Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the
use of cannabis by patients.
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http://www.cannabis-med.org/studies/study.php

Ye Medication(
Diagnosis Title Author(s) Design Major outcome(s)
ar s)

Efficacy of two
cannabis based
medicinal
extracts for relief Berman
of central JS, Significant pain relief
Sho 200 Cannabis;D Controlle
Pain neuropathic pain Symonds and improvement of
w 4 elta-9-THC d study
from brachial C, Birch sleep
plexus avulsion: R.
results of a
randomised
controlled trial.
Carroll
CB, Bain
PG, Teare
Cannabis for
L, Liu X,
dyskinesia in
Joint C, Cannabis had no
Parkinson
Sho Wroath C, 200 Controlle treatment effect on
Parkinson's disease disease: a Cannabis
w Parkin 4 d study levodopa-induced
randomized
SG, Fox dyskinesia.
double-blind
P, Wright
crossover study.
D, Hobart
J, Zajicek
JP.
Survey on
Venderov
cannabis use in
a K, 25% of the respondents
Parkinson's
Ruzicka had taken cannabis and
Sho disease: 200
Parkinson's disease E, Vorisek Cannabis Survey 45.9% of these
w subjective 4
V, described some form of
improvement of
Visnovsky benefit.
motor
P.
symptoms.
Does the
cannabinoid
dronabinol
reduce central Svendsen
pain in multiple KB,
Sho 200 Controlle Significant reduction of
Multiple sclerosis;Pain sclerosis? Jensen Delta-9-THC
w 4 d study pain by THC
Randomised TS, Bach
double blind FW
placebo
controlled
crossover trial
Sho Spasticity;Multiple Do cannabis- Wade DT, 200 Cannabis Controlle Spasticity scores were
w sclerosis;Pain;Tremor based medicinal Makela P, 4 d study significantly reduced by
extracts have Robson P, cannabis.
general or House H,
specific effects Bateman
on symptoms in C.
multiple
sclerosis? A
double-blind,
randomized,
 placebo-
controlled study
on 160 patients.
Efficacy of
tetrahydrocanna
binol in patients
refractory to
standard
antiemetic
Vaney C,
therapy.Efficacy,
Heinzel-
safety and
Gutenbru
tolerability of an
nner M, Significant reduction in
orally
Jobin P, spasm frequency in the
Sho Spasticity;Multiple administered 200 Controlle
Tschopp Cannabis 37 patients who
w sclerosis cannabis extract 4 d study
F, Gattlen received at least 90% of
in the treatment
B, Hagen the dose.
of spasticity in
U,
patients with
Schnelle
multiple
M, Reif M.
sclerosis: a
randomized,
double-blind,
placebo-
controlled,
crossover study.
Brady
An open-label CM,
pilot study of DasGupta
cannabis-based R, Dalton Urinary urgency, the
extracts for C, number and volume of
Sho 200 Open
Multiple sclerosis bladder Wiseman Cannabis incontinence episodes,
w 4 study
dysfunction in OJ, frequency and nocturia
advanced Berkley all decreased.
multiple KJ,
sclerosis. Fowler
CJ.
The effect of Fox P,
Cannabis;D
cannabis on Bain PG,
elta-9-
Sho tremor in Glickman 200 Controlle No significant
Multiple sclerosis;Tremor THC;Other
w patients with S, Carroll 4 d study improvement of tremor
cannabinoid
multiple C, Zajicek
s
sclerosis. J.
Attal N,
Brasseur
Are oral L,
cannabinoids Guirimand
No significant decraese
safe and D,
Sho 200 Open of pain in 7 patients,
Pain effective in Clermond- Delta-9-THC
w 4 study more than 60%
refractory Gnamien
decrease in one patient
neuropathic S, Atlami
pain? S,
Bouhassir
aD
The Spasticity in the
Cannabinoids in Ashworth scale was
MS (CAMS) significantly reduced by
Sho Spasticity;Multiple 200 Cannabis;D Controlle
study ¡V final Zajicek J, an average of 1.82 in
w sclerosis 4 elta-9-THC d study
results form 12 the THC group; no
months follow- significant reduction in
up. the cannabis group
A preliminary
Pain relief associated
controlled study
with both THC and CBD
to determine
Wade DT, was significantly
whether whole- Cannabis;D
Spasticity;Spinal cord Robson P, superior to placebo.
Sho plant cannabis 200 elta-9- Controlle
injury;Multiple House H, Impaired bladder
w extracts can 3 THC;Canna d study
sclerosis;Pain Makela P, control, muscle spasms
improve bidiol
Aram J. and spasticity were
intractable
improved by cannabis in
neurogenic
some patients
symptoms.
Sho Appetite loss/weight Safety and Patel S, 200 Delta-9-THC Open Weight gain in all,
w loss;Alzheimer's disease efficacy of Shua- 3 study reduction of agitation in
 dronabinol in the
treatment of
agitation in
patients with
Haim JR,
Alzheimer’s 65%.
Pass M
disease with
anorexia: A
retrospective
chart review
Abrams
DI, Hilton
JF, Leiser
RJ, Shade
SB, Elbeik
TA,
Aweeka
FT,
Short-term
Benowitz
effects of
NL, Bredt
cannabinoids in Cannabis and THC had
BM, Kosel
patients with no significant effect on
Sho B, Aberg 200 Cannabis;D Controlle
HIV/AIDS HIV-1 infection: HI virus load and on
w JA, Deeks 3 elta-9-THC d study
a randomized, CD4+ and CD8+ cell
SG,
placebo- count
Mitchell
controlled
TF,
clinical trial.
