A hypoglycemic herbal extract composition for reducing blood sugar levels

in mammals
WO 2009098702 A2
ABSTRACT
A hypoglycemic herbal extract composition for reducing blood sugar levels in mammals especially
humans suffering from diabetes mellitus comprising, dried aqueous extract of green young fruits
of Momordica Charantia; and dried aqueous extract other biological additives like herbs/ medicinal
plants Enicostemma Littorale, Eugenia Jambolana, Swertia Chirata, Trigonella Foenum,
Azadirachta Indica, Gymnema Sylvestre, Emblica Officinalis, Tinospora Cordifolia,
Picrorhiza Kurroa, and Curcuma Longa, dried extracts of Momordica Charantia and other
biological extracts are dried and mixed to obtain final composition.
DESCRIPTION (OCR text may contain errors)
TITLE OF INVENTION: A HYPOGLYCEMIC HERBAL EXTRACT COMPOSITION FOR REDUCING BLO D SUGAR
LEVELS IN MAMMALS
FILED OF THE INVENTION
The invention relates to herbal extract composition containing Motnordica Charantia and other
biological additives and use of this composition as hypoglycemic composition for reducing blood sugar
levels in mammals especially humans suffering from diabetes mellitus.
BACKGR OUND OF THE INVENTION
Diabetes mellitus;
The word diabetes was coined by Aretaeus (81-133CE) of cappadocia; The word is from the Greek
word diabainein and literally means "passing through", or "siphon", a reference to one of diabetes
'major symptoms-excessive urine discharge. The word became diabetes from the English adoption of
the medieval Latin diabetes, hi 1675 Thomas Willis added mellitus from the Greek word for honey (mel
in the sense of "honey sweet") when he noted that a person with diabetes's urine and blood has a
sweet taste. This had been noticed long before in ancient times by the Greeks, Chinese, Egyptians and
Indians. In 1776 it was confirmed that the sweet taste was because of an excess of a kind of sugar in
the urine and blood of people with diabetes. Passing abnormal amounts of urine is a symptom
common to several disorders (most commonly of the kidneys) and the single word diabetes has been
given to many of them. The most common of them are diabetes insipidus and the subject of this
article, diabetes mellitus.
Diabetes mellitus is a medical disorder characterized by persistent variable hyperglycemia (high blood
sugar levels) resulting either from inadequate secretion of the hormone insulin or from an inadequate
response by the body's cells to insulin. There are three kinds of diabetes mellitus, called type 1, type 2
and type 3, and some authors in the field of diabetes research identify a type 4 diabetes. The three
types of diabetes mellitus include: * Diabetes mellitus type 1 (previously called juvenile onset
diabetes, insulin-dependent diabetes mellitusIDDM). Type 1 diabetes is precipitated by a currently
unknown event that leads initially to decrease, and then to nil production of insulin. Type 1 diabetes
mellitus accounts for about 10% of all people with diabetes mellitus.
* Diabetes mellitus type 2 (previously called adult onset diabetes, obesity related diabetes or noninsulin dependent diabetes mellitus NIDDM), involves insulin resistance by the body's cells to the
action of normal insulin levels found in the bloodstream, and as the disease progresses, the production
and secretion of insulin may also diminish. Type 2 diabetes mellitus is the most common form of
diabetes, especially in highly developed countries, where it may account for as much as 90% of all
people with diabetes. Its causes are obscure, but are connected with heredity, body weight and
lifestyle (e.g., Western diet and obesity).
* Gestational diabetes ('diabetes type 3 ' designation rarely used in medical practice) is a condition
that occurs during pregnancy and is similar to type 2 diabetes in that it is related to a resistance of the
body's cells to insulin. The elevated blood glucose levels may result in abnormal increased fetal (baby)

weight, polyhydramnios (increased surrounding amniotic fluid caused by increased fetal urination),
fetal jaundice and low blood sugars after delivery and rarely intra-uterine death. Approximately 40% of
women who had gestational diabetes will develop full type 2 diabetes within 5-10 years after delivery.
Diabetes mellitus is an insidious disease for which there is presently no cure. Mammals afflicted with
diabetes mellitus will, unless the glucose level in the blood is controlled, ultimately suffer heart
attacks, strokes, loss of eyesight, loss of limbs and ultimately may die as the result of this disease.
