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Table of Contents
I.
Introduction ...............................................................1-1
II.
WBC IP Messages....................................................2-1
Abnormal, WBC Abn Scattergram .......................................... 2-1
Abnormal, NRBC Scattergram ............................................... 2-2
Suspect, Blast? ...................................................................... 2-3
Suspect, Immature Gran? ...................................................... 2-4
Suspect, Left Shift? ................................................................ 2-5
Suspect, Atypical Lympho? .................................................... 2-6
Suspect, Abn Lympho/L_Blasts?............................................ 2-7
Suspect, NRBC ...................................................................... 2-9
Suspect, RBC Lyse Resistance?.......................................... 2-11
III.
RBC IP Messages.....................................................3-1
Abnormal, RBC Abn Distribution ............................................ 3-1
Abnormal, Dimorphic Population ............................................ 3-2
Abnormal, RET Abn Scattergram ........................................... 3-3
Suspect, RBC Agglutination? ................................................. 3-5
Suspect, Turbidity/HGB Interference? .................................... 3-7
Suspect, Iron Deficiency?....................................................... 3-9
Suspect, HGB Defect? ......................................................... 3-10
Suspect, Fragments ............................................................. 3-11
IV.
PLT IP Messages......................................................4-1
Abnormal, PLT Abn Distribution ............................................. 4-1
Abnormal, PLT Abn Scattergram............................................ 4-3
Suspect, PLT Clumps?........................................................... 4-5
Suspect, PLT Clumps(S)? ...................................................... 4-7
V.
Interferences .............................................................5-1
VI.
References................................................................6-1
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One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
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Introduction
Objectives
The XE-Series Abnormal Specimen Troubleshooting Guide is designed to serve many
objectives. These include:
The following sections introduce the IP Messages. Definitions and examples of each
message are presented with suggested actions to be taken by qualified personnel to
verify the presence of specific cell types and obtain a correct result when interference
occurs.
Use of the XE-Series Quick Guide (laminated card) with this document will provide
the user with a better understanding of IP Message criteria. The Quick Guide
includes the information discussed in this guide in a condensed format along with
scattergrams that illustrate where normal and abnormal cells are distributed.
Some of these action steps may coincide with procedures previously established and
implemented in a lab. These action steps are merely suggested guidelines and should
be used in conjunction with your own laboratorys protocols.
IP Messages
The United States Federal Food and Drug Administration (FDA) classify modern
hematology analyzers as Automated Differential Cell Counters (ADCC). The XE-Series
format is designed to aid in the separation of specimens into POSITIVE and NEGATIVE
categories according to preset criteria. The system bases its judgments on
comprehensive surveys of numerical data, particle size distributions, scattergrams, and
provides easy-to-understand flags/messages indicating the instruments findings. These
flags and messages are referred to as Interpretive Program (IP) Messages.
A specimen is judged NEGATIVE when there are no predefined abnormalities present
in the specimen. The results are generally reported without review.
The XE-Series analyzers will generate a POSITIVE when an Interpretive Program (IP)
Message is present. An established review process by lab personnel should be
initiated.
POSITIVE or ERROR judgments indicate the possibility of sample abnormality.
These results should be reviewed carefully and may require further
examination in accordance with the protocol of your laboratory.
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Section 1: Introduction
Page 1 of 2
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Section 1: Introduction
Page 2 of 2
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XE-Series Results
WBC &
RBC
HGB
HCT
MCV
MCH
MCHC
PLT
RDW-SD
RDW-CV
MPV
RET%
RET#
IRF
NRBC#
NRBC%
NEUT#
LYMPH#
MONO#
EO#
BASO#
NEUT%
LYMPH%
MONO%
EO%
BASO%
48.17
1.77
6.1
19.6
110.7
34.5
31.1
200
81.8
21.0
11.2
1.99
0.0352
0.322
1.30
2.7
0.03 *
0.54 *
0.1 *
1.1 *
[103/L]
[106/L]
[g/dL]
[%]
[fL]
[pg]
[g/dL]
[103/L]
[fL]
[%]
[fL]
[%]
[10^6/L]
[ratio]
[103/L]
[/100 WBC]
[103/L]
[103/L]
[103/L]
[103/L]
[103/L]
[%]
[%]
[%]
[%]
[%]
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
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WBC
RBC
HGB
HCT
MCV
MCH
MCHC
PLT
RDW-SD
RDW-CV
MPV
RET%
RET#
IRF
NRBC#
NRBC%
XE-Series Results
6.48 *
[103/L]
3.72
[106/L]
10.4
[g/dL]
31.6
[%]
84.9
[fL]
28.0
[pg]
32.9
[g/dL]
317
[103/L]
48.7
[fL]
15.6
[%]
9.5
[fL]
1.05
[%]
0.0391 [106/L]
0.082
[ratio]
[106/L]
[/100 WBC]
4.43 *
1.02 *
0.61 *
0.35 *
0.07 *
68.4 *
15.7 *
9.4 *
5.4 *
1.1 *
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
[103/L]
[103/L]
[103/L]
[103/L]
[103/L]
[%]
[%]
[%]
[%]
[%]
www.sysmex.com
Suspect, Blast?
