Beruflich Dokumente
Kultur Dokumente
14:783--801 1994 The International Society of Cerebral Blood Flow and Metabolism
Published by Raven Press, Ltd., New York
Summary:
783
784
D . EIDELBERG ET AL .
785
TABLE 1.
Patient No.
(age ; yr)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
(45)
(48)
(48)
(6 1 )
(69)
(4 1 )
(47)
(49)
(53)
(69)
(45)
(57)
(62)
(7 1 )
(72)
(4 1 )
(62)
(63 )
(63 )
(64)
(60)
(73 )
PD patients
UPDRS ratinga
Duration
(yr)
H&Y
Stage
BK
6
7
5
1
7
1
6
4
11
1
5
8
3
23
11
11
14
7
17
13
9
24
I
I
I
I
I
II
II
II
II
II
III
III
III
III
III
IV
IV
IV
IV
IV
V
V
2
2
3
3
2
3
1
5
7
5
13
7
8
4
2
11
15
7
11
8
20
8
2
2
0
2
2
1
6
5
1
3
1
0
0
0
0
8
1
5
6
1
1
6
1
0
2
1
1
4
4
1
2
5
2
4
8
1
2
1
9
9
5
2
18
7
3
-4
5
6
5
4
4
-4
-4
-5
4
-1
-2
2
2
-3
-3
2
2
1
1
-2
Medication(s)b
4
1, 4
1, 4
1, 4
1, 4
3
3
5
1 , 2,
3, 4
1, 2
1, 2
1
1 , 2,
1 , 2,
1 , 3,
1 : 2,
1 , 2,
1
1 , 2,
1 , 2,
1, 2
3, 4
3, 4
4
4
4
4
4
UPDRS summed clinical scores for bradykinesia (BK), tremor (T), and rigidity (R). Asymmetry (A) is the right-left difference in the
sum of the individual unilateral limb score s . Positive and negative values , respectively, denote right- and left-sided clinical predomi
nance.
b ( 1 ) Levodopa/carbidopa ; (2 ) dopamine2 agonists ; (3 ) anticholinergics ; (4) monoamine oxidase inhibitors ; (5) none .
a
786
D . EIDELBERG ET AL .
787
RESULTS
Glucose metabolism
788
D . EIDELBERG ET AL.
TABLE 2.
Cerebellum
Pons
Midbrain
Caudate
Lentiform
Thalamus
Med. temporal
Lat. temporal
Operculum
Sup. temporal
Med. frontal
Lat. frontal
Calcarine
Cuneus
Inf. parietal
Paracentral
GMR
Normal
(n = 20)
PD 1
(n = 1 0)
7 . 570. 1 1 )
5 . 1 1 (0 .90)
5 . 89 ( 1 . 24)
7 . 89 ( 1 . 2 1 )
8 . 6 1 0 . 1 9)
7 . 78 ( 1 . 14)
6 . 09 ( 1 . 15)
7 . 54 ( 1 . 3 1 )
8 . 75 ( 1 .44)
9 . 06 ( 1 . 55)
8 . 020.33)
8 . 78 ( 1 . 52)
1 0 . 24 ( 1 . 62)
9.91 (1 .61)
8 . 5 1 ( 1 . 28)
7 . 85 ( 1 . 14)
8 . 35 ( 1 . 25)
6.93 ( 1 . 14)
4 . 85 0.06)
5 . 75 (1 . 1 8)
7 . 28 (1 .03)
8 . 20 ( 1 . 1 6)
7 . 54 (1 .04)
5 . 64 (1 . 0 1 )
7 . 27 ( 1 . 22)
8 . 04 ( 1 . 1 7)
8 . 55 ( 1 . 22)
7 . 340. 39)
7 . 89 ( 1 . 36)
9 . 30 ( 1 . 8 1 )
8 . 84 (2.09)
7 . 87 ( 1 . 30)
6 .42 (2 .53)
7 . 82 ( 1 . 22)
PD2
(n = 12)
6.51
4 . 38
4 . 54
6.21
7 . 36
6.38
4.88
5 . 55
6.40
6 .95
5 . 87
6.21
7 . 58
6 . 96
6 . 24
5 . 78
6.41
SND
(n = 1 0)
(0 .94)
(0 . 68)
(0 .83)
( 1 .07)
( 1 . 30)
(0 . 78)
(0 . 89)
( 1 . 29)
(0 . 87)
( 1 . 1 0)
(0 . 89)
(0 .92)
( 1 . 50)
( 1 . 24)
(1 . 1 1)
( 1 . 04)
(0 . 89)
6 . 62
4.40
5 . 09
5 . 96
6.15
6.04
5 .95
6. 17
6 .45
6 .03
5 . 63
6.07
6 . 63
6.77
7 .06
7 . 60
7 . 02
(1 .01)
(0 . 60)
(0 . 68)
(0 . 85)
( 1 .06)
( 1 . 02)
( 1 .05)
(0 . 69)
(0 .78)
(0 . 76)
(0 . 7 1 )
(0 . 68)
(0 . 75)
(0 . 84)
(0 . 86)
(0 . 85)
(0 .70)
Pons
Midbrain
2.11
0.42
Profile
0.79
-2.08
-0 .40
1.31
Left hemisphere
Cerebellum
Caudate nucleus
Lentiform nucleus
Thalamus
Med. temporal
Lat. temporal
Operculum
Sup. temporal
Med. frontal
Lat. frontal
Occipital
Parietooccipital
Inf. parietal
Paracentral
1.52
0.46
1.22
1.04
-0. 27
-1.47