Humans who suffer from this disease will usually have blood glucose levels in two principal categories,
i.e. those who have glucose levels of higher than 150 and are thus termed "insulin-dependent" and
those with glucose levels of 110-140 who are termed "non-insulin dependent".
Insulin-dependent diabetics must have insulin administered to them in a very rigorous, disciplined
manner and must have snacks between meals since it is necessary to maintain the proper level of
insulin in the bloodstream, i.e. undesirable side effects are experienced if the insulin level is too high
and the disease will continue unabated if the insulin level is too low.
The non-insulin dependent diabetes sufferer must follow a disciplined program of diet and exercise to
avoid the necessity of taking medication to control blood glucose levels. However, many non-insulin
dependent diabetes sufferers experience difficulty in conscientiously following such program and will
ultimately fall into the insulin- dependent category sooner or later.
There is a long-felt need for an herbal composition, Le. a natural, holistic edible composition, which will
serve as a hypoglycemic agent and maintain blood glucose levels below the levels obtainable by
insulin administration. Such need has especially been true in respect to heavy-set persons as well as
those who suffer side effects when taking insulin or synthetic hypoglycemic preparations as well as by
those whose life styles are such that they are unwilling or unable to adhere to a rigorous exercise/ diet
program throughout their lives.
DESCRIPTION OF THE PRIOR ART
Many patents applications and Patents teach use of the herbal compositions for the treatment of
diabetes.
U.S. Patent No 7,014,872 teaches use of the extract otMomordica Charantia. The invention disclosed in
this Patents is related to a herbal health protective, promotive and disease preventive nutraceutical
herbal f ormulation(s) for diabetics, and also relates to a process for the preparation of a herbal health
protective, promotive and disease preventive nutraceutical herbal formulation as food supplement to
ameliorate the general health of diabetics, said formulation comprises the base product of microwave
roasted seed powders mixture from selected genera of Glycine, Cicer, Phaseolus, Cyamompsis,
Mucuna, Hordeum, Amaranthus and Fagopyrum, fortified with herbs/ medicinal plants used are
selected from the genera of Gymnema, Momordica, Syzgium, Pterocarpus, Trigonella, Cinnamomum,
Withania, Coccinia, Pueraria, Asparagus, Boerhaavia and Aegle and also some other ingredients like
Piper longum, Chlorophytum tuberosum, Curcuma longa and Elettaria cardamomum were also added
to get the final nutraceutical product(s); the nutraceuticals are with optimum nutrition, non toxic,
natural herbal plant products, easy to digest, have health protective and promotive properties to
ameliorate the general health and vigor of diabetics. Patent application No. WO03055558 discloses
use of the Enicostemma Littorale in the herbal composition. The invention relates to a synergistic
herbal composition for the treatment of bronchial asthma and a process for preparing the same. The
said composition comprises the following herbs: Achyranthes aspera, Woodfordia furiticosa, Solanum
xanthocarpum, Justicia adhatoda, Acacia arabica Zingiber officinalis, Syzygium aromaticum bud,
Curcuma longa, Holarrhena antidysentercia, Enicostemma littorale.
ILS.Patent application No. US2001021401 discloses use of the Eugenia Jambolana as herbal
therapeutic product for controlling diabetes mellitus comprising at least one hypoglycemic compound
extracted from the pulp of fruit Eugenia jambolina. The said product is prepared from the pulp of the
fruit Eugenia jambolina comprising cleaning and drying the fruit to remove the extraneous material
from the outer layer of the said fruit, deseeding the said fruit, soaking the de-seeded pulp in water,
mixing the said mixture of water and pulp and keeping it overnight in controlled cooled conditions to
maintain the activity of hypoglycemic compounds.

United States Patent No.6080401 teaches an improved preparation of a drug having a known efficacy
at known therapeutic dosage in the treatment of a disease or disorder in humans and animals, wherein
the improvement comprises Swertia Chirata and other herbs.
Korean Patent application No KR20040081733 is related to a pharmaceutical composition containing a
fermentation product of the extract of Banaba (Lagerstroemia spesiosa L.), Fenugreek (Trigonella
foenum-graecum L.) and Bitter Mellon as an effective ingredient is provided. The composition exhibits
strong blood glucose-reducing activity and diabetic complications-reducing activity and has safety to
the human body. Therefore, the composition is used for the prevention and treatment of diabetes and
the reduction of diabetic complications Another U.S. Patent discloses a medical composition
comprising Trigonella foenum- graecum L for the purpose of a significant reduction in serum glucose
due to the regeneration of pancreatic islet cells.
