 290:169178, 2000
3. Agarwal A, Gupta S Role of reactive oxygen species in female reproduction.Part I.
Oxidative stress: a general overview, AgroFOOD industry hi-tech 16:21-25, 2005
4. Aherne, S.A. and N.M. OBrien (2002) Dietary flavonols: Chemistry, food content,
and metabolism. Nutrition 18(1): 75-81.
5. Alliangana DM. 1996. Effects of betacarotene, flavonoid quercitin and quinacrine on
cell proliferation and lipid peroxidation breakdown products in BHK-21 cells. East
Afr. Med. J. 73:752757
6. Alo PL, Visca P, Mazzaferro S, Eleuteri Serpieri D, Mangoni A, Botti C, Monaco S,
Carboni M, Zaraca F, Trombetta G, Di Tondo U: Immunohistochemical study of fatty
acid sythase, ki67, proliferating cell nuclear antigen and p53 expression in
hyperplastic parathyroids. Ann Diagn Pathol 1999, 3:287-293
7. Andersen HR, Nielsen JB, Nielsen F, Grandjean P Antioxidative enzyme activities in
human erythrocytes. Clin Chem 43:562568 (1997)
8. Antunes CMF, Stolley, PD, Rosenshein NB Davies JL, Tonascia JA, Brown C, Burnett
L, Rutledge A, Pokempner M, Garcia R. 1979 Endometrial cancer and estrogen use
(report of a large case-control study). N Engl J Med. 300: 9-13
9. Antunes, F., A. Salvador and R.E. Pinto (1995). PhGPx and phospholipase A2/GPx:
Comparative importance on the reduction of hydroperoxides in rat liver mitochondria.
Free Radic Biol Med 19: 669-677.
10. Anzai Y, Gong Y, Holinka CF, Murphy LJ, Murphy LC, Kuramoto H Gurpide E .,
Effects of transforming growth factors and regulation of their mRNA levels in two
human endometrial adenocarcinoma cell lines. J Steroid Biochem Mol Biol 1992, 42:
449-455.
11. Aoshima H, Satoh T, Sakai J, Yamada M, Enokido Y, et al. 1997. Generation of free
radicals during lipid hydroperoxidetriggered apoptosis in PC12h cells. Biochem.
Biophys. Acta. 1345:3542
12. Archer DF, Neoplasia of the female reproductive tract, Endocrine, 2004, 24:259-263
13. Archer DF, The effect of the duration of progestin use on the occurrence of
endometrial cancer in postmenopausal women. Menopause, 8: 245-251, 2001

14. Arner, E.S. and A. Holmgren (2000) Physiological functions of thioredoxin and
thioredoxin reductase. Eur J Biochem 267: 6102-6109.
15. Arnett-Mansfield RL, A Defazio, P A. Mote C L. Clarke Subnuclear Distribution of
Progesterone Receptors A and B in Normal and Malignant Endometrium J Clin
Endocrinol Metab, March 2004, 89(3):14291442
16. Arnett-Mansfield RL, deFazio A, Wain GV, Jaworski RC, Byth K, Mote PA, Clarke
CL 2001 Relative expression of progesterone receptors A and B in endometrioid
cancers of the endometrium. Cancer Res 61:45764582
17. Austin, H., Austin, J. M., Jr., Partridge, E. E., Hatch, K. D.,Shingleton, H. M.
Endometrial cancer, obesity, and body fat distribution. Cancer Res., 51: 568572,
1991.
18. Avissar, N., J.R. Slemmon, I.S. Palmer H.J. Cohen (1991). Partial sequence of human
plasma glutathione peroxidase and immunologic identification of milk glutathione
peroxidase as the plasma enzyme. J Nutr 121: 12431249.
19. Awasthi, Y.C., R. Sharma, S.S. Singhal (1994). Human glutathione S-transferases. Int
J Biochem 26: 295-308
20. Awwad JT; Toth TL; Schiff I ,Abnormal uterine bleeding in the perimenopause. Int J
Fertil Menopausal Stud 1993 38(5):261-9.
21. Baak JPA, Mutter GL, EIN and WHO94, J Clin Pathol 2005, 58:1-6
22. Baak JPA, Wisse-Brekelmans ECM, Fleege JC, van der Putten HWHM, Bezemer PD.
Assessment of the risk on endometrial cancer in hyperplasia by means of
morphological and morphometrical features. Path Res Pract 1992;188:856-859.
23. Baanders-van Halewyn EA, Blankenstein MA, Thijssen JHH, de Ridder CM, de
Waard F. A comparative study of risk factors for hyperplasia and cancer of the
endometrium. Eur J Cancer Prev 1996: 5:105-112
24. Babior, B.M. (2000). The NADPH oxidase of endothelial cells. IUBMB Life 50(4-5),
267-269
25. Bagchi K, Puri S (1998) Free radicals and antioxidants in health and disease. East
Mediterr Health J 4:350-360.
26. Baird DT, IS Fraser , Blood production and ovarian secretion rates of estradiol-17 beta
and estrone in women throughout the menstrual cycle J Clin Endocrinol Metab 1974
38: 1009-1017.
27. Balasubramaniyan N, Subramanian S, Govindasamy S. Status of antioxidant systems
in human carcinoma of uterine cervix. Cancer Lett. 1994, 87:187-192
28. Baldwin AS Jr. 1996. The NF-B and IB proteins: new discoveries and insights.
Annu. Rev. Immunol. 14:649683

29. Bandyopadhyay, S., D.W. Starke, J.J. Mieyal, R.M. Gronostajski (1998).
Thioltransferase (Glutaredoxin) Reactivates the DNA-binding Activity of Oxidationinactivated Nuclear Factor I. J Bio. Chem 273: 392397.

30. Bao, Y., P. Jemth, B. Mannervik , G. Williamson (1997) Reduction of thymine


hydroperoxide by phospholipid hydroperoxide glutathione peroxidase and glutathione
transferases. FEBS Letters 410: 210-212.
31. Barbarisi A, Petillo O, Di Lieto A, Melone MAB, Margarucci S, Cannas M , Peluso G
(2001) 17-b estradiol elicits an autocrine leiomyoma cell proliferation: evidence for a
stimulation of protein kinase-dependent pathway. J Cell Physiol 186,414-424.
32. Bashir, A., R.N. Perham, N.S. Scrutton , A. Berry (1995). Altering kinetic mechanism
and enzyme stability by mutagenesis of the dimer interface of glutathione reductase
Biochem J 312: 527-533.
33. Bednarek-Tupikowska, G U. Tworowska, I. Jedrychowska, B. Radomska, K.
Tupikowski, B. Bidzinska-Speichert, A. Milewicz Effects of oestradiol and
oestroprogestin on erythrocyte antioxidative enzyme system activity in
postmenopausal women Clinical Endocrinology (2006) 64 , 463468
34. Bednarek-Tupikowska, G., Bohdanowicz-Pawlak, A., Bidzinska, B., Milewicz, A.,
Antonowicz-Juchniewicz, J. Andrzejak, R. (2004) Serum lipid peroxides and total
antioxidant status in postmenopausal women on hormone replacement therapy.
Gynecological Endocrinology, 19, 5763.
35. Bendich, A. (1994). Recent advances in clinical research involving caroteoids. Pure &
Appl Chem 66(5): 1017-1024.
36. Berchuck A, Boyd J. Molecular basis of endometrial cancer. Cancer 1995;76:203440.

37. Bergstrom, A., Pisani, P., Tenet, V., Wolk, A., Adami, H. O. Overweight as an
avoidable cause of cancer in Europe. Int. J. Cancer, 91: 421430, 2001.
38. Berridge MJ. 1994. The biology and medicine of calcium signaling. Mol. Cell.
Endocrinol. 98:119124
39. Bhuvarahamurthy V, Balasubramanian N, Govindasamy S. Effect of radiotherapy and
chemoradiotherapy on circulatiog antioxidant system of human uterine cervical
carcinoma. Moll Cell Biochem 1996, 158:17-23
40. Block, G., M. Menkes Ascorbic acid in cancer prevention. In: Moon TE, Micozzi
MS., eds. Diet and Cancer Prevention. Investigating the Role of Micronutrients. New
York: Marcel Dekker, Inc., 341-388.

41. Blum J, Fridovich I (1985) Inactivation of glutathione peroxidase by superoxide


dismutase radical. Arch Biochem Biophys 240:500508.
42. Board, P.G., R.T. Baker, G. Chelvanayagam and L.S. Jermiin (1997). Zeta, a novel
class of glutathione transferases in a range of species from plants to humans. J Chem
328: 929-935.
43. Bokhman JV (1983). Two pathogentic types of endometrial carcinoma. Gynecol Oncol
15: 10-17
44. Bolzan AD, Bianchi MS, Bianchi NO (1997) Superoxide dismutase, catalase and
glutathione peroxidase activities in human blood: influence of sex, age and cigarette
smoking. Clin Biochem 30:449454
45. Bommer,U.A., Lazaris-Karatzas,A., De Benedetti,A., Nurnberg,P., Benndorf,R.,
Bielka,H. Sonenberg, N. (1994) Translational regulation of the mammalian growthrelated protein P23: involvement of eIF-4E. Cell. Mol. Biol. Res., 40, 633641.
46. Borras, C., Gambini, J., Gomez-Cabrera, M.C., Sastre, J., Pallardo, F.V., Mann, G.E.
Vina, J. (2005) 7beta-oestradiol up-regulates longevityrelated, antioxidant enzyme
expression via the ERK1 and ERK2[MAPK]/NFkappaB cascade. Aging Cell, 4, 113
118.
47. Borthwick JM, D.S Charnock-Jones, B D.Tom, M.L Hull, R Teirney, S C. Phillips, S
K.Smith Determination of the transcript profile of human endometrium Molecular
Human Reproduction 9 19-33, 2003
48. Bostwick DG, Alexander EE, Singh R, Shan A, Qian J, Santella RM, Oberley LW, Yan
T, Zhong W, Jiang X, Oberley TD: Antioxidant enzyme expression and reactive
oxygen species damage in prostatic intraepithelial neoplasia and cancer. Cancer 89:
123-134 2000
49. Bours V, Dejardin E, Goujon-Letawe F, Merville MP, Castronovo V. 1994. The NFB- and IB-related proteins in tumor cell lines. Biochem. Pharmacol. 47:145149
50. Boyd JA, Kaufman DG 1990. Expression of transforming growth factor beta 1 by
human endometrial carcinoma cell lines: inverse correlation with effects on growth
rate and morphology. Cancer Res. 50:3394-3399.
51. Bremer, H.J., M. Duran, J.P. Kamerling, H. Przyrembel, S.K. Wadman (1981).
Glutathione. In: Bremer, H.J., M. Duran, J.P. Kamerling, H. Przyrembel and S.K.
Wadman, eds. Disturbances of Amino Acid Metabolism: Clinical Chemistry and
Diagnosis. Baltimore-Munich: Urban and Schwarzenberg: 80-82.
52. Brigelius-Flohe R., F.J. Kelly, J.T. Salonen, J. Neuzil, J.M. Zingg, A. Azzi (2002). The
European perspective on vitamin E: current knowledge and future research. Am J Clin
Nutr 76(4): 703-716.
53. Brinton LA; Berman ML, Mortel R, Twiggs LB, Barrett RJ, Wilbanks GD, Lannom L,
Hoover RN Reproductive, menstrual, and medical risk factors for endometrial cancer:
results from a case-control study. Am J Obstet Gynecol 1992 167(5):1317-1325

