Numrul total de ore (pe semestru) din

planul de nvmnt
(44 SEM.I)

FIA DISCIPLINEI

Denumirea disciplinei
Anul de studiu

PHYSIOPATHOLOGY
III

Semestrul *

Tipul de evaluare final (E / V / C)

Regimul disciplinei (Ob obligatorie, Op opional, F - facultativ)

Total ore din planul de nvmnt
Titularul disciplinei

44

Total ore de studiu

individual

Ob

Numrul de credite

100

Total ore pe
semestru

Prof. Dr. Magda Bdescu

* Dac disciplina are mai multe semestre de studiu, se completeaz cte o fi pentru
fiecare semestru
Facultatea
Catedra

Medicine
2

Total
44

Profilul
Specializarea

C**

20

24

Medicine
General Medicine

** C curs, L activiti de laborator, P proiect

sau lucrri practice

Obiectivele disciplinei
1. Understand how the normal regulation and integration of physiological systems are altered
by diseases.
2. In-depth knowledge of specific mechanisms that lead to the alterated functions in
cardiovascular, lung, renal, digestive, and blood diseases.
3. Develop skills in laboratory techniques that are integral to the study of pathophysiology.
4. Develop skills in the analysis of data and presentation of results through written reports.
Coninutul disciplinei

Nr. ore

Curs (20 ore)

GENERAL PATHOPHYSIOLOGY
1. GENERAL INFORMATION ON HEALTH AND DISEASE:
Concepts of health and disease; General characteristics of disease
General etiology and pathogenesis of diseases

E1
3
144

2. GENERAL RESPONSE TO AGRESSION

- ALLOSTASIS, HOMEOSTASIS AND THE COST OF
ADAPTATION
General adaptation syndrome
Allostasis
Maladaptation
- PATHOPHYSIOLOGY OF SHOCK
Types of shock
Shock evolution
Multiple organ failure syndrome
3. LOCAL RESPONSE TO AGRESSION
ACUTE INFLAMMATORY REACTION
Vascular and cellular changes in acute inflammatory reaction
Chemical mediators of inflammation (cellular and plasmatic)
Abnormalities of inflammatory reaction
- ALTERATIONS IN TEPERATURE REGULATION
Fever reaction- definition, etiopathogensis, evolution, consequences
Hypertermia- heat shock, malignant hyperthermia
Hypothermia
4. PATHOHYSIOLOGY OF PROTEIN METABOLISM
Pathophysiology of dysproteinemias
Pathophysiology of amino acids
Pathophysiology of uric acid metabolism and endproducts of protein
metabolism
5. PATHOHYSIOLOGY OF LIPID METABOLISM aND
ATHEROSCLEROSIS
Primary hiperlypoproteinemias
Secondary hiperlypoproteinemias:diabetes, alcohol abuse, endocrine
diseases, kidney diseases and unbalanced nutrition
Pathophysiology of atherosclerosis- risk factors, mechanisms, evolution
II. PATHOPHYSIOLOGY OF BODY SYSTEMS
6. PATHOPHYSIOLOGY OF RESPIRATORY FAILURE
Hypoxemia
Hypercapnia
Signs of respiratory failure: dyspneea and cyanosis
7. PATHOPHYSIOLOGY OF LUNG DISEASES
Bronchial asthma
Chronic obstructive pulmonary disease
Acute pulmonary edema
Pleural diseases- pleural effusion, pneumothorax
Acute respiratory distress syndrome
8. PATHOPHYSIOLOGY OF PRESSURE HEMOSTASIS
Primary and secondary arterial hypertension
Arterial hypotension

9. PATHOPHYSIOLOGY OF ISCHEMIC HEART DISEASE

Mechanims and consequences of ischemia
Pathophysiology of angina, types of angina and patophysiological
characteristics
Pathophysiology of myocardial infarction mechanisms, evolution,
complications
10. PATHOPHYSIOLOGY OF HEART FAILURE
Etiology determinant and precipitating factors
Compensatory mechanisms in heart failure early and late
mechanisms
Mechanisms of heart failure decompensation
Types of heart failure
PATHOPHYSIOLOGY OF ARRHYTHMIAS
Mechanims of arrhythmias
Types of arrhythmias

