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6 authors, including:
Debra Moser
University of Kentucky
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Barbara Riegel
University of Pennsylvania
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Introduction
Promotion of effective self-care among individuals with
heart failure (HF) is vitally important to patient outcomes,
yet is one of the most difficult tasks facing clinicians today.
Most of the cost associated with the care of patients with HF
is the result of rehospitalization for exacerbations of HF
[14], many of which can be traced to failed self-care
[57]. There are multiple modifiable factors known to precipitate hospitalization for HF exacerbation, but the two
most common are nonadherence to prescribed medications
and diet, and failure to seek timely medical care for escalating symptoms [6, 814]. Both of these are prime examples
of poor self-care.
Patient nonadherence to recommended self-care activities
is common [8, 13, 15, 16]. Patients recently discharged from
A. Stromberg
Division of Nursing Science,
Department of Medicine and Health Sciences,
Faculty of Health Sciences, Linkping University,
Linkping, Sweden
e-mail: anna.stromberg@liu.se
A. Stromberg
Department of Cardiology, UHL, County Council of stergtland,
Linkping, Sweden
B. Riegel
University of Pennsylvania, School of Nursing,
Claire M. Fagin Hall, 418 Curie Boulevard,
Philadelphia, PA 19104-4217, USA
e-mail: briegel@nursing.upenn.edu
Certain general health and HF-specific self-care maintenance behaviors are associated independently with partial
neurohormonal deactivation and/or partial mitigation of systemic inflammation. For example, routine exercise training
is associated with partial neurohormonal deactivation and a
significant reduction in biomarkers of systemic inflammation in adults with HF [4548]. Vaccinations, presumably by
limiting infection, are associated with reductions in the risk
of hospitalization and death among adults with HF [49].
Several classes of HF medications target neurohormonal
activation. Thus, taking prescribed HF medications is associated with reductions in biomarkers of neurohormonal activation and systemic inflammation [5053]. Although there
are some notable exceptions [54], medication nonadherence
in HF is generally associated with increased risk of clinical
The greatest efficacy of HF medications occurs in the absence of clinical congestion [60]. As such, it is likely that
patients who recognize and respond to episodes of congestion more effectively have optimal benefit from HF medications. Patients who are able to detect and manage subtle
symptoms also may be less likely to require high-dose
diuretics that cause increases in neurohormonal activation
[61]. The greatest risk for bacterial translocation in HF also
occurs during episodes of congestion [62]. Thus, recognizing
and treating symptoms of clinical congestion early may limit
the risk of infection from gut bacteria. Moreover, there is
direct evidence that patients who recognize and respond to
HF symptoms more quickly and effectively are less likely to
have levels of neurohormonal activation and systemic inflammation that are associated with poor clinical outcomes such as
urgent advanced therapies and early death [63].
Importantly, the direct mediating effect of neurohormonal
deactivation/blockade and systemic inflammation between
symptom monitoring) likely mitigate, in part, neurohormonal activation and systemic inflammation inherent in progressive heart failure.
Collectively, better self-care maintenance behaviors are associated with
less frequent episodes of thoracic water accumulationthe culmination of neurohormonal activation. Moreover, heart failure self-care
management behaviors (eg, effective symptom recognition, evaluation,
treatment/treatment evaluation) are associated directly with lower levels of biomarkers of neurohormonal activation and systemic
inflammation
Knowing that one has heart failure and what the condition
is (and what it is not)
Determining how to get appropriate information at an
understandable level
Understanding the links between self-care activities and
symptoms
Understanding the meaning of escalating symptoms
Getting exercise
Learning how to monitor sodium intake, choose lowersodium foods, cook lower-sodium foods
Learning how to follow a heart healthy diet
Understanding what signs and symptoms to look for
Gaining the knowledge and skills to monitor for
symptoms and signs, and understanding what to do with
information
Knowing when to call the physician or nurse and what
information to provide them
Understanding how to weigh daily and what to do with
the information
Working with the physician or nurse to take early action
with escalating symptoms to avoid emergency
department visits or hospitalization
Determining how much, how often, what type
Determining how to start if never exercised or are
sedentary
Overcoming fears of activity if have injured self in past
Managing comorbidities
Comorbid conditions
Clinical interview
Cognitive impairment
Sleep disturbances
Vaglio J, Jr., Conard M, Poston WS, et al. Testing the performance of the ENRICHD Social Support Instrument in cardiac patients. Health Qual
Life Outcomes 2004, 2:24.
Complexities of Self-Care
Successful self-care management starts with the early recognition and accurate interpretation of symptoms. Unfortunately, patients with HF face numerous challenges in
symptom recognition. The reasons for poor symptom recognition are unclear but we do know that age-related
changes, comorbid conditions, and situational factors
contribute in important ways to symptom recognition and
interpretation.
Many HF patients are older adults and age appears to
contribute to poor symptom recognition. One explanation
for this difficulty is impaired interoception. Interoception is
the process by which sensory nerve receptors receive and
process stimuli that originate inside the body [74]. Interoceptors include physiological receptors that monitor ongoing function of visceral organs and mediate visceral reflexes.
Poor interoception may result from a loss of neurons in the
cortical regions of the brain (ie, insula and anterior cingulate) [75]. When we examined differences in age-related
symptom recognition in adults with HF, older adults (age
73 years) had more difficulty detecting and interpreting
shortness of breath and were half as likely as younger adults
(<73 years) to accurately perceive their shortness of breath
after exercise [76]. The older adults did not detect subtle
symptoms and were more likely to attribute symptoms like
fatigue or breathlessness to other conditions such as arthritis or being out of shape. Others have found that HF
patients who attribute their symptoms to other conditions
(eg, lung disorder, high blood pressure) or old age were less
likely to recognize symptoms [77].
HF rarely occurs in isolation. On average, HF patients
report three other concurrent conditions. Therefore, it is not
surprising that HF patients experience on average nine
symptoms [78], which are often vague, insidious in onset,
and overlapping. We demonstrated recently that HF patients
with comorbid conditions struggle to differentiate HF symptoms. When faced with multiple comorbid conditions,
patients tended to attribute vague symptoms like fatigue to
the condition with which they have the most experience
[79]. As a result, HF self-care management is delayed or
inadequate.
Conclusions
Promotion of effective self-care should be a priority of
all clinicians caring for patients with HF. Incorporation
of self-care into practice so that it receives the same
attention and status as medication prescription could
substantially improve outcomes in HF. Greater strides
in decreasing rehospitalization rates could be made if
promotion of self-care was the standard of care for
every HF patient.
Disclosure Conflicts of interest: D.K. Moser: has received grant
support from the National Institutes of Health (NIH); V. Dickson: none;
T. Jaarsma: none; C. Lee: is employed by Oregon Health & Science
University; and has received grant support from NIH/NINR, American
Heart Association, and NIH/ORWH; A. Stromberg: none; B. Riegel:
has received grant support from the NHLBI.
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