54. Burger HG Diagnostic role of follicle-stimulating hormone (FSH) measurements


during the menopausal transition--an analysis of FSH, oestradiol and inhibin. Eur J
Endocrinol 1994 Jan;130(1):38-42
55. Burger, H. G., Dudley, E. C., Hopper, J. L., Groome, N., Guthrie, J. R., Green, A.,
Dennerstein L (1999). Prospectively measured levels of serum follicle-stimulating
hormone, estradiol and the dimeric inhibins during the menopausal transition in a
population-based cohort of women. J Clil Endocrl Metabol,84 (11), 4025-4030.
56. Cadenas, E. and K.J. Davies (2000). Mitochondrial free radical generation, oxidative
stress, and aging. Free Radic Biol Med 29(3-4): 222-230.
57. Carr, B.R. Disorers of the ovary and female reproductive tract. In: Williams Textbook
of Endocrinology. 9th ed. / edited by Jean D. Wilson, Daniel W. Foster, Henry M.
Kronenberg, and P. Reed Larsen Philadelphia : Saunders, c1998, 733-798.
58. Cauley, J.A.; Gutal, J.P.; Kuller, L.H.; Ledonne, D.; Powell, J.G. The epidemiology of
serum sex hormones in postmenopausalwomen. American Journal of Epidemiology
129:11201131, 1989.
59. Ceballos-Picot I, Trivier JM, Nicole A, Sinet PM, Thevenin M (1992) Age-correlated
modifications of copperzinc superoxide dismutase and glutathione-related enzyme
activities in human erythrocytes. Clin Chem 38:6670
60. Cerutti P, Larsson R, Krupitza G. 1990. Mechanisms of oxidant carcinogenesis. In
Genetic Mechanisms in Carcinogenesis and Tumor Promotion, ed. CC Haws,LA
Liotta, pp. 6982. New York: Wiley-Liss
61. Cerutti PA. 1985. Prooxidant states and tumor promotion. Science 227:375381
62. Chae, H.Z., K. Robison, L.B. Poole, G. Church, G. Storz , S.G. Rhee (2000).
Identification of a new type of mammalian peroxiredoxin that forms an intramolecular
disulfide as as a reaction intermediate. J Biol Chem 275(27): 20346-20354.
63. Chance B, Sies H, Boveris A. (1979) Hydroperoxide metabolism in mammalian
organs. Physiol Rev. 59 (3):527-625.
64. Chang L, Karin M. 2001. Mammalian MAP kinase signalling cascades. Nature
410:3740
65. Chawla, R.K., F.W. Lewis, M.H. Kutner, D.M. Bate, R.G. Roy, D. Rudman (1984).
Plasma cysteine, cystine, and glutathione in cirrhosis. Gastroenterology 87(4): 770776.
66. Chiou JF, Hu ML (1999) Elevated lipid peroxidation and disturbed antioxidant
enzyme activities in plasma and erythrocytes of patients with uterine cervicitis and
myoma. Clin Biochem 32:189-192.

67. Cho, G, Kang S, Seo SJ, Kim Y, Jung G. The transcriptional repression of the human
Cu/Zn superoxide dismutase-(sod1) gene by anticancer drug, mitomycin C(MMC).
Biochem Mol Biol Int 42:949-956, 1997.
68. Chow, C.K. ,C.B. Hong (2002). Dietary vitamin E and selenium and toxicity of nitrite
and nitrate. Toxicology 180(2): 195-207.
69. Chu FF, R S Esworthy, PG Chu, JA. Longmate, M M. Huycke, S Wilczynski, J H.
Doroshow Bacteria-Induced Intestinal Cancer in Mice with Disrupted Gpx1 and Gpx2
Genes Cancer Res 64, 962968, 2004
70. Chu, F.F., J.H. Doroshow, R.S. Esworthy (1993). Expression characterization and
tissue distribution of a new cellular selenium-dependent glutathione peroxidase
GSHPx-GI. J Biol Chem 268: 25712576.
71. Chung-man Ho, J., Zheng, S., Comhair, S. A., Farver, C., Erzurum, S. C. Differential
expression of manganese superoxide dismutase and catalase in lungcancer. Cancer
Res., 61: 85788585, 2001.
72. Church SL, Grant JW, Meese, EU, Trent JM. Sublocalization of the gene encoding
manganese superoxide dismutase (MnSOD/SOD2) to 6q25 by fluorescence in situ
hybridization and somatic cell hybrid mapping. Genomics 14: 823-825, 1992.
73. Claiborne, A., T.C. Mallett, J.I. Yeh, J. Luba, D. Parsonage (2001). Structural, redox,
and mechanistic parameters for cysteinesulfenic acid function in catalysis and
regulation. Adv Protein Chem 58: 215276.
74. Cordon-Cardo C, Prives C. Commentary: at the crossroads of inflammation and
tumorigenesis. J Exp Med 1999;190:1367 1370.
75. Cotgreave I.A., P. Moldeus, S. Orrenius (1988). Host biochemical defense
mechanisms against prooxidants. Annu Rev Pharmacol Toxicol 28: 189-212.
76. Cotgreave, I. A., R.G. Gerdes (1998). Recent trends in glutathione biochemistryGlutathione-Protein interactions: A molecular link between oxidative stress and cell
proliferation? Biochem Biophys Res Commun 242: 1-9.
77. Cowey S, RW Hardy, The metabolic syndrome. A high-risk state for cancer? Am J
Pathol 2006, 169:1505-1522
78. Cullen, J. J., Mitros, F. A., Oberley, L. W. (2003) PancreasExpression of antioxidant
enzymes in diseases of the human pancreas: another link between chronic pancreatitis
and pancreatic cancer. 26, 23-27
79. DSouza RJ, Phillips EM, Jones PW, Strange RC, Aber GM. 1993. Interactions of
hydrogen peroxide with interleukin-6 and platelet-derived growth factor in
determining mesangial cell growth: effect of repeated oxidant stress. Clin. Sci.
86:747751

80. Dallenbach-Hellweg G, Schmidt D. Oestrogens and proliferation of endometrial cells.


J Cardiol Pharmacol 1996;28:24-28.
81. Dalton T.P., H.G. Shertzer, A. Puga (1999). Regulation of gene expression by reactive
oxygen. Ann Rev Pharmacol Toxicol 39: 67-101
82. Das KC, Guo XL, White CW Protein kinase Cdelta-dependent induction of
manganese superoxide dismutase gene expression by microtubule-active anticancer
drugs. J Biol Chem 273:34639-34645, 1998.
83. De Craemer, D., M. Pauwels, A. Vergeylen, F, Roels, C. Van den Branden (1993).
Peroxisomes in liver, kidney and duodenum of nude mice bearing xenografts of
human pancreatic adenocarcinomas. Virchows Arch B Cell Pathol Incl Mol Pathol
64(1): 7-12.
84. Devary Y, Gottlieb RA, Lau LF, Karin M. 1991. Rapid and preferential activation of
the c-jun gene during the mammalian UV response. Mol. Cell. Biol. 11:28042811
85. Di Cristofano A, Pandolfi PP (2000): The multiple roles of PTEN in tumor
suppression. Cell 100: 387-390.
86. Diaz-Flores, M. , Baiza-Gutman, L.A., Pedron, N.N. Hicks, J.J Uterine glutathione
reductase activity: modulation by estrogens and progesterone. Life Sci 1999 65:24812488
87. Durak I, Perk H, Kavutcu M, Canbolat O, Akyol O, Beduk Y. Adenosine deaminase,
5nucleotidase, xanthine oxidase, superoxide dismutase and catalase activities in
cancerous and noncancerous human bladder tissues. Free Radic Biol Med
1994;16:825-31
88. Dynan, WS Promoters for housekeeping genes. TIG 2:196-197, 1986.
89. Ehrlich CE, Young PC, Stehman FB, Sutton GP, Alford WM 1988 Steroid receptors
and clinical outcome of in patients with adenocarcinoma of the endometrium. Am J
Obstet Gynecol 158:796-807.
90. Elhafej AS, Papadimitriou JC, El-Hakim MS, El-Said AI, Ghannam BB, Silverberg
SG, Computerized image analysis of p53 and proliferating cell nuclear antigen
expression in benign, hyperplastic, and malignant endometrium Arch Pathol Lab Med
125:832-879, 2001
91. Ellenson LH, Wu TC (2004): Focus on endometrial and cervical cancer. Cancer Cell
5:533-538
92. Emons G, Fleckenstein G, Hinney B, Huschmand A, W Heyl Hormonal interactions in
endometrial cancer, Endocrine-Related Cancer, 2000, 7:227-242
93. Enoch, H.G. , Strittmatter P (1979) Cytochrome b5 reduction by NADPH-cytochrome
P-450 reductase. J Biol Chem 254: 8976-81.

94. Enomoto T, Fujita M, Inoue M, Rice JM, Nakajima R, Tanizawa O, Nomura T


Alterations of the p53 tumor suppressor gene and its association with activation of the
c-K-ras-2 protooncogene in premalignant and malignant lesions of the human uterine
endometrium. Cancer Res 1993, 53:1883-1888
95. Enomoto T, Inoue M, Weghorst CM, Tanizawa O, Rice, JM (1991). K-ras activation in
premalignant and malignant lesions of the human uterus. Cancer Res 51: 5308-5314.
96. Epstein E, Valentin L, Managing woman with the post-menopausal bleeding Best
Practice & Research Clinical Obstertrics and Gynaecology, 18: 125-143, 2004
97. Esteller, M., Levine, R., Baylin, S.B., Ellenson, L.H., Herman, J.G. (1998). MLH1
promoter hypermethylation is associated with the microsatellite instability phenotype
in sporadic endometrial carcinomas. Oncogene 17, 24132417.
98. Esworthy, R. S., Mann, J. R., Sam, M., Chu, F. F. Low glutathione peroxidase activity
in Gpx1 knockout mice protects jejunum crypts from -irradiation damage. Am. J.
Physiol. Gastrointest. Liver Physiol., 279: G426G436, 2000.
99. Farquhar CM; Lethaby A; Sowter M; Verry J; Baranyai J An evaluation of risk factors
for endometrial hyperplasia in premenopausal women with abnormal menstrual
bleeding. Am J Obstet Gynecol 1999 Sep;181(3):525-9.
100.
Ferenczy A, Gelfand M The biologic significance of cytologic atypia in
progestogen-treated endometrial hyperplasia.1989 Am J Obstet Gynecol 160: 126-131
101.
Fink G. Gonadotropin secretion and its control. In: Knobil E, Neill JD, eds,
The physiology of reproduction. Vol 1. New York: Raven, 1988: 1349-1377
102.
Finney, L.A. ,T.V. OHalloran (2003). Transition metal speciation in the cell:
Insights from the chemistry of metal ion receptors. Science 300: 931-936.
103.
Folz RJ , Crapo JD Extracellular superoxide dismutase (SOD3): tissue-specific
expression, genomic caracterization, and computer-assisted sequence analysis of the
human EC SOD gene. Genomics, 22: 161-171, 1994
104.
Frampton, J., D. Conkie, I. Chambers, W. McBain, M. Dexter, P.R. Harrison
(1987). Changes in minor transcripts from the alpha 1and beta maj globin and
glutathione peroxidase genes duringerythropoiesis. Nucleic Acids Res 15: 36713688.
105.
Freeman BA, Mason RJ, Williams MC, Crapo JD (1986) Antioxidant enzyme
activity in alveolar type II cells after exposure of rats to hyperoxia. Exp Lung Res 10:
203-222
106.
Fridovich I, Freeman B (1986) Antioxidant defenses in the lung. Annu Rev
Physiol 1986;48:693-702.

