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Thephysiomeofanindividual'sorspecies'physiologicalstateisthedescriptionof

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itsfunctionalbehavior.Thephysiomedescribesthephysiologicaldynamicsofthe
normalintactorganismandisbuiltuponinformationandstructure

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(genome,proteome,andmorphome).Thetermcomesfrom"physio"(nature)and

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"ome"(asawhole).

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Initsbroadestterms,itshoulddefinerelationshipsfromgenometoorganismand
fromfunctionalbehaviortogeneregulation.InthecontextoftheIUPSPhysiome
Project,itincludesintegratedmodelsofcomponentsoforganisms,suchas

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particularorgansorcellsystems,biochemical,orendocrinesystems.

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TheIUPSPhysiomeProjectisaworldwideefforttodefinethephysiomethroughthe

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developmentofdatabasesandmodelswhichwillfacilitatetheunderstandingofthe

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integrativefunctionofcells,organs,andorganisms.Theprojectisfocusedon
compilingandprovidingacentralrepositoryofdatabases,linkingexperimental

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informationandcomputationalmodelsfrommanylaboratoriesintoasingle,self

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consistentframework.Thiscoalescenceofresearcheffortwillpromote
comprehensivedatabasesandanintegrative,analyticalapproachtothestudy

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ofmedicineandphysiology.

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TheconceptofaphysiomeprojectwaspresentedtotheInternationalUnionof

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PhysiologicalSciences(IUPS)byitsCommissiononBioengineeringinPhysiologyin
1993.AworkshopondesigningthePhysiomeProjectwasheldin1997.Atitsworld

congressin2001,theIUPSdesignatedtheprojectasamajorfocusforthenext

decade.[1]TheprojectisledbythePhysiomeCommissionoftheIUPS.[2]

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Otherresearchinitiativesrelatedtothephysiomeinclude:

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TheEuroPhysiomeInitiative
TheNSRPhysiomeProjectoftheNationalSimulationResource(NSR)at
theUniversityofWashington,supportingtheIUPSPhysiomeProject
TheWellcomeTrustHeartPhysiomeProject,acollaborationbetween
theUniversityofAucklandandtheUniversityofOxford,partofthewiderIUPS
PhysiomeProject

https://en.wikipedia.org/wiki/Physiome

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PhysiomeWikipedia,thefreeencyclopedia

Seealso

[ edit ]

Physiomics
LivingHumanProject
VirtualPhysiologicalHuman
VirtualPhysiologicalRat
Cytome
HumanGenomeProject
Listofomicstopicsinbiology
Cardiophysics

References

[ edit ]

1.^Hunter,PeterJ.ThomasK.Borg(March2003)."Integrationfromproteinstoorgans:
thePhysiomeProject".Naturereviews.Molecularcellbiology4(3):pp.237
243.doi:10.1038/nrm1054

.PMID12612642

2.^"WelcometotheNSRPhysiomeProject" .NSRPhysiomeProject.28October
2008.Retrieved13December2008.

Externallinks

[ edit ]

IUPSPhysiomeProject
NSRPhysiomeProject
NationalResourceforCellAnalysisandModeling(NRCAM)
Categories: Physiology

Biophysics

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