MODULE

INFLAMMATION

DURATION

11 DAYS (1st FEBURARY- 13th FEBURARY)

CONTACT HOURS

Lectures 42 =31.50 hours + Practicals = 30 Hours + Hospital stay = 12 Hours

CREDIT HOURS

5th FEBURARY Holiday

2.6

TEACHING METHODOLOGIES

Lectures/Practicals/ small group discussion/clinics

OBJECTIVES
The course is designed primarily for 3 rd year M.B;B.S students and will cover the fundamental aspects of
inflammation ,
and pharmacology of anti inflammatory drugs with interrelated clinical aspects of medicine,
surgery, orthopaedic surgery ,eye , nose and throat. By the end of the module the students should be able to :
1. Describe :
the cells and types of inflammation , cellular and vascular events of inflammation .
Process of phagocytosis.
Outcome of inflammatory process
Acute and chronic inflammatory conditions of nose and throat
iInflammatory conditions of orbit and eyelid
2. Discuss the role of :
chemical mediators in inflammation and anti inflammatory drugs.
Autocoids , serotonin and its antagonists.

Medicolegal certification in different injuries

3 .Elaborate
Types of Injuries along with their mechanics
Difference between antemortem/postmortem injuries
Systemic effects of inflammation and choice of analgesics.

TIME

8.008.45am

COURSE CONTENT

PLAC
E

LEARNING OUTCOME

WEEK 1
DAY 1
01-02-16 (MONDAY)
General Features and types of
Understanding the general
concept of inflammation and
inflammation, Historical
being able to
background, its cardinal signs.
Acute Inflammation: introduction
and stimuli leading to
define inflammation
inflammation and vascular events.
along with its types
and cardinal signs
vascular
changes such as
change in caliber
and vascular
flow as wel as

Recommende DEPARTMEN
d books
T/ Facilitator

DURA
N

Robbins
Pathology

45 mi

Pathology

vascular
leakage.
8.45am9.30 am

Clinical aspects of inflammation

(immune, infections, chemical ).
Clinical differences between acute
and chronic inflammation

45 mi
Medicine

9.3010.15 am

Student should be able

to enumerate various
NSAIDs and
understand their
routes of
administration
absorption,
distribution,
metabolism and
excretion.

Classification of non-steroidal antiinflammatory drugs.

Pharmacokinetics of NSAIDs

Hospital
12.102.30
Practical

8.008.45am

4.

Physiology of pain
( central and peripheral pain)

45 mi
Basic and
clinical
pharmacology
12th edition
katzung

Pharmacology

work
10.30-12.00
Batch C:Acute
Respective
appendicitis
departments
Batch A : Small group
Class divisible
discussion
in three
Batch B : General
batches
description of injury
regarding age of injury.
DAY
2
02-02-16 (TUESDAY)
Students should be
physiology
able to differentiate
between central and
peripheral pain and
have clear

45 mi

8.45am9.30am

5.

9.3010.15am

6.

12.102.30

8.008.45am

7.

8.459.30am

8.

9.30-

9.

understanding of both.
Student should be able
Pharmacology
to describe MOA,
Basic and
Mechanism of action of NSAIDs,
adverse effects
clinical
Adverse effects, contraindications
contraindications and
pharmacology
and drug interactions of NSAIDs
drug interactions of
12th edition
NSAIDs with reference
katzung
to aspirin as prototype
Student should be able
Forensic
Classification Of Injuries
to classify different
Medicine
types of injuries
Hospital work
10.30-12.00
Batch A: Acute
Respective
Appendicitis
departments
Batch B : Small group
Class divisible
discussion
PRACTICAL
in three
Batch C : Batch A :
batches
General description of
injury regarding age of
injury.
DAY 3
03-02-16 (WEDNESDAY)
Clinical aspects of acute and
chronic inflammation. An
Medicine
introduction to vasculitis.
Student should be able
Basic and
to enumerate
clinical
Disease modifying anti- rheumatic
DMARDS and explain
pharmacology Pharmacology
drugs (DMARDS)
their MOA, adverse
12th edition
effects and
katzung
contraindications
Student should be able
Forensic

45 mi

45 mi

45 mi

45 mi

45 mi

10.15am

Mechanism of Each Type Of Injury

to describe the
mechanism of each
type of injury
work
Batch B : Acute
Appendicitis
Batch C : Small group
discussion
Batch A : General
description of injury
regarding age of injury.

Medicine

Hospital
12.102.30
PRACTICAL

DAY
8.008.45am

Class divisible
in three
batches

04-02-16 (THURSDAY)

10.