107.
Fujii, J., Y. Ikeda (2002). Advances in our understanding of peroxiredoxin, a
multifunctional, mammalian redox protein. Redox Report 7(3): 123-130.
108.
G. Bednarek-Tupikowska, A. Bohdanowicz-Pawlak, B. Bidziska, A.
Milewicz, J. Antonowicz-Juchniewicz, R. Andrzejak: Serum lipid peroxide levels and
erythrocyte glutathione peroxidase and superoxide dismutase activity in
premenopausal and postmenopausal women, Gynecological Endocrinology, 15: 298303 , 2001
109.
Gaetani GF, Ferraris AM, Rolfo M, Mangerini R, Arena S, Kirkman HN (1996)
Predominant role of catalase in the disposal of hydrogen peroxide within human
erythrocytes. Blood 87:1595-1599.
110.
Goldstein SR, Menorrhagia and abnormal bleeding before menopause, Best
Practice & Research Clinical Obstertrics and Gynaecology, 18: 59-69, 2004
111.
Goodman MT, Hankin JH, Wilkens LR Lyu LC, McDuffie K, Liu LQ, Kolonel
LN. Diet, body size, physical activity, and the risk of endometrial cancer Cancer Res
1997 57(22):5077-85.
112.
Grady, D., and Ernster, V. L. Endometrial Cancer. In: D. Schottenfeld and F. J.
Fraumeni (eds.), Cancer Epidemiology and Prevention, pp. 10581089. New York:
Oxford University Press, 1996.
113.
Graham JD, Clarke CL, 1997 Physiological action of progesterone in target
tissues Endocr Rev 18:502-519
114.
Grether-Beck S, Olaizola-Horn S, Schmitt H, Grewe M, Jahnke A, JP Johnson,
Briviba K, Sies H, Krutmann J 1996. Activation of transcription factor AP-2 mediates
UVA radiation-and singlet oxygen-induced expression of the human intercellular
adhesion molecule 1 gene. Proc. Natl. Acad. Sci. USA 93:1458614591
115.
Guemouri L, Artur Y, Herbeth B, Jeandel C, Cuny G, Siest G (1991) Biological
variability of superoxide dismutase, glutathione peroxidase, and catalase in blood. Clin
Chem 37(11):19321937
116.
Gull B, B Karlsson, I Milsom, S Granberg Can ultrasound replace dilation and
curettage? A longitudinal evaluation of postmenopausal bleeding and transvaginal
sonographic measurement of the endometrium as predictors of endometrial cancer
American Journal of Obstetrics and Gynecology, 188, 2003, 401-408
117.
Gupta S, A Agarwal, N Krajcir, JG Alvarez: Role of oxidative stress in
endometriosis. Reprod Biomed Online, 13:126-134, 2006
118.
Grdl F, ner-Iyidoan Y, Yalin , Gen S, Buyru F: Changes in enzymatic
antioxidant defense system in blood and endometrial tissues of women after
menopause Res Commun Mol Pathol Pharmacol. 1997 97(1):38-46.
119.
Gurin, C.C., Federici, M.G., Kang, L., Boyd, J. (1999). Causes and
consequences of microsatellite instability in endometrial carcinoma. Cancer Res. 59,
462466

120.
Guyton KZ ,TW Kensler Oxidative mechanisms in carcinogenesis British
Medical Bulletin, 49, 523-544, 1993
121.
Halliwell B, Gutteridge JMC. (1999) Free Radicals in Biology and Medicine.
3rd ed. New York: Oxford University Press. pp:134-140.
122.
Halliwell, B. (1995). Antioxidant characterization. Methodology and
mechanism. Biochem Pharmacol 49(10): 1341-1348.
123.
Halliwell, B. and J.M. Gutteridge (1992). Biologically relevant metal ion dependent hydroxyl radical generation. An update. FEBS Lett. 307(1): 108-112.
124.
Halliwell, B., M.V. Clement and L.H. Long (2000). Hydrogen peroxide in the
human body. FEBS Lett 486(1): 10-13.
125.
Hammond R, Johnson J (2004) Endometrial hyperplasia. Curr Obstet Gynaecol
14:99-103.
126.
Harris CA, Derbin KS, Hunte-McDonough B, Krauss MR, Chen KT, Smith
DM, Epstein LB (1991) Manganese superoxide dismutase is induced by IFN- in
multiple cell types, synergistic induction by IFN- and tumor necrosis factor on IL-1. J
Immunol 147: 149-154.
127.
Hasnain, S.S. R.W. Strange (2003). Marriage of XAFS and crystallography for
structure-function studies of metalloproteins. J Synchrotron Rad 10:(Pt 1) 9-15.
128.
Hayashi, T., T. Miyahara, Y. Aoyama, M. Kobayashi, H. Ogoshi (1994).
Intermolecular interaction between multifunctional porphyrin and ubiquinone
analogues. Pure & Appl Chem 66(4): 797-802.
129.
Hayes, J.D., D.J. Pulford (1995). The glutathione S-transferase supergene
family: regulation of GST and the contribution of the isoenzymes to cancer prevention
and drug resistance. Crit Rev Biochem Mol Biol 30(6): 445-600.
130.
Hebel RP, Erythrocyte antioxidants and membrane vulnerability. J Lab Clin
Med 107:401-405, 1986
131.
Hee J, MacNaughton J, Bangah M, Burger HG Perimenopausal patterns of
gonadotrophins, immunoreactive inhibin, oestradiol and progesterone. Maturitas 1993
Dec;18(1):9-20
132.
Heldin CH. 1995. Dimerization of cell surface receptors in signal transduction.
Cell 80:213223
133.
Henderson BE, Casagrande JT, Pike MC, Mack T, Rosario I, Duke A. The
epidemiology of endometrial cancer in young women. Br J Cancer, 1983 47(6):74956.

134.
Henderson, BE,
21:427-433

Fiegelson HS, Hormonal carcinogenesis, Carcinogenesis

135.
Hendrikson, DJ, Fisher JH, Jones C, Ho YS Regional localization of human
extracellular superoxide dismutase gene to 4pter-q21. Genomics 8:736-738, 1990.
136.
Hileman, E. O., Liu, J., Albitar, M., Keating, M. J., Huang, P. (2004) Intrinsic
oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity Cancer
Chemother. Pharmacol. 53, 209219
137.
Hill, H. A., Austin, H. Nutrition and endometrial cancer. Cancer Causes
Control, 7: 1932, 1996.
138.
Ho SP, Chan-Yeung M, Chow KK, Ip MS, Mak JC (2005) Antioxidant enzyme
activities in healthy Chinese adults: influence of age, gender and smoking.
Respirology 10(3):305309
139.
Hockenbery, D. M., Oltvai, Z. N., Yin, X. M., Milliman, C. L., and Korsmeyer,
S. J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell, 75: 241
251, 1993.
140.
Hofmann, B., H.J. Hecht and L. Flohe (2002). Peroxiredoxins. BiolChem
383(3-4): 347-364.
141.
Hoidal, J.R. (2001). Reactive oxygen species and cell signaling. Am J Respir
Cell Mol Biol 25(6): 661-663
142.
Horn LC, Dietel M, Einenkel J: Hormone replacement therapy (HRT) and
endometrial morphology under consideration of the different molecular pathways in
endometrial carcinogenesis. Eur J Obstet Gynecol Reprod Biol, 2005, 122:4-12
143.
Horn LC, Lax SF, Hckel M, Fischer U, Schmidt D: Precancerous lesions of
the endometrium: A review of the molecular pathogenesis and problems in
terminology. Geburtsh Frauenheilk 2001, 61:8-14
144.

Horwitt, M.K. (1986). The promotion of vitamin E. J Nutr 116(7): 1371-1377.

145.
Hristozov D, Gadjeva V, Vlaykova T, Dimitrov G (2001) Evaluation of
oxidative stress in patients with cancer. Arch Physiol Biochem 109:331-336.
146.
Hristozov D, Gadjeva V, Vlaykova T, Dimitrov G (2001) Evaluation of
oxidative stress in patients with cancer. Arch Physiol Biochem 109:331-336.
147.
Hsu W, Kerppola TK, Chen PL, Curran T, Chen-Kiang S. 1994. Fos and Jun
repress transcription activation by NF-IL6 through association at the basic zipper
region. Mol. Cell Biol. 14:268276
148.
Hu Y, Rosen DG, Zhou Y, Feng L, Yang G, Liu J, Huang P: Mitochondrial
manganese-superoxide dismutase expression in ovarian cancer: role in cell
proliferation and response to oxidative stress J Biol Chem. 2005 ;280:39485-39492

149.
Hulka BS, Fowler WC Jr, Kaufman DG, Grimson RC, BG Greenberg, Hogue
CJ, Berger, GS, Pulliam CC Estrogen and endometrial cancer: cases and two control
groups from North Carolina. Am J Obstet Gynecol, 1980 137(1):92-101
150.
Hurst, R., Y. Bao, P. Yemth, B. Mannervik, G. Williamson (1998).
Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione
transferases. Biochem J 332: 97-100.
151.
Ingold, K.U., V.W. Bowry, R. Stocker, C. Walling (1993). Autooxidation of
lipids and antioxidation by -tocopherol and ubiquinol in homogeneous solution and
in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as
exemplified by oxidation of human low density lipoprotein. Proc Natl Acad Sci USA
90(1):45-49.
152.
Inoue, M (2001) Current molecular aspects of the carcinogeneis of the uterine
endometrium, Int J Gynecol Cancer 11: 339-348.
153.
Islam, K. N., Kanyanoki, Y., Kaneto, H., Suzuki, K., Asahi, M., Fuiji, J.,
Taniguchi, N. TGF-1 triggers oxidative modifications and enhances apoptosis in HIT
cells through accumulation of reactive oxygen species by suppression of catalase and
glutathione peroxidase. Free Radic. Biol. Med., 22: 10071017, 1997.
154.
Ito K, Sasano H, Matsunaga G, Sato S, Yajima A, Nasim S, Garret CT
Correlations between p21 expression and clinicopathological findings, p53 gene and
protein alterations, and survival in patients with endometrial carcinoma. J Pathol
1997;183:318324.
155.
Itzkowitz SH, Yio X. Inflammation and cancer. IV. Colorectal cancer in
inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest
Liver Physiol 2004;287:G7 17.
156.
Jacks T, Weinberg A. Cell-cycle control and its watchman. Nature 1996;
381:6434.
157.
Jackson RM, Parish G, Helton ES (1998) Peroxynitrite modulates MnSOD
gene expression in lung epithelial cells. Free Radic Biol Med 25: 463-472
158.
Jackson RM, Parish G, Ho YS Effects of hypoxia on expression of superoxide
dismutases in cultured ATII cells and lung fibroblasts. Am J Physiol 271:L955-962,
1996
159.
Janisch, K.M., J. Milde, H. Schempp ,E.F. Elstner (2005). Vitamin C, vitamin E
and flavonoids. Dev Ophthalmol 38: 59-69.
160.
Jansson G 1991 Oestrogen-induced enhancement of myeloperoxidase activity
in human polymorphonuclear leukocytes: a possible cause of oxidative stress in
inflammatory cells. Free Radic Res Commun 14:195208

