TABLE OF

CONTENTS

www.gastrojournal.org

Vol. 146, No. 5

May 2014

Contents
1158 Is It Time to Recalibrate the MELD
Exception Points Attributed for
Hepatopulmonary Syndrome?

ON THE COVER
The Global Impact of HCV:
see Commentary on page 1145;
Editorial on page 1164; Review on
page 1176; and Articles on pages
1249, 1351, 1361, and 1373.

M. Ghabril and M. Lucey

See Goldberg DS et al on page 1256.

1160 Identifying Molecular Factors That

Contribute to Resolution of Liver Fibrosis

COVERING THE COVER

1139 A. W. Lowe and R. H. Moseley

J. P. Iredale and R. Bataller

See Yang L et al on page 1339.

PRESS HIGHLIGHTS
G. L. Su and K. Novak

Colorectal Cancer Incidence and Mortality Fall

Gene Fusion Found to Cause Fibrolamellar
Hepatocellular Carcinoma

1164 Hepatitis C Virus Replication

COV
Compartment Formation: Mechanism
and Drug Target
V. Chukkapalli and G. Randall
See Wang H et al on page 1373 and Madan V
et al on page 1361.

To read these and other Press Highlights

scan the QR code to the left or visit
http://bit.ly/Xc9xpv.

GASTROENTEROLOGY IN MOTION

COMMENTARIES
1143 Cellular and Molecular Gastroenterology and
Hepatology: The Evolution of AGA Publishing

1168 Cryorecanalization for In-stent

V
Recanalization in the Esophagus
M. Goetz, N. P. Malek, L. Kanz, and J. Hetzel

J. R. Turner, J. R. Goldenring, R. G. Wells,

L. M. Brounstein, and E. C. Dubnansky

1145 Impact of New Hepatitis C Treatments in

Different Regions of the World
COV
WWW

L. Wei and A. S. F. Lok

CLINICAL CHALLENGES AND IMAGES IN GI

1171 Upper Gastrointestinal Bleed: Old Is Not
Always Gold
K. Kumar, U. C. Ghoshal, and S. Mohindra

MENTORING, EDUCATION, AND

TRAINING CORNER

See page 1429 for answers.

1151 Developing a Fellowship Curriculum in

Womens Gastrointestinal Health

1173 A Diagnosis Thats Up in the Air

P. A. Hart, S. Sweetser, and T. H. Baron

D. Devuni and R. V. Chokshi

See page 1429 for answers.

EDITORIALS
1156 The Alcoholic Hepatitis Histologic Score:
Structured Prognostic Biopsy Evaluation
Comes to Alcoholic Hepatitis

1174 A 70-Year-Old Woman With Dysphagia

Beginning 6 Decades After Caustic
Ingestion

S. Liangpunsakul and D. E. Kleiner

T. Nunes, M. de Souza Chagas, and B. Biccas

See Altamirano J et al on page 1231.

See page 1430 for answers.

CME

CME quiz

Podcast

Video

Editorial accompanies this article

CGH

Related article in CGH

WWW

Additional online content available

COV

Cover

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1175 Is This an Infected Liver Cyst?

TABLE OF
CONTENTS

Y. Fukita, S. Adachi, and H. Ishibashi

See page 1431 for answers.

ELECTRONIC CLINICAL CHALLENGES

AND IMAGES IN GI
e1

Full Reports
ClinicalAlimentary Tract
1212 Inuence of Sucrose Ingestion on
Brainstem and Hypothalamic Intrinsic
Oscillations in Lean and Obese Women
L. A. Kilpatrick, K. Coveleskie, L. Connolly, J. S. Labus,
B. Ebrat, J. Stains, Z. Jiang, B. Y. Suyenobu,
H. E. Raybould, K. Tillisch, and E. A. Mayer

A Rare Cause of Epigastric Pain and

Diarrhea
I. Soykan, A. Ensari, and K. Karayalcin

e3

Large Abdominal-Pelvic Tumors:

A Diagnostic Conundrum

1222 Budesonide Is More Effective Than

Mesalamine or Placebo in Short-term
Treatment of Collagenous Colitis
WWW

S. Miehlke, A. Madisch, L. Kupcinskas,

D. Petrauskas, G. Bhm, H.J. Marks, M. Neumeyer,
T. Nathan, F. FernndezBaares, R. Greinwald,
R. Mohrbacher, M. Vieth, O. K. Bonderup
and the BUC-60/COC Study Group

M.h. Chang, M.h. Chew, and G.K. Chew

e6

Incidentally Found Unusual Polyp

on Cecum
H. R. Kim, J. J. Hyun, and H. S. Lee

e8

Some Like It Raw: An Unwanted Result

of a Sushi Meal
Y. Fukita, T. Asaki, and Y. Katakura

e10

ClinicalLiver
1231 A Histologic Scoring System for Prognosis
CME
of Patients With Alcoholic Hepatitis
E
WWW

Visual Disturbances in Total Parenteral

Nutrition Dependent Liver Transplant
Pediatric Patient
A. N. Benidir, S. Laughlin, and V. L. Ng

e12

Unusual Complication of Endoscopic

Cystogastrostomy
A. Ahmed, A. Bailey, and D. Agrawal

J. Altamirano, R. Miquel, A. Katoonizadeh,

J. G. Abraldes, A. DuarteRojo, A. Louvet, S. Augustin,
R. P. Mookerjee, J. Michelena, T. C. Smyrk, D. Buob,
E. Leteurtre, D. Rincn, P. Ruiz, J. C. GarcaPagn,
C. GuerreroMarquez, P. D. Jones, A. S. Barritt IV,
V. Arroyo, M. Bruguera, R. Baares, P. Gins,
J. Caballera, T. Roskams, F. Nevens, R. Jalan,
P. Mathurin, V. H. Shah, and R. Bataller
Editorial, page 1156.

1240 Effects of Tenofovir Disoproxil

Fumarate in Hepatitis B e AntigenPositive Patients With Normal Levels of
Alanine Aminotransferase and High
Levels of Hepatitis B Virus DNA
WWW

REVIEWS AND PERSPECTIVES

Reviews in Basic and Clinical
Gastroenterology and Hepatology

H. L. Y. Chan, C. K. Chan, A. J. Hui, S. Chan,

F. Poordad, T.T. Chang, P. Mathurin, J. F. Flaherty,
L. Lin, A. Corsa, A. Gaggar, G. M. Subramanian,
J. G. McHutchison, S. Lee, and E. J. Gane

1176 New Hepatitis C Therapies: The Toolbox,

COV
Strategies, and Challenges
J.M. Pawlotsky

1193 Hepatic Immune Regulation and Its

Involvement in Viral Hepatitis Infection
P. A. Knolle and R. Thimme

1249 A New Laboratory-Based Algorithm to

CGH
Predict Development of Hepatocellular
Carcinoma in Patients With Hepatitis C
COV
and Cirrhosis
WWW

ORIGINAL RESEARCH

H. B. ElSerag, F. Kanwal, J. A. Davila, J. Kramer,

and P. Richardson

Brief Report

See related article, Gopal P et al, on page

870 in CGH.

1208 Risk of Colorectal Cancer for Carriers of

Mutations in MUTYH, With and Without a
Family History of Cancer
WWW

A. K. Win, J. G. Dowty, S. P. Cleary, H. Kim,

D. D. Buchanan, J. P. Young, M. Clendenning, C. Rosty,
R. J. MacInnis, G. G. Giles, A. Boussioutas, F. A. Macrae,
S. Parry, J. Goldblatt, J. A. Baron, T. Burnett,
L. Le Marchand, P. A. Newcomb, R. W. Haile,
J. L. Hopper, M. Cotterchio, S. Gallinger, N. M. Lindor,
K. M. Tucker, I. M. Winship, and M. A. Jenkins

1256 Impact of the Hepatopulmonary Syndrome

P
MELD Exception Policy on Outcomes of
CME
Patients After Liver Transplantation: An
E
Analysis of the UNOS Database
WWW

D. S. Goldberg, K. Krok, S. Batra, J. F. Trotter,

S. M. Kawut, and M. B. Fallon
Podcast interview: www.gastro.org/
gastropodcast. Also available on iTunes.
Editorial, page 1158.