The Blast? IP indicates that the
instrument has detected abnormal
clustering in the region for blasts in the
IMI and/or DIFF scattergram.
An asterisk (*) appears next to the
Neutrophil, Lymphocyte and
Monocyte % and #. The asterisk (*)
indicates these results are unreliable if
abnormalities are found during the
laboratorys review of the sample.
It is common for the Blast? IP to occur
with WBC Abn Scattergram. For this
reason, the DIFF scattergram is
abnormal and the data is replaced with
dashes instead of having asterisks to
right.
XE-Series Results
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
PLT
RDW-SD
RDW-CV
MPV
RET%
RET#
IRF
NRBC#
NRBC%
NEUT#
LYMPH#
MONO#
EO#
BASO#
NEUT%
LYMPH%
MONO%
EO%
BASO%
18.40
3.90
11.2
33.9
86.9
28.7
33.0
55
44.9
14.3
10.1
0.26
0.0101
0.166
0.00
0.0
0.0
0.07
0.0
0.4
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
[103/L]
[106/L]
[g/dL]
[%]
[fL]
[pg]
[g/dL]
[103/L]
[fL]
[%]
[fL]
[%]
[106/L]
[ratio]
[106/L]
[/100 WBC]
[103/L]
[103/L]
[103/L]
[103/L]
[103/L]
[%]
[%]
[%]
[%]
[%]
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IG Present/Immature Gran?
XE-2100 analyzers that have the
IG Master software can generate
quantitative Immature Granulocyte
results. The IG Present flag is userdefined and is generated when the IG%
or IG# exceed the user-defined value.
In cases where the instrument has
detected abnormal clustering in the
region for immature granulocytes in the
IMI and/or DIFF scattergrams, the
IG Present flag is replaced with
Immature Gran? IP .
In these cases an asterisk (*) appears
next to the Neutrophil, Eosinophil and
Basophil % and #. The asterisk (*)
indicates these results are unreliable if
abnormalities are found during the
laboratorys review of the sample.
XE-Series Results
WBC &
RBC
HGB
HCT
MCV
MCH
MCHC
PLT
RDW-SD
RDW-CV
MPV
RET%
RET#
IRF
NRBC#
NRBC%
NEUT#
LYMPH#
MONO#
EO#
BASO#
NEUT%
LYMPH%
MONO%
EO%
BASO%
IG%
IG#
19.40
2.85
8.6
25.0
87.7
30.2
34.4
58
50.5
16.2
13.3
2.43
0.0693
0.449
1.81
9.3
14.38 *
1.41
1.98
0.86 *
0.38 *
74.1*
7.3
10.2
4.4 *
2.0 *
2.0*
0.39*
[103/L]
[106/L]
[g/dL]
[%]
[fL]
[pg]
[g/dL]
[103/L]
[fL]
[%]
[fL]
[%]
[106/L]
[ratio]
[106/L]
[/100 WBC]
[103/L]
[103/L]
[103/L]
[103/L]
[103/L]
[%]
[%]
[%]
[%]
[%]
[%]
[103/L]
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
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XE-Series Results
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
PLT
RDW-SD
RDW-CV
MPV
RET%
RET#
IRF
NRBC#
NRBC%
NEUT#
LYMPH#
MONO#
EO#
BASO#
NEUT%
LYMPH%
MONO%
EO%
BASO%
13.98
2.95
9.3
27.6
93.6
31.5
33.7
135
46.4
13.6
10.6
0.75
0.0221
0.090
0.00
0.0
13.08 *
0.58
0.26
0.06 *
0.00
93.6 *
4.1
1.9
0.4 *
0.0
[103/L]
[106/L]
[g/dL]
[%]
[fL]
[pg]
[g/dL]
[103/L]
[fL]
[%]
[fL]
[%]
[106/L]
[ratio]
[106/L]
[/100 WBC]
[103/L]
[103/L]