161.
Jellinck PH, Lovsted J, Newcombe AM 1983 Oxidation of
[14C]diethylstilbestrol epoxide by uterine peroxidase: a possible protective
mechanism. Biochem Pharmacol 32:32473249
162.
Jornot, L. A.F. Junod (1992). Response of human endothelial cell antioxidant
enzymes to hyperoxia. Am J Respir Cell Mol Biol 6: 107-115
163.
Jung, K., Seidel, B., Rudolph, B., Lein, M., Cronauer, M. V., Henke, W.,
Hampel, G., Schnorr, D., and Loening, S. A. (1997) Free Radic. Biol. Med. 23, 127133 Antioxidant enzymes in malignant prostate cell lines and in primary cultured
prostatic cells
164.
Kaaks R, Lukanova A, Kurzer MS (2002) Obesity, Endogenous Hormones, and
Endometrial Cancer Risk Cancer Epidemiol Biomarkers Prev 11: 1531-1543
165.
Kalayci A, A Ozturk, K Ozturk, E Karagozoglu, D Dolanmaz Superoxide
dismutase and glutathione peroxidase enzyme activities in larynx carcinoma Acta OtoLaryngologica 125, 312-315, 2005
166.
Karlsson B, Granberg S, Wikland M, Ylostalo P, Torvid K, Marsal K, Valentin
L. Transvaginal ultrasonography of the endometrium in women with postmenopausal
bleeding-a Nordic multicenter study Am J Obstet Gynecol 1995; 172: 1488-94
167.
Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H, Chambon P
1990 Two distinct estrogen-related promoters generate transcripts encoding the two
functionally different human progesterone receptor isoforms A and B.EMBO J
9:16031614
168.
Katzenellenbogen BS, Choi I, Delage-Mourroux R, Ediger TR, Martini PGV,
Montano M, Sun J, Weis K, Katzenellenbogen JA, Molecular mechanisms of estrogen
action: selective ligands and receptor pharmacology, J Steroid Biochem Molec Biol
74: 279-285, 2000
169.
Kettle, A.J., C.C. Winterbourn (1988). Superoxide modulates the activity of
myeloperoxidase and optimizes the production of hypochlorous acid. Biochem J
252(2): 529536.
170.
Key TJ, Allen NA, Verkasalo PK, Banks E: Energy balance and cancer: the role
of sex hormones. Proceedings of the Nutrition Society, 2001, 60: 81-89.
171.
Kidd, P.M. (1997). Glutathione: systemic protectant against oxidative and free
radical damage. Altern Med Rev 1: 155-176
172.
Kim HT, Kim HY, Nam YW, Lee HJ, Rho HM, Jung G (1994) Study of 5 flanking region of human Cu/Zn superoxide dismutase. Biochem Biophys Res
Commun, 201:1526-1533
173.
Kirkman, H.N., M. Rolfo, A.M. Ferraris, G.F. Gaetani (1999). Mechanisms of
Protection of Catalase by NADPH. Kinetics and stoichiometry. J Biol Chem 274(20):
13908-13914.

174.
Klaunig JE., L M. Kamendulis The role of oxidative stress in carcinogenesis
Annu. Rev. Pharmacol. Toxicol. 2004. 44:239267
175.
Klausner,R.D., Rouault,T.A., Harford,J.B. (1993) Regulating the fate of
mRNA: the control of cellular iron metabolism. Cell, 72, 1928
176.
Kolanjiappan K, Manoharan S, Kayalvizhi M (2002) Measurement of
erythrocyte lipids, lipid peroxidation, antioxidants and osmotic fragility in cervical
cancer patients. Clin Chim Acta 326:143-149.
177.
Komatsu H., I. Okayasu, H. Mitomi, H. Imai, Y. Nakagawa, F. Obata (2001).
Immunohistochemical detection of human gastrointestinal glutathione peroxidase in
normal tissues and cultured cells with novel mouse monoclonal antibodies. J
Histochem Cytochem 49(6): 759766
178.
Konishi H, Matsuzaki H, Tanaka M, Takemura Y, Kuroda S, Ono Y, Kikkawa
U 1997. Activation of protein kinase B (Atk/RAC-protein kinase) by cellular stress
and its association with heat shock protein Hsp27.FEBSLett. 410:493498
179.
Kono Y, Fridovich I (1982) Superoxide radical inhibits catalase. J Biol Chem
57:15711578.
180.
Koul A, Willen R, Bendahl PO, Nilbert M, Borg A (2002). Distinct sets of gene
alterations in endometrial carcinoma implicate alternate modes of tumorigenesis.
Cancer 94: 2369-2379.
181.
Kovcs KA, Oszter A, Gcze PM, Krnyei JL,Szab I (2001) Comparative
analysis of cyclin D1 and oestrogen receptor ( and ) levels in human leiomyoma and
adjacent myometrium. Mol Hum Reprod 7,1085-1091.
182.
Krinsky, N.I. (1994). The biological properties of carotenoids. Pure & Appl
Chem 66(5): 1003-1010
183.
Kuhl H. Pharmacokinetics of estrogens and progestogens. Maturitas 1990;
12:171-197
184.
Kuppusamy, P. (2004). EPR spectroscopy in biology and medicine.
Antioxidants & Redox Signaling 6: 583-585.
185.
Kurman RJ, Kaminski PF, Norris HJ. The behavior of endometrial hyperplasia.
A long-termstudy of untreated hyperplasia in 170 patients. Cancer 1985;56:403-412.
186.
Kurman RJ, Norris HJ. Evaluation of criteria for distinguishing atypical
endometrial hyperplasia from well-differentiated carcinoma. Cancer 1982; 49:25472559.
187.
L.C. Horn, U. Schnurrbusch, K. Bilek, B. Hentschel, J. Einenkel Risk of
progression in complex and atypical endometrial hyperplasia: clinicopathologic

analysis in cases with and without progestogen treatment. Int J Gynecol Cancer 2004,
14, 348-353
188.
La Vecchia, C., Franceschi, S., DeCarli, A., Gallus, G., Tognoni, G. (1984)
Risk factors for endometrial cancer at different ages. J. natl Cancer Inst, 73:667-671
189.
Lakari, E., P. Pkk, P. Pietarinen-Runtti , V.L. Kinnula (2000). Manganese
Superoxide Dismutase and Catalase Are Coordinately Expressed in the Alveolar
Region in Chronic Interstitial Pneumonias and Granulomatous Diseases of the Lung.
Am J Respir Crit Care Med 161: 615-621.
190.
Lapointe J, S Kimmins, L A. MacLaren, J F Bilodeau: Estrogen Selectively
Up-Regulates the Phospholipid Hydroperoxide Glutathione Peroxidase in the Oviducts
Endocrinology, 2005, 146(6):25832592
191.
Lardinois OM. Reactions of bovine liver catalase with superoxide radicals and
hydrogen peroxide. Free Radic Res 1995, 22:251-274
192.
Lareyre J. J., Claessens F., Rombauts W., Dufaure J. P. Drevet J. R. (1997)
Characterization of an androgen response element within the promoter of the
epididymi-specific murine glutathione peroxidase 5 gene. Mol. Cell. Endocrinol. 129:
3346
193.
Larsson R, Cerutti P. 1989. Translocation and enhancement of
phosphotransferase activity of protein kinase C following exposure in mouse
epidermal cells to oxidants. Cancer Res. 49:56275632
194.
Latasa MJ, Moon YS, Kim KH, Sul HS: Nutritional regulation of the fatty acid
synthase promoter in vivo: sterol regulatory element binding protein functions through
an upstream region containing a sterol regulatory element. Proc Natl Acad Sci USA
2000, 97:10619-10624.
195.
Lauer C, A Vlkl, S Riedl, H D Fahimi, K Beier: Impairment of peroxisomal
biogenesis in human colon carcinoma Carcinogenesis, 20: 985-989, 1999
196.
Leccia MT, Yaar M, Allen, N, Gleason M, Gilchrest BA Solar simulated
irradiation modulates gene expression and activity of antioxidant enzymes in cultured
human dermal fibroblasts. Exp Dermatol 10: 272-279, 2001
197.
Lee SJ, EA Lenton, L Sexton , ID Cooke The effect of age on the cyclical
patterns of plasma LH, FSH, oestradiol and progesterone in women with regular
menstrual cycles Human Reproduction, 3, 851-855, 1988
198.
Leiserowitz GS, Harris SA, Subramaniam M, Keeney GL, Podratz KC,
Spelsberg TC (1993) The proto-oncogene c-fms is overexpessed in endometrial
cancer. Gynecol Oncol 49: 190-196.
199.
Lentz SS 1998, Endocrine therapy of endometrial cancer. Cancer Treat Res 94:
89-106

200.
Levanon D, Lieman-Hurwitz J, Dafni N, Wigderson M, Sherman L, Berstein Y,
Laver-Rudich Z, Danciger E, Stein O, Groner Y, Architecture and anatomy of the
chromosomal locus in human chromosome 21 encoding Cu/Zn superoxide dismutase.
Biochem Biophys Res Commun 201: 1526-1533, 1994.
201.
Levine, R.L., Cargile, C.B., Blazes, M.S., van Rees, B., Kurman, R.J.,
Ellenson, L.H. (1998). PTEN mutations and microsatellite instability in complex
atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma. Cancer
Res. 58, 32543258.
202.
Li J., Oberley L., St. Clair D., Ridnour L., Oberley T., Phenotypic changes
induced in human breast cancer cells by overexpression of manganese-containing
superoxide dismutase, Oncogene 10 (1995) 1989-2000.
203.
Li N, Karin M. 1998. Ionizing radiation and short wavelength UV activate NFB through two distinct mechanisms. Proc.Natl. Acad. Sci. USA 95:1301213017
204.
Lippman ME, S.M. Swain 1998. Endocrine-responsive cancer in humans. In:
Williams Textbook of Endocrinology. 9th ed. / edited by Jean D. Wilson, Daniel W.
Foster, Henry M. Kronenberg, and P. Reed Larsen. Philadelphia : Saunders, c1998,
733-798.
205.
Liu Y, Luo L, Zhao H 2001 Levels of lipid peroxides and superoxide dismutase
in peritoneal fluid of patients with endometriosis. Journal of Tongji Medical
University 21, 166167
206.
Longcope C, Franz C, Morello C, Baker R, Johnston CC Jr. Steroid and
gonadotropin levels in women during the peri-menopausal years. Maturitas. 1986
8(3):189-196.
207.
Longcope C. Hormone dynamics at the menopause. Ann NY Acad Sci
1990;592:21-30.
208.
Lotharius, J. and P. Brundin (2002). Pathogenesis of Parkinson's disease:
dopamine, vesicles and alpha-synuclein. Nat Rev Neurosci 3(12): 932-42.
209.
Luisi S, P. Florio, F M. Reis, F. Petraglia Inhibins in female and male
reproductive physiology: role in gametogenesis, conception, implantation and early
pregnancy Hum Reprod Update 2005 11(2):123-135;
210.
Lundberg M., C. Johansson, J. Chandra, M. Enoksson, G. Jacobsson, J. Ljung,
M. Johanssoni A. Holmgren (2001). Cloning and expression of a novel human
glutaredoxin (Grx2) with mitochondrial and nuclear isoforms. J Biol Chem 276(28):
2626926275.
211.
Lutosawska G, Tkaczyk J, Panczenko-Kresowska B, Hbner-Woniak E,
Skierska E, Gajewski A: Plasma TBARS, blood GSH concentrations, and erythrocyte
antioxidant enzyme activities in regularly menstruating women with ovulatory and
anovulatory menstrual cycles. Clin Chim Acta 2003, 159-163
212.

Maeda H, Akaike T (1998) Nitric oxide and oxygen radicals in infection,

inflammation, and cancer. Biochemistry (Mosc.) 63:854-865.