Mulligan
K,
Bacchetti
P,
McCune
JM,
Schambel
an M
The treatment of
spasticity with Hagenbac
D9- h U, Luz
Sho Spasticity;Spinal cord tetrahydrocanna S, 200 Controlle Significant reduction of
Delta-9-THC
w injury binol (D9-THC) Brenneise 3 d study spasticity
in patients with n R, M
spinal cord ‫ה‬der M
injury
Experiences
with THC- Uncontro Positive effects of THC
Sho Spasticity;Dystonia;Epileps 200
treatment in Lorenz R Delta-9-THC lled case in children with severe
w y;Anxiety 3
children and report neurological disorders
adolescents
Randomised
controlled trial of
cannabis based
medicinal Young
Sho 200 Controlle Significant reduction in
Multiple sclerosis;Pain extracts (CBME) CA, Rog Cannabis
w 3 d study pain
in central DJ
neuropathic pain
due to multiple
sclerosis.
Efficacy of two Berman J,
cannabis-based Lee J,
medicinal Cooper M,
extracts for relief Cannon
of central A, Sach J, Significant pain relief
Sho 200 Cannabis;D Controlle
Pain neuropathic pain McKerral and improvement of
w 3 elta-9-THC d study
from brachial S, Taggart sleep
plexus avulsion: M,
results of a Symonds
randomised C, Fishel
controlled trial K, Birch R
Sho Pain Analgesic effect Karst M, 200 Other Controlle Significant reduction of
w of the synthetic Salim K, 3 cannabinoid d study pain
cannabinoid CT- Burstein s
3 on chronic S, Conrad
neuropathic I, Hoy L,
pain: a Schneider
 randomized
U.
controlled trial.
Cannabis use Ware MA,
for chronic non- Doyle CR, Cannabis use is
Sho cancer pain: Woods R, 200 prevalent among the
Pain Cannabis Survey
w results of a Lynch 3 chronic non-cancer pain
prospective ME, Clark population
survey. AJ
Open-label
study of
dronabinol in the
treatment of Ross JS,
Sho 200 Open Significant reduction of
Alzheimer's disease refractory Shua- Delta-9-THC
w 3 study agitation
agitation in Haim JR
Alzheimer’s
disease: a pilot
study
Abrams
DI, Jay
The effects of
Ch,
smoked
Petersen
cannabis in
K, Shade 10 of the 16 participants
painful
Sho S, Vizoso 200 Open experienced a greater
HIV/AIDS;Pain peripheral Cannabis
w H, Reda 3 study than 30% reduction in
neuropathy and
H, their pain
cancer pain
Benowitz
refractory to
N,
opiods.
Rowbotha
m M.
Muller-
Delta 9- Vahl KR,
tetrahydrocanna Schneider
binol (THC) is U,
Results provide
effective in the Prevedel
Sho 200 Controlle evidence that THC is
Tourette's syndrome treatment of tics H, Theloe Delta-9-THC
w 3 d study effective in the
in Tourette K, Kolbe
treatment of tics.
syndrome: a 6- H,
week Daldrup T,
randomized trial. Emrich
HM.
Buggy DJ,
Lack of
Toogood
analgesic
L, Maric
efficacy of oral
S, Sharpe 5 mg was ineffective in
Sho delta-9- 200 Controlle
Pain P, Delta-9-THC reduding postoperative
w tetrahydrocanna 3 d study
Lambert pain.
binol in
DG,
postoperative
Rowbotha
pain.
m DJ
Cannabinoids
for treatment of Zajicek J,
spasticity and Fox P,
No effect of
other symptoms Sanders
cannabinoids on
related to H, Wright
spasticity as measured
Sho Spasticity;Multiple multiple D, Vickery 200 Cannabis;D Controlle
by the Ashworth scale,
w sclerosis;Pain sclerosis (CAMS J, Nunn A, 3 elta-9-THC d study
while patient-reported
study): Thompso
spasticity and pain
multicentre n A, on
decreased.
randomised behalf of
placebo- the UK
controlled trial.
A case of Krenn H
cannabinoid Daha LK THC reduced pain with
Delta-9- Uncontro
Sho rotation in a Oczenski 200 low side effects;
Pain THC;Nabilon lled case
w young woman W 3 nabilone caused strong
e report
with chronic Fitzgerald psychic side effects
cystitis RD
Cannabis
reduces opioid Lynch Uncontro Improvement in pain,
Sho 200
Pain dose in the ME, Clark Cannabis lled case spasticity, bladder
w 3
treatment of AJ. report spasm, and sleep.
chronic non-
 cancer pain.
Jatoi A,
Windschitl
HE,
Dronabinol Loprinzi
versus CL, Sloan
megestrol JA, Dakhil
acetate versus SR,
combination Mailliard
therapy for JA,
Sho Appetite loss/weight 200 Controlle megestrol acetate was
cancer- Pundalee Delta-9-THC
w loss;Cancer 2 d study superior to THC
associated ka S,
anorexia: a Kardinal
North Central CG, Fitch
Cancer TR, Krook
Treatment JE,
Group study. Novotny
PJ,
Christens
en B.
Clermont-
[The therapeutic
Gnamien
use of delta-9-
S, Atlani
tetrahydrocanna
S, Attal N,
binol
Sho Le 200 Open No signficant effect of
Pain (dronabinol) in Delta-9-THC
w Mercier F, 2 study THC on pain
refractory
Guirimand
neuropathic
F,
pain] [Article in
Brasseur
French].
L.