Patent application No. WO2006030426 discloses use of Azadirachta Indica in the herbal composition.
The invention provides an herbal composition comprising a plant extract from Azadirachta indica, Aloe
vera and cinnamon, useful for the treatment of diabetes and type II diabetes associated complications
such as atherosclerosis, hypertension, diabetic retinopathy, diabetic nephropathy, diabetic
polyneuropathies, thyroid disorders, leg ulcers, diabetic foot and liver diseases, and for improving the
immune function in a diabetic patient.
Patent application No. WO2005076750 teaches about a novel synergistic herbal formulation for
diabetes cure comprising extracts from selected Indian medicinal herbs Azadirachta Indica,
Momordica Charentia, Embtica Officinalis, Gymnema Sylvestres, Trigonella FoenumGracum, Curcuma Longa, Garcinia Camboga, Commiphor Mukul and Ocimum Sanctum with
active ingredients and mixed in proportion without using any external solvents to produce
hypoglycemic effect without causing hypoglycemia. The invention relates to a method of extracting
and standardizing the extract of claimed herbs into a synergistic herbal formulation. The invention
further relates to the method of administering.
U.S.Patent No. US 5900240 teaches use of Gymnema Sylvestre in an edible composition comprising a
mixture of at least two herbs selected from the group consisting of Syzygium curnini, Gymnema
sylvestre, Momordica charantia and Solanum melongena. Preferably, the composition comprises a
mixture of Syzygium cumini and Momordica charantia. A mixture of Syzygium cumini, Gymnema
sylvestre and Momordica charantia is particularly preferred. The herbal mixtures are useful as dietary
supplements and are especially useful for lowering the glucose level of the blood in mammals,
particularly humans suffering from diabetes mellitus. United States Patent 7250181 discloses
polyhebral composition containing Emblica Officinalis.
Patent application No. WO0172316 describes an edible Ayurvedic herbal composition for reducing
blood sugar levels in humans, specially suffering from diabetes mellitus comprising a mixture of
ingredients selected from the group consisting of Cinnamomum zeylanicum, Artocarpus heterophyllus,
Salacia reticulata, Tinospora cordifolia and Pterocarpus marsupium. The mixture of the ingredients of
the five selected herbs present in therapeutically effective proportions depending on the required
strength of the mixture to treat abnormal levels of blood sugar and diabetes mellitus. United States
Patent 20070065456 tecahes use of Picrorhiza Kurroa as a constituent of Nutritional supplement
formulations are disclosed, such as nutritional supplement formulations that include Wasabia japonica.
Methods for using the same to supplement a human diet are also disclosed
U.S. Patent application US2007042062 teaches about a novel herbal preparation comprises of Glycine
max active fraction containing 7S globulin protein extract, Curcuma longa and Zingiber officinale Linn,
rhizome extract used in treatment of diabetes and diabetic related diseases.
In Chinese Patent No CN1631379 the invention provides a medicinal composition for treating diabetes,
which is prepared from pancreatic of plateau yak, goldthread root, Swertia, curcuma longa, areca-nut,
and tartary buckwheat by a predetermined weight proportion. The invention also provides the method
for preparation and use of the pharmaceutical composition.
OBJECT OF THE INVETION

The main object of the present invention relates to the herbal composition contains Momordica
Charantia for reducing blood sugar levels in mammals especially humans suffering from diabetes
mellitus.
Another object of the present invention is to provide an herbal health protective nutraceutical
formulation, which further comprises biological additives that forms synergistic effect for the
treatment of diabetes.
Still another object of the present invention is to develop health protective and disease preventive
nutraceutical formulation, to ameliorate the general health of diabetics, as food supplements with
specific functional attributes by fortifying nutritional base material with herbs/ medicinal plants.
SUMMARY OF THE INVENTION
The present invention is related to the herbal composition of Motnordica Charantia along with the
other biological additives. The extract of the Motnordica Charantia is mixed with the other biological
additives such as Enicostemma Littorale, Eugenia Jambolana, Swertia Chirata, Trigonella Foenum,
Azadirachta Indica, Gymnema Sylvestre, Emblica Officinalis, Tinospora Cordifolia, Picrorhiza Kurroa,
and Curcuma Longa.
The various parts of these plants are such as leaves, fruits, flowers, steam; roots are used for the
extraction.