213.
Maeda, S., Otsuka, M., Hirata, Y., Mitsuno, Y., Yoshida, H., Shiratori, Y.,
Masuho, Y., Muramatsu, M., Seki, N., Omata, M. cDNA microarray analysis of
Helicobacter pylori-mediated alteration of gene expression in gastric cancer cells.
Biochem. Biophys. Res. Commun., 284: 443449, 2001.
214.
Mahesh VB, Brann DW: Regulation of the preovulatory gonadotropin surge by
endogenous steroids. Steroids 1998;63:616-629.
215.
Maiorino, M., Gregolin, C. F. Ursini (1990). Phospholipid hydroperoxide
glutathione peroxidase. Methods Enzymol 186: 448457.
216.
Malafa, M., Margenthaler, J., Webb, B., Neitzel, L., and Christophersen, M.
MnSOD expression is increased in metastatic gastric cancer (2000) J. Surg. Res. 88,
130-134
217.
Mannervik, B. U.H. Danielson (1988). Glutathione transferases: structure and
catalytic activity. Crit Rev Biochem Mol Biol 23(3): 283-337
218.
Manoharan S, Kolanjiappan K, Kayalvizni M (2004) Enhanced lipid
peroxidation and impaired enzymic antioxidant activities in the erythrocytes of
patients with cervical carcinoma. Cell Mol Biol Lett 9:699-707.
219.
Mantovani G, Macci A, Maddedu C, Mura L, Massa E, Gramignano G, Lusso
MR, Murgia V, Camboni P, Ferreli L: Reactive oxygen species, antioxidant
mechanisms and serum cytokine levels in cancer patients: impact of an antioxidant
treatment. J Cell Mol Med 6:570-582, 2002.
220.
Manju V, Kalaivani-Sailaja J, Nalini N (2002) Circulating lipid peroxidation
and antioxidant status in cervical cancer patients: a case-control study. Clin Biochem
35:621-625.
221.
Mariani E, V. Cornacchiola, M. C. Polidori, F. Mangialasche, M. Malavolta, R.
Cecchetti, P. Bastiani, M. Baglioni, E. Mocchegiani, P. Mecocci Antioxidant enzyme
activities in healthy old subjects: influence of age, gender and zinc status
Biogerontology (2006) 7:391398
222.
Marinho, H.S., F. Antunes, R.E. Pinto (1997). Role of glutathione peroxidase
and phospholipid hydroperoxide glutathione peroxidase in the reduction of
lysophospholipid hydroperoxides. Free Radic Biol Med 22(5): 871-883.
223.
Marklund S.L. (1984). Extracellular superoxide dismutase in human tissues
and human cell lines. J Clin Invest 74(4): 1398-1403.
224.

Marnett LJ. 2000. Oxyradicals and DNA damage. Carcinogenesis 21:361370

225.
Marsden DE, Hacker NF, 2001, Optimal management of endometrial
hyperplasia Best Pract Res Clin Obstet Gynaecol 15:393-405

226.
Marsden DE, Hacker NF, The classification, diagnosis and management of
endometrial hyperplasia. Rev Gynaecol Pract 2003, 3:89-97
227.
Martin, B., Rotten, D., Jolivet, A. Gautray, J.P., Binding of steroids by proteins
in follicular fluid of the human ovary, J. Clin Endocrinol Metab 35:443-447 (1981)
228.
Martindale JL, Holbrook NJ. 2002. Cellular response to oxidative stress:
signaling for suicide and survival. J. Cell. Physiol.192:115
229.
Maruo T, N. Ohara, J. Wang, H.Matsuo Sex steroidal regulation of uterine
leiomyoma growth and apoptosis Human Reproduction Update, 10, 207-220, 2004
230.
Maseki, M, Nishigaki I, Hagihara, Tomoda, Y, Yagi K (1981): Lipid peroxide
levels and lipid content of serum lipoprotein fractions of pregnant subjects with or
without pre-eclampsia. Clin Chim Acta, 115:155-161
231.
Massafra C, Buonocore G, Berni S, Gioia D, Giuliani A, Vezzosi P 1993
Antioxidant erythrocyte enzyme activities during oral contraception. Contraception 47
591596.
232.
Massafra C, Buonocore G, Gioia D, Sargentini I 1996 Changes in the
erythrocyte antioxidant enzyme system during transdermal estradiol therapy for
secondary amenorrhea. Gynecological Endocrinology 10 14.
233.
Massafra C, Buonocore G, Gioia D, Sargentini I, Farina G 1997 Effects of
estradiol and medroxyprogesterone acetate treatment on erythrocyte antioxidant
enzyme activities and malondialdehyde plasma levels in amenorrheic women. Journal
of Clinical Endocrinology and Metabolism 82 173175.
234.
Massafra C, De Felice C, Gioia D, Buonocore G, Variations in erythrocyte
antioxidant glutathione peroxidase activity during the menstrual cycle Clin Endocrinol
1998,49:63-67
235.
Massafra C, Gioia D, De Felice C, Picciolini E, De Leo V, Bonifazi M,
Bernabei A: Effects of estrogens and androgens on erythrocyte antioxidant superoxide
dismutase, catalase and glutathione peroxidase activities during the menstrual cycle. J
Endocrinol 2000 167:447-52.
236.
Maxwell, G.L., Risinger, J.I., Gumbs, C., Shaw, H., Bentley, R.C., Barrett, J.C.,
Berchuck, A., Futreal, P.A. (1998). Mutation of the PTEN tumor suppressor gene in
endometrial hyperplasias. Cancer Res. 58, 25002503
237.
Mayo JC, R.M. Sainza,, I. Antoln, F. Herrera,V. Martin C. Rodrigueza,
Melatonin regulation of antioxidant enzyme gene expressionCMLS, Cell. Mol. Life
Sci. 59 (2002) 17061713
238.
Mecocci P, Polidori MC, Troiano L, Cherubini A, Cecchetti R, Pini G,
Straatman M, Monti D, Stahl W, Sies H, Franceschi C, Senin U (2000) Plasma

antioxidants and longevity: a study on healthy centenarians. Free Radic Biol Med
28:12431248
239.
Meldrum DR, Davidson BJ, Tartaryn IV, Judd HL. Changes in circulating
steroids with aging in postmenopausal women. Obstet Gynecol 1981; 57: 624628.
240.
Metcalf MG, Donald RA, Livesey JH Pituitary-ovarian function in normal
women during the menopausal transition. Clin Endocrinol (Oxf) 198114(3):245-255
241.
Mila-Kierzenkowska C, Kedziora-Kornatowska K, Wozniak A, Drewa T,
Wozniak B, Drewa S, Krzyzynska-Malinowska E, Makarewicz R (2004) The effect of
brachytherapy on antioxidant status and lipid peroxidation in patients with cancer of
the uterine cervix. Cell Mol Biol Lett 9:511-518.
242.
Mills, G.C. (1957). Hemoglobin catabolism. I. Glutathione peroxidase, an
erythrocyte enzyme which protects hemoglobin from oxidative breakdown. J Biol
Chem 229: 189-197.
243.
Miyata, T., K. Kurokawa, C. van Ypersele de Strihou, (2000). Advanced
Glycation and Lipoxidation End Products. Role of Reactive Carbonyl Compounds
Generated during Carbohydrate and Lipid Metabolism. J Am Soc Nephrol 11(9):17441752.
244.
Mollerstrom, G., Carlstrom, K., Lagrelius, A., Einhorn, N. Is there an altered
steroid profile in patients with endometrial carcinoma? Cancer (Phila.), 72: 173181,
1993.
245.
Monari, M.; Trinchero, A.; Calabrese, C.; Cattani, O.; Serrazanetti, G. P.;
Foschi, J.; Fabbri, A.; Zahlane, D.; Di Febo, G.; Tonini, V.; Cervellera M, Tosi MR,
Tugnoli V, Superoxide dismutase in gastric adenocarcinoma: is it a clinical biomarker
in the development of cancer? Biomarkers 11: 574-584 , 2006
246.
Moraes EC, SM Keyse, M Pidoux, RM Tyrrell (1989) The spectrum of
mutations generated by passage of a hydrogen peroxide damaged shuttle vector
plasmid through a mammalian host Nucl Acids Res 17(20): 8301-8312.
247.
Mossman BT, Marsh JP, Shakatos MA (1986) Alteration of superoxide
dismutase activity in tracheal epithelial cells by asbestos and inhibition of cytotoxicity
by antioxidants. Lab Invest 54: 204-212.
248.
Mote PA, Balleine RL, McGowan EM, Clarke CL 1999 Colocalization of
progesterone receptors Aand B by dual immunofluorescent histochemistry in human
endometrium during the menstrual cycle. J Clin Endocrinol Metab 84:29632971
249.
Mueck AO Seeger H, Hormone therapy after endometrial cancer, EndocrineRelated Cancer 2004, 11: 305-314
250.
Mueller S, Riedel HD, Stremmel W (1997) Direct evidence for catalase as the
predominant H2O2-removing enzyme in human erythrocytes. Blood 90:4973-4978.

251.
Mller JM, Cahill MA, Rupee RA, Baeuerle PA, Nordheim A. 1997.
Antioxidants as well as oxidants activate c-fos via Ras-dependent activation of
extracellularsignal-regulated kinase 2 and Elk-1. Eur.J. Biochem. 244:4552
252.
Mller JM, Ziegler-Heitbrock HW, Baeuerle PA. 1993. Nuclear factor kappa B,
a mediator of lipopolysaccharide effects. Immunobiology 187:233256
253.
Murphy LJ, Gong Y, Murphy LC, Bhavnani B. 1991 Growth factors in normal
and malignant uterine tissue. Ann N Y Acad Sci, 622: 383-391.
254.
Murray, RK: Red and white blood cells. In: Harpers Biochemistry, (Murray
RK, Granner, DK, Mayes PA and Rodwell VW, Eds.), 24th edition, Prentice-Hall
International, Singapore, 1998, 733-738
255.
Mutter GL, Diagnosis of premalignant endometrial disease, J Clin Pathol,
2002, 55:326-331
256.
Mutter GL, Lin MC, Fitzgerald JT, Kum JB, Baak JP, Lees JA, Weng LP, Eng
C. Altered PTEN expression as a diagnostic marker for the earliest endometrial
precancers. J Natl Cancer Inst. 2000 92(11):924-930.
257.
Mutter GL, The Endometrial Collaborative group. Endometrial intraepithelial
neoplasia (EIN): Will it bring order to chaos? Gynecol Oncol, 2000, 76: 287-290
258.
Nagababu E, Chrest FJ, Rifkind JM (2003) Hydrogen-peroxide-induced heme
degradation in red blood cells: the protective roles of catalase and glutathione
peroxidase. Biochim Biophys Acta 1620:211-217.
259.
Nakamura, T., T. Ohno, K. Hirota, A. Nishiyama, H. Nakamura, H. Wada, J.
Yodoi (1999). Mouse glutaredoxin - cDNA cloning, high level expression in E. coli
and its possible implication in redox regulation of the DNA binding activity in
transcription factor PEBP2. Free Radic Res 31(4): 357-365.
260.
Nakashima R, Fujita M, Enomoto T, Haba T, Yoshino K, Wada H, Kurachi H,
Sasaki M, Wakasa K, Inoue M, Buzard G, Murata Y. Alteration of p16 and p15 genes
in human uterine tumours. Br J Cancer 1999;80:458467.
261.
Narimoto K, Noda Y, Shiotani M, Tokura T, Goto Y, Takakura K, Mori T,
Fujimoto K, Ogawa K, Immunohistochemical assesment of superoxide dismutase
expression in the human endometrium throughout the menstrual cycle. Acta
Histochem Cytochem 23;487-498, 1990
262.
Natraj U, Richards JS 1993 Hormonal regulation, localization and functional
activity of the progesterone receptor in granulosa cells of rat preovulatory follicles.
Endocrinology 133 (2)761769
263.
Ness RB, Cottreau C 1999 Possible role of ovarian epithelial infl ammation in
ovarian cancer. Journal of the National CancerInstitute 91, 14591467.

