ews Perspect. 2006 Nov;19(9):575-83.

Systems biology: Potential to improve decision making in pharmaceutical development.

Mujagic H.
Source
Massachusetts General Hospital, Harvard University, Boston, Massachusetts, USA. HMUJAGIC@partners.org

Abstract
On October 5, 2006, the New England Systems Biology Association held its first annual meeting at Bentley College, Waltham, Massachusetts. The
meeting was organized under the title "Systems Biology in Drug Discovery" and was devoted to the presentation of current status and advances in this
new and ever-expanding field in medical sciences. It brought together biologists, biochemists, physicians, physicists and engineers, as well as leaders
in biopharmaceutical industry interested in this field of science and its possible impact on anticancer drug discovery. The meeting consisted of two
sessions, one in the morning and one in the afternoon and a panel discussion at noon. Each session hosted four speakers and a panel discussion
featuring five discussants. Each session also included keynote speakers. Systems biology can help to identify disease-specific molecules and drugspecific targets. This is especially useful as a new tool in diagnostic approaches and drug discovery. Using specific techniques like gene profiling,
marker detection and kinase-specific substrate definition, and combining them with large databases and computational methods it is possible to look at
the organism as a complex association of gene activation and control networks, and their products, and thus gain better and more realistic insights into
disease processes and into drug mechanisms.
Copyright 2006 Prous Science. All rights reserved.
PMID:

17220963

[PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Congresses
MeSH Terms

Antineoplastic Agents
Decision Making
Drug Design*
Gene Expression Profiling
Humans
Models, Genetic
Neoplasms/metabolism
Protein-Tyrosine Kinases/metabolism
Systems Biology*
Vascular Diseases/chemically induced
Substances

Antineoplastic Agents
Protein-Tyrosine Kinases

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