Amlodipine

Anti-Anginal Drugs / Calcium Antagonists

Amlodipine relaxes peripheral and coronary vascular
smooth muscle. It produces coronary vasodilation by
inhibiting the entry of Ca ions into the slow channels
or select voltage-sensitive channels of the vascular
smooth muscle and myocardium during
depolarisation. It also increases myocardial oxygen
delivery in patients w/ vasospastic angina.
Cilostazol
Anticoagulants, Antiplatelets & Fibrinolytics
(Thrombolytics)
Cilostazol is a reversible, selective inhibitor of
phosphodiesterase-III (PDE-III), thereby suppressing
cyclic adenosine monophosphate (cAMP)
degradation. Increase in cAMP in platelets and blood
vessels leads to inhibition of platelet aggregation and
vasodilation. Cilostazol also inhibits adenosine
uptake into cells, which augments the cAMPelevating effect of PDE-III inhibition.
Pantoprazole
Antacids, Antireflux Agents & Antiulcerants
Pantoprazole is a substituted benzimidazole, and also
known as PPI due to its property to block the final
step of acid secretion by inhibiting H+/K+ ATPase
enzyme system in gastric parietal cell. Both basal and
stimulated acid are inhibited.
Erceflora
Antidiarrheals
The administration of Bacillus clausii contributes to
the recovery of the intestinal microbial flora altered
during the course of microbial disorders of diverse
origin.
Salbutamol
Drugs Acting on the Uterus / Antiasthmatic & COPD
Preparations
Salbutamol activates adenyl cyclase, the enzyme that
stimulates the production of cyclic adenosine-3', 5'monophosphate (cAMP). Increased cAMP leads to
activation of protein kinase A, which inhibits
phosphorylation of myosin and lowers intracellular
ionic Ca concentrations, resulting in smooth muscle
relaxation.
Acetylcysteine
Cough & Cold Preparations

Acetylcysteine exerts mucolytic action through its

free sulfhydryl group which opens up the disulfide
bonds in the mucoproteins thus lowering mucous
viscosity. In paracetamol toxicity, acetylcysteine acts
as a hepatoprotective agent by restoring hepatic
glutathione, serving as a glutathione substitute, and
enhancing the nontoxic sulfate conjugation of
paracetamol.
Levofloxacin
Eye Anti-Infectives & Antiseptics / Quinolones
Levofloxacin exerts antibacterial action by inhibiting
bacterial topoisomerase IV and DNA gyrase, the
enzymes required for DNA replication, transcription
repair and recombination. It hasin vitro activity
against a wide range of gm-ve and gm+ve
microorganisms.
Metformin
Antidiabetic Agents
Metformin is a biguanide w/ antihyperglycaemic
effects, lowering both basal and postprandial plasma
glucose. It decreases hepatic glucose production by
inhibiting gluconeogenesis and glycogenolysis;
delays intestinal absorption of glucose; and enhances
insulin sensitivity by increasing peripheral glucose
uptake and utilisation.
Aspirin
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) /
Anticoagulants, Antiplatelets & Fibrinolytics
(Thrombolytics)
Aspirin is an analgesic, anti-inflammatory and
antipyretic. It inhibits cyclooxygenase, which is
responsible for the synthesis of prostaglandin and
thromboxane. It also inhibits platelet aggregation.
Clovix
Anticoagulants, Antiplatelets & Fibrinolytics
(Thrombolytics)
Clopidogrel selectively inhibits adenosine
diphosphate (ADP) from binding to its platelet
P2Y12 receptor and subsequent activation of
glycoprotein GPIIb/IIIa complex thus reducing
platelet aggregation.
Fenofibrate
Dyslipidaemic Agents
Fenofibrate, a fibric acid derivative, lowers plasma
triglyceride by activating lipoprotein lipase thus
increasing catabolism of VLDL w/ consequent
increase in HDL levels