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Laboratory:
Imaging investigation :
-hepatomegaly;
-splenic enlargement;
-in acute (blastic crisis) : sometimes, l;ymph nodes enlargement
How ?
= to directly inhibit the molecular cause of the disease, that is, using a protein-
tyrosine kinase inhibitor that inhibits the bcr-abl tyrosine kinase, the constitutive
abnormal tyrosine kinase created by the Ph chromosome translocation
abnormality:
Surgical Care
• Splenectomy and splenic irradiation have been used in patients with large
and painful spleens, usually in the late phase of chronic myelogenous
leukemia (CML).
o This is rarely needed in patients whose disease is well controlled.
o Some authors believe that splenectomy accelerates the onset of
myeloid metaplasia in the liver. Splenectomy is associated with high
perioperative morbidity and mortality rates because of bleeding or
thrombotic complications.