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Anti-inflammatory, analgesic, and antipyretic activities

of virgin coconut oil

February 2010, Vol. 48, No. 2 , Pages 151-157 (doi:10.3109/13880200903062614)
S. Intahphuak1, P. Khonsung2, A. Panthong2
McCormick Faculty of Nursing, Payap University, Chiang Mai, Thailand
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Address for CorrespondenceSophaphan Intahphuak, McCormick Faculty of Nursing, Payap University, Chiang Mai
50000, Thailand. Tel: 668-1341-7342. Fax: 66-5343-1993. E-mail::

This study investigated some pharmacological properties of virgin coconut oil (VCO), the natural pure oil
from coconut [Cocos nucifera Linn (Palmae)] milk, which was prepared without using chemical or highheat treatment. The anti-inflammatory, analgesic, and antipyretic effects of VCO were assessed. In acute
inflammatory models, VCO showed moderate anti-inflammatory effects on ethyl phenylpropiolateinduced ear edema in rats, and carrageenin- and arachidonic acid-induced paw edema. VCO exhibited an
inhibitory effect on chronic inflammation by reducing the transudative weight, granuloma formation, and
serum alkaline phosphatase activity. VCO also showed a moderate analgesic effect on the acetic acidinduced writhing response as well as an antipyretic effect in yeast-induced hyperthermia. The results
obtained suggest anti-inflammatory, analgesic, and antipyretic properties of VCO.

Read More:

In vivo antinociceptive and anti-inflammatory activities of dried

and fermented processed virgin coconut oil.
Zakaria ZA1, Somchit MN, Mat Jais AM, Teh LK, Salleh MZ, Long K.


The present study was carried out to investigate the antinociceptive and anti-inflammatory
activities of virgin coconut oil (VCO) produced by the Malaysian Agriculture Research and
Development Institute (MARDI) using various in vivo models.


Two types of VCOs, produced via standard drying (VCOA) and fermentation (VCOB) processes
were used in this study. Both VCOA and VCOB were serially diluted using 1% Tween 80 to
concentrations (v/v) of 10, 50 and 100%. Antinociceptive and anti- inflammatory activities of
both VCOs were examined using various in vivo model systems. The antinociceptive activity of
the VCOs were compared to those of 1% Tween 80 (used as a negative control), morphine (5
mg/kg) and/or acetylsalicylic acid (100 mg/kg).


Both VCOA and VCOB exhibited significant (p < 0.05) dose-dependent antinociceptive activity
in the acetic acid-induced writhing test. Both VCOs also exerted significant (p < 0.05)
antinociceptive activity in both phases of the formalin and hot-plate tests. Interestingly, the
VCOs exhibited anti-inflammatory activity in an acute (carrageenan-induced paw edema test),
but not in a chronic (cotton-pellet-induced granuloma test) model of inflammation.


The MARDI-produced VCOs possessed antinociceptive and anti-inflammatory activities. Further

studies are needed to confirm these observations.