PIRAMAL DISCOVERY SOLUTIONS

Delivering Globally Integrated

Solutions across the drug lifecycle
We are the Contract Development & Manufacturing
arm of Piramal Pharma Solutions, a part of Piramal
Enterprises Ltd. Our capability as an integrated
solutions provider enables us to serve Innovator
and Generic companies worldwide.
Our customers can avail a comprehensive range
of services across all phases of the drug lifecycle
which includes Drug Discovery & Development,

Manufacturing and Packaging of Clinical Trial

Supplies, Delivering Commercial Volumes of APIs
as well as Finished Dosage products. To provide
flexibility and scalability of operations, we have
invested in a network of contract development and
manufacturing facilities located in North America,
Europe and Asia.

India
Ahmedabad | Ennore
Pithampur | Digwal | Mumbai

Canada
Toronto

United Kingdom
Grangemouth | Morpeth
Cambridge

U.S.A
Boston | Kentucky

China
Shanghai (Sourcing Office)

Our roots
We are an integral part of Piramal Enterprises Ltd.,
a leading business group in India with multiple
business interests. As a Group, we are committed to
achieving excellence and leadership by practicing

leading pharmaceutical company in India and a

dominant player on a global level.

our core values of knowledge, action and care.

We adhere to innovative, value-driven practices
in our diverse business initiatives, ranging from
healthcare and glass manufacturing to real-estate.

industry worldwide, innovation and cost have

emerged as key challenges for pharmaceutical
companies worldwide. We enable our customers to
address these challenges by offering cost effective
and reliable delivery solutions across the product
lifecycle.

Our beginning in the Healthcare business goes

back to the year 1988 when we acquired Nicholas
Laboratories. Since then we have grown into a

With the changing dynamics of the pharmaceutical

The advantage we carry

Our customers enjoy the benefits of

our global network of assets spread
across Europe, North America and
Asia. Our network enables us to
deliver benefits by strategically
placing projects to take advantage
of low costs, local supply chains and
s pec if ic c ustom er/ m arke t
requirements.

Global
Network

Piramal
Enterprises
Ltd.,
currently valued at more
than 1 billion
USD, is
amongst the largest business
conglomerates in India. We
embrace a rich legacy of over
20 years in the business of
healthcare.

Integrated
Solutions

With
capabilities across drug
discovery, development, scaleup and manufacturing of APIs as
well as Formulations, we are well
positioned to address customers
needs across the entire drug
lifecycle. Our specialization in
Antibody
Drug
Conjugation,
Clinical Trial Supplies, Packaging
and Biocatalysis enables us to
provide differentiated services to
our customers.

Financial
Stability

Our R&D team is led by scientists

with experience of working with
pharma companies across the
globe and hold expertise across
various chemistries and range of
formulation types.

Consistent
Track
Record

We are a pioneer in the Contract

Development and Manufacturing
Services market and have an
experience of over two decades.
We have advanced manufacturing
facilities approved by leading
regulatory
agencies including
the US-FDA and MHRA. We are a
trusted supplier to more than 100
pharma companies across the
US, Europe and Japan including
all major Big Pharma and large
Generic companies.

People &
Science

Hallmark
of Quality
& Safety

We believe that the best can

be delivered if only there is
an internal focus on quality.
Stringent quality and safety
norms are followed across
our facilities worldwide.

PIRAMAL DISCOVERY
SOLUTIONS
We, Piramal Discovery Solutions (formerly known as O2h) are an integral part of Piramal
Pharma Solutions and deliver early stage drug discovery services to Pharma companies,
Biotech companies and Academic institutions.
Our 10,000 m (100,000+ ft) greenfield campus is located in a Special Economic Zone
(SEZ), which is a government sponsored industrial park with specialized infrastructure
to encourage export and industrialization. Our campus benefits from on-site customs
clearance, central waste and power management and secure buildings with access
control points.
Our modern and advanced facility hosts 28 lab units (12 fume-hood reconfigurable
modules), a write-up area and research campus that accommodates over 300 scientists.
Our specialized areas are
- Medicinal and Synthetic Chemistry
- In vitro Biology

MEDICINAL
AND
SYNTHETIC CHEMISTRY
We are a reputed service provider of discovery chemistry. We have partnered with
a range of well known pharmaceutical and biotechnology companies from Europe,
USA and Japan. Our specialized team at PDS has a wide array of experience in
preparing small molecule NCEs with the requisite high quality specifications.
Our medicinal chemistry expertise includes hit expansion, hit to lead optimisation,
lead generation and lead optimisation. All of these can be accessed as stand-alone
offerings or as a part of an integrated drug discovery project.

Our demonstrated expertise lies in the

following chemistries

Our techniques include

Microwave chemistry

Complex / multi-stage synthesis

High pressure chemistry

Heterocyclic

Cryogenic chemistry

Chiral

Parallel synthesis

Carbohydrate
Peptide
Aliphatic
Nucleoside
Natural product

Our specificities include

Cambridge (UK) project office providing logistical, communications and objective project
management support
We have perfected clear templates which enable the systematic day-to-day reporting and
measurement of scientific progress in the most effective manner
Performance and productivity metrics are represented in a graphical form and shared internally
as well as with the client
Communications with clients range from direct communication to secure space on our intranet
site for depositing documents and data arising during the projects
Our dedicated team of personnel includes purchasing officers, store/stock managers as well as
in-house customs liaising officer for efficient sourcing of starting materials
Our IP (Intellectual Property) security model is designed to protect the IP of the clients during
the project lifecycle and beyond
Our scientists at are supported by a 360 support system which aims at maximising their time
to focus on their projects
We value integrity in communication and action; social responsibility with respect to
waste management and making a contribution to the community