264.
Niederacher D, An HX, Cho YJ, Hantschmann P, Bender HG, Beckmann MW.
Mutations and amplification of oncogenes in endometrial cancer. Oncology
1999;56:5965.
265.
Nishikawa, T., D. Edelstein, X.L. Du, S. Yamagishi, T. Matsumura, Y. Kaneda,
M. A. Yorek, D. Beebek, P. J. Oatesk, H.P. Hammes, I. Giardino, M. Brownlee (2000).
Normalizing mitochondrial superoxide production blocks three pathways of
hyperglycaemic damage. Nature 404: 787-790.
266.
Nishino, T. (1994). The conversion of xanthine dehydrogenase to xanthine
oxidase and the role of the enzyme in reperfusion injury. J Biochem 116(1) 1-6.
267.
Nisker JA, Ramzy I, Collins JA. Adenocarcinoma of the endometrium and
abnormal ovarian function in young women. Am J Obstet Gynecol 1978, 130:546-550
268.
Nordengren,J., Casslen,B., Gustavsson,B., Einarsdottir,M. Willen,R. (1998)
Discordant expression of mRNA and protein for urokinase and tissue plasminogen
activators (u-PA, t-PA) in endometrial carcinoma. Int. J. Cancer, 79, 195201
269.
Oberley LW, Bize IB, Sahu SK, Leuthause SW, Gruber HE. Superoxide
dismutase activity of normal murine liver, regenerating liver, and H6 hepatoma. J Natl
Cancer Inst 61:375-379
270.
Oberley LW, St.Clair DK, Autor AP, Oberley TD. (1987) Increase in
manganese superoxide dismutase activity in the mouse heart after X-irradiation. Arch
BiochemBiophys 254:69-80
271.
Oberley, T. D., and Oberley, L. W. Antioxidant enzyme levels in cancer. Histol.
Histopathol., 12: 525535, 1997.
272.
Oehler MK, Brand A, Wain GV, Molecular genetics and endometrial cancer.
Journal of the British Menopause Society, 2003, 9:27-31
273.

Ogata, M. (1991).Acatalasemia. Hum Genet 86(4): 331-40.

274.
Ohlemiller, K.K., S.L. McFadden, D.L. Ding, D.G. Flood, A.G. Reaume, E.K.
Hoffman, R.W. Scott, J.S. Wright, G.V. Putcha, R.J. Salvi (1999). Targeted deletion of
the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to
noise-induced hearing loss. Audiol Neurootol 4(5): 237-246.
275.
Ohwada M, Suzuki M, Sato I, Tsukamoto H, Watanabe K: Glutathione
peroxidase activity in endometrium: effects of sex hormones and cancer, 1996,
Gynecol Oncol 60:277-282
276.
Olson SH, Trevisan M, Marshall JR Graham S, Zielezny M, Vena JE,
Hellmann R, Freudenheim JL Body mass index, weight gain, and risk of endometrial
cancer Nutr Cancer, 1995 - 1995;23(2):141-149
277.
Orihuela PA, Parada-Bustamante A, Cortes PP, Gatica C, Croxatto HB 2003
Estrogen receptor, cyclic adenosine monophosphate, and protein kinase A are involved

in the nongenomic pathway by which estradiol accelerates oviductal oocyte transport


in cyclic rats. Biol Reprod 68:12251231
278.
Orrell, R., J. de Belleroche, S. Marklund, F. Bowe, R. Hallewell (1995). A
novel SOD mutant and ALS. Nature 375: 504-505
279.
Orrenius S, M J. Burkitt, G E. N. Kass, J M. Dypbukt, P Nicotera Calcium ions
and oxidative cell injury Annals Neurol 32 (S1): S33 - S42 2004
280.
Oshima H, Bartsch H. 1994. Chronic infections and inflammatory processes as
cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat. Res.
305:253264
281.
Ota H, Igarashi S, Hatazawa M, Tanaka T Immunohistochemical assesment of
superoxide dismutase expression in the endometrium in endometriosis and
adenomyosis. Fertil Steril 1999, 72: 129-134
282.
Ota H, Igarashi S, Kato N, Tanaka T: Aberrant expression of glutathione
peroxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis
Fertil Steril 2000 74:313-318
283.
Ota H, Igarashi S, Sato N, Tanaka H, Tanaka T: Involvement of catalase in the
endometrium of patients with endometriosis and adenomyosis. Fertil Steril 78: 804809, 2002
284.
zden, S., Dilar, K., Kadir, Y.H. & Glizar, K. (2001) The effects of hormone
replacement therapy on lipid peroxidation and antioxidant status. Maturitas, 38, 165
170.
285.
Paech, K., Webb, P., Kuiper, G., Nilsson, S., Gustafsson, J.-A., Kushner, P.,
Scanlan, T. (1997). Differential ligand activation of estrogen receptors ERa and ERb at
API sites. Science 277, 15081510.
286.
Pahl HL, Baeuerle PA. 1994. Oxygen and the control of gene expression.
BioEssays 16:497502
287.
Palazzo JP, Mercer WE, Kovatich AJ, McHugh M. Immunohistochemical
localization of p21(WAF1/CIP1) in normal, hyperplastic, and neoplastic uterine
tissues. Hum Pathol 1997;28: 6066.
288.
Parkin DM, Whelan SL, Ferlay J, Raymond L, Yound J, Cancer incidence in
five continents, vol. 7, Lyon: IARC; 1997.
289.
Parslov M, O Lidegaard, S Klintorp, B Pedersen, L Jonsson, Eriksen PS,
Ottesen B Risk factors among young women with endometrial cancer: a Danish casecontrol study. 2000 182(1 Pt 1):23-9.
290.
Parthasarathy S, Santanam N, Ramachandran S, Meilhac O 2000 Potential role
of oxidized lipids and lipoproteins in antioxidant defense. Free Radic Res 33:197215

291.
Peiffer SL, Bartsch D, Whelan AJ, Mutch DG, Herzog TJ, Goodfellow PJ. Low
frequency of CDKN2 mutation in endometrial carcinomas. Mol Carcinog
1995;13:210212.
292.
Pelicano, H., Carney, D., Huang, P. (2004) ROS stress in cancer cells and
therapeutic implications. Drug Resist. Updat. 7, 97110
293.
Peltomki P, Vasen HF. Mutations predisposing to hereditary nonpolyposis
colorectal cancer: database and results of a collaborative study. The International
Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer.
Gastroenterology 1997;113:11461158.
294.
Petit-Thevenin J, Lerique B, Nobili O, Boyer J 1991 Estrogen modulates
phospholipid acylation in red blood cells: relationship to cell aging. Am J Physiol
261:C423C427
295.
Pietarinen-Runtti P, Raivio KO, Saksela M, Asikainen TM, VL Kinnula (1998)
Antioxidant enzyme regulation and resistance to oxidants of human bronchial
epithelial cells cultured under hyperoxic conditions. Am J Respir Cell Mol Biol 19:
286-292.
296.
Pitot HC, Goldsworthy T, Moran S. 1981. The natural history of
carcinogenesis: implications of experimental carcinogenesis in the genesis of human
cancer. J.Supramol. Struct. Cel. Biochem. 17:133146
297.
Piyathilake CJ, Frost AR, Manne U, Bell WC, Weiss H, Heimburger DC,
Grizzle WE The expression of fatty acid synthase is an early event in the development
and progression of squamous cell carcinoma of the lung. Human Pathol 2000,
31:1068-1073
298.
Podratz KC, Mariani A Webb MJ, 1998 Staging and therapeutic value of
lymphadenectomy in endometrial cancer, Gynecology and Oncology, 70:163-164
299.
Pka R, Szks S, dny R, Szikszay E: Stage-related superoxide anion
production of granulocytes of gynecologic cancer patients. Eur J Obstet Gynecol,
2000, 89:55-57
300.
Popov B, V. Gadjeva, P. Valkanov, S. Popova , A. Tolekova Lipid
Peroxidation, Superoxide Dismutase and Catalase Activities in Brain Tumor Tissues
Archives of Physiology and Biochemistry 111, 455 459,2003
301.
Porter, N.A (1984). Chemistry of lipid peroxidation. Methods Enzymol 105:
273-82.
302.
Potischman, N., Hoover, R. N., Brinton, L. A., Siiteri, P., Dorgan, J.
F.,Swanson, C. A., Berman, M. L., Mortel, R., Twiggs, L. B., Barrett, R. J., Wilbanks,
G. D., Persky, V., Lurain, J. R. Case-control study of endogenous steroid hormones
and endometrial cancer. J. Natl. Cancer Inst. (Bethesda), 88:11271135, 1996.

303.
Powis, G., W.R. Montfort (2001). Properties and biological activities of
thioredoxins. Annu Rev Biophys Biomol Struct 30: 421-455.
304.
Punnonen R, Kudo R, Punnonen K, Hietanen E, Kuoppala T, Kainulainen H,
Sato K, Ahotupa M: Activities of antioxidant enzymes and lipid peroxidation in
endometrial cancer. Eur J Cancer, 29A: 266-269, 1993.
305.
Purdie DM Green AC, Epidemiology of endometrial cancer.2001, Best Pract
Res Clin Obstet Gynaecol 15:341-354
306.
Purdie DM, Epidemiology of endometrial cancer, Reviews in Gynaecological
Practice 3:217-220, 2003
307.
Rahman I, Clerch LB, Massaro D, Rat lung antioxidant enzyme induction by
ozone. Am J Physiol 260: L412-418, 1991
308.
Ramadurai S. M., Nielsen H. C., Chen Y., Hatzis D. Sosenko I. R. (1998)
Differential effects in vivo of thyroid hormone on the expression of surfactant
phospholipid, surfactantprotein mRNA and antioxidant enzyme mRNA in fetal rat
lung. Exp. Lung Res. 24: 641657
309.
Rannevik G, Jeppsson S, Johnell O, Bjerre B, Laurell-Borulf Y, Svanberg L. A
longitudinal study of the perimenopausal transition: altered profiles of steroid and
pituitary hormones, SHBG and bone mineral density. Maturitas 1995 21(2):103-113
310.
Reddy, J.K. T. Hashimoto (2001). Peroxisomal -oxidation and peroxisome
proliferator-activated receptor : An Adaptive Metabolic System. Ann Rev Nutr 21:
193-230.
311.
Rein, 2000, Advances in uterine leiomyoma research: the progesterone
hypothes, Environ Health Perspect. 108 Suppl 5:791-793
312.
Reth, M (2002). Hydrogen peroxide as second messenger in lymphocyte
activation. Nature Immunol 3(12): 1129-1134.
313.
Ribeiro AJ, R.C., Webb, P., Gustafsson, J.A., Kushner, P.J., Baxter, J.D.,
Leitman, D.C. (1999). Estradiol repression of tumor necrosis factor-alpha transcription
requires estrogen receptor activation function-2 and is enhanced by coactivators. Proc.
Natl. Acad. Sci. USA 96, 1516115166.
314.
Ricci E, S.Moroni, F.Parazzini, M.Surace, G.Benzi, B.Salerio, G.Polverino,
C.La Vecchia Risk factors for endometrial hyperplasia: Results from a casecontrol study Int J Gynecol Cancer 2002;12:257260.
315.
Richardson S. J. and J. F. Nelson Follicular depletion during the menopausal
transition Ann NY Acad Sci 1990 592: 13-20.
316.

Rose, P. G. Endometrial carcinoma. N. Engl. J. Med., 335: 640649, 1996.

