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In any given one-year period, 9.5% of the population, or about 18.8 million American adults,
suffer from depression.1 The indirect and direct costs of mood disorder illnesses in he U.S. totals
over $43 billion a year. Depression and related mood disorders rank just behind high-blood
One in three doctor's visits by women, now involve a prescription for an antidepressant
medication. And one in 10, American women takes at least one antidepressant drug.2 Americans
now spend more money on antidepressants than the Gross National Product of two-thirds of the
world’s countries.3
Most individuals who consult their medical doctor for mood disorders are placed on prescription
medications, and, in fact, as many as 10% of the U.S. population has taken one of these
medications. Prescription antidepressants reached a total of $37 billion in sales in 2003, which
came out to $9 million more than was spent on treatments for the heart, arteries, and blood
pressure.4
The largest growth spurt in antidepressant use has been among preschoolers, ages two to four.5
In 2003, over one million American children were taking an antidepressant medication.6
Interestingly, several studies show that between 19-70% of those taking antidepressant
medications do just as well by taking a placebo or sugar pill.7 While patients are attempting to
correct their mood disorders with prescription drugs that may or may not be more effective than a
sugar pill, all of these drugs have potential - sometimes serious - side effects. Prozac alone has
been associated with over 1,734 suicide deaths and over 28,000 adverse reactions.8
Prescription antidepressants can cause depression, anxiety, addiction, suicidal tendencies, tremors
or involuntary muscle spasms, and senility. Yes, prescription antidepressants and antianxiety
The most popular antidepressant drugs are known as selective serotonin re-uptake inhibitors
(SSRIs). SSRIs, including the drugs Lexapro, Prozac, Paxil, Celexa, and Zoloft are supposed to
prevent the brain from re-up taking the brain chemical, or neurotransmitter, serotonin. Effexor
and Cymbalta are designed to inhibit the re-uptake of the neurotransmitters serotonin and
norepinephrine. Using these drugs is analogous to using a gasoline additive to help your car get
Unfortunately, many of the individuals who suffer from mood disorders are extremely low in
serotonin- blocking the re-uptake of what little serotonin there is, allowing it to stay active longer,
does little to boost overall serotonin levels. Using a gasoline additive poured into an empty
gasoline tank doesn’t help much, if at all. This may explain why patients often switch from one
Those suffering from anxiety are commonly prescribed one of the benzodiazepine (tranquilizer)
medications including Ativan, Xanax, or Klonopin. National surveys show that 5.6 million adults
over the age of 65 are now taking tranquilizers.10 These medications are associated with numerous
unwanted side effects including poor sleep, seizures, mania, depression, suicide, ringing in the
ears, amnesia, dizziness, anxiety, disorientation, low blood pressure, nausea, fluid retention,
headaches.11 Additionally, over 73,000 older adults experience drug-induced tardive dyskinesia
Orthomolecular Medicine
Fortunately, for those looking for a safer, oftentimes more effective way to beat mood disorders, a
group of progressive-minded physicians helped pioneer a new way of treating mental disorders,
known as orthomolecular medicine. In 1968, two-time Nobel Prize winner Linus Pauling, Ph.D.,
originated the term "orthomolecular" to describe an approach to medicine that uses naturally
occurring substances normally present in the body. "Ortho" means correct or normal, and
vitamins, minerals, amino acids, and other similar substances within the body. Unlike drug
therapy, which attempts to cover up the symptoms associated with a mood disorder,
orthomolecular medicine seeks to find and correct the cause of the illness.
Medical science has now determined that how we feel is largely controlled by the foods we eat
and how well these building blocks are converted into brain-transmitting chemicals called
neurotransmitters. Neurotransmitters are brain chemicals that control our moods. You may
remember that chains of essential and nonessential amino acids make up proteins. Many of these
amino acids are converted into neurotransmitters. The brain needs adequate amounts of protein
along with B vitamins and minerals, produce the neurotransmitters. The neurotransmitters that
norepinephrine (adrenaline) are derived from the amino acids phenylalanine and tyrosine.
The inhibitory or relaxing neurotransmitter serotonin is produced from the amino acid tryptophan.
levels. 5-HTP is available over the counter and works extremely well for most patients.
Studies show that 5-HTP can be as effective as antidepressant drug therapy including SSRI
medications.13-14
synthesized in the body from the amino acid methionine. SAMe has been proven through 100-
plus studies to be an effective over-the-counter supplement for reversing depression. 15-17 Meta-
analysis studies showed that 92% of those on SAMe improved compared to 85% on Elavil or
Amino acid replacement therapy offers far less risk and far more long-term benefits than
Perhaps its time we start correcting nutritional insufficiencies instead treating Prozac deficiencies.
private practice since 1990. He is the founder and past clinic director for a large integrated
medical practice located on the campus of Brookwood Hospital in Birmingham, Alabama. The
clinic was staffed with medical doctors, chiropractors, acupuncturists, nutritionists, and massage
therapists. The clinic combined prescription and natural medicines for acute and chronic illnesses.
He is the author of five books including Treating and Beating Fibromyalgia and Chronic Fatigue
Syndrome, Heart Disease: What Your Doctor Won’t Tell You, and Treating and Beating Anxiety
In 2003, Dr. Murphree sold his integrative medical practice. He now maintains a busy solo
private practice and conducts one- and two-day medical continuing education seminars. He can
www.TreatingandBeating.com.
1. Robins L.N., Regier D.A. (Eds). Psychiatric Disorders in America, The Epidemiologic
http://thestreetspirit.org/August2005/madinterview.htm
3. ibid
4. Hawkins B. A Pill is not Enough, Vol 25, issue 1225 Minneapolis, MN. Available at
5. Zito J., PhD; Safer D., MD; dosReis S, PhD; Gardner F.,, ScM; Boles M, PhD; Lynch F., PhD
6. Waters R. Drug report barred by FDA. Scientist links antidepressants to suicide in kids. Special
8. Whittle T.J., Wiland R. The story behind Prozac, the killer drug, Freedom Magazine, Los Angeles, CA.
9. Monthly Prescribing Reference Haymarket Media Publication. New York, NY: Nov 2005.
10. Wolfe S., Sasich L., Hope R. Worst Pills, Best Pills. New York, NY: Pocket Books; 1999. pg
179.
11. Wolfe S., Sasich L., Hope R. Worst Pills, Best Pills. New York, NY: Pocket Books; 1999. pg 11.
12. Ibid
13. Birdsall T. 5-Hydroxytryptophan: A Clinically Effective Serotonin Precursor. Alt Med Rev.
1998;3(4):271-280.
Psychopathology. 1991;24:53-81.
17. Berlanga, C., Ortega-Soto, H.A., Ontiveros M., Senties H. Efficacy of S-adenosyl-L-
methionine in speeding the onset of action of imipramine. Psychiatry Res. 1992 Dec;44(3):257-
62.
18. Meyers S. Use of neurotransmitter precursors for treatment of depression. Altern. Med. Rev.