The extraction of the biological additives along with the main ingredients of the herbal composition is
carried in water at the temperature around 1000C till it reduces to the particular concentration.
The extracts/ residue such obtained after boiling the plant parts of the main ingredient and other
biological additives are dried at room temperature. After drying all the residues of the plant extracts is
pulverized to the fine powder, and mixed in the particular ratio. The mixture of the dried powder of the
plant extracts which is pre- mixed in particular ratios is filled in the capsules of the various strength.
The capsules are finally administered as the dosage forms. DETAILED DESCRIPTION
Accordingly, the present invention provides a herbal health protective, promotive and disease
preventive extract composition useful as ameliorate the general health of people having diabetics with
optimum nutrients and also help to control the blood sugar level, wherein the said composition
comprising extract of plant parts leaves, fruits, seeds, steam, roots, flowers. The composition is varied
in the mixture form 10- 90% by wt. Also, the present invention provide composition^) used as herbal
health protective, promotive extract composition for diabetics, said composition(s) comprising boiled
seed powders, of biological additives or herbs/ medicinal plants extract of Enicostemma Littorale,
Eugenia Jambolana, Swertia Chirata, Trigonella Foenum, Azadirachta Indica, Gymnema Sylvestre,
Emblica Officinalis, Tinospora Cordifolia, Picrorhiza Kurroa, and Curcuma Longa
The present invention also provide a process for the preparation of herbal health protective, promotive
and disease preventive nutraceutical composition^) useful as food supplement to ameliorate the
general health of diabetics with optimum nutrients and also helps to control the blood sugar .
Momordica Charantia is the key ingredient of the herbal extract; the green young fruits of the plant
are used in this herbal extract composition.
Bitter Melon, also known, as Karela is an herb that helps regulate blood sugar levels and keeps
body functions operating normally. It contains Gurmarin, a polypeptide considered to be similar to
bovine insulin, which has been shown in experimental studies to achieve a positive sugar regulating
effect by suppressing the neural response to sweet taste stimuli. Momordica Charantia's principle
constituents are lectins, charantin and momordicine. The fruits have long been used in India as a folk
remedy for diabetes mellitus. Lectins from the bitter gourd have shown significant antilipolytic and
lipogenic activities.
The herbal extract the fruits of Momordica Charantia the plant is prepared by boiling the fruits of the
plant in the boiling water and reducing the contents to the 30% of the more preferably to the 20% and
most preferably to the 10% of the weight of the initial weight of the fruits of Momordica Charantia.
Enicostemma littorale fresh green leaves of this plant are boiled in water to obtain the extract.
Enicostemma littorale has curative property for the diabetes patient, which is evidenced form simple
experiment such as Enicostemma littorale (Gentianaceae) is administered to 84 patients with Type 2
Diabetes for three months.
Estimation of various biochemical parameters showed that E. littorale reduced blood glucose as well as
serum insulin levels and prevented the progression of complications in diabetic patients. Significant

improvement in kidney function, lipid profile and blood pressure was observed suggesting that E.
littorale is an effective herbal anti-diabetic. The herbal extract the leaves of Enicostemma littorale the
plant is prepared by boiling the leaves of the plant in the boiling water and reducing the contents to
the 30% of the more preferably to the 20% and most preferably to the 10% of the weight of the initial
weight of the leaves of Enicostemma littorale.
Eugenia Jamboana seeds are pulverized and boiled in water to obtain the herbal extract of the
Eugenia Jambolana.
Leaves, seeds of the Eugenia Jambolana, posseses properties Extract of Eugenia jambolana leaves,
seeds exhibited significant hypoglycemic activity in normal and hyperglycemic rabbits. 20-30 Percent
reduction in blood sugars of two volunteer patients (who consumed decoction of 6 or 12 g of the
leaves) was also observed. Maximum reductions in blood sugars of human volunteers were observed
after 2 hours of administration. Seed powder of Eugenia jambolana given in a dose of 12 Gms daily in
three divided doses for three months showed marked symptomatic relief, which progressively
increased with the duration of treatment.
The herbal extract the seeds of the plant is prepared by boiling the seeds of the plant in the boiling
water and reducing the contents to the 30% of the more preferably to the 20% and most preferably to
the 10% of the weight of the initial weight of the seeds of Eugenia Jambolana.