317.
Roveri, A., A. Casasco, M. Maiorino, P. Dalan, A. Calligaro, F. Ursini (1992).
Phospho-lipid hydroperoxide glutathione peroxidase of rat testis. Gonadotropin
dependence and immunocytochemical identification. J Biol Chem 267: 61426146.
318.
Sabuncu T, Vural H, Harma M, Harma M, Oxidative stress in polycystic ovary
syndrome and its contribution to the risk of cardiovascular disease. Clin Biochem
2001, 43:407-413
319.
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF. Amplification
and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with
overall survival. Cancer Res 1995;55:56938.
320.
Salonen, R.M., K. Nyyssonen, J. Kaikkonen, E. Porkkala-Sarataho, S.
Voutilainen, T.H. Rissanen, T.P. Tuomainen, V.P. Valkonen, U. Ristonmaa, H.M.
Lakka, M. Vanharanta, J.T. Salonen , H.E. Poulsen (2003). Six-year effect of
combined vitamin C and E supplementation on atherosclerotic progression: the
antioxidant supplementation in atherosclerotic prevention (ASAP) study. Circulation
107(7): 947-953.
321.
Salvesen HB, Akslen LA (2002) Molecular pathogenesis and prognostic factors
in endometrial carcinoma. APMIS 110: 673-689.
322.
Salvesen HB, Das S, Akslen LA. Loss of nuclear p16 protein expression is not
associated with promoter methylation but defines a subgroup of aggressive
endometrial carcinomaswith poor prognosis. Clin Cancer Res 2000;6:153159.
323.
Salvesen HB, Iversen OE, Akslen LA. Prognostic significance of angiogenesis
and Ki-67, p53and p21 expression: a population-based endometrial carcinoma study. J
Clin Oncol 1999;17: 13821390.
324.
Sanchez M, J V Torres, C Tormos, A Iradi, P Muiz, O Espinosa, A Salvador, J
Rodriguez-Delgado, M Fandos, G T. Sez Impairment of antioxidant enzymes, lipid
peroxidation and 8-oxo-2-deoxyguanosine in advanced epithelial ovarian carcinoma
of a Spanish community Cancer Lett 2006, 233: 28-35
325.
Saran M, Bors W. 1989. Oxygen radicals acting as chemical messengers: A
hypothesis. Free Rad. Res. Commun. 7:213220
326.
Saroja M, Balasenthil S, Nagini S, (2000), Tissue lipid peroxidation
glutathione-dependent enzyme status in patients with oral squamous cell carcinoma.
Anticancer Res, 20:2519-2524
327.
Sato, S Evaluation of the degree of biological behaviour in endometrial
hyperplasia and endometrial carcinoma: an investigation of proliferative activity,
oncogene, and extracellular matrix. Nippon Sanka Fujinka Gakkai Zasshi. 1993,
45:776-788.
328.
Satomi A, Murakami S, Hashimoto T, Ishida K, Matsuki M, Sonoda M:
Significance of superoxide dismutase (SOD) in human colorectal cancer tissue:
Correlation with malignant intensity, 30:177-182, 1995

329.
Sattler, M., Verma, S., Shrikhande, G., Byrne, C. H., Pride, Y. B., Winkler, T.,
Greenfield, E. A., Salgia, R., Griffin, J. D. (2000) The BCR/ABL tyrosine kinase
induces production of reactive oxygen species in hematopoietic cells. J. Biol. Chem.
275, 2427324278
330.
Schmeler KM, Soliman PT, Sun CC, Slomovitz BM, Gershenson DM, Lu KH:
Endometrial cancer in young, normal-weight women. Gynecol Oncol 2005, 99(2):38892,
331.
Schmidt KN, Armstad P, Cerutti P, Baeuerle PA. 1995. The roles of hydrogen
peroxide and superoxide as messengers in the activation of transcription factor NFB.
Biol. Chem. 2:1322
332.
Schreck R, Rieber P, Baeuerle PA. 1991. Reactive oxygen intermediates as
apparently widely used messagers in the activation of the NF-B transcription factor
and HIV-1. EMBO J. 10:22472258
333.
Schulte-Hermann R, Grasl-Kraupp B, BurschW. 1994. Tumor development and
apoptosis. Int. Arch. Allergy Immunol.105:363367
334.
Schulze-OshoffK, Ferrari D, Los M, Wesselborg S, Peter ME. 1998. Apoptosis
signaling by death receptors. Eur. J. Biochem.254:439459
335.
Schulze-Osthoff K, Bauer MK, Vogt M, Wesselborg S. 1997. Oxidative stress
and signal transduction. Int. J. Vitam. Nutr. Res. 67:336342
336.
Schutte J, Minna JD, Birer MI. 1989. Deregulated expression of human c-jun
transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene
and transforms rat-la cells as a single gene. Proc. Natl. Acad. Sci. USA 86:22572261
337.
Schwarz PE, Progesterone isoforms and endometrial cancer, J Soc Gynecol
Investig 12:219-221, 2005
338.
Sebastiani V, Visca P, Botti C, Santeusanio G, Galati GM, Piccini V, Capezzone
de Joannon B, Di Tondo U, Alo PL: Fatty acid synthase is a marker of increased risk
of recurrence in endometrial carcinoma. Gynecol Oncol 92:101-105
339.
Serviddio G, Loverro G, Vicino M, Prigigallo F, Grattagliano I, Altomare E,
Vendemiale G 2002 Modulation of endometrial redox balance during the menstrual
cycle: relation with sex hormones. J Clin Endocrinol Metab 87:28432848
340.
Sevanian, A., S.F. Mukkassah-Kelley S. Montestruque (1983). The influence of
phospholipase A2 and glutathione peroxidase on the elimination of membrane lipid
peroxides. Biochem Biophys Acta 223: 441-452.
341.
Sharma R, Awasthi S, Zimniak P, Awasthi YC (2000) Transport of glutathioneconjugates in human erythrocytes. Acta Biochim Pol 47:751-762.

342.
Sharma RK, Agarwal A, Role of reactive oxygen species in gynecologic
diseases Reproductive Medicine and Biology 3:177-199,2004
343.
Shay JW, Werbin H. 1992. New evidence for the insertion of mitochondrial
DNA into the human genome: significance for cancer and aging. Mutat. Res. 275:227
235
344.
Sherman BM, West JH, Korenman SG: The Menopausal Transition: Analysis
of LH, FSH, Estradiol and Progesterone Concentrations during Menstrual Cycles of
Older Women. J Clin Endocr Metab 42:629-636, 1976
345.
Sherman ME, 2000 Theories of endometrial
multidisciplinary approach, Mod Pathol 13:295-308

carcinogenesis:

346.
Shiozawa T, Nikaido T, Shimizu M, Zhai Y, Fujii S. Immunohistochemical
analysis of the expression of cdk4 and p16INK4 in human endometrioid-type
endometrial carcinoma. Cancer1997;80:22502256.
347.
Shrivastava V, Singh S, Singh N, Sapre S, Status of antioxidant enzymes and
trace metals in postmenopausal women J Obstet Gynecol India Vol. 55 2005 64-66
348.
Sies, H. (1991). Oxidative stress II. Oxidants and Antioxidants., Academic
Press, London.pp 1-8
349.
Siiteri, P.K. Murai J T., Hammond, G.L., Nisker, J.A., Raymoure, W.J. Kuhn,
R.W., The serum transport of steroid hormones, Rec. Prog. Horm Res. 38:457-510
(1982)
350.
Simpson, E.R., McDonald, P.C., Endocrinology of Pregnancy. In: Textbook of
Endocrinology, Ed.: Williams, R.H., pp 412-422, Saunders Company, Philadelphia
(1981).
351.
Skrzydlewska E, Sulkowski S, Koda M, Zalewski B, Kanczuga-Koda L,
Sulkowska M (2005) Lipid peroxidation and antioxidant status in colorectal cancer.
World J Gastroenterol 11:403-406.
352.
Smith, M.A., C.A. Rottkamp, A. Nunomura, A.K. Raina G. Perry (2000).
Oxidative stress in Alzheimer's disease. Biochim Biophys Acta 1502(1): 139-44.
353.
Soliman PT, J C. Oh, K M. Schmeler, C C. Sun, B M. Slomovitz, DM.
Gershenson, T W. Burke, K H. Lu, Risk Factors for Young Premenopausal Women
With Endometrial Cancer Obstetrics & Gynecology 2005;105:575-580
354.
Spandidos D.A., G. Sourvinos, C. Tsatsanis, A. Zafiropoulos: Normal ras
genes: Their onco-suppressor and pro-apoptotic functions (Review) Int J Oncol 21:
237-241, 2002
355.
Stadtman, E.L. , R.L. Levine (2000). Protein oxidation. Ann N Y Acad Sci
899(1): 191-208.

356.
Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T,
Ruland J, Penninger JM, Siderovski DP , Mak TW 1998: Negative regulation of
PKB/Akt-dependent cell survival by the tumor supressor PTEN. Cell 95: 29-39.
357.
Steinberg, D. (1997). Low density lipoprotein oxidation and its pathobiological
significance. J Biol Chem 272(34): 20963-20966.
358.
Stocker, R., V.W. Bowry, B. Frei (1991). Ubiquinol-10 protects human low
density lipoprotein more efficiently against lipid peroxidation than does alphatocopherol. Proc Natl Acad Sci USA 88(5): 1646-1650.
359.
Stone K, Ksebati M, Marnett LJ. 1990. Investigation of the adducts formed by
reaction of malondialdehyde with adenosine. Chem. Res. Toxicol. 3:3338
360.
Strange, R.C., P.W. Jones ,A.A. Fryer (2000). Glutathione S-transferase:
genetics and role in toxicology. Toxicol Letts 112-113: 357-363.
361.
Strobelt N, Ghidini A, Cavallone M, Pensabene I, Ceruti P, Vergani P. Natural
history of uterine leiomyomas in pregnancy. J Ultrasound Med 1994;13:399401
362.
Subbiah, M.T., Kessel, B., Agrawal, M., Rajan, R., Abplanalp, W.
Rymaszewski, Z. (1993) Antioxidant potential of specific estrogens on lipid
peroxidation. Journal of Clinical Endocrinology and Metabolism, 77, 10951097.
363.
Sugino N, Karube-Harada A, Kashida S, Takiguchi S, Kato H, Differential
regulation of copper-zinc superoxide dismutase by progesteron withdrawal in human
endometrial stromal cells. Mol Hum Reprod 8:68-74, 2002a
364.
Sugino N, Karube-Harada A, Sakata A, Takiguchi S, Kato H: Different
mechanisms for the induction of copper-zinc superoxide dismutase and manganese
superoxide dismutase by progesterone in human endometrial stromal cells, Hum
Reprod, 17:1709-1714, 2002b
365.
Sugino N, Kashida S, Takiguchi S, Nakamura Y, Kato H, 2000a Induction of
superoxide dismutase by decidualization in human endometrial stromal cells. Mol
Hum Reprod 6:178-184
366.
Sugino N, Shimamura K, Takiguchi S, Tamura H, Ono M, Nakata M,
Nakamura Y, Ogino K, Uda T, Kato H, Changes in the activity of superoxide
dismutase in the human endometrium throughout the menstrual cycle and in early
pregnancy. Hum Reprod 11:1073-1078, 1996
367.
Sugino N., Takiguchi S., Kashida S., Karube A., Nakamura Y. Kato H. (2000b)
Superoxide dismutase expression in the human corpus luteum during the menstrual
cycle and in early pregnancy. Mol. Hum. Reprod. 6: 1925
368.
Sugioka, K., Shimmosegawa, Y. Nakano, M. (1987) Estrogens as natural
antioxidants of membrane phospholipid peroxidation. FEBS Letters, 210, 137139

369.
Suzuki YJ, Forman HJ, Sevanian A. 1997.Oxidants as stimulators of signal
transduction. Free Rad. Biol. Med. 22:269285
370.
Szczepanska M, Kozlik J, Skrzypczak J, Mikolajczyk M. 2003 Oxidative stress
may be a piece in the endometriosis puzzle. Fertility and Sterility 79, 12881293.
371.
Takahashi, K. H.J. Cohen (1986). Selenium-dependant glutathione peroxidase
protein and activity: immunological investigations on cellular and plasma enzymes.
Blood 68: 640-645.
372.
Takahashi, K., M. Akasaka, Y. Yamamoto, C. Kobayashi, J. Mizoguchi J.
Koyama (1990). Primary structure of human plasma glutathione peroxidase deduced
from cDNA sequences. J Biochem (Tokyo) 108(2): 145-148.
373.
Takashima, Y., K. Hirota, H. Nakamura, T. Nakamura, K. Akiyama, F.S.
Cheng, M. Maeda J. Yodoi (1999). Differential expression of glutaredoxin and
thioredoxin during monocytic differentiation. Immunol Lett 68(2-3): 397-401.
374.
Tashiro, H., Blazes, M.S., Wu, R., Cho, K.R., Bose, S., Wang, S.I., Li, J.,
Parsons, R., Ellenson, L.H. (1997). Mutations in PTEN are frequent in endometrial
carcinoma but rare in other common gynecologic malignancies. Cancer Res. 57,
39353940
375.
Tee MK, I Rogatsky, C Tzagarakis-Foster, A Cvoro, J An , R J. Christy, K R.
Yamamoto , D C. Leitman Estradiol and Selective Estrogen Receptor Modulators
Differentially Regulate Target Genes with EstrogenReceptors and Molecular
Biology of the Cell. 15, 12621272, 2004
376.
Terakawa N, Kanamori Y, Yoshida S (2003). Loss of PTEN expression
followed by Akt phosphorylation is a poor prognostic factor for patients wot
endometrial cancer. Endocrine-Related Cancer 10: 203-208
377.
Thom SR, Kang M, Fisher D, Ischiropoulos H (1997) Release of glutathione
from erythrocytes and other markers of oxidative stress in carbon monoxide
poisoning. J Appl Physiol 82:1424-1432.
378.
Thomas, J.P., M. Maiorino, F. Ursini, A.W. Girotti (1990). Protective action of
phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid
peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides. J Biol
Chem 265: 454-461.
379.
Thomas, S.R. R. Stocker (2000). Molecular action of vitamin E in lipoprotein
oxidation implications for atherosclerosis. Free Radic Biol Med 28(12): 1795-1805
380.
Toyokuni S (1998) Oxidative stress and cancer: The role of redox regulation.
Biotherapy 11:147-154.
381.
Toyokuni S, Novel aspects of oxidative stress-associated carcinogenesis, 2006,
8:1373 -1377
382.