Pathology

Cellular events of inflammation :

Leucocyte recruitment and
activation

8.459.30am

10.30-12.00
Respective
departments

Student should be able

to describe the cellular
events taking place
during inflammation
such as
Margination, rolling
and adhesion to
endothelium
Transmigration across
the endothelium
Migration towards a
chemotactic stimulus

45 mi

Robbins
Pathology

11.

45 mi
Regional Injuries

Students should have

sound knowledge of
regional injuries

Forensic
Medicine

9.3010.15 am

12.

12.102.30

8.008.45am

13.

14
8.45am9.30am

Students should have

Cellulitis, Boil,Folliculitis and
sound understanding
Impetigo erythemia
of acute inflammatory
conditions
Hospital work
BATCH C : Chronic
cholecystitis
Batch A : Small
PRACTICAL
group Discussion
Batch B :
Certification of injury
MLCs
DAY 5
06-02-16 ( SATURDAY)
Student should have a
sound knowledge of
Prostaglandins
and leucotrienes
Cell derived Chemical Mediators of
Differences
Inflammation : details of
between
Vasoactive amines Arachidonic
different
acid metabolites ,Platelet
mediators
activation factors.
involved in
cyclooxygenase
and
lipooxygenase
pathways.
Student should be able
Autacoids histamine and
to recall various
antihistamine.
generations of
antihistamines and role
of antihistamine in

Surgery

45 mi

10.30-12.00
Respective
departments
Class divisible
in three
batches

45 mi

Robbins
pathology

Basic and
clinical
pharmacology
12th edition
katzung

Pathology

Pharmacology

45 mi

9.3010.15am

15
Serotonin agonist and antagonists

10.1511.00 am

16

11.0011.45 am

17

11.4512.30 pm

18

Inflammatory conditions of bones

and joints
Regional Injuries/Manner of
Injuries

Overview of Acute inflammatory

conditions of nose and throat.

12.452.30 pm

PRACTICAL

allergic conditions.
Their adverse effects
and drug interactions.
Student should be able
to explain/understand
the use of serotonin
agonist and
antagonists
Students should be
able to describe the
various steps In
fracture healing

Basic and
clinical
pharmacology
12th edition
katzung

45 mi
Pharmacology

45 mi
Orthopaedics

45 mi
Student should be able
to enumerate Regional
Injuries/Manner Of
Injuries

Forensic
medicine and
toxicology

Students should be
able to describe:
Acute tonsillitis
Acute pharingitis
Acute laryngitis
Acute sinusitis

Batch B: Chronic
cholecystitis
Batch C : small group
discussion

45 mi

ENT

Class divisible
in three
batches

Respective
departments

8.008.45am

8.459.30am

Batch A : Certification
of injury MLCs
DAY
6
08-02-16 (MONDAY)
19.
Students should have
sound knowledge of
Cell derived chemical mediators of
Different
inflammation cont: Details of
components of
cytokines,TNF,Chemokines,Reactiv
cytokines and
e oxygen species and nitrous oxide
chemokines

12.452.30

Pathology

20.
Prostaglandins pharmacological
effects, Clinical uses of
prostaglandins

9.3010.15am

45 mi

21.
Bacterimia,Pyaemia ,Sepsis,
Abscess, Septic Shock
PRACTICAL

The use of
prostaglandins in
various clinical
conditions

Students should be
able to describe
various inflammatory
processes.
Batch C : ESR
determination and its
importance
Batch A :
Therapeutic modalities
and choice of
analgesics

Basic and
clinical
pharmacology
12th edition
katzung

Pharmacology

45 mi
Surgery
Class divisible
in three
batches

Respective
departments

Batch
B :Trauma
cases which are kept
under observation
DAY
8.008.45am

22.
Plasma protein derived Chemical
Medicators of inflammation
(details of complement system,
kinin system, clotting system)

8.45- 9.30
am

23.

9.3010.15 am

24.

12.102.30

Cytokine storm

Glucocorticoids
Natural + synthetic
MOA

Practical

WEEK 2
09-02-16 (TUESDAY)
. The student should
be able to
i) Enumerate vasoactive
amines
Ii ) Describe the 3
systems of plasma
proteins integrating
during course of
inflammation
Students should have
sound understanding
of cytokine storm and
its clinical implications
Student should be able
to understand
secretion and control
of glucocorticoids and
how do they act as
anti-inflammatory
drugs
Hospital work
Batch A: ESR
determination and its
importance

45 mi

Robbins
Pathology

Pathology

45 mi
Medicine

Pharmacology

Class divisible
in three
batches

10.30-12.00
Respective
departments

Batch B :
Therapeutic modalities
and choice of
analgesics
Batch
C :Trauma
cases which are kept
under observation
8.008.45am

8.45-9.30
am

9.3010.15 am

DAY
25.