Muller-
Vahl KR,
Treatment of
Schneider
Tourette's
U, Significant improvement
syndrome with
Koblenz of tics and obsessive-
Sho Delta 9- 200 Controlle
Tourette's syndrome A, Jobges Delta-9-THC compulsive behavior
w tetrahydrocanna 2 d study
M, Kolbe after treatment with
binol (THC): a
H, THC.
randomized
Daldrup T,
crossover trial.
Emrich
HM.
Randomised,
double-blind,
Fox SH,
placebo-
Kellett M,
controlled trial to
Moore
assess the No significant reduction
Sho AP, 200 Controlle
Dystonia potential of Nabilone in dystonia following
w Crossman 2 d study
cannabinoid treatment with nabilone
AR,
receptor
Brotchie
stimulation in
JM
the treatment of
dystonia.
Killestein
J,
Hoogervor
st EL, Reif
M,
Kalkers
Safety,
NF, Van
tolerability, and Compared with placebo,
Loenen
Sho Spasticity;Multiple efficacy of orally 200 Cannabis;D Controlle neither THC nor plant-
AC,
w sclerosis administered 2 elta-9-THC d study extract treatment
Staats
cannabinoids in reduced spasticity.
PG,
MS.
Gorter
RW,
Uitdehaag
BM,
Polman
CH
Sho Preliminary Neff GW, 200 Delta-9-THC Open THC signficantly
w observation with O'Brien 2 study reduced intractable
dronabinol in CB, cholestatic related
 Reddy
KR,
Bergasa
patients with NV,
intractable Regev A,
pruritus Molina E,
pruritus
secondary to Amaro R,
cholestatic liver Rodriguez
disease. MJ,
Chase V,
Jeffers L,
Schiff E.
Sieradzan
Cannabinoids
KA, Fox
reduce
SH, Hill
levodopa-
M, Dick significant reduction of
Sho induced 200 Controlle
Parkinson's disease JP, Nabilone levodopa-induced
w dyskinesia in 1 d study
Crossman dyskinesia
Parkinson's
AR,
disease: a pilot
Brotchie
study.
JM
Antiemetic
efficacy of
smoked
Soderpal
marijuana:
m AH, Ondansetron superior to
Sho subjective and 200 Controlle
Nausea/vomiting Schuster Cannabis cannabis in reducing
w behavioral 1 d study
A, de Wit nausea and vomiting
effects on
H
nausea induced
by syrup of
ipecac.
Clinical
investigation of
delta-9- Hagenbac
tetrahydrocanna h U,
binol (THC) as Ghafoor
Significant improvement
Sho an alternative N, 200 Controlle
Spinal cord injury Delta-9-THC of some parameters of
w therapy for Brenneise 1 d study
bladder function
overactive n R, Luz
bladders in S, M ‫ה‬der
spinal cord M.
injury (SCI)
patients.
Acute and
chronic effects
of cannabis Brady
based medicinal CM,
extract on DasGupta
refractory lower R, Mean maximum
Sho 200 Open
Multiple sclerosis urinary tract Wiseman Cannabis cystometric capacity
w 1 study
dysfunction in OJ, increased
patients with Berkley
advanced KJ,
multiple Fowler CJ
sclerosis – early
results
[Tetrahydrocann
Elsner F,
abinol for
Radbruch Uncontro
Sho treatment of 200 Sufficient pain relief in
Pain L, Delta-9-THC lled case
w chronic pain] 1 three patients
Sabatows report
[Article in
ki R.
German]
Treatment of Muller-
Tourette's Vahl KR,
Uncontro Improvement of tics and
Sho syndrome with Schneider 199
Tourette's syndrome Delta-9-THC lled case obsessive-compulsive
w delta-9- U, Kolbe 9
report behavior
tetrahydrocanna H, Emrich
binol. HM.
Sho Bipolar disorders The use of Grinspoon 199 Cannabis Uncontro A number of patients
w cannabis as a L, Bakalar 8 lled case find cannabis
mood stabilizer JB. report (marihuana) useful in
in bipolar the treatment of their
 disorder:
anecdotal
evidence and bipolar disorder
the need for
clinical research.
Cannabinoids:
Muller-
possible role in
Vahl KR, Evidence that marijuana
patho-
Sho Kolbe H, 199 improves tics and
Tourette's syndrome physiology and Cannabis Survey
w Schneider 8 behavioural disorders in
therapy of Gilles
U, Emrich TS.
de la Tourette
HM.
syndrome.
The effects of
the cannabinoid
receptor agonist Sieradzan Activation of
nabilone on L- KA, Fox cannabinoid receptors
Sho DOPA induced SH, Dick 199 Controlle can reduce L-DOPA-
Parkinson's disease Nabilone
w dyskinesia in J, 8 d study induced dyskinesia in
patients with Brotchie man without aggravating
idiopathic JM. parkinsonism.
Parkinson's
disease (PD).
The perceived
effects of Consroe In more than 80%
Spasticity;Multiple smoked P, Musty improvement of
Sho 199
sclerosis;Pain;Tremor;Depr cannabis on R, Rein J, Cannabis Survey spasticity, pain, tremor,
w 7
ession patients with Tillery W, depression, anxiety, and
multiple Pertwee R paresthesia
sclerosis.
Holdcroft
A, Smith
Pain relief with
M, Jacklin
oral
A,
Sho cannabinoids in 199 Controlle reduction of need for
Pain Hodgson Cannabis
w familial 7 d study morphin
H, Smith
Mediterranean
B, Newton
fever.