TOTAL CURSURI

20

1. Leukocyte disorders I screening tests

2. Leukocyte disorders II analytical tests and diagnostic tests in leukemias
3. Inflammatory response diagnostic tests
CNS disorders: diagnostic test in meningitis and electroencephalography
(EEG)
4. Protein metabolism disorders diagnostic tests
5. Respiratory system disorders I: ventilation control, diagnostic of ventilatory
dysfunctions
6. Respiratory system disorders II: gas exchange analysis; bronchomotricity tests
7. Lipid metabolism disorders diagnostic tests
8. Pathologic ECG: disorders in atrial and ventricular enlargements
9. Pathologic ECG II: disorders of impulse conduction
10. Pathologic ECG III: disorders of cardiac rhythm
11. Pathologic ECG IV: ST segment disorders
12. Cardiovascular disorders: diagnostic tests in myocardial infarction, heart
failure, hypertension
TOTAL LUCRARI PRACTICE

2
2
2

Lucrari practice (24 ore)

La stabilirea notei finale se iau n considerare

2
2
2
2
2
2
2
2
2
24

Ponderea n notare exprimat n

procente
(Total = 100%)

- rspunsurile la examen / colocviu (evaluarea final):

50%

- rspunsurile finale la lucrrile practice de laborator

35%

- testarea periodic prin lucrri de control

15%

- activitile gen teme / referate / eseuri / traduceri /

proiecte etc.

- alte activiti (PRECIZAI) : colocviu

Descriei modalitatea practic de evaluare final E/V (de exemplu: lucrare scris (descriptiv i
/ sau test gril i / sau probleme etc.), examinare oral, colocviu individual ori n grup, proiect,
etc.)
- Asignments (3) and midterm test
- Final examination: practical and written (60 MCQ) examination
Estimai timpul total (ore pe semestru) al activitilor de studiu individual pretinse
studentului
(completai cu 0 activitile care nu sunt cerute)
10
1. Descifrarea i studiul notielor de curs
8. Pregtire prezentri orale
0
2. Studiu dup manual, suport de curs

20

9. Pregtire examinare final

10

3. Studiul bibliografiei minimale indicate

10

10. Consultaii

10

11. Documentare pe teren

10

12. Documentare pe Internet

10

13. Alte activiti ....

10

14. Alte activiti ....

4. Documentare suplimentar n
bibliotec
5. Activitate specific de pregtire
SEMINAR i / sau LABORATOR
6. Realizare teme, referate, eseuri,
traduceri, etc.
7. Pregtire lucrri de control

TOTAL ore studiu individual (pe

semestru) = 165

References for the study of Pathophysiology

Required references
1. Colev Luca V., Mocanu V., Vornicu M., Musta G.T., Pathophysiology course,
Litografia UMF Iai, 2000
2. Colev Luca V., Mocanu V., Vornicu M., Musta G.T., Handbook of practical
pathophysiology, Litografia UMF Iai, 1999

Recommended references
1. Kumar V., Abbas A.K., Fausto N., Robbins & Cotran Pathologic Basis of Disease,
7th edition, Elsevier Health Sciences, 2004
2. Porth Carol Marttsen, Matfin Glenn, Essentials in pathophysiology: concepts of
altered health states, Philadelphia: Lippincott Williams & Wilkins, 2007
3. Porth Carol Marttsen, Matfin Glenn, Pathophysiology: concepts of altered health
states, 8th edition, New York: Wolters Kluwer, 2009
4. Riede U.N., Werner M., Color atlas of pathology, Stuttgart - New York,Thieme, 2004
5. Silbernagl S., Lang F., Color atlas of pathophysiology, Stuttgart - New York, Thieme,
2000
6. CHETA D.M. Preventing Diabetes: Theory, Practice and New Approaches, John
Wiley & Sons, Chichester, UK, 1999 (187 p.)
Data completrii: 2012

Coordonator of Patophysiology Department,

Prof. Dr. Magda Badescu