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Aggett, P.J., Agostoni, C., Axelsson, I., Bresson, J., Goulet, O., Hernell, O., et
al., 2002. Medical position paper iron metabolism and requirements in
early childhood: Do we know enough?: A commentary by the ESPGHAN
committee on nutrition. J Pediatr Gastroenterol Nutr; 34(4):337-345.
Ahluwalia, N., 1998. Diagnostic utility of serum transferrin receptors
measurement in assessing iron status. Nutr Rev 56(5):133-9.
Akesson, A., Bjellerup, P., Berglund, M., Bremme, K., Vahter, M., 1998. Serum
transferrin receptor: a spesific marker of iron deficiency in pregnancy. Am
J Clin Nutr 68(4):1241-6.
Atkobeng, A. K., 2007. Review article. Understanding diagnostic tests 3: receiver
operating characteristic curves. Acta Pdiatrica 96:644-47
Allen, J., Backstrom, K.R., Cooper, J.A.,1998. Measurement of serum transferrin
receptor in serum of healthy adults. Clinical chemistry 44:135-39.
Allen, L.H., 2000. Anemia and iron deficiency: effects on pregnancy outcome. Am
J Clin Nutr;71(5):1280s-4s.
Andrews, N.C., 1999. Medical Progress : Disorders of iron metabolism. N.Engl.J.
Med. 341(26):1986-95.
Anonim1, 2005 Tina-quant soluble transferrin receptor (sTfR). Roche Diagnostics
GmbH, Germany.
Anonim2,2006. Human sTfR ELISA. Bio vendor GmbH, Germany
Apriyanti, W.S., 2012. Universitas Gadjah Mada. Uji diagnostik feritin serum
untuk deteksi defisiensi besi pada anak balita.
Baker, R.D., Greer, F.R., 2010. The committee on nutrition diagnosis and
prevention of iron deficiency and iron-deficiency anemia in infants and
young children (0 -3 Years of Age). Pediatrics 126:1040-50
Bakr, A. F., Sarette, G., 2006. Measurement of reticulocyte hemoglobin content to
diagnose iron deficiency in Saudi children. Eur J Pediatr 165:442-445
Baynes, R.D., 1996. Assessements of iron status. Clin Biochemistry 29(3):209-15.
Beard, J., 2003. Iron deficiency alters brain development and functioning. J. Nutr
Beard, J., de Regnier, R., Shaw, M.D., Rao, R., Georgieff, M., 2007. Review
diagnosis of iron deficiency in infants. Lab medicine; 38(2):103-07.
Beguin,Y., 2003. Soluble transferrin receptor for the evaluation of erythropoiesis
and iron status. Clin Chem Act.329:9-22.
Behrman, R.E., Kliegman, R.M., Jenson, H.B., 2003. Nelson Textbook of
Pediatrics 17th ed. WB Saunders.Philadelphia.1026-1132
Bridges, K.R., Pearson, H.A (ed). 2008. Overview anemia. In: Anemias and other
red cell disorders. Bridges, K.R. The McGraw-Hill Companies,
Brugnara, C., Zurakowski, D., DiCanzio, J., Boyd, M.S.T., Platt, O., 1999.
Reticulocyte hemoglobin content to diagnose iron deficiency in children.,
Turk J Haematol. 30(2):153-56.



