DRUG

Generic Name:
omeprazole

Brand Name:
Prilosec
Drug Classification:
proton pump inhibitors
(PPI)

INDICATION

ACTION

DRUG INTERACTION

Short-term treatment of
activeduodenal ulcer; Firstlinetherapy in treatment
of heartburn or symptoms
of gastroesophageal
refluxdisease (GERD);
Short-termtreatment of
active benigngastric ulcer;
GERD, severeerosive
esophagitis,
poorlyresponsive
symptomatic GERD;Longterm therapy: Treatmentof
pathologic
hypersecretoryconditions
(Zollinger-Ellisonsyndrome,
multiple
adenomas,systemic
mastocytosis);Eradication
of
H. pylori
With amoxicillin or
metronidazole.

Gastric acid-pump
inhibitor: Suppresses
gastric acid secretion by
specific inhibition of the
hydrogen-potassium ATP
as enzyme system at
the secretory surface
of the gastric parietal
cells; blocks the final
step of acid production.

Omeprazole potentially can

increase the concentrations in
blood

CONTRAINDICATION
Contraindicated with
hypersensitivity to
omeprazoleor its
components;Use cautiously
with pregnancy,lactation.

of diazepam (Valium), warfarin (C

oumadin),
andphenytoin (Dilantin) by
decreasing the elimination of
these drugs by the liver. The
absorption of certain drugs may
be affected by stomach acidity.
Therefore, omeprazole as well as

NURSING
CONSIDERATION

ADVERSE EFFECT
Diarrhea, nausea,
fatigue, constipation,
vomiting, flatulence, acid
regurgitation, taste
perversion, arthralgia,
myalgia, urticaria, dry
mouth, dizziness,
headache, paraesthesia,
abdominal pain, skin
rashes, weakness, back
pain, upper respiratory
infection, cough.

Potentially
Fatal: Anaphylaxis.

other PPIs reduce the absorption

and concentration in blood
of ketoconazole (Nizoral) and

Caution patient to swallow

capsules wholenot to
open, chew, or crush them.
Arrange for further
evaluation of patient after 8
weeks of therapy for gastro
reflux disorders; not
intended for maintenance
therapy.
Administer antacids with
omeprazole, if needed.
Teaching points: Take the
drug before meals. Swallow
the capsules whole; do not
chew, open, or crush them.
This drug will need to be
taken for up to 8wk (shortterm therapy) or for a
prolonged period(> 5 yr in
some cases).Have regular
medical follow-up visits.

increase the absorption and

concentration in blood
of digoxin (Lanoxin). This may
reduce the effectiveness of
ketoconazole or increase digoxin
toxicity

Cloxacillin
Brand Name: Cloxapen, Tegopen
Classification:anti-infective
Dose: 500 mg 1 cup q 6 hours P.O
Mechanism of action: inhibits cell wall synthesis and causes
call lysis or death in bacteria that make rigid,cross-linked call wall
in several steps.
Indications: to treat mild respiratory track infections or localized
skin and soft-tissue infection cause by penicillinase-producing
staphylococci.
Contraindications: Hypersensitivity to penicillins.
Adverse effects: Cloxacillin may cause stomach upset,
diarrhea, nausea, and vomiting during the first few days as your

Instruct patient to take the drug with one full glass of water.
DRUG,
MECHANISM
INDICATIONS
CONTRADOSAGE &
OF ACTION
INDICATIONS
ROUTE

body adjusts to the medication. If these symptoms persist or

become severe, inform your doctor. An allergic reaction may
occur while taking Cloxacillin.
Symptoms include:
- Skin rash;
- Itching;
- Hives;
- Difficulty breathing;
Common side effects are:
- Diarrhea Less Severe;
- Feel Like Throwing Up Less Severe;;
- Head Pain Less Severe;
SIDE EFFECTS

ADVERSE REACTIONS

- Throwing Up Less Severe

Nursing responsibilities:

Determine previous exposure and sensitivity to

penicillins and cephalosporins and other allergic
reactions of any kind before treatment is initiated.

Monitor for S&S of anaphylactoid reaction (see Appendix

G) or other signs or symptoms of hypersensitivity
reaction (see Appendix F) as with other penicillins.

Take medication around the clock, do not miss a dose,

and continue taking the medication until it is finished.

Report to physician the onset of hypersensitivity

reaction and superinfections.

Check with physician if GI adverse effects (nausea,

vomiting, diarrhea) appear.
DRUG
INTERACTIONS

NURSING
RESPONSIBILITIES

REMARKS

Lactulose
30 cc syrup
OD HS
8pm
Laxative,
Ammonia
reduction
drug

The drug passes

unchanged into
the colon where
bacteria break it
down to organic
acids that
increase the
osmotic pressure
in the colon and
slightly acidify
the colonic
contents,
resulting in an
increase in stool
water content,
stool softening,
laxative action.
This also results
in migration of
blood ammonia
into the colon
contents with
subsequent
trapping and
expulsion of
feces.

Treatment of
constipation.
Prevention and
treatment of
portal-systemic
encephalopathy.

Contraindicated with
allergy to lactulose,
low-galactose diet.
Use cautiously with
diabetes, pregnancy,
and lactation.

Company Pro Bio Pharma, Incorporated Content 12 strains of lactobacillus &

bifidus bacteria. PPD Classification Digestives Prescription Class Non-Rx
Indication Maintenance & restoration of intestinal microbial balance during &
after treatment w/ antibiotics, chemotherapy, diarrhea, & other digestive
disorder. Dosaging 1-3 caps/day for 5 days preferably 1 hr before meals.

Abdominal
fullness,
flatulence,
belching.

GI
Transient flatulence, distention,
intestinal cramps, belching,
diarrhea, nausea.

DRUG-DRUG
Do not administer
other laxatives
with lactulose.

Other
Acid-base imbalances

DRUG-FOOD
May be taken with
fruit juice or milk
to increase
palatability.

History
Allergy to lactulose,
low-galactose diet.
diabetes, pregnancy,
and lactation.
Physical
Abdominal
examination, bowel
sounds, serum
electrolytes, serum
ammonia levels.
Do not freeze laxative
form. Ask patient to
report diarrhea, severe
belching, abdominal
fullness.