4/10/2016

Longtermimprovementinobsessionsandcompulsionswithsubthalamicstimulation

Longtermimprovementinobsessionsand
compulsionswithsubthalamicstimulation
MirceaPolosan,MD,PhD,StephanChabardes,MD,PhD,ThierryBougerol,MD,PhD,ClaireArdouin,MS,PierrePollak,MD,
PhD,AlimLouisBenabid,MD,PhDandPaulKrack,MD,PhD
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SHOWAFFILIATIONS |+SHOWFULLDISCLOSURES
CorrespondencetoDr.Krack:paul.krack@hcuge.ch

PublishedonlinebeforeprintSeptember21,2016,doi:http://d x.d oi.o rg/1 0.1 212/WNL.0 000000000003248

Neurology10.1212/WNL.0000000000003248

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Obsessivecompulsive disorder (OCD) may be conceptualized as a disorder of selfcontrol and behavioral inhibition.1 Recent
studies2,3 suggestedinterestindeepbrainstimulation(DBS)ofdifferentsubcorticalbraintargetssuchasthenucleusaccumbens,
anteriorinternalcapsule/ventralstriatum,andsubthalamicnucleus(STN)insevere,resistantOCD.STNisacriticalnodeofthe
indirect and hyperdirect basal gangliathalamocortical circuit. STNDBS may release its function as a brake on behavioral
programs,disinhibitinghabitualresponsesandenablingmoreflexiblegoaldirectedbehaviorcontrolinOCD.4,5 Little is known
aboutlongtermoutcomeofSTNDBSinOCD.BasedonexperienceinParkinsondisease,STNDBScaninduceachangefrom
apathetictodisinhibitedbehavior.6 Thistargethasalsoapotentialimpactonaddictions.4,6
ReceivedNovember21,2015.
AcceptedinfinalformJuly11,2016.

http://www.neurology.org/content/early/2016/09/21/WNL.0000000000003248.short?rss=1

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