Brugnara, C., 2000. Reticulocyte cellular Indices: A new approach in the

diagnosis of anemias and monitoring of erythropoetic function. Critical
Reviews of Clinical laboratory Sciences 37(2):93-130.
Ceylan, C.,Miskiog, M., Olak HC., Kilic B., Iog, C., Zdemir, O., 2007.
Evaluation of reticulocyte parameters in iron deficiency, vitamin b12
deficiency and thalassemia minor patients. Int J Lab Hem.29(5):327-34.
Choi, J.W., Soo ,H.P., Im, M.W., 1999. Change in transferrin receptor
concentrations with age. Clinical Chemistry 45(9):1562-3.
Choi, J.W., Soo, H.P., Im, M.W., 2000. Serum transferrin receptor concentrations
during normal pregnancy. Clin Chem 46(5):725-727.
Choi, J.W., 2005. Sensitivity, specificity, and predictive value of serum soluble
transferrin receptor at different stages of iron deficiency. Ann Clin Lab
Chuoliaras, G.L., Prementis, E., Tsiftis, F., Drosatou, P., Papassotiriou, I.,
Stamoulakatou, A., et al. 2009. Serum transferrin receptors: Distributions
and diagnostic performance in pre school children. Blood cell molekule,
and disease 43(2):163-68.
Clark, S.F., 2009. Iron deficiency anemia: diagnosis and management. Current
Opinion in Gastroenterology 25(2):122-28.
Cobas c 311, 2010. sTfR Tina-quant soluble transferrin receptor. Roche/Hitachi
cobas c systems.
Cooper, M.J., Zlotkin, S.H., 1996. Day-to-day variation of transferrin receptor and
ferritin in healthy men and women. Am J Clin Nutr 64(5):1807-13.
Cotton, F, Thiry, P, Boeynaems, J., 2000. Measurement of soluble transferrin
receptor by immunoturbidimetry and immunonephelometry. Clin Biochem
Danise, P., Maconi, M., Morelli., G. Di Palma, A., Rescigno, D., Esposito, C. et
al., 2008. Reference limit and behaviour of serum transferrin receptor in
children 6-10 years of age. Int J Hem 30:306-311.
Dawson, E.B., McGanity, W.J., 1987. Protection of maternal iron stores in
pregnancy. J Reprod Med 32:478-87
Demaeyer, E.M., Dallman, P., Gurney, J.M., Hallberg, L., Sood S.K., Srikantia
S.G., 1989. Preventing and controlling iron deficiency anaemia through
primary health care. A guide for health administrators and programme
managers. World Health Organization.Geneva
DOnofrio, G., Zini, G., Rowan, R.M., 2002. Reticulocyte counting: method and
clinical application. In: Rowan RM, van Assendelft OW, Preston FE,eds.
Advance laboratory methods in haematology.1st ed. Oxford University
Press Inc. London.
De Benoist, B., Mc Lean, E., Egli, I., Cogswell, M., 2008. Worldwide prevalence
of anaemia 1993-2005. World Health Organization.
De Souza Queiroz, S., De A. Torres, M.A., 2000. Iron deficiency anemia in
children. J.Pediatr 76(3):S298-S304.
Dobson, A.J., 1984. Calculating sample size: Transaction of the menzies
foundation 7:75-9.


Domellf, M., Lnnerdal, B., Dewey, K.G., Cohen, R.J., Rivera, L.L., Hernell, O.,
2002. Sex diferences in iron status during infancy. Pediatrics 110(3):54552.
Ervasti, M., 2008. Doctoral dissertation. Evaluation of iron status using methods
based on the features of red blood cells and reticulocytes. Kuopio
University Publications D. Medical Sciences.
Fitzsimons, E.J., Brock, J. H., 2001. The anemia of chronic disease. BMJ. 322:
Gleason, G., Scrimshaw, N. S., 2007. An overview of the functional significance
of iron deficiency, Nutritional Anemia. Sight And Life,Swiss Federal
Institute of Technology 46-57.
Guyatt, G.H., oxman, A.D., Willan, A., Mcllroy,W., Patterson,C., Ali, M.,
1992.Laboratory Diagnosis of Iron-deficiency Anemia. J Gen Intern Med
Greenwood R, Golding J, McCaw-Binns A, Keeling J, Ashley D. 1994. The
epidemiology of perinatal death in Jamaica. Paediatr perinat epidemiol
Hanif, E., Ayyub, M., Anwar, M., Ali, W., Bashir, M., 2005. Evaluation of Serum
Transferrin Receptor concentration in diagnosing and differentiating Iron
deficiency anaemia from anaemia of chronic disorders. J Pak Med
Hay, W.W., Sondheimer, J.M., Levin, M.J., Deterding, R. R., 2005. Current
Pediatric Diagnosis & Treatment17th Edition. Lange Medical
Books/McGraw-Hill. New York.
Hay, G., Refsum, H., Whitelaw, A., Melbye, E.L., Haug, E., Johnsen, B.B., 2007.
Predictors of serum ferritin and serum soluble transferrin receptor in
newborns and their associations with iron status during the first 2 y of life.
Am J Clin Nutr 86:64-73.
Hentze, M.w., Muckenthaler, M.U., Andrews,N.C., 2004. Balancing Acts:
Molecular control of mammalian iron metabolism. review European
Molecular Biology Laboratory 117:285-297.Hoffbrand, A.V., Pettit, J.E.,
1998. Essential Haematology 3rd ed. Blackwell Science Ltd. Oxford.
Hoffbrand, A.V., Hershko, C., Camaschella, C. 2011. Iron metabolism, iron
deficiency and disorders of haem synthesis. Editor : Hoffbrand A Victor.
Catovsky Daniel, Tuddenham Edward GD, Green Anthony R. In :
Postgraduate haematology. 6th ed. Wiley Blackwell Publishing Ltd.
London. 26-46.
Hueber, H.A., Finch, C., 1987. The physiology of transferrin and transferrin
receptors. Physiol Rev 67:520.
Irwin, J.J., Kirchner, J.T., 2001. Anemia in children. Am Fam Physician
Israels, L.G., Israel, E.D., 2002. Mechanisme in Haematology. 3ed. Core Health
services. Inc. Ontario.


