PCB 3063

Problem Set 2
1. Magical ability is a dominant trait controlled by two loci. Consider the following
cross:
aaBb x Aabb
a. What are the phenotypes of these two individuals?
b. Use a Punnett square to determine the genotypic and phenotypic probabilities in
the progeny.
2. In humans, alkaptonuria is a metabolic disorder in which affected persons produce
black urine. Alkaptonuria results from an autosomal allele (a) that is recessive to the
allele for normal metabolism (A). Sally has normal metabolism, but her brother has
alkaptonuria. Sallys father has alkaptonuria, and her mother has normal metabolism.
a. Construct a pedigree of this family and indicate the genotypes of Sally, her
mother, her father, and her brother.
b. If Sallys parents have another child, what is the probability that this child will
have alkaptonuria?
3. The following pedigree is for an X-linked trait:
(Note: the carrier symbol was not used in this pedigree.)

a. Is this trait dominant or recessive?

b. Indicate the genotypes of all the individuals in the pedigree.

4. The following pedigree illustrates the inheritance of Nance-Horan syndrome (n), a rare
X-linked genetic condition in which affected persons have cataracts and
abnormally shaped teeth. (Note: the carrier symbol was not used in this
pedigree.)

If III-2 and III-7 mated, what would be the expected genotypic and phenotypic ratios
in their progeny? Draw a Punnett square.
5. The cross between AaBb and aabb yielded the following phenotypic proportions:
AB
37.4%
Ab
11.9%
aB
12.6%
ab
38.1%
a.
b.
c.
d.

What do the symbols on the premise represent?

What do the symbols on the table represent?
What is the configuration of the alleles in the heterozygous parent?
What is the map distance between the two genes?

6. The cross between AaBb and aabb yielded the following results:
AB
97
Ab
159
ab
105
aB
164
a. What is the configuration of the alleles in the heterozygous parent?
b. What is the map distance between the two genes?
2

7. The cd-sr (cardinal eyes-stripe body) linkage cross yielded the following results:
cd+ sr+ 7%
cd+ sr 44%
cd sr+ 43%
cd sr 6%
a.
b.
c.
d.

What do the symbols on the premise represent?

What do the symbols on the table represent?
What is the configuration of the alleles in the heterozygous parent?
What is the map distance between the two genes?

8. The genes dumpy wing (dp), clot eye (cl), and apterous wing (ap) are linked on
chromosome 2 in Drosophila. In a series of two-point mapping crosses, the following
crossing-over frequencies were obtained:
dp-ap 44%
dp-cl 4%
ap-cl 39%
a. What do the symbols in the premise represent?
b. What do the symbols on the table represent?
c. Construct a linkage map.
9. In Drosophila, ebony body color (e), scarlet eyes (st), and spineless bristles (ss) are
autosomally linked. When a wild type female (heterozygous for all three genes) was
test-crossed with an ebony, scarlet, spineless male, the following progeny was
obtained:
wild type
43
ebony
278
scarlet
5
spineless
52
ebony, scarlet
50
ebony, spineless
3
scarlet, spineless
283
ebony, scarlet, spineless
41
a.
b.
c.
d.
e.

What do the symbols in the premise represent?

What do the words on the table represent?
What is the configuration of the alleles in the heterozygous parent?
Construct a linkage map showing map distances.
Calculate the coefficient of coincidence and the interference.

10. Waxy endosperm (wx), shrunken endosperm (sh) and yellow seedling (y) are
autosomally linked in corn. A testcross produced the following results:
wild type
3030
yellow
560
yellow, waxy
6954
yellow, waxy, shrunken
3062
shrunken
6960
yellow, shrunken
174
waxy, shrunken
584
waxy
188
a. What is the configuration of the alleles in the heterozygous parent?
b. Construct a linkage map showing map distances.
c. Calculate the coefficient of coincidence and the interference.
11. In Drosophila, ebony body color (e), brevis bristles (bv), and rough eyes (ro) are
autosomally linked. A test cross yielded the following results:
wild type
169
ebony
619
brevis
14
rough
93
ebony, brevis
97
ebony, rough
9
brevis, rough
621
ebony, brevis, rough
165
a. What is the configuration of the alleles in the heterozygous parent?
b. Construct a linkage map showing map distances.
c. Calculate the coefficient of coincidence and the interference.
12. In Drosophila, cherub wings (ch), black body, (b) and cinnabar eyes (cn) are
autosomally linked on chromosome 2. A heterozygous fly was mated with a cherub,
black and cinnabar fly. The following progeny were produced from the testcross:
cherub, cinnabar
105
wild type
750
black, cinnabar
40
cinnabar
4
cherub, black, cinnabar
753
cherub
41
black
105
cherub, black
5
a. What is the configuration of the alleles in the heterozygous parent?
b. Construct a linkage map showing map distances.
c. Calculate the coefficient of coincidence and the interference.

13. The ability to taste the compound PTC is controlled by a dominant allele T, while
individuals homozygous for the allele t are unable to taste PTC. In a genetics class of
125 students, 88 can taste PTC and 37 cannot. Calculate the frequency of the T and t
alleles in this population and the frequency of the genotypes. Assume that the
population is at Hardy-Weinberg equilibrium.
14. Consider rare disorders in a population caused by autosomal recessive mutations.
From the frequencies of the disorders in the population given, calculate the
percentage of carriers (assume that the populations are at Hardy-Weinberg
equilibrium):
a. 0.0064
b. 0.000081
c. 1/100