M, Evans
F
Intractable
nausea and
vomiting due to patients was treated
gastrointestinal Gonzalez- with several antiemetic
Uncontro
Sho Nausea/vomiting;Cancer;C mucosal Rosales 199 drugs, but it was not
Delta-9-THC lled case
w ancer chemotherapy metastases F, Walsh 7 until dronabinol was
report
relieved by D added that the nausea
tetrahydrocanna and vomiting stopped
binol
(dronabinol).
Beal JE,
Olson R,
Lefkowitz
L,
Laubenste
Long-term in L,
efficacy and Bellman
safety of P, Yangco
dronabinol for B,
Sho Appetite loss/weight 199 Open tendency to stable
acquired Morales Delta-9-THC
w loss;HIV/AIDS 7 study weight for 7 months
immunodeficien JO,
cy syndrome- Murphy R,
associated Powderly
anorexia. W, Plasse
TF,
Mosdell
KW,
Shepard
KV
Sho Appetite loss/weight The safety and Timpone 199 Delta-9-THC Controlle weight loss with THC,
w loss;HIV/AIDS pharmacokinetic JG, 7 d study weight gain with
s of single-agent Wright DJ, megestrol acetate
and combination Li N,
therapy with Egorin
 megestrol
acetate and
dronabinol for
the treatment of
MJ,
HIV wasting
Enama
syndrome. The
ME,
DATRI 004
Mayers J,
Study Group.
Galetto G
Division of AIDS
Treatment
Research
Initiative.
Effects of
dronabinol on Volicer L,
anorexia and Stelly M, higher weight gain with
Sho Appetite loss/weight disturbed Morris J, 199 Controlle THC; reduction of
Delta-9-THC
w loss;Alzheimer's disease behavior in McLaughli 7 d study disturbed behaviour with
patients with n J, THC
Alzheimer's Volicer BJ
disease.
Marijuana to
prevent nausea Schwartz
and vomiting in RH, Voth Only a small percentage
Sho Nausea/vomiting;Cancer 199
cancer patients: EA, Cannabis Survey of oncologists
w chemotherapy 7
a survey of Sheridan prescribed marijuana
clinical MJ.
oncologists.
The effect of
orally and
rectally Brenneise
improvement of joint
administered n R, Egli
function and ability to
Sho Multiple sclerosis; Spinal delta-9- A, Elsohly 199
Delta-9-THC walk; in 1 patient
w cord injury; Spasticity; Pain tetrahydrocanna MA, Henn 6
additional alleviation of
binol on V, Spiess
pain
spasticity: a pilot Y
study with 2
patients.
Abrahamo
An efficient new
v A,
cannabinoid
Sho Cancer chemotherapy; Abrahamo 199 Open complete prevention of
antiemetic in Delta-9-THC
w Nausea/vomiting v A, 5 study emesis
pediatric
Mechoula
oncology.
mR
Nabilone in the Martyn
improvement of muscle
Sho Multiple sclerosis; treatment of CN, Illis 199 Controlle
Nabilone spasms and frequency
w Spasticity multiple LS, Thom 5 d study
of nocturia
sclerosis. J
Beal JE,
Olson R,
Laubenste
in L,
Dronabinol as a
Morales
treatment for
JO,
anorexia increased appetite;
Sho Appetite loss/weight Bellman 199 Controlle
associated with Delta-9-THC improvement in mood;
w loss;HIV/AIDS;Depression P, Yangco 5 d study
weight loss in stabel weight
B,
patients with
Lefkowitz
AIDS.
L, Plasse
TF,
Shepard
KV
Kogel
RW,
Treatment of
Johnson
spasticity in
PB,
spinal cord Spasticity was markedly
Sho Spasticity;Spinal cord Chintam 199 Open
injury with Delta-9-THC improved in 2 o 5
w injury R, 5 study
dronabinol, a patients
Robinson
tetrahydrocanna
CJ,
binol derivative.
Nemchau
sky BA.
 A phase II study
of delta-9-
Nelson K,
tetrahydrocanna
Walsh D,
Sho Appetite loss/weight binol for appetite 199 Open increase of appetite in
Deeter P, Delta-9-THC
w loss;Cancer stimulation in 4 study 13 patients
Sheehan
cancer-
F
associated
anorexia.
Greenber
Short-term
g HS,
effects of
Werness
smoking
SAS,
marijuana on
Pugh JE, Cannabis reduced
Sho balance in 199 Controlle
Multiple sclerosis Andrus Cannabis posture and balance in
w patients with 4 d study
RO, patients with MS
multiple
Anderson
sclerosis and
DJ,
normal
Domino
volunteers
EF
Effect of
Lewis IH, Nabilone and
nabilone on
Campbell metoclopramide were
Sho nausea and 199 Controlle
Nausea/vomiting DN, Nabilone equally effective in
w vomiting after 4 d study
Barrowcliff reducing nausea and
total abdominal
e MP. vomiting
hysterectomy.
Struwe M,
Kaempfer
SH,
Geiger
Effect of CJ, Pavia Trends toward weight
Sho Appetite loss/weight dronabinol on AT, 199 Controlle gain, improved appetite,
Delta-9-THC
w loss;HIV/AIDS nutritional status Plasse 3 d study decreased symptom
in HIV infection. TF, stress
Shepard
KV, Ries
K, Evans
TG.
Dronabinol
Plasse T,
stimulates
HIV/AIDS; Appetite Conant M,
Sho appetite and 199 Controlle increase in appetite,
loss/weight loss; Gorter R, Delta-9-THC
w causes weight 2 d study trend toward weight gain
Depression Shepard
gain in HIV
KV
patients.