-0 . 5 5
-0 . 1 8
-0 . 74
-1.20
-0 . 29
-1.31
-0 .95
-1.15
0 . 86
0.12
-0 .78
-0 . 1 9
-1.39
-1 . 01
0.14
-0 .06
-0 . 1 3
0.20
2 .13
1.11
1.16
-0 .60
Right hemisphere
0 . 69
0. 1 1
-0 .62
-0. 3 5
1.53
1.19
-1.28
-0 .75
-1.36
-0 .37
-0 . 1 8
1.67
0 .95
-1.19
1.66
0 . 84
1.49
0.78
0.81
-0 .58
-0 .48
0.49
-0 . 65
-0 .86
-0 .42
-0 .97
0 . 03
-0 .79
1.34
-0 .43
-0 .70
-0 . 1 0
-1 .12
-1.73
-0 . 04
-0. 1 5
-0 .23
-0 . 1 3
1.99
0 . 86
0 . 65
-0 .47
The topographic profiles were identified by SSM analysis of bihemispheric rCMRglc data
combined group of 22 PD patients and 20 normal control subjects. Positive and negative
indicate regions of relative metabolic increases and decreases, respectively. Region weights
italicized ; those also associated with motor control networks are boldfaced. Med., medial ; lat.,
sup., superior; inf., inferior.
0.91
-0 . 24
-0 .88
-0 . 3 1
0.79
1 . 03
-1.05
0.08
-1.34
-0 .59
-0 . 28
1 .3 8
1 .23
-1.69
from a
values
;;. 1 are
lateral ;
789
790
D. EIDELBER G ET AL .
(A)
(B)
791
(C)
FIG. 1.
790.
C:
2
FIG. 2. Scatter diagram showing the SSF1
scores (see text) in normals (0) and in the P01
(.) and P02 (A) subgroups. M ean valuEls (::SO)
are displayed by vertical bars. SSF1 values were
significantly increased in the P02 subgroup
compared with the P01 subgroup and normals.
u..
CJ)
CJ)
0
tl
-1
-2
NORMAL
PD1
792
TABLE 4.
D . EIDELBERG ET AL .
Region weights on the two topographic
contrast profiles
Profile
2
Cerebellum
Caudate
Lentiform
Thalamus
Med. temporal
Lat. temporal
Operculum
Sup. temporal
Med. frontal
Lat. frontal
Occipital
Parietooccipital
Inf. parietal
Paracentral
-0. 1 9
-0.60
0.5 1
-2.30
1.76
-0.55
-0.0 1
-1.24
0.55
-0.05
0.69
0.50
-0. 1 0
1.04
-0.84
1.85
-0.67
-1.76
-1.80
0.21
0.32
0.20
0.42
0.06
0.86
0.30
0.93
-0.09
DISCUSSION
793
3
2
"l
u..,U
C/)
C/)
:1
:
.
f:
(;
-1
-2
-3
------
Normal
II-V
18
en
15
"
C
0..
::l
0
u
U)
>
.....
'5
'0,
i:i:
12
FIG. 4. Correlations in PO patients be
tween UPORS rigidity ratings .and SSF1
scores. A significant positive correlation
(r = 0.62, P < 0.01) was found between
these two variables.
o +----=,-----,-----._--r_--_.
-1.00
-0.50
0.00
0.50
1.00
1.50
2.00
2.50
3.00
SSF,
794
D. EIDELBERG ET AL .
(A)
3
2
.
u.
en
en
0
(
-1
I
I
. - ......
- - - - - - - - - - _
. . . .
-2
-3
NORMAL
PO
(8)
3
FIG. 5. Scatter diagram showing the subject
scores for the three topographic profiles (A,
SSF1; 8, SSF2; and C, SSF3) identified in a combined-group SSM analysis of the 10 SND patients (A), 10 age- and severity-matched PD patients (_), and 10 age-matched normal subjects
(0). (See text.) M ean values (SD) are displayed
by vertical bars. The discrimination line
(dashed) based on SSF1 (A) correctly identifies
9 of 10 members of the SND group and 9 of 10
members o f the age- and severity-matched PD
group.
SNO
u.N
en
en
-1
-2
-3
NORMAL
PO
SNO
(C)
M
U.
en
en
c'
c'
-1
-2
-3
NORMAL
PO
SNO
795
796
D . EIDELBERG ET AL .
797
798
D . EIDELBERG ET AL .
799
800
D. EIDELBERG ET AL .
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