Jandl, J.H., 1991, Hypochromic anemias and disorders of iron metabolism. In

Jandl JH eds Blood Phatophysiology1st edition. Boston Blackwell
Scientific Publication, 121-4,131.
Joosten, E., Loon,R.V., Billen, J., Blanckaert, N., Fabri, R., Pelemans, W., 2002.
Serum transferrin receptor in the evluation of the iron status in elderly
hospitalized patients with anemia. American J Hem 69(1):1-6.
Kamer, B., Dka, E., Pasowska, R., witkowska, E., 2012. The usefulness of
soluble transferrin receptor (sTfR) in differentiating anemia occurring in
young children. Folia Histochemica et Cytobiologica 50(3):473-79.
Kazal, L.A., 2002. Prevention of Iron Deficiency in Infants and Toddlers. Am Fam
Physician 66(7):1217-1225.
Kern, W. F., 2002. PDQ Hematology.Department of Pathology University of
Oklahoma Health Sciences Center. Oklahoma.25-77
Kjeldsberg. 2006. Practical diagnosis of hematologic disorders. Hematology
reference values. 4th (1):408-15.
Kodyat, B., Kosen, S., de Pee, S. 1998. Iron Deficiency in Indonesia: Current
Situation and Intervention. Nutrition Research 18(2).
Kottke-Marchant K., Davis H.B., 2012. Laboratory Hematology Practice.
International Society for Laboratory Hematology. First edition. WileyBlackwell. Calveland 650-53.
Kraemer, K., Zimmermann, M.B., 2007. Nutritional Anemia. Sight And Life
Press. Switzerland.
Kratovil, Tonya, Deberardinis, Jennifer, Gallagher, Navi, et al., 2007. Age
specific reference intervals for soluble transferrin receptor (sTfR). Clin
Chim Acta 380(1-2):222-224.
Lee, E.J., Park, J.J., Lee, H.K., 2002. Soluble Transferrin Receptor (sTfR),
Ferritin, and
sTfR/log Ferritin Index in Anemic Patients with
Nonhematologic Malignancy and Chronic Inflamations. Clinical
Chemistry 48(7):1119.
Loggetto, S.R. 2010. Erythrocyte index and serum ferritin in newborns. Rev Bras
Hematol Hemoter.; 32(5):346-347.
Longo, D. L. 2010. HARRISONS Hematology And Oncology. Harrisons
Principles of Internal Medicine, 17th Ed. Bethesda and Baltimore 70-143
Lopez, A.V., 2006. The usefulness of serum transferrin receptor for discriminating
iron deficiency without anemia in children. J hematology 91(2):264-65.
Lozoff, B., Georgieff, M.K. 2006. Iron Deficiency and Brain Development. Semin
Pediatr Neurol 13:158-165.
Mast, AE., Blinder, MA., Gronowski, AM., Chumley, C., Scott, MG., 1998.
Clinical utility of the soluble transferrin receptor and comparison with
serum ferritin in several populations. Clin Chemistry 44(1): 45-51.
Nadeem, S., Shah, S., Iqbal, T., Iqbal, Z., Hanif, E., 2011 Serum Transferrin
Receptor, Serum Ferritin And Serum Transferrin Receptor-Ferritin Index
In Adults With Iron Deficiency Anaemia. J Ayub Med Coll Abbottabad


