In Othello, Iago easily deceives the main character Othello.

One reason
Iago can so easily deceive Othello is due to Othello's trusting nature.
Othello truly believes that Iago is an honest man. In Act II, Scene III,
Othello makes the following comment about Iago:
Iago is most honest.
No doubt, Othello is too trusting. Iago testifies to this in Act I, Scene III.
Iago comments on Othello's free and open nature. He compares Othello
to an ass which can easily be led by the nose:
[Othello] the Moor is of a free and open nature,
That thinks men are honest that only seem to be so;
And will as tenderly be led by the nose
As asses are.
In the beginning, Othello seems to trust Desdemona. He seems to believe
that Desdemona truly loves him and supports him. Then Iago plants seeds
of doubt in Othello's heart and mind. He accuses Desdemona of having an
affair with Cassio. Next, Iago subtly points out that Desdemona is capable
of lying. He points out that she lied to her own father about her marriage
to Othello:
She deceived her father by marrying you;
Iago's comment causes Othello to doubt his lovely wife. Othello truly
trusts Iago for Iago keeps assuring Othello of his love:
My lord, you know I love you.
Othello believes Iago's empty words. Again, Iago deceives Othello with his
mere words. He apologizes for loving Othello too much:

I humbly beg your pardon

Because I was loving you too much.
Iago is saying that he had to express the truth about Desdemona because
he loves Othello so much. Othello responds that he is forever indebted to
Iago for Iago's honesty in sharing the truth about Desdemona:
I am bound to you forever.
Clearly, Othello is convinced that Iago is honest and truthful. Iago realizes
that Othello is upset by Iago's insinuation that Desdemona is dishonest.
Othello is thinking that if Desdemona will lie to her father, she may lie to
him. Iago uses mere words to deceive Othello while professing his love:
I hope you will consider that what I have spoken
Comes from my love;
Truly, Othello is easily deceived. Also, no doubt, Othello has self-esteem
issues. Because of his own insecurities, it is easy for Othello to believe that
Desdemona would be unfaithful. Othello states his reasons that
Desdemona would be unfaithful:
Maybe, because I am black,
And dont have those soft parts of conversation
That gentlemen have; or because I am getting
Much older, still that's not much,
She's already unfaithful; I am abused, and my relief
Must be to hate her. O curses on marriage,
Clearly, Othello is not secure in being a black man. He even uses figurative
language to insinuate that he is insecure in being black. He compares
Desdemona's unfaithfulness to his own black face:

Her name, that was as fresh

As Diana's face, is now as grimy and black
As my own face.
After making the comment that Desdemona's face is as grimy and black as
his own, it is clear that Othello is not happy with being black.
Also, Othello shows how confused he is. He wants to believe his wife. He
admits that he is not sure what to believe. He is divided in his heart. He
admits to Iago that he is torn in his mind on who to believe or what to
think:
I think my wife is honest, and think she is not;
I think that you are just, and think you are not.
I'll have some proof.
Because Othello is emotionally unstable during Iago's scheme, it is easy
for Iago to deceive him.