Depression and Mood

IMPORTANT NOTICE: The stack pages are not being updated and have been kept for archival purposes.
Due to the extreme complexity of stacking with proper consideration to demographics such as age, requirements, and gender, we have released a far more
encompassing t - The Stack Guides (http://examine.com/referstack/subid/'stackspagetop-depression-and-mood)
With FREE lifetime updates and authored by over a dozen researchers, it is the clearest guide to supplementation there is.

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Information
This stack page encompasses supplements that are able to treat depression, with focus mostly on those compounds that can confer anti-depressant properties
over a long period of time or those with fairly reliable mechanisms.
Some supplements may also be catered towards 'mood'. This does not necessarily refer to antidepressant actions, but more a small boost in well being that is
barely noticeable unless the subject had anhedonia initially.

If you are taking antidepressant pharmaceuticals currently, your medical doctor must be informed of any supplements
that you plan on adding to your regimen before your purchase of the supplement. It is always possible that
supplements and drugs can adversely interact, and your medical doctor should oversee any attempts for combination
therapy

Suggested Supplements
Agmatine
Zinc
Fish Oil

Agmatine (/supplements/Agmatine)

Agmatine (/supplements/Agmatine)
Dosage: 6.4mg
6.4mg/kg is the estimated human dose extrapolated from rat research and suggests a dose near maximal ecacy for antidepressive (and anxiolytic) eects; more
is not better, and this dose (for a 150lb human) is 435mg. If you are obese, a lower dose (in the 1.6-6.4mg/kg range) may be prudent.
Agmatine appears to be a synergist more than anything, and any antidepressant molecule that seems to work via signalling through receptors and ultimately
acting on potassium channels (this includes buproprion, SSRIs, adenosine, imipramine, folic acid, etc.) appears to have its ecacy increased.
Agmatine alone does have antidepressant eects, but they are either comparable to or weaker than the reference drugs that it is compared against (Imipramine,
usually).

SUPPLEMENTS
Zinc (/supplements/Zinc)

NUTRITION

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Dosage: 25
The 25mg dosage refers to elemental zinc (see zinc dosing instructions), and is useful specically for treatment resistant depression. Beyond that, persons
decient in zinc may have a slight impairment in mood (not necessarily depressive symptoms) and this impairment in mood state is resolved with
supplementation of zinc to restore adequate levels.

Fish Oil (/supplements/Fish+Oil)

Dosage: 1,000
Fish oil is eective in reducing depressive symptoms specically for major depression, and in persons with minor depression or just 'a bad mood' sh oil does not
seem to signicantly outperform placebo.
The dosage refers to 1,000mg EPA. While doses used in trials vary, that seems to be the ideal target (the overall dose of DHA doesn't matter too much, but should
be less than the EPA dosage).

Tags

depression, sad, mood, booster, elevate, happy

IMPORTANT NOTICE: The stack pages are not being updated and have been kept for archival purposes.
Due to the extreme complexity of stacking with proper consideration to demographics such as age, requirements, and gender, we have released a far more
encompassing t - The Stack Guides (http://examine.com/referstack/subid/'stackspagebottom-depression-and-mood)
With FREE lifetime updates and authored by over a dozen researchers, it is the clearest guide to supplementation there is.

Must Get!

Saving You Money & Time!

Supplement Stack Guides

Supplements
Calcium (/supplements/calcium/)
Creatine (/supplements/creatine/)
Curcumin (/supplements/curcumin/)
Fish Oil (/supplements/sh-oil/)
Vitamin D (/supplements/vitamin-d/)

Nutrition
Detoxes: an undened scam (http://examine.com/blog/detoxes-an-undened-scam/)