Dronabinol Gorter R,
effects on Seefried
Sho Appetite loss/weight 199 Open
weight in M, Delta-9-THC weight gain
w loss;HIV/AIDS 2 study
patients with Volberdin
HIV infection. gP
Dronabinol and Lane M,
prochlorperazine Vogel CL,
in combination Ferguson prochlorperazine better
Sho Nausea/vomiting;Cancer;C for treatment of J, 199 Controlle than THC, both drugs
Delta-9-THC
w ancer chemotherapy cancer Krasnow 1 d study combined better than
chemotherapy- S, Saiers both alone
induced nausea JL, Hamm
and vomiting. J
Plasse
TF, Gorter
RW,
Krasnow
Recent clinical
Sho Appetite loss/weight SH, Lane 199 Open
experience with Delta-9-THC Significant weight gain
w loss;HIV/AIDS M, 1 study
dronabinol.
Shepard
KV,
Wadleigh
RG
Sho Controlled Consroe 199 Cannabidiol Controlle CBD was neither
w clincal trial of P, Laguna 1 d study symptomatically
cannabidiol in J, effective nor toxic.
Huntington's Allender
disease. J, Snider
S, Stern
 L, Sandyk
R,
Kennedy
K, Schram
K
Marijuana as
antiemetic
Doblin 54% of oncologists
medicine: a
Sho Nausea/vomiting;Cancer RE, 199 thought marijuana
survey of Cannabis Survey
w chemotherapy Kleiman 1 should be available on
oncologists'
MA. prescription
experiences and
attitudes.
Delta-9-
tetrahydrocanna
Maurer M,
binol shows
Henn V, THC and codeine
Sho Spinal cord injury; antispastic and 199 Controlle
Dittrich A, Delta-9-THC reduced pain; THC
w Spasticity; Pain analgesic effects 0 d study
Hofmann reduced spasticity
in a single case
A
double-blind
trial.
Wadleigh
R,
Spaulding
GM, Patients continued to
Dronabinol
Lumbersk loose, but the weight
Sho Appetite loss/weight enhancement of 199 Open
y B, Delta-9-THC loss decreased in all
w loss;Cancer appetite in 0 study
Zimmer groups; appetite and
cancer patients.
M, mood increased
Shepard
K, Plasse
T
Frankel
Marijuana for JP,
Sho 199 Open No improvement of
Parkinson's disease parkinsonian Hughes A, Cannabis
w 0 study tremor
tremor. Lees AJ,
Stern GM.
Wadleigh
R,
Spaulding
GM,
Dronabinol
Lumbersk
Sho Appetite loss/weight enhancement of 199 Open Dronabinol stimulated
y B, Delta-9-THC
w loss;Cancer appetite in 0 study mood and appetite
Zimmer
cancer patients.
M,
Shepard
K, Plasse
T.
Effect of
Meinck
cannabinoids on
Sho Multiple sclerosis; HM, Sch 198 Controlle improvement of tremor,
spasticity and Cannabis
w Spasticity; Ataxia ‫צ‬nle PW, 9 d study spasticity and ataxia
ataxia in multiple
Conrad B
sclerosis.
McCabe
M, Smith
Efficacy of FP,
tetrahydrocanna Goldberg
THC decreased nausea
Sho Nausea/vomiting;Cancer;C binol in patients D, 198 Controlle
Delta-9-THC and vomiting in 23 of 36
w ancer chemotherapy refractory to Macdonal 8 d study
(64%) patients
standard anti- d J,
emetic therapy Woolley
PV,
Warren R
Sho Nausea/vomiting;Cancer;C A randomized Cunningh 198 Nabilone Open Metoclopramide/dexam
w ancer chemotherapy trial of oral am D, 8 study ethasone superior to
nabilone and Bradley nabilone/prochlorperazi
prochlorperazine CJ, ne
compared to Forrest
intravenous GJ,
metoclopramide Hutcheon
and AW,
dexamethasone Adams L,
in the treatment Sneddon
 of nausea and
vomiting M,
induced by Harding
chemotherapy M, Kerr
regimens DJ,
containing Soukop
cisplatin or M, Kaye
cisplatin SB.
analogues.
Inhalation Vinciguerr
marijuana as an a V,
Sho Nausea/vomiting;Cancer;C 198 Open Marijuana effective as
antiemetic for Moore T, Cannabis
w ancer chemotherapy 8 study antiemetic agent
cancer Brennan
chemotherapy. E.
Ungerleid
Delta-9-THC in er JT,
significant subjective
the treatment of Andyrsiak
improvement in
Sho Multiple sclerosis; spasticity T, 198 Controlle
Delta-9-THC spasticity at doses of
w Spasticity associated with Fairbanks 7 d study
7.5 mg and above; no
multiple L, Ellison
objective improvement
sclerosis. GW,
Myers LW
Nabilone versus
prochlorperazine
for control of Chan HS,
cancer Correia Nabilone effective as
Sho Nausea/vomiting;Cancer;C 198 Controlle
chemotherapy- JA, Nabilone antiemetic drug for
w ancer chemotherapy 7 d study
induced emesis MacLeod children
in children: a SM
double-blind,
crossover trial.
A double-blind
randomised
Priestman
cross-over
SG,
comparison of Nabilone similar
Sho Priestman 198 Controlle
Nausea/vomiting nabilone and Nabilone effective as
w TJ, 7 d study
metoclopramide metoclopramide
Canney
in the control of
PA.
radiation-
induced nausea.