Swertia Chirata fresh leaves of this plant are boiled in water to obtain the extract. Swertia chirayita
(Chirata) has antidiabetic activity. Researchers studied the effects of the hypoglycemic agent;
swerchinin in normal as well as diabetic rats. Except in rats with severe pancreatic damage, swerchinin
showed effective glucose lowering. The ethanolic extract of S.chirayita exhibits hypoglycemic activity.
The hexane fraction containing swerchirin, the main hypoglycemic principle, induced a significant fall
in blood sugar in albino rats.
The herbal extract the leaves of Swertia Chirata the plant is prepared by boiling the leaves of the plant
in the boiling water and reducing the contents to the 40% of the more preferably to the 30% and most
preferably to the 15% of the weight of the initial weight of the leaves of Swertia Chirata

Trigonella Foenum, seeds of this plant are pulverized to fine powder and boiled in water to obtain
the extract.
Fenugreek is a spice commonly used in India and the Middle East in cooking. Numerous studies have
shown that fenugreek can reduce blood sugar and cholesterol levels in individuals with diabetes.
Fenugreek seeds exert hypoglycemic effects by stimulating glucose-dependant insulin secretion from
pancreatic cells.
The herbal extract the leaves of Trigonella Foenum the plant is prepared by boiling the seeds of the
plant in the boiling water and reducing the contents to the 30% of the more preferably to the 20% and
most preferably to the 10% of the weight of the initial weight of the seeds of Trigonella Foenum.
Azadirachta Indica fresh leaves are crushed in to the small pieces and boiled in water to obtain the
extract.
Diabetes is a disease of excess sweetness so bitter herbs and foods must be used to counteract the
imbalance. Azadirachta Indica being very bitter was often used to treat diabetes in Ayurved. Modern
clinical studies reveal that Azadirachta Indica has been affective in treating and preventing Diabetes.
Azadirachta Indica significantly and consistently reduced insulin requirements for nonkeytonic, insulin
fast, and insulin sensitive forms of Diabetes. Because of the numerous and successful clinical studies
with
Azadirachta Indica on Diabetes.
The herbal extract the crushed leaves of Azadirachta Indica the plant is prepared by boiling the leaves
of the plant in the boiling water and reducing the contents to the 30% of the more preferably to the
20% and most preferably to the 10% of the weight of the initial weight of the leaves of Azadirachta
Indica.
Gymnema Sylvestre fruits are dried and grounded to the uniform size and boiled in water
to obtain herbal extract.

Gymnema Sylvestre, also known as Gurmar and Meshashringi, whose Hindi name literally means
'sugar destroyer1, has been used in Ayurveda for several centuries to regulate sugar metabolism. The
hypoglycemic (blood sugar-lowering) action of gymnema leaves was first documented in the late
1920s. This action is gradual in nature, differing from the rapid effect of many prescription
hypoglycemic drugs. Gymnema leaves raise insulin levels by regeneration of the cells in the pancreas
that secrete insulin. Other research has shown that gymnema also improves uptake of glucose into
cells by increasing the activity of the glucose utilizing enzymes, and prevents adrenaline from
stimulating the liver to produce glucose, thereby reducing blood sugar levels. The leaves are also
noted for lowering serum cholesterol and triglycerides. It also abolishes the taste of sugar, which
effectively suppresses and neutralizes the craving for sweets. The herbal extract the crushed fruits of
Gymnema Sylvestre the plant is prepared by boiling the fruits of the plant in the boiling water and
reducing the contents to the 30% of the more preferably to the 20% and most preferably to the 10% of
the weight of the initial weight of the fruits of Gymnema Sylvestre.
Emblica Officinalis dried fruits of this plant are boiled in water to obtain extract. This herb, due to its
high vitamin C content, is effective in controlling diabetes. It stimulates the pancreas and enables it to
secret insulin, thus reducing blood sugar levels. The herbal extract the crushed dried fruits of Emblica
Officinalis the plant is prepared by boiling the dried fruits of the plant in the boiling water and reducing
the contents to the 30% of the more preferably to the 20% and most preferably to the 10% of the
weight of the initial weight of the dried fruits of Emblica Officinalis. Tinospora Cordif olia fresh vines are
dried and grounded. These are then boiled in water to obtain extract.
T. Cordif olia is widely used in Indian Ayurvedic medicine for treating Diabetes. Oral administration of
T.Cordif olias' root extract to alloxan rats caused a significant reduction in blood glucose levels. It has
been studied that the daily administration of T.Cordif olia decreases the blood glucose level, and
increases glucose tolerance.
