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2 types of synapse
1. Chemical synapse- no need for
physical contact; require
neurotransmitters (e.g.
epinephrine, acetylcholine),
unidirectional movement
2. Electrical synapse- e.g. gap
junctions> direct
communication
- In smooth muscles, cardiac
muscles
PHYSIOLOGY OF SYNAPSES
Presynaptic terminals, 10,000 to
200000 minute synaptic knobs>
-ends of nerve fibrils, may be
inhibitory or excitatory
- varied anatomical forms
- no direct contact with other neurons
but with synaptic cleft (200 to 300
angstroms wide)
INTERNAL STRUCTURE OF
PRESYNAPTIC TERMINAL
Depolarization of presynaptic
membrane- influx of Ca through
channels
Ca binds release sites (where
vesicles go and
neurotransmitters are released)
EXCITATROY OR INHIBITORY
RECEPTORS
EXCITATION (INCREASE NEG)
-opening of Na channels
- depress conduction of Cl or K
channels
INHIBITION
-
Open of Cl channels
Increase onduction of K
OUTSIDE
SYNPTIC
TRANSMITTERS/NEUROTRANSMITTERS
- the larger the more prolonged the
action
Class I- Ach (excitatory, inhibitory in
parasymp)
Class II: amines
Negative 65 mV
DECREMENTAL CONDUCTION
more dendrites, decreasing conduction