Olivares, M., Walter,T., Cook, J.D., Hertrampf, E., Pizarro, F., 2000. Usefulness
of serum transferrin receptor and serum ferritin in diagnosis of iron
deficiency in infancy. Am J Clin Nutr 72:1191-5.
Ooi, C.L., Lepage, N., Nieuwenhuys,Ed., Sharma, A. P., Filler, G., 2009. Pediatric
reference intervals for soluble transferrin receptor and transferrin receptorferritin index. World J Pediatr 5(2):122-26.
Oski, F.A. 1993. Iron deficiency in Infancy and Childhood. N Engl J Med
Oustamanolakis, P., Koutroubakis, I.E., Messaritakis, I., Ninirakic, M.,
Kouroumalis, E.A., 2011. Soluble transferrin receptor-ferritin index in the
evaluation of anemia in inflammatory bowel disease: a case-control study.
Ann Gastroenterol 24(2):108-114.
Pan, B.T., Blostein, R., Jhonstone,R.M., 1983. Loss of transferrin receptor during
the maturation of sheep reticulocyte in vitro, an immunological approach.
Biochem J 15(210):37-47.
Phiri, K.S., Calis, J.C.J., Siyasiya, A., Bates, I., Brabin, B., Hensbroek, M.B.V.,
2009. New cut-off values for ferritin and soluble transferrin receptor for
the assessment of iron deficiency in children in a high infection pressure
area. J Clin Pathol 62:1103-06.
Qureshi, M.F., Rafique, H., Mahmood, K.T., Amin, F., Zaka,M., 2011. Factors
Responsible for Iron Deficiency Anemia in Children. J Biomed Sci and
Res 3(1):308-14.
Ratnaningsih, T. 2006. Universitas Gadjah Mada. Uji diagnostik serum transferrin
receptor (sTfR) untuk diagnosis anemia defisiensi besi pada pasien
Ratnadi, A., Soetjiningsih. 2001. Iron Status In Breast-Fed Infants. Paediatr
Indones 41:191-196.
Ringoringo, H.P. 2009. Insidens defisiensi besi dan anemia defisiensi besi pada
bayi berusia 0-12 bulan di Banjarbaru Kalimantan Selatan: studi kohort
prospektif. Sari Pediatri 11:8-14.
Riset Kesehatan Dasar 2007. Badan Penelitian dan Pengembangan Kesehatan
Kementrian Kesehatan Indonesia.
Roy, C.N., Weinstein, D.A., Adrews,N.C. 2003. The molecular Biology of the
Anemia of Chronic Disease: A Hypothesis. Pediatric Research 53(3):50712.
Sastroasmoro, S., Ismael, S. 2008. Dasar-dasar Metodologi Penelitian Klinis.
Edisi ke-3. CV Sagung Seto. Jakarta.
Sazawal,S,, Black, R. E., Ramsan, M., et al. 2006. Effects of routine prophylactic
supplementation with iron and folic acid on admission to hospital and
mortality in preschool children in a high malaria transmission setting:
community-based, randomised, placebo-controlled trial. 367:133-43.
Schumacher, Y.O., Schmid, A., Konig,D., Berg, A., 2002. Effect excercise on
soluble transferrin receptor and other variables of the iron status. Br J
Sport Med 36:195-200.
Sekartini, R., Soedjatmiko., Wawolumaya, C., Yuniar I., Dewi, R., Nycane., et al.
2005. Prevalensi Anemia Defisiensi Besi pada Bayi Usia 4-12 Bulan di