The herbal extract the crushed fresh vines of Tinospora Cordif olia the plant is prepared by boiling the
fresh vines of the plant in the boiling water and reducing the contents to the 30% of the more
preferably to the 20% and most preferably to the 10% of the weight of the initial weight of the fresh
vines of Tinospora Cordif olia.
Picrorhiza Kurroa seeds are grounded and boiled water to obtain the extract. Picrorhiza Kurroa is known
to be useful in the maintaining good health of the liver is an extremely essential organ in maintaining
glucose homeostasis in the body. It maintains a normal blood glucose concentration by controlling
glycogenesis and glycogenolysis. Picorrhiza kurroa exerts its hepatoprotective & corrective actions due
to its glycosides, picrosides II & I.
The herbal extract the crushed dried seeds of Picrorhiza Kurroa the plant is prepared by boiling the
seeds of the plant in the boiling water and reducing the contents to the 30% of the more preferably to
the 20% and most preferably to the 10% of the weight of the initial weight of the seeds of Picrorhiza
Kurroa.

Curcuma Longa dried roots are pulverized and extracted in water to obtain the extract.
In the traditional system of medicine, Ayurveda, several spices and herbs are thought to possess
medicinal properties. Among the spices, turmeric rhizomes (Curcuma Longa) are used as flavoring and
coloring agents in the Indian diet everyday
Alloxan was used to induce diabetes. Administration of turmeric or curcumin to diabetic rats reduced
the blood sugar, Hb and glycosylated hemoglobin levels significantly. Turmeric and curcumin
supplementation also reduced the oxidative stress encountered by the diabetic rats. This was
demonstrated by the lower levels of TBARS (thiobarbituric acid reactive substances), which may have
been due to the decreased influx of glucose into the polyol pathway leading to an increased NADPH/
NADP ratio and elevated activity of the potent antioxdiant enzyme GPx.
Moreover, the activity of SDH (sorbitol dehydrogenase), which catalyzes the conversion of sorbitol to
fructose, was lowered significantly on treatment with turmeric or curcumin.
The herbal extract the dried roots of Curcuma Longa the plant is prepared by boiling the leaves of the
plant in the boiling water and reducing the contents to the 40% of the more preferably to the 30% and

most preferably to the 15% of the weight of the initial weight of the dried roots of Curcuma Longa. The
extracts obtained of Momordica Charantia and other biological additives, which is in the form of the
thick paste. Then it allows drying by evaporation in a complete hygienic environment.
After complete drying the extracts are pulverized in to the fine powder and mixed together in different
ratio.
The mixture obtained after mixing the all the ingredients heated to dry in electric tray heaters. The
finely derived mixed powder composition of herbal extracts is ready to put in capsulated dosage form.
Capsules of the different capacity are prepared from such composition, apart form the capsules form
these may be directly used as the medicines or mixed other pharmaceutically acceptable vehicles.
EXAMPLES 1
Momordica Charantia is mixed with the other biological additives such as Enicostemma Iittorale,
Eugenia Jambolana, Swertia Chirata, Trigonella Foenum, Azadirachta Indica, Gymnema Sylvestre,
Emblica Officinalis, Tinospora Cordif olia, Picrorhiza Kurroa, Curcuma Longa,
Process to obtain the extracts
Following procedure is to create approximately 200 kg. of mix to produce about 2000 bottles
(approx.4, 00,000 capsules).
STEP 1: Above named ingredients in their original forms are picked by experienced people, brought in
our plant and thoroughly washed and steamed before processing 500 kilograms of Momordica
Charantia (red or yellow once must be avoided) boiled till it becomes 1/10* i.e.50 kgs. Remains known
as residue or extract 1. 100 Kgs. of Enicostemma Littorale fresh green leaves boiled till it remains
1/10* i.e. 10 kgs The remains is part of the biological additives. 100 kilograms of Eugenia Jambolana
(seeds grounded) boiled till it becomes l/lO* i.e. 50 kgs. The remains is part of the biological additives.
100 kilograms of Swertia Chirata fresh green leaves boiled till it remains 1/6.5* i.e. 15 kgs .The
remains is part of the biological additives.
100 kilograms of Azadirachta Indica fresh green leaves boiled till it remains l/lO* i.e. 10 kgs. The
remains is part of the biological additives.