Toyokuni S, Okamoto J, Yodoi J, Hiai, H (1995) Persistent oxidative stress in

cancer. FEBS Lett. 16:3581-3583.


383.
Tran BN, Connell PP, Waggoner S, Rotmensch J, Mundt AJ, Characteristics
and outcome of endometrial carcinoma patients age 45 years and younger. Am J Clin
Oncol 2000, 23: 476-480
384.
Tranquilli, A.L., Mazzanti, L., Cugini, A.M., Cester, N., Garzetti, G.G.,
Romaini, C. (1995) Transdermal estradiol and medroxyprogesterone acetate in
hormone replacement therapy are both antioxidants. Gynecological Endocrinology, 9,
137141.
385.
Trentham-Dietz A, HB Nichols, JM Hampton, PA Newcomb Weight change
and risk of endometrial cancer International Journal of Epidemiology 2006 35(1):151158;
386.
Tsan M.F., E. J.E. White, B. Caska, C.J. Epstein, C.Y. Lee (1998).
Susceptibility of heterozygous MnSOD gene-knockout mice to oxygen toxicity. Am. J.
Respir. Cell Mol. Biol. 19: 114120.
387.
Tsan MF (2001) Superoxide dismutase and pulmonary oxygen toxicity: lessons
from transgenic and knockout mice. Int J Mol Med 7: 13-19.
388.
Tsan, M.F., J.E. White, T.A. Santana, C.Y. Lee (1990). Tracheal insufflation of
tumor necrosis factor protects rats against oxygen toxicity. J Appl Physiol 68: 12111219.
389.
Turrens, J.F. (2003). Mitochondrial formation of reactive oxygen species. J
Physiol 552(2): 335-344.
390.
Ursini F, Maiorino M, Brigelius-Flohe R, Aumann KD, Roveri A, Schomburg
D, Flohe L. Diversity of glutathione peroxidases. Methods Enzymol 252:3853;1995.
391.
Ursini, F., M. Maiorino, C. Gregolin (1985). The selenoenzyme phospholipid
hydroperoxide glutathione peroxidase. Biochim Biophys Acta 829: 62-72.
392.
Ursini, F., M. Maiorino, R. BrigeliusFlohe, K.D. Aumann, A. Roveri, D.
Schomburg, L. Flohe (1995). Diversity of glutathione peroxidases. Methods Enzymol
252: 3853
393.
Van den Bogert C, Muus P, Haanen C, Pennings A, Melis TE, Kroon AM.
1988. Mitochondrial biogenesis and mitochondrial activity during the progression of
the cell cycle of human leukemic cells. Exp.Cell Res. 178:143153
394.
Van Ginkel G, Sevanian A (1994) Lipid peroxidation induced membrane
structural alterations. Methods Enzymol 233:273288.

395.
Vatassery G.V., T. Bauer, M. Dysken (1999). High doses of vitamin E in
treatment of disorders of the central nervous system in the aged. Am J Clin Nutr 70(5):
793-801.
396.
Vignais P.V. (2002). The superoxide-generating NADPH oxidase: structural
aspects and activation mechanism. Cell Mol Life Sci 59(9): 1428-1459.
397.
Wachtel SS, Wachtel G, Shulman LP, Phillips O, Miller B, Photopoulos G,
Identification of p53 mutations in endometrial adenocarcinoma by polymerase chain
reaction-single-strand conformation polymorphism. J Soc Gynecol Invest 1994, 1:234237
398.
Wakil S; Fatty acid synthase: a proficient multifunctional enzyme.
Biochemistry 1989, 28:4523-4530
399.
Wan XS, Devalaraja MN, St Clair DK, (1994) Molecular structure and
organization of the human manganese superoxide dismutase gene. DNA Cell Biol 13:
1127-1136
400.
Wang Y, Matsuo H, Kurachi O, Maruo T (2002) Down-regulation of
proliferation and up-regulation of apoptosis by gonadotropin-releasing hormone
agonist in cultured uterine leiomyoma cells. Eur J Endocrinol 146,447-456.
401.
Warner BB, Burhans MS, Clark JC, Wispe JR (1991) Tumor necrosing factor
alpha increases MnSOD expression: protection against oxidant injury. Am J Physiol
260:L296-L301
402.
Warner BB, Stuart L, Gebb S, Wisp JR (1996) Redox regulation of manganese
superoxide dismutase. Am J Physiol 15: L150-L158.
403.
Weber AM, Belinson JL, Piedmonte MR. Risk factors for endometrial
hyperplasia and cancer among women with abnormal bleeding , Obstet Gynecol 1999,
93:594-598
404.
Weiss L, Hoffman GE, Schreiber R, Andres H, Fuchs E, Korber E, Kolb HJ:
Fatty acid biosynthesis in man: a pathwayof minor importance. Purification, optimal
assay conditions and organ distribution of fatty acid synthase. Biol Chem HoppeSeyler 1986, 367:905-912
405.
Weiss, N. S., Hill, D. A. Postmenopausal estrogens and progestogens and the
incidence of gynecologic cancer. Maturitas, 23: 235239, 1996.
406.
Weller BL, Crapo JD, Slot J, Posthuma G, Plopper CG, Pinkerton KE (1998)
Site and cell-specific alteration of lung copper/zinc and manganese superoxide
dismutases by chronic ozone exposure. Am J Respir Cell Mol Biol 17: 552-560
407.
Wells, W.W., D.P. Xu, Y.F. Yang, P.A. Rocque (1990). Mammalian
thioltransferase (glutaredoxin) and protein disulfide isomerase have dehydroascorbate
reductase activity. J Biol Chem 265(26): 15361-15364.

408.
Whiteside C., Blackmon R. H., Bremmer T. A. (1983) Estrogen regulation of
superoxide dismutase in normal rat mammary tissues and mammary tumors. Biochem.
Biophys. Res.Commun. 113: 883887
409.
Wijayagunawardane MP, Miyamoto A, Taquahashi Y, Gabler C, Acosta TJ,
Nishimura M, Killian G, Sato K 2001 In vitro regulation of local secretion and
contraction of the bovine oviduct: stimulation by luteinizing hormone, endothelin- 1
and prostaglandins, and inhibition by oxytocin. J Endocrinol 168:117 130
410.
Wijnen J, de Leeuw W, Vasen H, van der Klift H, Moller P, Stormorken A,
Meijers-Heijboer H, Lindhout D, Menko F, Vossen S, Moslein G, Tops C, BrockerVriends A, Wu Y, Hofstra R, Sijmons R, Cornelisse C, Morreau H, Fodde R. Familial
endometrial cancer in female carriers of MSH6 germline mutations. Nat Genet
1999;23:142144.
411.
Wilentz RE, Witters LA, Pizer ES, Lipogenic enzymes fatty acid synthase and
acetyl-CoA carboxylase are co-expressed with sterol regulatory element binding
protein and ki-67 in fetal tissues. Pediatr Dev Pathol 2000, 3:525-531
412.
Wong, G. H. , D. V. Goeddel (1988). Induction of manganous superoxide
dismutase by tumor necrosis factor: possible protective mechanism. Science
242(4880): 941-944.
413.
Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. 1995. Opposing
effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:13261331
414.
Xu WH ; Xiang YB ; Ruan ZX; Zoeng W; Cheng JR ; Dai Q ; Gao YT ; Shu
XO Menstrual and reproductive factors and endometrial cancer risk: Results from a
population-based case-control study in urban Shanghai (Int. j. cancer) 2004, 108, 613619
415.
Yabuki, M., Kariya, S., Ishisaka, R., Yasuda, T., Yoshioka, T., Horton, A. A.,
and Utsumi, K. Resistance to nitric oxide-mediated apoptosis in the HL-60 variant
cells is associated with increased activities of Cu, Zn-superoxide dismutases and
catalase. Free Radic. Biol. Med., 26: 325332, 1999.
416.
Yakes FM, Van Houten B. 1997. Mitochondrial DNA damage is more
extensive and persists longer than nuclear DNA damage in human cells following
oxidative stress. Proc. Natl. Acad. Sci. USA 94:514519
417.
Yamamoto Y., E. Komuro and E. Niki (1990). Antioxidant activity of ubiquinol
in solution and phosphatidylcholine liposome. J Nutr Sci Vitaminol (Tokyo) 36(5):
505-511.
418.
Yamaoka K, Sato EF, Utsumi K. Induction of two species of superoxide
dismutase in some organs of rats by low dose X-irradiation. Physiol Chem Phys Med
NMR 26:205-214, 1994

419.
Yamazawa K, Seki K, Matsui H, Kihara M, Sekiya S Prognostic factors in
young women with endometrial carcinoma: a report of 20 cases and review of
literature. Int J Gynecol Cancer 2000: 10:212-222
420.
Yoo HY, Chang, MS, Rho, HM Induction of the rat Cu/Zn superoxide
dismutase gene through the peroxisome proliferator-responsive element by
arachidonic acid. Gene 234: 87-91, 1999
421.
Yoo HY, Chang, MS, Rho, HM The activation of rat copper/zinc superoxide
dismutase gene by hydrogen peroxide through the hydrogen peroxide-responsive
element and by paraquat and heat shock through the same heat shock element. J Biol
Chem 274:23887-23892, 1999
422.
Yoo HY, Chang, MS, Rho, HM, Heavy metal-mediated activation of rat Cu/Zn
superoxide dismutase gene via a metal-responsive element. Mol Gen Genet 262:310313, 1999
423.
Zafari, AM, Ushio-Fukai M; Akers M; Yin Q; Shah A; Harrison DG.; Taylor
WR Griendling KK. Role of NADH/NADPH oxidase-derived H2O2 in angiotensin IIinduced vascular hypertrophy Hypertension. 1998 32:488-495
424.
Zelko IN, Mariani TJ, RJ Folz Superoxide dismutase multigene family: A
comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene
structures, evolution, and expression Free Radic Biol Med 33(3): 337-349, 2002.
425.
Zhou, Y., Hileman, E. O., Plunkett, W., Keating, M. J., Huang, P. (2003) Free
radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity
to ROS-generating anticancer agents Blood 101,40984104 Lu H, W Ouyang, C
Huang: Inflammation, a Key Event in Cancer Development. Mol Cancer Res
2006;4:221-233

Das könnte Ihnen auch gefallen