Open label 20-50% improvement of
evaluation of Consroe dystonia; deterioration
Sho Dystonia; Parkinson's cannabidiol in P, Sandyk 198 Open of tremor and
Cannabidiol
w disease dystonic R, Snider 6 study hypokinesia in 2
movement SR patients with
disorders. Parkinson's disease
Anticonvulsant no significant effect in
Sho Ames FR, 198 Controlle
Epilepsy effect of Cannabidiol addition to standard
w Cridland S 6 d study
cannabidiol. medication
Effect of Delta-
Truong
9-THC on EMG THC reduced several
Sho XT, 198 Controlle
Spasticity Measurements Delta-9-THC types of spastic
w Hanigan 6 d study
in Human manifestations
WC
Spasticity
Nabilone and
metoclopramide
in the treatment Crawford
No difference between
Sho Nausea/vomiting;Cancer;C of nausea and SM, 198 Controlle
Nabilone nabilone and
w ancer chemotherapy vomiting due to Buckman 6 d study
metoclopramide
cisplatinum: a R.
double blind
study.
Nabilone: an Dalzell
Even for young children
alternative AM,
Sho Nausea/vomiting;Cancer;C 198 Controlle nabilone is an effective
antiemetic for Bartlett H, Nabilone
w ancer chemotherapy 6 d study antiemetic, superior to
cancer Lilleyman
domperidone.
chemotherapy. JS.
Sho Nausea/vomiting;Cancer;C Crossover Niederle 198 Nabilone Controlle Nabilone superior to
w ancer chemotherapy comparison of N, Schutte 6 d study alizapride.
the antiemetic J, Schmidt
efficacy of CG.
 nabilone and
alizapride in
patients with
nonseminomato
us testicular
cancer receiving
cisplatin
therapy.
Prospective
randomized
double-blind trial Pomeroy
of nabilone M,
Sho Nausea/vomiting;Cancer;C 198 Controlle Nabilone superior to
versus Fennelly Nabilone
w ancer chemotherapy 6 d study domperidone
domperidone in JJ,
the treatment of Towers M.
cytotoxic-
induced emesis.
Sandyk R,
Cannabidiol in Snider
Uncontro Cannabidiol (CBD)
Sho dystonic SR, 198
Dystonia Cannabidiol lled case reduced dystonic
w movement Consroe 6
report movements
disorders. P, Elias
SM.
Hanigan
The effect of Delta-9-THC proved
WC,
Sho delta-9-THC on 198 Controlle clinically beneficial in
Spasticity Destree Delta-9-THC
w human 6 d study two of five patients with
R, Truong
spasticity. intractable spasticity.
XT.
Ungerleid
er JT,
THC or
Sarna G,
Compazine for
Fairbanks nausea reduction was
the cancer
LA, the main determinant of
Sho Nausea/vomiting;Cancer;C chemotherapy 198 Controlle
Goodnight Delta-9-THC preference between
w ancer chemotherapy patient--the 5 d study
J, THC and
UCLA study.
Andrysiak prochlorperazine
Part II: Patient
T,
drug preference.
Jamison
K.
A cross-over
comparison of
nabilone and Niiranen
Nabilone is a
Sho Nausea/vomiting;Cancer;C prochlorperazine A, 198 Controlle
Nabilone moderately effective
w ancer chemotherapy for emesis Mattson 5 d study
anti-emetic drug
induced by K.
cancer
chemotherapy.
Beneficial and
adverse effects
of cannabidiol in Snider
Uncontro
Sho a Parkinson SR, 198 Improvement of
Parkinson's disease Cannabidiol lled case
w patient with Consroe 5 dyskinesia
report
sinemet-induced P.
dystonic
dyskinesia.
Randomized
double blind
9 patients no
comparison of
Levitt M, preference; 7 preferred
delta-9-
Sho Nausea/vomiting;Cancer;C Faiman C, 198 Cannabis;D Controlle oral THC, 4 preferred
tetrahydroicanna
w ancer chemotherapy Hawks R, 4 elta-9-THC d study marijuana cigarettes
binol (THC) and
Wilson A (double-blind, double
marijuana as
dummy crossover study)
chemotherapy
antiemetics.
Sho Asthma Acute and Gong H 198 Delta-9-THC Open acute bronchodilator
w subacute Jr, 4 study activity of delta 9-THC;
bronchial effects Tashkin no effect of cannabidiol;
of oral DP, daily use of delta 9-THC
cannabinoids. Simmons not associated with
MS, tolerance
Calvarese
B, Shapiro
 BJ
Treatment of Snider
Uncontro 50% improvement in
Sho Meige's S.R, 198
Dystonia Cannabidiol lled case spasm severity and
w syndrome with Consroe 4
report frequency
cannabidiol. P.
Tetrahydrocann
2 patients with objective
Sho abinol for tremor Clifford 198 Controlle
Multiple sclerosis; Tremor Delta-9-THC improvement, 5 with
w in multiple DB 3 d study
subjective improvement
sclerosis.
Comparison of
Gong H
bronchial effects
Jr, moderate bronchodilator
of nabilone and
Sho Tashkin 198 Controlle action in healthy
Asthma terbutaline in Nabilone
w DP, 3 d study subjects; no difference
healthy and
Calvarese to placebo in asthmatics
asthmatic
B
subjects.
Gross H,
Ebert MH,
A double-blind Faden
trial of delta 9- VB,
no significant difference
Sho tetrahydrocanna Goldberg 198 Controlle
Appetite loss/weight loss Delta-9-THC between THC and
w binol in primary SC, Kaye 3 d study
diazepam
anorexia WH,
nervosa. Caine ED,
Hawks R,
Zinberg N
Ungerleid
er JT,
Cannabis and
Andrysiak
cancer
T,
chemotherapy: a No significant
Fairbanks
Sho Nausea/vomiting;Cancer comparison of 198 Controlle differences between
L, Delta-9-THC
w chemotherapy oral delta-9-THC 2 d study THC and
Goodnight
and prochlorperazine
J, Sarna
prochlorperazine
G,
.