100 kilograms of Trigonella Foenum, (seeds grounded) boiled till it remains 1/10* i.e. 10 kgs. The
remains is part of the biological additives.
100 kilograms of Gymnema Sylvestre (fruits dried and grounded) boiled till it remains
1/10* i.e.10 kgs. The remains is part of the biological additives.
100 kilograms of Emblica Officinalis (fruits dried and grounded) boiled till it remains
1/10* Le.10 kgs. The remains is part of the biological additives.
100 kilogram of Curcuma Longa (dried and grounded roots) boiled till it remains 176.5 th i.e. 15 kgs.
The remains is part of the biological additives.
100 kilogram of Tinospora Cordifolia (seeds grounded) boiled till it remains 1/10* i.e. 10 kgs. The
remains is part of the biological additives.
500 kilogram of Picrorhiza Kurroa, (fresh vines dried and grounded) boiled till it remains l/lO* i.e. 10
kgs. The remains is part of the biological additives.
We use stainless steel vessels for above boiling process.
STEP 2:
Now, this extracts/ residue which is in form of thick paste dried in natural heat (it can be dried in
artificial heat in during different circumstances) While drying utmost care is taken to cover the residue
avoiding dust and foreign particles. Once dried these ingredients are then again grounded to a fine
powder and put in the mixture according to their formulation ratio.
Final mixture is now heated and dried in electric tray heaters. Now it is ready to be filled in capsules.
STEP 3:
Before filling the powder in the capsules and agreed quantity along with the batch no is sent to the
recognized laboratory just to make sure that it is absolutely safe for human consumption.
Once satisfied, the mixture then is filled in vegetarian capsules (the size of the capsule is zero) each
capsule contains 0.5 Gms. of the mixture.
Again about 500 capsules send to the laboratory for final check.
STEP 4:
Capsules are then packed in a polythene bag with drying agent and then sealed and packed and
sealed in a plastic jar.

The normal suggested dose for diabetics is 2 capsules three times a day. The result has shown that the
best possible result can be obtained to re-activate the pancreas within three months time.
The foregoing detailed description has been directed to particular embodiments of the invention for
the purposes of illustration and explanation. It will be apparent, however, to those skilled in this art
that modifications and changes in the compositions and processes set forth will be possible without
departing from the scope and spirit of the invention.
LAIMS (OCR text may contain errors)
WE CLAIM
1. A hypoglycemic herbal extract composition for reducing blood sugar levels in mammals especially
humans suffering from diabetes mellitus comprising;
dried aqueous extract of green young fruits of Momordica Cliarantia ; and
dried aqueous extract other biological additives like herbs/ medicinal plants Enicostemma Littorale,
Eugenia Jambolana, Swertia Chirata, Trigonella Foenum, Azadirachta Indica, Gymnema Sylvestre,
Emblica Officinalis, Tinospora Cordifolia, Picrorhiza Kurroa, and Curcuma Longa,
dried extracts of Momordica Charantia and other biological extracts are dried and mixed to obtain final
composition,
2. A hypoglycemic herbal extract composition for reducing blood sugar levels in mammals especially
humans suffering from diabetes mellitus of claim 1 wherein the aqueous extract of Momordica
Charantia is obtained by steaming the green young fruits in water and reducing it to 1/10 of the total
weight of the initial weight of fruits taken.
3. A hypoglycemic herbal extract composition for reducing blood sugar levels in mammals especially
humans suffering from diabetes mellitus of claim 1 wherein the aqueous extract of biological additives
like Enicostemma Littorale, Eugenia Jambolana, Trigonella Foenum, Azadirachta Indica, Gymnema
Sylvestre, Emblica Officinalis, Tinospora Cordifolia, Picrorhiza Kurroa is obtained by steaming the plant
parts in water and reducing it to 1/10 of the total weight of the initial weight of plant parts taken.
4. A hypoglycemic herbal extract composition for reducing blood sugar levels in mammals especially
humans suffering from diabetes mellitus of claim 1 wherein the aqueous extract of biological additives
like Curcuma Longa, Swertia Chirata is obtained by steaming the plant parts in water and reducing it
to 15% of the total weight of the initial weight of plant parts taken
5. A hypoglycemic herbal extract composition for reducing blood sugar levels in mammals especially
humans suffering from diabetes mellitus of claim 1 wherein fresh green leaves of Enicostemma
Littorale, Swertia Chirata, Azadirachta Indica are used to prepare extract.
