Drug Name

Generic Name
Fluphenazine
hydrochloride
Brand Name
Prolixin
Permitil

Therapeutic
Class
Antipsychotic

Action

Unknown.
Though
antagonize
dopamine and
serotonin type
2 in CNS. Also
antagonizes
muscarinic
receptors
in
respiratory
tract, causing
cholinergic
activation.

Indication

PROLIXIN is
indicated in the
management of
manifestations
of
psychotic
disorders.

PROLIXIN
has not been
shown effective
in
the
management of
behavioral
complications
in
patients
with mental
retardation.

Contraindicati
on

Phenothiazines
are
contraindicated in
patients
with
suspected
or
established
subcortical brain
damage,
in
patients receiving
large doses of
hypnotics, and in
comatose
or
severely
depressed states.
The
presence
of blood
dyscrasia or liver
damage precludes
the
use
of
fluphenazine
hydrochloride.
PROLIXIN
(fluphenazine
hydrochloride) is
contraindicated in
patients who have

Adverse
Effect

Nursing Responsibility

Use exactly as directed; do not increase

dose or frequency.
Do not discontinue without consulting
prescriber.
Dilute with water, milk, orange or
pseudoparkinso
grapefruit juice; do not dilute with beverages
nism,
containing caffeine, tannin, or pectinate (eg,
coffee, colas, tea, or apple juice). Do not
dystonia,
take within 2 hours of any antacid. Avoid
dyskinesia,akat alcohol or caffeine and other prescription or
OTC medications not approved by
hisia,
prescriber.
Avoid skin contact with medication; may
oculogyric
cause contact dermatitis (wash immediately
crises,
with warm, soapy water).
Maintain adequate hydration unless
opisthotonos,
instructed to restrict fluid intake. You may
and
experience
excess
drowsiness,
hyperreflexia.
lightheadedness, dizziness, or blurred
vision(use caution driving or when engaging
Autonomic
in tasks requiring alertness until response to
Nervous
drug is known); dry mouth, upset stomach,
System
nausea, vomiting (small frequent meals,
frequent mouth care, chewing gum, or
Central
Nervous
System

sucking lozenges may help); constipation

shown
Hypertension a (increased exercise, fluids, fruits, or fiber
hypersensitivity
nd
may help); postural hypotension (use caution
to fluphenazine;
climbing stairs or when changing position
cross-sensitivity
fluctuation in
from lying or sitting to standing); urinary
to phenothiazine
retention (void before taking medication);
derivatives may
blood pressure ejaculatory
dysfunction
(reversible);
occur.
decreased perspiration (avoid strenuous
have
been
exercise
in hot environments);
or
reported with
photosensitivity (use sunscreen, wear
protective clothing and eyewear, and avoid
fluphenazine
direct sunlight).
hydrochloride.
Metabolic and
Endocrine

Weight change,
peripheral
edema,
abnormal
lactation,
gynecomastia,
menstrual

irregularities,
false results on
pregnancy tests,
impotency
men

in

and
increasedlibido
in women have
all
been known to
occur in some
patients
on
phenothiazine
therapy.
Allergic
Reactions

Skin disorders
such
as itching, eryth

ema,
urticaria, seborr
hea,
photosensitivity
,eczema and
even
exfoliative der
matitis have
been reported
with
phenothiazine
derivatives.