Jamison
K.
Malec J,
Cannabis effect
Harvey
Sho Spasticity;Spinal cord on spasticity in 198 Decreased spasticity
RF, Cannabis Survey
w injury spinal cord 2 with marijuana use
Cayner
injury.
JJ.
Treatment of
human spasticity Petro DJ,
Sho 198 Controlle reduced spasticity with
Spasticity with delta 9- Ellenberg Delta-9-THC
w 1 d study 10 mg THC
tetrahydrocanna er C Jr
binol.
Chang
A prospective AE,
evaluation of Shiling
delta-9- DJ,
no significant reduction
tetrahydrocanna Stillman
of the number of
binol as an RC,
Sho Nausea/vomiting;Cancer;C 198 Controlle vomiting, volume of
antiemetic in Goldberg Delta-9-THC
w ancer chemotherapy 1 d study emesis, degree of
patients NH, Seipp
nausea, or duration of
receiving CA,
nausea
adriamycin and Barofsky
cytoxan I,
chemotherapy. Rosenber
g
Dose vs
Levitt M,
response of THC 15 mg was the
Wilson A,
tetrahydroannab most effective against
Bowman
Sho Nausea/vomiting;Cancer;C inol (THC) vs 198 Controlle vomiting,
D, Faiman Delta-9-THC
w ancer chemotherapy prochlorperazine 1 d study prochlorperazine was
C, Kemel
as the most effective
S, Krepart
chemotherapy antinauseant
G
antiemetics.
Sho Pain Evaluation of Jain AK, 198 Other Controlle significant pain relief
w intramuscular Ryan JR, 1 cannabinoid d study compared with placebo
levonantradol McMahon s
 and placebo in
acute FG, Smith
postoperative G.
pain.
Topical delta 9-
Merritt JC,
tetrahydrocanna
Perry DD,
Sho binol and 198 Controlle
Glaucoma Russell Delta-9-THC no effect
w aqueous 1 d study
DN, Jones
dynamics in
BF
glaucoma.
Neidhart
Comparative JA,
trial of the Gagen
Sho Nausea/vomiting;Cancer;C 198 Controlle THC and haloperidol
antiemetic MM, Delta-9-THC
w ancer chemotherapy 1 d study equally effective
effects of THC Wilson
and haloperidol HE,
Young DC
Levitt M,
Physiologic Wilson A,
observations in Bowman
a controlled D, Kemel
clinical trial of S, Krepart
the antiemetic G, Marks
Patients were
effectiveness of V,
Sho Cancer 198 Controlle remarkably free of
5, 10, and 15 Schipper Delta-9-THC
w chemotherapy;Glaucoma 1 d study adverse physiologic
mg of delta 9- H,
effects.
tetrahydrocanna Thomson
binol in cancer G,
chemotherapy. Weinerma
Ophthalmologic n B,
implications. Weinerma
nR
Antiemetics in
patients
no nausea and vomiting
receiving
in 36 of 79 courses of
chemotherapy
Sallan SE, chemotherapy with THC
for cancer: a
Cronin C, compared to 16 of 78
Sho Cancer chemotherapy; randomized 198 Controlle
Zelen M, Delta-9-THC courses in patients who
w Nausea/vomiting comparison of 0 d study
Zinberg received
delta-9-
NE prochlorperazine;
tetrahydrocanna
improved appetite with
binol and
THC
prochlorperazine
.
Antiemetic effect
of
tetrahydrocanna
binol. Compared
with placebo Orr LE, no nausea and no
Sho Cancer chemotherapy; and McKernan 198 Controlle vomiting (complete
Delta-9-THC
w Nausea/vomiting prochlorperazine JF, 0 d study response) in 73% (40/55
in Bloome B courses) in THC group
chemotherapy-
associated
nausea and
emesis.
Cunha
JM,
Carlini
EA,
Pereira
Chronic
AE, 4 of the 8 CBD subjects
administration of
Ramos remained almost free of
cannabidiol to
Sho OL, 198 Controlle convulsive crises and 3
Epilepsy healthy Cannabidiol
w Pimentel 0 d study other patients
volunteers and
C, demonstrated partial
epileptic
Gagliardi improvement
patients.
R, Sanvito
WL,
Lander N,
Mechoula
mR
 Merritt JC,
Crawford
Effect of WJ,
marihuana on Alexander Marihuana inhalation
Sho 198 Controlle
Glaucoma intraocular and PC, Cannabis decreased intraocular
w 0 d study
blood pressure Anduze and blood pressure.
in glaucoma. AL,
Gelbart
SS
Frytak S,
Delta-9- Moertel
tetrahydrocanna CG,
binol as an O'Fallon
antiemetic for JR, Rubin THC and PCP equally
patients J, effective; both better
Sho Nausea/vomiting;Cancer;C 197 Controlle
receiving cancer Creagan Delta-9-THC than placebo; THC
w ancer chemotherapy 9 d study
chemotherapy. ET, produced psychic
A comparison O'Connell effects in 82%
with MJ,
prochlorperazine Schutt AJ,
and a placebo. Schwarta
u NW
Chang
AE,
Delta-9-
Shiling
tetrahydrocanna
DJ,
binol as an
Stillman
antiemetic in
RC,
cancer patients 14 of 15 patients had
Sho Nausea/vomiting;Cancer;C Goldberg 197 Controlle
receiving high- Delta-9-THC decreased vomiting and
w ancer chemotherapy NH, Seipp 9 d study
dose nausea
CA,
methotrexate. A
Barofsky
prospective,
I, Simon
randomized
RM,
evaluation.
