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I. Introduction
A. Endocrine system work with or in harmony with the nervous system to
control and coordinate all the activities of the body.
1. Endocrine glands=ductless glands that produce hormones
(examples: Pineal gland, pituitary gland, thyroid gland,
thymus, pancreas, etc.)
2. Exocrine glands=glands with ducts producing non-hormone
substances (examples: salivary glands, sebaceous glands,
sweat glands, the liver, etc.)
B. Substances secreted by the endocrine glands are called hormones,
chemical messengers released to the blood to be transported throughout
the body and to regulate the metabolic functions of other cells in the
body.
1. Other chemicals similar to hormones:
a. Paracrine=hormones that diffuse to nearby target cells
in the body.
b. Autocrine=hormones that act on the cell that made it.
c. Eicosaniods=hormone-like substances derived from
arachidonic acid and act only on cells in their
immediate vicinity (example: leukotrienes and
prostaglandin)
2. Chemical nature of hormones:
a. Amino-acid based hormones=the majority of
hormones are of this type
1. Amines= simple hormones derived from the
amino acid tyrosine. (example: Epinephrine)
2. Protein and peptides=chains of amino acids
hooked together (examples: ADH and
Oxytoxin)
b. Steroid based hormones=lipid soluble hormones
derived from cholesterol (examples: testosterone)
3. Major functions of hormones
a. Integrative=reach all the cells of the body and permit
different tissue groups to act as a whole in response to
internal or external stimuli.
Endocrine Glands
A. Pituitary Gland (Hypophysis)
1. Also known as the master gland.
2. Located within the sella turcica of the sphenoid bone.
3. Associated closely with the hypothalamus by
the infindibulum.
4. Differentiated into the anterior pituitary (adenohypophysis, or
the glandular portion), the posterior pituitary
(neurohypophysis, or the nervous portion) and the avascular
pars intermedia located in between.
a. Posterior lobe (neurohypophysis)
1. Connected with the hypothalamus via the
supraopticohypophyseal tract.
2. Doesnt produce the secretions; it merely stores
the secretions produced by the hypothalamus:
i. Oxytoxin=stimulates contraction of the
smooth muscle of the uterus in pregnancy
and initiates labor cycle.
ii. Anti-diuretic hormone (ADH)=controls
water reabsorption by the distal convoluted
tubules and collecting ducts of the kidney
nephrons and stimulates smooth muscles
of the digestive tract and blood vessels.
b. Anterior lobe (adenohypophysis)
1. Controlled by hormones produced by the
hypothalamus such as TRH and LHRH.
2. More appropriately called the master gland
i. Growth Hormone (GH) = produced by
somatotropic cells of the anterior lobe
stimulate most body cells to increase in
size and divide (particularly bones and
skeletal muscle cells).
ii. Thyroid-Stimulating Hormone (TSH or
thyrotropin) = stimulates the thyroid to
grow and increase secretions of thyroid
hormone.
iii. Adrenocorticotropic Hormone (ACTH
or corticotropin) = stimulates
adrenocortical (adrenal gland) growth and