Basic and TranslationalAlimentary Tract

1351 Hepatitis C Virus Attenuates InterferonInduced Major Histocompatibility

COV
Complex Class I Expression and
Decreases CD8D T Cell Effector Functions

WWW

F. Rieder, I. Nonevski, J. Ma, Z. Ouyang, G. West,

C. Protheroe, G. DePetris, A. Schirbel, J. Lapinski,
J. Goldblum, T. Boneld, R. Lopez, K. Harnett, J. Lee,
I. Hirano, G. Falk, P. Biancani, and C. Fiocchi

1278 Increased Production of Retinoic Acid by

Intestinal Macrophages Contributes to
Their Inammatory Phenotype in
Patients With Crohns Disease

W. Kang, P. S. Sung, S.H. Park, S. Yoon,

D.Y. Chang, S. Kim, K. H. Han, J. K. Kim,
B. Rehermann, Y.J. Chwae, and E.C. Shin

1361 Inhibition of HCV Replication by

E
Cyclophilin Antagonists Is Linked to
Replication Fitness and Occurs by
COV
Inhibition of Membranous Web Formation
WWW

V. Madan, D. Paul, V. Lohmann, and

R. Bartenschlager

WWW

T. J. Sanders, N. E. McCarthy, E. M. Giles,

K. L. M. Davidson, M. L. R. Haltalli, S. Hazell,
J. O. Lindsay, and A. J. Stagg

1289 Nanoparticles With Surface Antibody

Against CD98 and Carrying CD98 Small
Interfering RNA Reduce Colitis in Mice

Editorial, page 1164.

1373 Oxysterol-Binding Protein Is a

E
Phosphatidylinositol 4-Kinase Effector
Required for HCV Replication Membrane
COV
Integrity and Cholesterol Trafcking
WWW

H. Wang, J. W. Perry, A. S. Lauring,

P. Neddermann, R. De Francesco, and A. W. Tai

WWW

B. Xiao, H. Laroui, E. Viennois, S. Ayyadurai,

M. A. Charania, Y. Zhang, Z. Zhang, M. T. Baker,
B. Zhang, A. T. Gewirtz, and D. Merlin

1301 PHLPP Is a Negative Regulator of RAF1,

Which Reduces Colorectal Cancer
Cell Motility and Prevents Tumor
Progression in Mice
WWW

Editorial, page 1164.

Basic and TranslationalPancreas

1386 Fascin Is Regulated by Slug, Promotes
V
Progression of Pancreatic Cancer in
Mice, and Is Associated With
Patient Outcomes
WWW

A. Li, J. P. Morton, Y. Ma, S. A. Karim, Y. Zhou,

W. J. Faller, E. F. Woodham, H. T. Morris,
R. P. Stevenson, A. Juin, N. B. Jamieson, C. J. MacKay,
C. R. Carter, H. Y. Leung, S. Yamashiro, K. Blyth,
O. J. Sansom, and L. M. Machesky

X. Li, P. D. Stevens, J. Liu, H. Yang, W. Wang,

C. Wang, Z. Zeng, M. D. Schmidt, M. Yang, E. Y. Lee,
and T. Gao

1313 Biomarkers of Coordinate Metabolic

Reprogramming in Colorectal Tumors
in Mice and Humans
WWW

S. K. Manna, N. Tanaka, K. W. Krausz,

M. Haznadar, X. Xue, T. Matsubara, E. D. Bowman,
E. R. Fearon, C. C. Harris, Y. M. Shah, and
F. J. Gonzalez

Basic and TranslationalBiliary

1397 Activating Mutations in PTPN3 Promote
Cholangiocarcinoma Cell Proliferation
and Migration and Are Associated With
Tumor Recurrence in Patients
WWW