Rosenber
g SA.
Delta-9-
Kluin-
tetrahydrocanna
Nelemans
binol (THC) as
JC, dronabinol superior to
an antiemetic in
Nelemans placebo (P<.01 for
Sho Nausea/vomiting;Cancer;C patients treated 197 Controlle
FA, Delta-9-THC difference between
w ancer chemotherapy with cancer 9 d study
Meuwisse groups at days 1 and 8
chemotherapy; a
n OJATh, independently)
double-blind
Maes
cross-over trial
RAA
against placebo
Effects of
tetrahydrocanna Crawford drop in IOP parallel with
Sho 197 Controlle
Glaucoma binol on arterial WJ, Cannabis drop in arterial blood
w 9 d study
and intraocular Merritt JC pressure
hypertension.
Amelioration of
Ekert H,
cancer
Waters
chemotherapy- THC was effective in
KD, Jurk
Sho induced nausea 197 Controlle reducing nausea and
Nausea/vomiting IH, Delta-9-THC
w and vomiting by 9 d study vomiting but not in all
Mobilia J,
delta-9- patients
Loughnan
tetrahydrocanna
P
binol.
Jochimse
Effect of n PR,
benzopyranoperi Lawton Other Bezopyranoperidine
Sho 197 Controlle
Pain dine, a delta-9- RL, cannabinoid was not more effective
w 8 d study
THC congener, VerSteeg s than placebo
on pain. K, Noyes
Jr R
Effect of delta-9-
tetrahydrocanna
Sho binol on Cooler P, 197 Controlle reduction in intraocular
Glaucoma Delta-9-THC
w intraocular Gregg JM 7 d study pressure
pressure in
humans.
 Effects of
intravenous
tetrahydrocanna
binol on
Raft D,
experimental
Sho Gregg J, 197 Controlle
Pain and surgical Delta-9-THC No pain relief with THC
w Ghia J, 7 d study
pain.
Harris L
Psychological
correlates of the
analgesic
response.
Tashkin
Bronchial effects
DP, Reiss THC effective in healthy
of aerosolized
S, Shapiro subjects and 3
delta 9-
Sho BJ, 197 Controlle asthmatic subjects;
Asthma tetrahydrocanna Delta-9-THC
w Calvarese 7 d study aerosol caused
binol in healthy
B, Olsen bronchoconstriction in 2
and asthmatic
JL, Lodge asthmatic subjects
subjects.
JW.
Regelson
W, Butler
JR,
Cancer; Appetite Schulz J,
Sho 197 Controlle weight gain with THC;
loss/weight loss; Kirk T, Delta-9-THC
w 6 d study weight los with placebo
Depression Peek L,
Green
ML, Zalis
MO
Bronchodilator
effect of delta1- Williams significant
tetrahydrocanna SJ, broncholdilation with
Sho binol Hartley 197 Controlle THC; faster action of
Asthma Delta-9-THC
w administered by JP, 6 d study salbutamol but both
aerosol of Graham drugs equivalent at 1
asthmatic JD hour
patients.
for patients completing
Antiemetic effect
the study there were 5
of delta-9- Sallan SE,
complete responses (no
Sho Cancer chemotherapy; tetrahydrocanna Zinberg 197 Controlle
Delta-9-THC vomiting) and 7 partial
w Nausea/vomiting binol in patients NE, Frei E 5 d study
responses (50%
receiving cancer 3d
decrease of vomiting) of
chemotherapy.
overall 15 courses
Noyes R
Analgesic effect Jr, Brunk
Sho of delta-9- SF, 197 Controlle pain relief with 15-20 mg
Cancer; Pain Delta-9-THC
w tetrahydrocanna Baram 5 d study THC
binol. DA,
Canter A
The analgesic
Noyes R
properties of
Jr, Brunk milde analgesic effect;
Sho delta-9- 197 Controlle
Cancer; Pain SF, Avery Delta-9-THC with 20 mg THC strong
w tetrahydrocanna 5 d study
DAH, adverse effects
binol and
Canter AC
codeine.
Consroe Cannabis was able to
Anticonvulsant
PF, Wood Uncontro control seizures in
Sho nature of 197
Epilepsy GC, Cannabis lled case conjunction with
w marihuana 5
Buchsbau report phenobarbital and
smoking.
mH diphenylhydantoin.
Tashkin
after experimental
Effects of DP,
induction of acute
smoked Shapiro
Sho 197 Controlle bronchospasm prompt
Asthma marijuana in BJ, Lee Cannabis
w 5 d study correction of the
experimentally YE,
bronchospasm with
induced asthma. Harper
cannabis
CE
Sho Glaucoma Marijuana Flom MC, 197 Delta-9-THC Open IOP reduction in 7 of 15
w smoking and Adams 5 study
reduced AJ, Jones
pressure in RT
 human eyes:
drug action or
epiphenomenon
?
The perceived
effects of
Sho Spasticity;Spinal cord Dunn M, 197 Decrease in pain and
marijuana on Cannabis Survey
w injury;Pain Davis R. 4 spasticity.
spinal cord
injured males.
Marihuana
Hepler 9 of 11 had drop in
Sho smoking and 197 Open
Glaucoma RS, Frank Cannabis intraocular pressure of
w intraocular 1 study
IR 16-45%
pressure.
Cannabis
substitution. An
Uncontro Marijuana consumption
Sho adjunctive Mikuriya 197
Dependency/withdrawal Cannabis lled case may help to decrease
w therapeutic tool TH 0
report alcolholic intake.
in the treatment
of alcoholism.

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