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Different structures
One thing in common - have some kind of protein protected coat
Contains genetic material - dna or rna
See common structures of viruses
Left - first viruses identified
Tobaco mosiac
2nd - common cold
Influenza - flu
Right - bacteriofague - attack bacteria
Types of reproduction
Two general ways viruses can operate
Lytic cycle - virus enters cell, takes over, has host cell make new viruses and then
typically cell dies as new virus particles released
Along the lines of example previously
Lysogenic cycle - enters cell, inserts its dna into the dna of host, dna is part of the
host cell, host cell goes to do various things of dna, also makes gene products
useful for virus
In this case, virus doesn't kill the host cell, allows host cell to keep replicating like
normal cell
Each time it replicates carries copy of virus dna as well as normal dna
These cells have virus dna - are dormant and become active
Produce more virus
Latent infections
Become infected - some time before symptoms shown up
Hiv shows up
Dormant period
Herpes - viral infection
Periods of time - lying dormanti nside host cells and sometimes it becomes active
Retroviruses - rna as genome rather than dna
Require special enzymes to turn rna into dna
Hiv retrovirus
Virus genome
At some point - environmental trigger
Causes virus to turn on and start taking over cell and directing it to make new virus
particles
Lambda - lysogenic and lidic stage
Attack plants, animals, fungi, bacteria
Viral diseases - most interested in ones that effect humans
Viral diseases - cannot be cured
No anditiotics that can destroy it once it affects cell
Problems - goes inside cell
Very difficult to get at virus without killing cell itself or recognize infected cell by non
infected cell
Raise body's immune system
Exposed to viral diseases can stop it from taking over
Viral diseases common - polio - vaccination gone but exists in some parts
Used to be fairly common now dissapeared
Colds - very common
True flu - flue shots for - viral disease, warts, smallpox (historically killed 60 million
people, now gone from planet, vaccination program worldwide - eliminated it),
measles, mumps
Rabies, chickenpox, hiv, vaccine for chickenpox
Might be whiped out as well
Some are difficult to develop vaccine for
Virus changes quite frequently
Can't have vaccine for common cold
Vaccines you have - for one type but another type comes along
Those diseases
Associated with open sores in genital area
Infected more likely to produce fluids
Uninfected pick up infection - exposed to
Easier transmitted from one person to another
Talk about sexual transmission
Can be either through homosexual ex or heterosexual sex
Discovered in homosexual male populations - first discovered
Most people infected by homosexual males
Not disease restricted to homosexual males
Look at possibility of transmission through homosexual act
Homosexual act - through anal sex - higher risk of transmission
Higher risk activity
Increased likelyhood - breakage of blood vessels and virus moving from one
individual to another
Woman twice likely to woman get from indefted man to man get it from infected
woman
Blood - transfusions - screen blood supply for hiv
Transfusion now from stranger - little chance of hiv infection
Store own blood - to make sure
Number of cases where before this whole disease well known
Did get into blood supply
Needed repeated transfusion got aids because of that
Contact with fresh blood another way of transmitting it
Sports events - sit out for a while till it stops
Needle use - at risk group - consits of iv drug users that share needles
Pulling up blood when you inject and those get blood who others iject with needles
Infected mothers transmit to children - utero, at birth, during breast-feeding - virus
is in breast milk
Can pass on infection onto cihld
Hiv - real nasty thing - virus attacks certain cells in immune system
It attacks in specific way
One way that virus can infect cells - insert their genes into genome of host cell
This particular virus - retrovirus - way it propogates
Genes in host cell genes and in this case - cells in immune system targeted
Cells in immune system - the genes for making this virus
Virus can come near these immune system cells
Make copies of themselves if infection is incurring
In response to hiv
At same time, hidden, genetic message to make more of virus
Eventually immune system breaks down
Aids - individual immune system very suseptical to infections, and cancer
No treatment - 10 years of infection
In time infected with hiv? Cures?
No cure
No cures for virual infection in immune system
Do have some powerful antiretroviral drugs
Slow down progress of disease
Hiv levels become very low
Individuals treated with these drugs (azt) life expenctancy - 24 years