Hormone measurement interpretation (120) “why messurehormores? conf cna spon + Disgnes sutelicl rebems + Time preceoites seeing nena hypshyoasn) Factor atecting es ase e Nowmalhonosas + Gammon cnse of estuncion ewe 5 eiiy test Senay secety + conottee + Governmenzeglstion Dynamic testing Sing at mull me pont apd may involve stimulating otpeeing the lands eet reszonde sepropratey Uses + Suelncldease show abnormal ifstressed but ata basa att ees + vestigatingabnomal ests sua ses phyla or parmacolegeal mechanisms oes he syst. we think that the and may ba nderaeive ytstalte overactive (suppesi xaples nce: cose lean te, Dex the eu seoid shuld suppress nmal areal production of carts, we measure corto evs Before and ater the test there norma suppres: no evidence of CUS syne, heres fale of suzpression, theres evidence of Cashing’ ssyarome + Ghstumutaton test: stimulate GH lease and see eres an increas stimlte with eee, hypsheers) + hstppreion tse: ovate lucas should cause suppression of GH " Comptiine mmuncesy- competion between specimen nayane i added beled Hormone fot lted amount fatboy. We then meatre the amount of bel 1 Sinduchinrunoasay amigen held betwwen 2 antag, oe of whieh eed Thereisingroved ‘pectic ather are? dng tes ws Problems + Sandton "en ey standards soul erasable back to an international freee preparation of rows Constituents ~aiferent manufactures may use ferent standards ferent rests rom aferent Istoratoes) Sample statist & quay esl are dependent on guaty of sample Some anaes ae very temperate sre and ned to betel cota ore at stone sepaed fo blood, (the aralyes requ speci tubes o spec preservatives to prevent deyeaton 1 Patent wthbormoneavtoentibody ‘ryt haeieret fects depending on typeof sty se + Potent theteophile antibody ‘Bho eco rvs te ot prcjuowrooe|das jostui0gyuoULIOY Pavou# YonuI oO], poonpas aero 0 FD + pores (audonorewos) suOWLIOY YIMOID axons suas pow eee eneces (ram qsos8 1-491 Souaioyap auowa0y ysouySiow) suLsopusomnou Suuseury we swowosa2od tewoTaee 119 + fps pus aap aseaseus Heng eins wg apeoneOS + sou pom + ssuoBe sumodop oj u0ua9as Romsey i sm, (usiampanoxqeurs 199) Sewn “yr mi amar} 4p soonpaAEHONRHOS, ueisorewiog suondo quouneayy, eysuompuod prossyssod spy4) suuousipory uisiprossypodayy SOUTUMON |18 Forpay supra 1 sps0e) ‘raed out ur penog esta Wag + or wopinsuas aye snow ay + (FL) eupcosyy,yey woman LOW 24 MOY © uowssoxddns jousape astuntunyyy : wopanudneounipe desoq poososoonj3 yp wouray duos soe)“ype Diabetes (208) + toni: an abnormality that cn be detected ate markers ofeseas ther than mediators of ese ‘As veulofdaeave: beta class inereass as bay develops bu theres then asleady eine 5 they arose the deste process nt the taal beached sve dabetes + ain matkeroFendogenouinsin resuton= peptie pratein ocala paucadsprosormens with nmoim eaie®C papi ores the 2.¢ Dept der ewves toradcamatorensin nimature bet cle Cpeptdeeaeretes am call with Inulnthereineteaguuamarter Theres declines ppt wit ee progrestin ‘iy not mesure sun? Exogenous &endegenusinsuin ar nasingushabe InedenceoF 20's over secades ts ncear why disease fequecy has creas but suggest tha there Ismoreshonttgeneticcontrbutng:o dscase thre ae aerator factor Concordance between menor tan’s ate nt 20D contin eno comely EEN Beene romentl wigs of atemmnity timate til not wellundestod) Uv et, deus tue Specie compounds (dine) + nection tinal oymptoms: weight, todas, nin requirement excessive wight oss Bunton 1 Gteneautimmane iabetsin ats ths need ote way that i ose ‘Tab pathogenesis “yu mportan ot duce