Q. Gao, Y.J. Zhao, X.Y. Wang, W.J. Guo, S. Gao,

L. Wei, J.Y. Shi, G.M. Shi, Z.C. Wang, Y.N. Zhang,
Y.H. Shi, J. Ding, Z.B. Ding, A.W. Ke, Z. Dai,
F.Z. Wu, H. Wang, Z.P. Qiu, Z.A. Chen,
Z.F. Zhang, S.J. Qiu, J. Zhou, X.H. He, and J. Fan

Basic and TranslationalLiver

1325 Heme Exporter FLVCR1a Regulates Heme
Synthesis and Degradation and Controls
Activity of Cytochromes P450
WWW

F. Vinchi, G. Ingoglia, D. Chiabrando, S. Mercurio,

E. Turco, L. Silengo, F. Altruda, and E. Tolosano

1339 Vascular Endothelial Growth Factor

E
Promotes Fibrosis Resolution and
Repair in Mice
WWW

L. Yang, J. Kwon, Y. Popov, G. B. Gajdos, T. Ordog,

R. A. Brekken, D. Mukhopadhyay, D. Schuppan,
Y. Bi, D. Simonetto, and V. H. Shah
Editorial, page 1160.

CONTINUING MEDICAL EDUCATION

(CME) ACTIVITIES
e14

Exam 1: A Histologic Scoring System for

Prognosis of Patients With Alcoholic
Hepatitis

e15

Exam 2: Impact of the Hepatopulmonary

Syndrome MELD Exception Policy on
Outcomes of Patients After Liver
Transplantation: An Analysis of the
UNOS Database

TABLE OF
CONTENTS

WWW

1266 T-Helper 2 Cytokines, Transforming

Growth Factor b1, and Eosinophil
Products Induce Fibrogenesis and Alter
Muscle Motility in Patients With
Eosinophilic Esophagitis

AGA SECTION
TABLE OF
CONTENTS

1408 Our New PresidentJohn I. Allen, MD,

MBA, AGAF
L. Laine and R. A. Ganz

1413 AGA Institute Guidelines for Colonoscopy

Surveillance After Cancer Resection:
Clinical Decision Tool
American Gastroenterology Association

SELECTED SUMMARIES
1415 Response to Empiric Proton Pump
Inhibitor Therapy in Patients With
Esophageal Eosinophilia

1423 Website Review: Patient-Oriented

Websites (MedicineNet, WebMD,
Wikipedia, eMedicine, Department of
Veterans Affairs, and UpToDate) on
Hepatocellular Carcinoma
J. A. Marrero

1424 The Pancreapedia (http://www.

pancreapedia.org/)
E. Thrower

CORRESPONDENCE
1426 Natural History of Eosinophilic
Esophagitis in Asymptomatic Patients
W. ElMatary

J. W. Chen and J. H. Rubenstein

1417 Molecular Changes Leading to Gastric

Cancer: A Suggestion From Rare-Type
Gastric Tumors With GNAS Mutations
K. Ikuta, H. Seno, and T. Chiba

1426 Reply
A. Schoepfer and A. Straumann

1427 Liver and Atherosclerosis

T. Purnak, C. Efe, and O. Basar

1418 Diagnosing Irritable Bowel Syndrome

With a Combination of Biomarkers and
Psychomarkers

1427 Reply
M. S. Siddiqui

R. Sood and A. C. Ford

1420 Predictive Models for Hepatocellular

Carcinoma
M. Naveed, A. K. Waljee, and A. G. Singal

1428 Toll-like Receptor 2 Regulates Intestinal

Inammation by Controlling Integrity of
the Enteric Nervous System: Why Were
TLR3s Roles Not Tested?
Y. X. Yang, X. Chen, and H. T. Gan

PRINT AND DIGITAL MEDIA REVIEWS

1422 Motor Dysfunction, Etiology and
Pathogenesis of Gallstones

ANSWERS TO THE CLINICAL

CHALLENGES AND IMAGES IN GI
1429

C. Ko

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