[103/L]
[103/L]
[103/L]
[%]
[%]
[%]
[%]
[%]
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
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11.0
5.19 *
1.68 *
0.80 *
0.11
0.04
66.4 *
21.5 *
10.2 *
1.4
0.5
[fL]
[103/L]
[103/L]
[103/L]
[103/L]
[103/L]
[%]
[%]
[%]
[%]
[%]
XE-Series Results
WBC
7.82
[103/L]
RBC
3.64
[106/L]
HGB
10.2
[g/dL]
HCT
32.3
[%]
MCV
88.7
[fL]
MCH
28.0
[pg]
MCHC
31.6
[g/dL]
PLT
215
[103/L]
RDW-SD
49.6
[fL]
[%]
RDW-CV
15.5
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
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XE-Series Results
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
PLT &
RDW-SD
RDW-CV
MPV
RET%
RET#
IRF
NRBC#
NRBC%
NEUT#
LYMPH#
MONO#
EO#
BASO#
NEUT%
LYMPH%
MONO%
EO%
BASO%
25.56
3.34
10.1
31.6
94.6
30.2
32.0
8
52.7
18.5
3.83
0.1279
0.120
0.0
0.0
2.94 *
21.44 *
0.89 *
0.23
0.06
11.5 *
83.9 *
3.5 *
0.9
0.2
[103/L]
[106/L]
[g/dL]
[%]
[fL]
[pg]
[g/dL]
[103/L]
[fL]
[%]
[fL]
[%]
[106/L]
[ratio]
[106/L]
[/100 WBC]
[103/L]
[103/L]
[103/L]
[103/L]
[103/L]
[%]
[%]
[%]
[%]
[%]
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
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3. If lymphoblasts, immature
lymphocytes, or immature
monocytes are present, perform a
manual differential according to your
laboratorys policy.
4. Report any abnormal morphological
findings according to individual
laboratory criteria.
5. If no abnormalities are found, the
data with the asterisk (*) can be
reported.
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
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Suspect, NRBC?
The NRBC? IP can only appear when a
NRBC count is not performed on the XESeries. This is generated when
clustering is detected in the NRBC area
between the lymphocytes and the RBC
ghosts on the DIFF scattergram. (Figure
14)
An asterisk (*) appears next to the WBC,
Neutrophils, Lymphocytes, Monocytes
and Eosinophils % and #. The asterisk
(*) indicates these results are unreliable
if abnormalities are found during the
laboratorys review of the sample.
The NRBC Present IP is operator
programmable. It only appears if an
NRBC is ordered and the NRBC exceeds
the programmed limit. If NRBCs are >
0.01/100 WBC, the WBC and Lymph
counts are corrected. This is denoted by
an & to the left of the data.
XE-Series Results
WBC &
RBC
HGB
HCT
MCV
MCH
MCHC
PLT &
RDW-SD
RDW-CV
MPV
RET%
RET#
IRF
NRBC#
NRBC%
NEUT#
LYMPH# &
MONO#
EO#
BASO#
NEUT%
LYMPH% &
MONO%
EO%
BASO%
15.38
3.86
11.3
33.4
86.5
29.3
33.8
273
60.0
19.5
10.5
6.44
0.2486
0.230
0.52
3.4
9.43
4.47
1.34
0.10
0.04
61.2
29.1
8.7
0.7
0.3
[103/L]
[106/L]
[g/dL]
[%]
[fL]
[pg]
[g/dL]
[103/L]
[fL]
[%]
[fL]
[%]
[106/L]
[ratio]
[103/L]
[/100 WBC]
[103/L]
[103/L]
[103/L]
[103/L]
[103/L]
[%]
[%]
[%]
[%]
[%]
www.sysmex.com
Suspect, NRBC?