26.

27.

10-02-16 (WEDNESDAY)
Student should be able
to explain p/k of
Glucocorticoids
various
P/K:Therapeutic indications,
glucocorticoids, their
Adverse effects, contraindications
clinical uses ,adverse
and drug interactions
effects,
contraindications and
drug interactions
Student should be able
Mineralocorticoid and
to understand uses of
mineralocorticoid antagonist
various
.
mineralocorticoid
agonist and
antagonist.
Investigation and management of
inflammatory case.
Hospital

12.102.30

Practical

work
Batch B: ESR
determination and its
importance

45 mi
Basic and
clinical
pharmacology
12th edition
katzung
Basic and
clinical
pharmacology
12th edition
katzung

Pharmacology

45 mi
Pharmacology

Medicine
10.30-12.00
Class divisible
Respective
in three
departments
batches

45 Min

Batch C :
Therapeutic modalities
and choice of
analgesics
Batch
A : Trauma
cases which are kept
under observation
DAY
8.008.45am

28.

Phagocytosis.

8.45-9.30

29.

Drugs/Age Of Injury

11-02-16 (THURSDAY)
Student should
develop the
understanding of
leucocyte activation
and being able to
describe:
Recognition and
attachment of
leucocytes
Engulfement
Killing and
degradation
Release of
leucocyte
products and
tissue injury
caused by it
Briefly the defects in
leucocyte dysfunction
and its effects on
inflammation
Students should have

Pathology

Forensic

45 mi

am

9.3010.15 am

30.

12.102.30

DAY 10
8.0031
8.45am

understanding of
various drugs and be
able to define age of
injury
Inflammatory conditions of eye :
Students should be
Stye,Chlazion,Blephritis, Preseptal
able to identify the
Cellulitis and Herpes zoster
various inflammatory
Infection
conditions of eye.
Hospital work
Batch C :
Tuberculosis of lung/
Granuloma
Batch A : small
Practical
group discussion
Batch
B : (Final
Opinion )Interpretation
of results

32.

45 mi
Eye
10.30-12.00
Respective
departments
Class divisible
in three
batches

12-02-16 (FRIDAY)

Phagocytosis by macrophages

8.459.30am

Medicine and
Toxicology

Antagonists of adrenocortical
agents

Students should have

sound knowledge of
various recetors
present on
macrophages, their
function and steps of
phagocytosis in
machrophages.
They should have a
sound knowledge of
adverse effects and
contraindications to

Basic and
clinical
pharmacology
12th edition

Pathology

45 mi

Pharmacology

45 mi

the use of
adrenocortical agents.
9.3010.15 am

33
Chronic
Inflammation:Granulomatous
Inflammation with special
emphasis on Tuberculosis

12.002.30
Practical

Day 11
8.0034
8.45am
8.459.30am

35.

katzung

Student should be
able to describe
Cells of Chronic
inflammation
Formation of
granuloma
Tuberculous
granuloma

Pathology

Batch A :
Tuberculosis of lung/
Granuloma
Batch B : small
group discussion
Batch
C : (Final
Opinion )Interpretation
of results

Respective
departments

45 MIN

Class divisible
in three
batches

13-02-16 (SATURDAY)
Lymphangitis, Fascitis, Folliculitis
Paronychia , Subungal
abscess,Hideradenitis

Students should be
able to describe the
the various acute
inflammatory coditions
Students should be
able to describe the
acute inflammatory
conditions and should

Surgery

Dermatology

45 mi

9.3010.15am

36
Anti TB drugs

10.1511.00 am

37

Overview of chronic inflammatory

conditions of nose and throat.

11.0011.45 am

38

11.4512.30 am

39

Inflammatory conditions of bones

and joints

Orbital Cellulitis, Pseudo tumors of

orbit , Dacrocystitis

have sound knowledge

of septic shock
Students should have
knowledge of various
Anti tuberculous drugs
and their adverse
effects.
Students should be
able to describe:
Chronic tonsillitis
Quinsy(Peritonsillar
Abcess)
Chronic pharyngitis
Chronic laryngitis
Chronic sinusitis
Rhinitis
Students should
develop understanding
of mechanism and
complications of
wound contamination
Students should be
able to describe
Orbital Cellulitis,
Pseudo tumors of
orbit , Dacrocystitis

Basic and
clinical
pharmacology
12th edition
katzung

Pharmacology
ENT

45 mi

Orthopaedics

45 mi

Eye

45 mi

12.452.30 am
Practical

Batch B :
Tuberculosis of lung/
Granuloma
Batch C : small
group discussion
Batch
A : (Final
Opinion )Interpretation
of results

Respective
departments
Class divisible
in three
batches