SEROLOGIA DE LA HEPATITIS VIRAL

HEPATITIS A
HAAg
anti-HAV
anti-HAV, IgM
HEPATITIS B
HBsAg
anti-HBs
HBeAg
anti-Hbe
anti-HBc
anti-HBc,IgM
HBV DNA

HEPATITIS C
HCAg
Anti-HCV
HCV RNA

HEPATITIS D
HDAg
anti-HDV
anti-HDV,IgM
HEPATITIS E
anti-HEV

EPATITIS VIRAL

Hepatitis A antigen
Antibody against HVA
Antibody against HVA ( acute infeccion )

Hepatitis B surface antigen

Antibody against HBsAg
Hepatitis B antigen ( part of the core protein, marker for active replication )
Antibody against HBeAg ( marker of virus elimination )
Antibody against HBcAg ( HBcAg: core protein, no demonstrable in the serum )
IgM antibody against HBcAg, signals acute infection
.Persistence > 6 months indicates chronic hepatitis.
Hepatitis B virus-DNA ( determined with " spot-hybridization " or `
polymerase chain reaction. Proves active replicacion )

Hepatitis C antigen ( cannot be measured on account of

the low concentration of the viruses in the serum )
Antibodies againts various proteins of the hepatitis C virus
Hepatitis C virus-RNA ( tested by reverse transcription and polymerase
chain reaction. Proves active replication of the virus )

Hepatitis D antigen
Antibody against HDV
Antibody againts HDV ( in acute infection )

Antibody againts HEV

HEPATITIS B : TYPICAL SEROLOGICAL FINDINGS

HBsAg

Anti-HBs

Anti-HBc

HBeAg

Anti-Hbe

IgM

IgG

IgG

+/-

+/-

IgM

+/-

+/-

IgG

+/-

IgG

+/-

Meaning
acute hepatitis B, highly infeccious
chronic hepatitis B, highly infectious
subsiding of chronic hepatitis b, low infectiousness
infection with 2 different hepatitis b subtypes
current seroconversion, veri rare
acute hepatitis b or anti-HBc "window"
old hepatitis B or HBs carrier with low replication
subsiding acute hepatitis B
cured hepatitis B or post-vaccinal reaction or false positive

or

CHARACTERISTICS OF THE HEPATITIS VIRUSES

HEPATITIS

Family
Diametro

Picornavirus
27 - 32 nm

Nucleic acid

RNA
single DNA
double RNA
single
strand, linear.
strand, circular.
strand, linear

Transmision
. Fecal-oral route
. Blood
. Vertically
. Sexually
Antigens
Antibodies

Fulminant hepatitis
Spontaneouly resolving acute
hepatitis
Chronic active hepatitis
Liver Cirrhosis
Active Vaccination
Passive inmunoprophylaxis

Hepadnavirus
42 nm

Flavivirus
?

yes

no

no

no
no
no
HAAg
anti-HAV
anti-HAV
IgM

yes
yes
yes
HBsAg,HBeAg
Anti-HBs
Anti-HBe
Anti-HBc
Anti-HBc IgM
0.5-1.0 %

yes
yes
yes
?
anti-HCV
anti-HCV
IgM

> 90 %

5 - 15 %

0.001-0.5 %
> 99 %

0% < 10 %
< 0.1 %
yes
yes

yes
yes

0.5-1.0 %

80 - 95 %
1% 5 - 30 % ?
no
no

D
Viroid
36 nm

E
Calicivirus
32 - 34 nm

RNA
single RNA,
single
strand, circular strand, linear
no

yes

yes
yes
yes
HDAg
anti-HDV
anti-HDV
IgM

no
no
no
HEAg

1-3-25 %

2% ( 25%-? )

50 - 80 %

> 95 %

20 - 50 %
10 % ?
no
no

?(<5%)
?
no
no

anti-HEV