Kecamatan Matraman dan Sekitarnya, Jakarta Timur. Sari Pediatri,

Schiza, V., Giapros, V., Pantou, K., Theocharis, P., Challa, A., Andronikou, S.,
2007. Serum transferrin receptor, ferritin, and reticulocyte maturity indices
during the first year of life in largepreterm infants. J compilation 79:439446.
Shih, Y.J., Baynes,R.D., Hudson, B.G., Flower, C.H., Skikne, B.S., Copk, J.D.,
1990. Serum transferrin receptor is a truncated from of tissue receptor. J
Biol Chem 265(31):19077-81.
Skikne, B.S., Flowers,C.H., James, D.C., 1990. Serum Transferrin Receptor: A
Quantitative Measure of Tissue Iron Deficiency. Blood 75(9):1870-6.
Skikne, B.S., Punnonen, K., Caldron, P.H., Bennett, M.T., Rehu, M., Gasior,
G.H., 2011. Improved differential diagnosis of anemia of chronic disease
and iron deficiency anemia: A prospective multicenter evaluation of
soluble transferrin receptor and the sTfR/log ferritin index. Am. J. Hematol
Stiene Martin, E.A., Lotspeich Steininger, C.A., Koepke, J.A. 1998. Clinical
Hematology, Second Edition. Lippincott. Philadelphia-New York 27:463465.
Suega, K., Bakta, IM., Adnyana, L., Darmayuda, T. 2007. Perbandingan
Beberapa Metode Diagnosis Anemia Defisiensi Besi: usaha mencari cara
diagnosis yang tepat untuk penggunaan klinik. J Peny Dalam, 8(1).
Soemantri, A. G., Pollitt, E., Kim, I. 1985. Iron deficiency anemia and educational
achievement. Am J Clin Nutr 42:1221-8.
Suominen. Punnonen,K., Rajamaki, A., Irjala, K., 1997. Serum Transferrin
Receptor and Transferrin Receptor-Ferritin Index Identify Healthy
Subjects With Subclinical Iron Deficits. Blood 92(8):2934-39
Souminen, P., Punnonen, K., Rajamaki, A., Majuri, R., Hanninen, H., 1999.
Automated Immunoturbidimetric Method for Measuring Serum
Transferrin Receptor. Clin Chem 45(8):1302-5.
Souminen, P., Mottonen, T., Rajamaki, A., Irjala, K., 2000. Single Velue of
Serum Transferrin Receptor and Transferrin Receptor ferritin index can be
used to detect true and functional iron deficiency in rheumathoid arthritis
patient with anemia. J Arthritis rheum 43(5):1016-20.
Syaiful, 2012. Universitas Gadjah Mada. Prevalensi anemia defisiensi besi pada
balita di Yogyakarta.
Thomas, C., Thomas, L. 2002. Biochemical markers and hematologic indices in
the diagnosis of functional iron deficiency. Clinical Chemistry 48(7):106676.
Thurnham DI, McCabe GP. 2012.Influence of infection and inflammation on
biomarkers of nutritional status with an emphasis on vitamin A and iron.
In: World Health Organization. Report: Priorities in the assessment of
vitamin A and iron status in populations, Panama City, Panama, 15-17
September 2010. Geneva, World Health Organization.


Vendt, N., Grnberg Heli, Leedo Sirje, Tillmann Vallo, Talvik Tiina. 2007.
Prevalence and causes of iron deficiency anemias in infants aged 9 to 12
months in Estonia. Medicina (Kaunas) 43(12):947-952
Vikstedt, R., Lode, P., Takala, T., Irjala, K., 2004. Rapid One-Step
Immunofluorometric Assay for Measuring Soluble Transferrin Receptor in
Whole Blood. Clinical Chemistry 50(10):1831.
Wang, Y.P., Shao, J., Zhuang, X.L., 2011.Value of soluble transferrin receptor in
the diagnosis of iron deficiency in children. Article in Chinese 13(7):535538.
Wians, F.H., Urban, J.E., Keffer, J.H.,MD,. Kroft, S. H., 2001. Discriminating
Between Iron Deficiency Anemia and Anemia of Chronic Disease Using
Traditional Indices of Iron Status vs Transferrin Receptor Concentration.
Am J Clin Pathol 15:112-18.
Widiaskara, I.M., Pramitha, P.T., Bikin, S., Ugrasena, I.D.G. 2012. Gambaran
Hematologi Anemia Defisiensi Besi pada Anak. Sari Pediatri 13(5):362-6
Widiastuti, E., 2009. Anemia defisiensi pada bayi dan anak. Indonesia Pediatric
Society 11(3):207-09
World Health Organization. 2001. Iron Deficiency Anemia: Assessment,
Prevention, and Control-Geneva, Switzerland 41-71
World Health Organization. 2007. Assessing the iron status of populations.
Second edition.
World Health Organization 2008. Worldwide prevalence of anaemia 19932005 :
WHO global database on anaemia. Edited by Bruno de Benoist, Erin
McLean, Ines Egli and Mary Cogswell. Geneva 3-7
Wu, A.C., Lesperance, L., Bernstein, H. 2002. Screening for Iron Deficiency.
Pediatrics in Review 23(5):171.