(continued)
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XE-Series Results
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
PLT
RDW-SD
RDW-CV
MPV
NEUT#
LYMPH#
MONO#
EO#
BASO#
NEUT%
LYMPH%
MONO%
EO%
BASO%
12.06 *
3.69
11.0
34.2
92.7
29.8
32.2
248
53.1
15.7
10.2
10.32 *
0.63 *
0.89 *
0.14 *
0.08 *
85.5 *
5.2 *
7.4 *
1.2 *
0.7 *
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
[103/L]
[106/L]
[g/dL]
[%]
[fL]
[pg]
[g/dL]
[103/L]
[fL]
[%]
[fL]
[103/L]
[103/L]
[103/L]
[103/L]
[103/L]
[%]
[%]
[%]
[%]
[%]
www.sysmex.com
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
XE-Series Results
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
PLT
RDW-SD
RDW-CV
MPV
RET%
RET#
6.13
0.47 *
11.2
5.0 *
106.4 *
238.3 *
224.0 *
225
11.5
3.69
0.0173 *
[103/L]
[106/L]
[g/dL]
[%]
[fL]
[pg]
[g/dL]
[103/L]
[fL]
[%]
[fL]
[%]
[106/L]
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
PLT
RDW-SD
RDW-CV
MPV
RET%
RET#
IRF
XE-Series Results
14.13 [103/L]
2.40 * [106/L]
10.8
[g/dL]
30.6 * [%]
127.5 * [fL]
45.0 * [pg]
35.3 * [g/dL]
80
[103/L]
[fL]
[%]
11.5
[fL]
6.22
[%]
0.1493 [106/L]
0.196 [ratio]
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
XE-Series Results
WBC &
RBC
HGB
HCT
MCV
MCH
MCHC
PLT
RDW-SD
RDW-CV
MPV
RET%
RET#
IRF
NRBC#
NRBC%
15.38
3.86
11.3
33.4
86.5
29.3
33.8
273
60.0
19.5
10.5
6.44 *
0.2486*
0.230 *
0.52
3.4
[103/L]
[106/L]
[g/dL]
[%]
[fL]
[pg]
[g/dL]
[103/L]
[fL]
[%]
[fL]
[%]
[106/L]
[ratio]
[106/L]
[1.00 WBC]
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
XE-Series Results
Pre-warmed at 37 degrees Celsius for 15-30 minutes
XE-Series Results
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
PLT
RDW-SD
RDW-CV
MPV
RET
RET
NEUT#
LYMPH#
MONO#
EO#
BASO#
NEUT%
LYMPH%
MONO%
EO%
BASO%
6.12
0.24 *
11.2
2.9 *
120.8 *
466.7 *
386.2 *
272
11.7
3.40
0.0082
3.53
1.94
0.47
0.14
0.04
57.6
31.7
7.7
2.3
0.7
[103/L]
[106/L]
[g/dL]
[%]
[fL]
[pg]
g/dL]
[103/L]
[fL]
[%]
[fL]
[%]
[106/L]
[103/L]
[103/L]
[103/L]
[103/L]
[103/L]
[%]
[%]
[%]
[%]
[%]
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
PLT
RDW-SD
RDW-CV
MPV
RET
RET
NEUT#
LYMPH#
MONO#
EO#
BASO#
NEUT%
LYMPH%
MONO%
EO%
BASO%
5.23
2.82
8.4
27.0
95.7
29.8
31.1
205
53.6
18.3
3.16
0.0891
2.97
1.70
0.37
0.15
0.04
56.7
32.5
7.1
2.9
0.8
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
[103/L]
[106/L]
[g/dL]
[%]
[fL]
[pg]
g/dL]
[103/L]
[fL]
[%]
[fL]
[%]
[106/L]
[103/L]
[103/L]
[103/L]
[103/L]
103/L]
[%]
[%]
[%]
[%]
[%]
www.sysmex.com
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
XE-Series Results
(continued)
XE-Series Results
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
PLT &
RDW-SD
RDW-CV
MPV
RET
RET
IRF
NRBC#
NRBC%
4.64
2.17
10.0 *
18.9
87.1
46.5 *
53.4 *
184
47.1
15.7
14.4
1.07
0.0232
0.058
0.00
0.0
[103/L]
[106/L]
[g/dL]
[%]
[fL]
[pg]
g/dL]
[103/L]
[fL]
[%]
[fL]
[%]
[106/L]
[ratio]
[106/L]
[/100 WBC]
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
www.sysmex.com
XE-Series Results
RBC
HGB
HCT
MCV
MCH
MCHC
PLT &
RDW-SD
RDW-CV
MPV
RET %
RET #
IRF
5.86
8.3
29.1
49.7
14.2
28.5
351
39.5
22.5
1.81
0.1061
0.215
[106/L]
[g/dL]
[%]
[fL]
[pg]
g/dL]
[103/L]
[fL]
[%]
[fL]
[%]
[106/L]
[ratio]
372 *
351
[103/L]
[103/L]
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
XE-Series Results
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
PLT &
RDW-SD
RDW-CV
MPV
RET%
RET#
IRF
NRBC#
NRBC%
10.55
4.73
9.9
30.7
64.9
20.9
32.2
149
33.6
14.4
1.02
0.0482
0.107
0.00
0.0
[103/L]
[106/L]
[g/dL]
[%]
[fL]
[pg]
[g/dL]
[103/L]
[fL]
[%]
[fL]
[%]
[106/L]
[ratio]
[106/L]
[/100 WBC]
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
Suspect, Fragments?
The Fragments? IP Message is
determined from RET Scattergram
and/or by calculation and size
comparison of certain RBC and PLT
items (MCV, RDW-SD, MCHC, RL*,
PU*, PU%*).