celled (eersin slacton in thymus =autriactve Tee Paneeatics cans pancreas, most mune esporse beg here + Recapnan andstoy bets el Teel rele grange & prt) ‘+ betacal farther released on sletsether om physical presses or trough pathol proteses wa destruction thus perpetuates loop of presentation in ctaning IN cel action Date process ey paticintarpeting blac erhops other al ce same antigens for dseae. Theres tesignicant ls of bystandng cll neghboring care ot mage. + inapabie-fmimkng yloge laone contol therfore can't prevent completions sucha: wpegcemas ong term complain + ust be nectee multiple tmesdoy unauety burdensome sot 2 cure 1 Faure therapy aims to: etre Inn rodction (Wonspa/eeereat)ablsh disease recrence conectingautrimanty it altransstans (go) Primary: ood conrl freedom fram hypogienia Secondary isin independence, cease inns dose Severe hyposicemi af suitable ore ann Proce: donot preras ested exacie tissue with enyme lagers) pres wets (endocine sso} fusedinto portal vn reetesine andthe they make sul Probleme orn danorvolabty, obit funcional be, mmunenmpreion ngs wa functon,aasorsiaaton cos ow cam weeorttl ane suppress the Ag pei congonent he inne tem without Supresing ete syste ther autoimmune conan a/w TLD aesIPEX APS syndrome“10 management 2st) Psthophysology summary oF TD + Goudy bile detcency finan caused by autinmune tack estroving pancreatic bet cl Consequence ofitulin det hyperhcomi, vont ooh &inereated protandetradtion Presertatin walt oss a/v pours & pope. Uncontole pees to etoscdose Types aun ‘open sin bon & human) ‘ong acing sn Genetlymodied sin: Gagne Deters Sonacing nai Tesln neal Bovine & hua forms) racing Genet modes llns, lpr, pat a Delve Skin continuo at Bakground ate, alent prea baton to deer "plctinstin regime ‘+ Bacludusoneinection olen act insulin @ bedtime (largin/Oetemis) + Gheinjesonat non actginlnimmedistey cr each eal spar soo, Gane) ‘etic pncrse ‘lows cantnusu ote senor teeter own fom pum (closed oop system) Cos 0p ‘very mayimoroveovernght cos contl ana Yedce rk of nctral hypogyersin Ss wih 10 “Tenslamtaton iain sues) Transpl tee seit + Ufelorg mnrosuperestion ‘Complication prevention ins therapy oper of ety deat & owe suri 18+ Discovered that lovato los tox to body causing eamase to 3 turer in parte eon, ney 8 e705 ‘meretreompleations of 720 ded Retnpathy poles, dns] ~8Vs spptng tira become anon &upepltes Fs 8 hormones thathep new vests to grou to sappy the sea. The ew vse stable eaely burt caing ledigino the ee leading tbindnes Topevetths ophthalmologists conse scant ofthe eyet ee whch ate oe anon then wie laser wapy totam he ese, stopping new vers goth = _Reptopth (eal are} ~ test won for albumin whith ative of rena ure © Nakropty snr, autonome) numbness hind eet unntied damage "robes tte autonome rem patent oul expen ut pretest mon Ealeohaue rect dytontion Means of mortorng {eve ef conta: estar Dao oor, HAL, ucouaine ‘Therese 29965 0 yeoslation: esate aon enzymatic hen Boss hgh on eneymatealy nds to protein via reversible covane bond HbIsoneprtein tat snr enymatcaty leone by hypethcenia Ameasie ol he of He ht pyeanisted pend mesure ofthe verge lee of boos hucose te preceding} months ar ABV for 1204973), ‘Thetaqettalestould be 7% ‘Though recat tes hve sosgested hat 9st 6-6 5) may be oct wth cessed (kal monty possibly at reared ingence of podem Patients wth igh ABC tumor wihave a atily ow Hea high nomber felons) Insich ese conten be determined by mesg staringAssessment of completions 2 Ecamnton eins ea) 1 Meszareren of winayeroatbuin Vea 1 Ginea