Senyawa Uji

(R)-3-(4-(benzyloxy)phenyl)-2(carboxyformamido)propanoic acid
3-(4-methoxybenzylamino)pyridine2,4-dicarboxylic acid
(R)-3-(4-(3-fluorobenzyloxy)phenyl)-2(carboxyformamido)propanoic acid
(R)-2-(carboxyformamido)-3-(4-(2-(4(pyrrolidin-1yl)phenyl)allyloxy)phenyl)propanoic
acid
(R)-2-(carboxyformamido)-3-(4-(2-(3methoxyphenyl)allyloxy)phenyl)propan
oic acid
(R)-2-(carboxyformamido)-3-(4-(furan2-carbonyloxy)phenyl)propanoic acid
3-(o-toluidino)pyridine-2,4dicarboxylic acid
2-(4-(methoxycarbonyl)pyridin-2yl)isonicotinic acid
3-(4-pyridinyl)-2-[5-(trifluoromethyl)1,3-benzothiazol-2-yl]acrylonitrile

KDM1A
Energi Ikatan
Konstanta
(G)
Inhibisi
(ki)

KDM4A
Energi Ikatan
Konstanta
(G)
Inhibisi
(ki)

KDM4C
Energi Ikatan
Konstanta
(G)
Inhibisi
(ki)

KDM4E
Energi Ikatan
Konstanta
(G)
Inhibisi
(ki)

KDM5B
Energi Ikatan
Konstanta
(G)
Inhibisi (ki)

-8,72 kcal/mol

406,94 nM

-7,49 kcal/mol

3,26 M

-7,37 kcal/mol

3,93 M

-6,97 kcal/mol

7,72 M

-5,90 kcal/mol

47,53 M

-7,17 kcal/mol

5,55 M

-6,45 kcal/mol

18,56 M

-6,61 kcal/mol

14,22 M

-6,36 kcal/mol

21,85 M

-6,11 kcal/mol

33,21 M

-8,15 kcal/mol

1,07 M

-6,88 kcal/mol

9,13 M

-7,20 kcal/mol

7,20 M

-5,89 kcal/mol

48,16 M

-8,44 kcal/mol

653,03 nM

-7,06 kcal/mol

6,65 M

-5,60 kcal/mol

78,47 M

-8,21 kcal/mol

959,61 nM

-6,15 kcal/mol

30,88 M

-7,10 kcal/mol

6,23 M

-6,28 kcal/mol

24,83 M

-6,61 kcal/mol

14,30 M
-7,35 kcal/mol

4,08 M

-6,75 kcal/mol

11,23 M

-5,98 kcal/mol

41,22 M