GE ASSESSMENT 2015

MTF
1) Eukaryotic nuclear DNA replication machinery involves
A. DNA Polymerase
B. DNA Polymerase
C. DNA Polymerase
D. DNAa
E. DNA ligase 1

3) Eukaryotic transcription
A.
B.
C.
D.
E.

requires RNA nucleotide as a substrate

involves the activity of RNA polymerase II
transcribes RNA from one DNA strand within a single gene
requires a promoter for binding of transcription apparatus
ceases when RNA polymerase recognises a TATA Box.

4) Epigenetics include control of

A. DNA methylation
B. Histone methylation
C. DNA base sequences
D. Histone acetylation
E. Nucleosome repositioning
5) Genetic codes
A.
B.
C.
D.
E.

has its information stored as codon

is regenerate
is ordered
consists of 64 amino acids-coding codons
is species-specific

6)regarding the growth factor

A.
B.
C.
D.

they bind to a specific receptor and be activated within the cell

they are protein or polypeptide
presence in cytoplasm
the mutation of growth factor will associate to cancer

SAQ
1) Distinguish the difference between a germline mutation and somatic mutation.
Give example for each of the mutation.
(15 mark)
2) genomic level control is type of the regulation of gene expression. give another
two difference level of the regulation of gene expression (8 marks)

3) what the difference between euchromatin and heterochromatin (2 mark)

4) glucocorticoid hormone as an example of hormonal response effects on
enhancer activate gene expression, briefly explain how this phenomenon regulate gene
expression on human metallothionein protein. (5 marks)