Beruflich Dokumente
Kultur Dokumente
com | Medicine
NSAIDs
Mechanism of action
COX-I Inhibition - Unwanted effects on GIT & kidney
- ↓ Platelet aggregation
COX-II Inhibition - Anti inflammatory
- Analgesic
- Antipyretic
NSAIDs
Salicylism
Allergy
Reye’s syndrome
jslum.com | Medicine
Selective COX-II Celecoxib Block production of prostaglandins Analgesic ↑ heart attack risk
Inhibitors Rofecoxib (without interfering gastric protection Anti-inflammatory
Valdecoxib or platelet activity) Headache, dyspepsia, diarrhoea,
Metabolised in liver abdominal pain (Celecoxib)
Excreted in feces and urine