Our capabilities include

Synthesis of small molecules on mg to kg scale (non-GMP) with the required high quality
specifications, using diverse synthetic methodologies
Modular custom-built lab units accommodating 12 FTE chemists each
Lab units can be tailored to customer requirement, with key-card access and IP / IP security
Supported with latest equipment - NMR, LC-MS / MS, microwave, combiflashes and access
to literature (journals, patents etc.)
Typical projects undertaken by us include: design and synthesis of discrete or series of
compounds, as well as synthesis of focused libraries for SAR / SPR optimization

IN VITRO BIOLOGY
Our biology facilities have been developed to provide faster decision-making
points for our chemistry clients. Since 2008, we have doubled both our
capacity as well as capability to include a range of In vitro services to evaluate
activity and/ or potential liability of compounds. Currently, we are executing
biology studies for several of our clients whose medicinal chemistry work is
also being carried out by us; thus reducing the iterative cycle time of drug
discovery and helping clients progress their compounds faster through the
discovery stage. The biology work is available on a stand-alone basis as well
as part of an integrated drug discovery project.

I. In vitro assays
ADME: solubility, permeability, CYP inhibition / induction, plasma stability (across different
species), microsomal / S9 stability (across different species), plasma protein binding
Target-based: enzymatic / kinase assays, binding assays, GPCR assays
Cell-based: ELISA, proliferation, apoptosis, phosphorylation status, insulin sensitizer assays,
cytokine production assays using hPBMCs, signal transduction assays

Our capabilities
Purpose-built labs include industry standard formats of fluorescence, luminescence and
absorbance to help develop and optimize biochemical and / or cellular assays in a range of
therapeutic areas
In-depth expertise in pathophysiologically relevant experimental models for multiple
therapeutic indications
Customization of assays based on clients requirement(s)

INTEGRATED
DRUG DISCOVERY
Our highly skilled team of scientists deliver services in Integrated
Drug Discovery (IDD) projects incorporating medicinal chemistry (lead
generation, hit-to-lead and lead optimisation), and in vitro and in vivo
pharmacology. We offer expertise in multiple therapeutic indications.

We consider the ultimate metric to measure

the success of an IDD project is the capacity
to create intellectual property and value to
our customers. Our goal of IDD is to afford
our clients access to specialized skills without
incurring their own fixed costs and operating
in a dynamic, flexible manner that suits the
competitive commercial environment of drug
discovery.
Successful IDD projects rely on efficient
integration of various disciplines
- Medicinal chemistry
- In vitro & in vivo discovery biology / pharmacology
- ADMET
- Computer-Aided Drug Discovery
- Operational excellence and expertise

Each of the varied modules of the drug

discovery process is available as a unique
point of entry individually as a subset of
services or as the traditional drug discovery
pathway from hit identification through to
lead generation and beyond. Our expertise
includes medicinal chemistry: hit expansion,
hit to lead, lead generation/ optimization,
computational chemistry, in vitro enzymatic
and cell-based screening, DMPK.

Our Core Values

Our Intellectual Property Policy

The cornerstone of our philosophy on
intellectual property rights (IPR) is built
on upholding the IP generated by the
company and all its associates. In order to
achieve this objective, we have set up
various systems which ensure that we:

Respect the IPR of all its clients, partners and competitors

Do not infringe any process or product knowingly and / or unknowingly
Protect and enforce the IPR of the Company, our clients and partners
Introduce measures to reduce IPR infringement related risks
Promote a culture of IPR compliance within the organization
Conduct periodic Intellectual Property Audits for effective IPR
management and monitoring

Respect
for IP

We value the relationships we have

built with our customers. We believe
that Customer Centricity is the driver
behind all our actions. Our performance
is measured on the value delivered to
our customers. We partner with our
customers in developing and delivering
solutions.

All our manufacturing sites have been approved

by leading global regulatory agencies. All major
sites have been approved by the US-FDA without
any 483s

Customer
Centricity

Client

Quality

Our aspiration is to be the best in class in global

standards. Our process has evolved through the
stages of:
Create robust quality base
Strengthen and implement system
Quality culture across the organization
Execute best in class standards

Environment

We function as an environmental-friendly organization and our practices have enabled us to

Pursue continuous improvement: Periodic audits and gap analysis are conducted
by Corporate EHS and cross functional teams
Implementing EHS best practices through: ISO: 14001 and OHSAS: 18001
Aim towards the goal of Sustainable Development by targeting the triple bottom
line growth in the fields of Economics, Environment and Society
Ensuring continuity of the business processes through Business Continuity Plans
Execute Process safety by implementing safety systems at all sites
Enhance awareness, knowledge and skills of employees towards a safe, clean,
greener and healthier work place

Win Awards and Recognition

Safety Award from National Safety Council of India, 2004 and 2005
Runners-up at the NE Business Awards Corporate Responsibility
& Environment, 2009
CII-National Award for Energy Efficient Operations, 2009
Winner of States Environment Award, 2010
Golden Peacock Award for Occupational Health & Safety, 2012
Frost and Sullivans Green Manufacturing Excellence award, 2012

PPS/PDS/DEC2015

Piramal Enterprises Limited

247 Business Park, A - Wing, 6th floor,
LBS Marg, Vikhroli (W), Mumbai 400 083. India.
Phone: +91 22 3095 6666 Fax: +91 22 3095 6665
Email: strategicmarketing.cell@piramal.com
www.piramal.com/pharmasolutions/