examination pier nerve sansstion/ migafiiment Managing emergencies {ow ood cre fmol assed by t0 much nel fc pati staton Tete are 2 impos: ohapidate of gaat falteges sputter de ening to eed, swe ay mouth ‘Aozoite low laos vee bain malfunction can cause peas coma anit severfpolonged death > tpstentieconstus,p luce oa followed by 2 mea contain arbohyerates 2 potent ae diminsedconsovanensWelucouecn be phen, glucagon maybe somintered 2 mvstnate why hypodicemiascerea Aetoaeois ‘Hongstanang T1Dis thou adequate insta ora day, tere willbe uneotaie pos Keto aes. severe can become ktoaeidss wih lwp = die emergency & patent must be Rosaleed rapture] lin, sara wasn nw ot faba ana n oon | prespingcwet romming | paid ooo: Mates routs 5. Coma ee ‘of potassium. 5. ifs known TAD diabetic, investigate reasons for ketoacidosis developrnent. ‘Gut honsone summary (shoud flow athe ns 1 lets Longerhons = ender arto the panera contain cl typeof which falls are most, +> Instn, amin, lagen, panceatle polypeptide & somatostatin are sereted yt celepes in responce ro ntint vem he gt orm the custo |& These hormones module sae other secretion and a coordinated fenon, modulate uote metabo,ok of Gn cbasy (288) {uthormanesthatnfuencappette vet ‘ogenous growth hormone,» petive tat antagonist action tru “xtuation olfypothalime newopepte YY receptor twa) Sines bungee Coxismadeasa pre pohommone & aleve to ceveral peptides etude Ota (LK a al log! poteney) ‘Secreted predominant rom clo he sm testi, as avery shor hale vera mines) {otis moved n gestion stimulates emaying of gl adder role of ‘este enna. Ins though 2 Cox reaps (COR & CCA. rv isa 36 amino al peptide made the cli of the dita leat Feeaed a YI 3, is converted ta the ete PY 35 by epi pepiae W F138 ehowshih fin lor the 2 receptor. F155 has ben Shown a reduce ood intake nboth odes ni hana 2178 Onymtamodn canbe 26d Inthe tfc on food nak nth verwsght obese Product ofthe eagon gene eessd from the eal fe itso i response to food "dmmistatan reduces fond intake reve eneayexendure in bth oes Mayen tects athe GLP receptor Insnated by DPW “asic iibtary pepe, ao known a lcoe-dependent sunt fetrpeatise (P) {222 gartrontestial polyp lee rom den &sunal Kel ter oe ingestion of nutiens (tore 8 FA 1+ as ben shown facta te poral of both acne a a ip prometes Te clearance rom the relaon by aetatng opts pss (2 + Binds to recoterson beta als aetnates porate pe suey iP orsatne ified navenous a begin of a test malin obese sabes anger fess ood cole were scene th vas aslgue sale Gants empving was assessed with actaminahen, Feng 2" curt nisin suena pong prod reduce felngs of hanger, Ssh to : ‘tad prospective consumption ater temeal jan + Thevteofgastic empty was ime durnginaion of LP Potent Giemal | oP pronotssatety& eduesfoodntake nptents ith 20 seentor 120 Secreted tom Lees ofsmah interne, elesed in esponse to gaoee 8 at ac Binds to spate receptor on bs cl Stent preimiin bonnes ‘nhs: gos emptying, eueagon secretion Seyler: ein yes & bat cll atrsin Promote: bata cl rtferaton &sietentation ‘Gatfovmoneshavean important olin the defense ofbady were Fin ataced digas tasrating how th ut ors contrite 0 obsong ostomy of I Pe | Yocoe metabolam Pancreat funtion (2A) ho pancreas re ecto barbenat, sat, yp chyetrypi &catboeoepidse. + tnocine portion 1-2 pane weight fits of ongehons ets of angerhans ‘There are oureposot eas shatecet dierent harmones> =a goegen 10% set cel poputon = Bo lnelndcomyl 0% tcl popation = Sp omtortatin ifsc charge > monetneapy combo therapy [ral ut] > combo therapy, oa rg ln