*
XE-Series Results
RBC
HGB
HCT
MCV
MCH
MCHC
PLT &
RDW-SD
RDW-CV
MPV
RET%
RET#
IRF
2.95
8.0
28.2
95.6
27.1
28.4
191
98.4
29.6
3.62
0.1068
0.353
[106/L]
[g/dL]
[%]
[fL]
[pg]
[g/dL]
[103/L]
[fL]
[%]
[fL]
[%]
[106/L]
[ratio]
PLT-I
PLT-O
233 *
191
[103/L]
[103/L]
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
Suspect, Fragments?
(continued)
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
XE-Series Results
RBC
HGB
HCT
MCV
MCH
MCHC
PLT &
RDW-SD
RDW-CV
MPV
RET %
RET #
IRF
2.95
8.0
28.2
95.6
27.1
28.4
191 *
98.4
29.6
3.62
0.1068
0.353
[106/L]
[g/dL]
[%]
[fL]
[pg]
g/dL]
[103/L]
[fL]
[%]
[fL]
[%]
[106/L]
[ratio]
255
191
[103/L]
[103/L]
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
PLT
RDW-SD
RDW-CV
MPV
RET
RET
IRF
NEUT
LYMPH
MONO
EO
BASO
NEUT
LYMPH
MONO
EO%
BASO%
XE-Series Results
480.00 @ [103/L]
3.80
[106/L]
11.5
[g/dL]
32.1
[%]
84.5
[fL]
30.3
[pg]
35.8
g/dL]
222*
[103/L]
42.0
[fL]
15.2
[%]
10.6*
[fL]
2.73
[%]
0.1037
[106/L]
0.672
[ratio]
[103/L]
[103/L]
[103/L]
0.62*
[103/L]
103/L]
[%]
[%]
[%]
0.3*
[%]
[%]
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
XE-Series Results
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
PLT &
RDW-SD
RDW-CV
MPV
RET%
RET#
IRF
5.28 *
2.84
8.8
27.2
95.8
31.0
32.4
30 *
56.9
16.5
10.2 *
0.81
0.023
0.212
[103/L]
[106/L]
[g/dL]
[%]
[fL]
[pg]
[g/dL]
[103/L]
[fL]
[%]
[fL]
[%]
[106/L]
[ratio]
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
XE-Series Results
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
PLT
RDW-SD
RDW-CV
MPV
8.40 *
4.48
11.8
37.7
84.2
26.3
31.3
191 *
69.5
22.5
[103/L]
[106/L]
[g/dL]
[%]
[fL]
[pg]
[g/dL]
[103/L]
[fL]
[%]
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
www.sysmex.com
Interferences
Some abnormal samples may interfere with automated cell counting methods. The
following is a list from the Sysmex XE-Series Operators Manual (Main Unit,
Introduction) of possible substances that may interfere with these parameters.
WBC:
Cold agglutinins, platelet aggregation, nucleated RBCs, cryoglobulins, lyseresistant RBCs in patients with hemoglobinopathies, severe liver disease or
neonates
RBC:
HGB:
HCT:
PLT:
RET#:
RET%:
Note:
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
Section 5: Interferences
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Section 5: Interferences
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References
Brown, Barbara A. Hematology: Principles and Procedures, Sixth Edition, Lippincott
Williams & Wilkins, Media, PA, 1993, pp. 102 107, 111 - 116.
Cornbleet Joanne, M.D., Spurious Results from Automated Hematology Cell Counters.
Laboratory Medicine, Vol. 14, No. 8, August 1983.
Harmening, Denise M. Clinical Hematology and Fundamentals of Hemostasis, 3rd
Edition, F. A. Davis Company, Philadelphia, PA, 1997.
Koepke, John, Lipemia and Hemoglobin Determinations, Medical Laboratory Observer,
Vol. 15, No. 1, January 1983.
Rodak, Bernadette, Diagnostic Hematology, W. B. Sunders Company, Philadelphia, PA,
1995, pp. 618-619.
Schwartz RS, Silberstein LE, Berkman EM. Autoimmune Hemolytic Anemias.:
Hematology: Basic Principles and Practice, (eds. Hoffman R, et al). Churchill Livingston
Inc. 1995; 710-729.
Sysmex XE-2100 Main Unit Operators Manual, Sysmex Corporation, April 2004.
Sysmex XE-2100 IPU Operators Manual, Sysmex Corporation, April 2004.
One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
Section 6: References
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One Nelson C. White Parkway, Mundelein, IL 60060 Phone 847-996-4500 1-800-3SYSMEX (1-800-379-7639)
Section 6: References
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