6. A hypoglycemic herbal extract composition for reducing blood sugar levels in mammals especially
humans suffering from diabetes mellitus of claim 1 wherein dried pulverized seeds of Eugenia
Jambolana, Trigonella Foenum, Picrorhiza Kurroa are used to prepare extract.
7. A hypoglycemic herbal extract composition for reducing blood sugar levels in mammals especially
humans suffering from diabetes mellitus of claim 1 wherein fruits of Gymnema Sylvestre, Emblica
Officinalis are used to prepare extract.
8. A hypoglycemic herbal extract composition for reducing blood sugar levels in mammals especially
humans suffering from diabetes mellitus of claim 1 wherein fresh vines/ roots of Tinospora Cordifolia,
Curcuma Longa are dried and grounded and used to obtain extract.
9. A hypoglycemic herbal extract composition for reducing blood sugar levels in mammals especially
humans suffering from diabetes mellitus of claim 1 dried extracts of Momordica Charantia other
biological additives are mixed in the ratio 10-90 or 90-10% w/ V to obtain the composition.
10. A hypoglycemic herbal extract composition for reducing blood sugar levels in mammals especially
humans suffering from diabetes mellitus of claim 1 wherein dried extract mixture composition is filled
in the capsules as dosage form.
11. A hypoglycemic herbal extract composition for reducing blood sugar levels in mammals especially
humans suffering from diabetes mellitus of claim 1 wherein capsules are of 500-1000 mg strengths.
12. A process for the preparation of a hypoglycemic herbal extract composition for reducing blood
sugar levels in mammals especially humans suffering from diabetes mellitus comprises;
(a) extraction of green fruits of Momordica Cliarantia to obtain residue/ extract,
(b) extraction of different plant parts of biological additives,,
(c) mixing the extracts of (a) and (b),

(d) filling mixture extract into capsules of the 1000-500 mgs strengths,
13. A process for the preparation of a hypoglycemic herbal extract composition for reducing blood
sugar levels in mammals especially humans suffering from diabetes mellitus of claim 12 comprises
wherein biological extracts are Enicostemma littorale, Eugenia Jambolana, Trigonella Foenum,
Azadirachta Indica, Gymnema sylvestre, Emblica officinalis, Tinospora cordifolia, Picrorhiza kurroa is
obtained by steaming the plant parts in water and reducing it to 1/10 of the total weight of the initial
weight of plant parts .
14. A process for the preparation of a hypoglycemic herbal extract composition for reducing blood
sugar levels in mammals especially humans suffering from diabetes mellitus of claim 12 comprises
wherein fresh green leaves of Enicostemma Littorale, Swertia Chirata, Azadirachta Indica are used to
prepare extract.
15. A process for the preparation of a hypoglycemic herbal extract composition for reducing blood
sugar levels in mammals especially humans suffering from diabetes mellitus of claim 12 comprises
wherein fresh vines/ roots of Tinospora Cordifolia, Curcuma Longa are dried and grounded and used to
obtain extract.
16. A process for the preparation of a hypoglycemic herbal extract composition for reducing blood
sugar levels in mammals especially humans suffering from diabetes mellitus of claim 12 comprises
wherein fruits of Gymnema Sylvestre, Emblica Officinalis are used to prepare extract.
17. A process for the preparation of a hypoglycemic herbal extract composition for reducing blood
sugar levels in mammals especially humans suffering from diabetes mellitus of claim 12 comprises
dried pulverized seeds of Eugenia Jambolana, Trigonella Foenum, Picrorhiza Kurroa are used to prepare
extract.
18. A process for the preparation of a hypoglycemic herbal extract composition for reducing blood
sugar levels in mammals especially humans suffering from diabetes mellitus of claim 12 dried herbal
extracts are mixed with the ratio of 10-90-90-10w/w of the Momordica Charantia and biological
extracts.
19. A process for the preparation of a hypoglycemic herbal extract composition for reducing blood
sugar levels in mammals especially humans suffering from diabetes mellitus of claim 12 mixture of the
herbal extracts filled in capsules.
20. A process for the preparation of a hypoglycemic herbal extract composition for reducing blood
sugar levels in mammals especially humans suffering from diabetes mellitus of claim 12 as described
herein with the descriptions and examples.