= Methotrexate, Mercaptopurine Trinucleotide Repeat Expansion : Fredrich goes hu

nting then he is becoming fragi le because of muscle problem - Fredrich ataxia Huntington disease - Fragile X syndrome - Myotonic dystrophy From mnemonic book
s pharma: Examples of the mnemonic or memory techniques or strategies used in th
is PharMne monics: 1> Linking a drug name (Pilocarpine) to its action (Pupil con
striction): PILOCARPINE: A PILE of CAR-delivered PINEs is used for the pupil con
stri(u)ction project (illustruated with a figure). 2> Linking a drug class stem
(-pril) to its action (Inhibition of an enzyme call ed ACE): PRIL: PERIL is gone
with E (Enzyme ACE). By knocking out the E, the PERIL is rep laced with a -PRIL
pill and the capital PERIL of hypertension and CHF can be dim inished by captoP
RIL (illustruated with a figure). 3> Linking a drug name (Sumatriptan) to its us
e (treatment of Migraine):

SUMATRIPTAN: If you have migraine in the SUMMER, simply take A TRIP for TAN. Jus
t relax (illustruated with a figure). 4> Linking a drug name (PHENyTOIN) to its
side effects: Peripheral neuropathy. Hyperplasia of gingiva, Hirsutism and coar
se facial features. Hypersensitivity: skin rash and even Stevens-Johnson syndrom
e. Enlarged lymph nodes (lymphadenopathy). Nystagmus, diplopia and sedation. Ter
atogenicity ("Fetal hydantoin syndrome"). Osteomalacia (due to decreased Vitamin
D), megalOblastic anemia (due to deceased folate levels). Inhibition of ADH and
insulin secretion. Nausea and vomiting 5> Linking a drug class (SSRIs) to its s
ide effects: Sick stomach, leading to anorexia, nausea, etc. Sexual dysfunction.
Restless: agitation, anxiety and tremor. Insomnia. Serotonin syndrome. Caused b
y concurrent use of MAOIs 6> Linking a disease name (DIABETES mellitus) to its d
rugs or drug classes: DDP-4 inhibitors (Sitagliptin) Insulins. Amylin analog (Pr
amlinitide). Acarbose (Alpha-glucosidase inhibitors). Biguanides (Metformin). Ex
enatide (GLP-1 agonists). Thiazolidinediones (PPARr agonists). Excercise and wei
ght control (Essential for the control of type II DM). Sulfonylureas(Insulin sec
retagogues). 7> Dr. Bright's hint: Intern: Doc, of drugs used in Parkinson's dis
ease, what drugs are better for rel ieving Bradykinesia? Dr: Bromocriptine and r
elated DA agonists. Intern: Then, what drugs are better for attenuating Tremor?
Dr: Trihexyphenidyl and related antimuscarinic agents. 8> Dr. Bright's hint: Int
ern: Doc, why can lithium cause nephrogenic diabetes insipidus? Dr: As you can s
ee in the figure on the left, this is because the lithium batter y overcharges t
he water pump in the kidney. 9> Cartoons and humors: This feature may be sensed
from the Front cover image: The man in the platelet on the left side stands for
ASPIRIN (AS a PI [Platelet I nhibitor], I REIN COX-1 [the wheel] with an acetyl
chain [CH3-CO-]); The dog on the top of the platelet on the right side represent
s CLOPIDOGREL (As a CLOPI [CLOt/Platelet Inhibitor], this DOG is for REaL in blo
cking the ADP rece ptor)