Beruflich Dokumente
Kultur Dokumente
in a biologically important molecule; specifically : one with mutagenic activity that inhibits cell
division and growth and is used to treat some cancers
Cyclophosphamide
Undergoes hepatic
Lymphoma, mammary
Nausea, vomiting
biotransformation to
adenocarcinoma,
(infrequent), moderate
active metabolites
sarcomas,
to severe
lymphocytic leukemia
myelosuppression,
alkylation leads to
sterile hemorrhagic
cystitis
cross-linking of DNA
strands.
Melphalan
Nausea, vomiting,
anorexia, moderate
linking of DNA
myelosuppression (may
strands
be more
myelosuppressive in cats)
Chlorambucil
leukemia, small-cell
moderate
linking of DNA
lymphoma
myelosuppression
Nausea, vomiting,
tumor, histiocytic
moderate to severe
linking of DNA
sarcoma, CNS
myelosuppression (may
neoplasias, multiple
myeloma
hepatotoxicity,
nephrotoxicity, pulmonary
toxicity
alkylating agents
Streptozotocin
Inhibits DNA
Insulinoma
synthesis; high
cells
hepatotoxicity, nausea
(immediate and delayed),
vomiting, mild
myelosuppression
Lymphoma, sarcomas
biotransformation to
vomiting, phlebitis,
active metabolites
moderate
myelosuppression,
inhibits RNA
hepatotoxicity, anecdotal
synthesis
Ifosfamide
Analogue of
Various sarcomas
Nausea, vomiting,