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Carbohydrates are the polyhydroxy organic compounds made up of carbon, hydrogen and oxygen in
which the ratio of hydrogen and oxygen hydrogen is 2:1 exactly as H2O (2:1).
Sources of Carbohydrates
The main sources of carbohydrates are plants, e.g., starch (storage forms carbohydrate of
chlorophyll containing plants), sugars, cereals, potatoes, legumes, millets, roots and other
vegetables. Sugars are found in fruits, juice, cane, honey, palm, milk, etc.
angular cheilitis see cheilitis treatment cheilitis treatment chelitis chelitis.
Structure of Carbohydrates
Chemically, they are aldehyde or ketone derivatives of higher polyhydric alcohol (having
more than one "OH" group). They may be identified by the type and number of monosaccharide
residues (glucose/ fructose molecule) in their molecules. The general formula of carbohydrate is
Cn (H2O)n where n=3-9.
Each sugar molecule consists of a backbone of carbon atoms linked together in a linear
array by single bonds. Each carbon atom is linked to a single hydroxyl group except for one that
bears a carbonyl (C=O) group. If the carbonyl group is located at an internal position, the sugar
is a ketose (e.g., fructose). If the carbonyl is located at one end of the sugar, it forms an
aldehyde group or aldose (e.g., glucose).
Classification of Carbohydrates
Carbohydrates may be classified into the following four major groups 1. Monosaccharides: Monosaccharides are the simplest form of carbohydrates. All
carbohydrates are reduced to this state before absorption and utilization. They contain three
to six carbon atoms. General formula is Cn(H2O)n.
2. Disaccharide: Disaccharides Consist of two covalently joined monosaccharide units. They
are produced as two molecules of the same or different monosaccharides on hydrolysis.
General formula is Cn(H2O)n-1, e.g., lactose, sucrose, maltose etc.
3. Oligosaccaharides: Oligosaccaharides consist of few number (2-6) of monosaccharide units
e.g., glycoproteins.
4. Polysaccharides: Polysaccharides are composed of many molecules of monosaccharides
linked together. General formula is (C6 H10 O5)x. e.g., Glycerole.
Importance of Carbohydrates
1. Carbohydrates, such as energy yielding compounds D-Ribose, are the structural elements of
nucleic acid and coenzymes.
2. Act as intermediates in hexose monophosphate stant.
3. D-Lyxose, a constituent of a lyxoflavin isolated from human muscle.
4. D-glucose carried out by the blood and used in tissues.
5. D-fructose can be changed to glucose in the liver and intestine and used in the body.
Functions of Carbohydrates
1. Glucose act as energy yielding compounds, the major fuel of the tissue, constitutes the
structural material of the organism, converted to other carbohydrates having highly specific
functions.
2. Glycogen acts as important storage of food material of the organism.
3. Play a key role in the metabolism of aminoacids and fatty acids.
4. Act as protective function-mucosubstance.
5. Act as intermediates in respiration and carbohydrates metabolism e.g., (trioses).
6. Participate in lipid synthesis.
7. Pentoses - Synthesis of nucleic acid; Some co-enzymes (e.g., NAD, FAD, FMN, etc.); ATP,
ADP, AMP, and also synthesis of polysaccharides.
Hyperglycemia
Glycosuria
Galactosemia
Pentosuria
Ketone
Under weight.
Proteins
Proteins are complex organic compounds. They are macromolecules or bio molecules composed of
amino acids linked by peptide bond. The constituent elements of proteins are carbon (54%),
hydrogen (7%), nitrogen (16%), oxygen (22%) and some may contain sulpher (1%) or phosphorus
(0.6%). They are macromolecules of high MW and consisting of chains of amino acids e.g.,
hemoglobin, albumin, globulin, enzymes, etc.
Sources of Proteins
Peas, beans, poultry, cereals, lentils, milk, cheese, eggs, meat, wet and dry fishes, pulses, and nuts.
Structure of Protein
The basic unit of the protein molecule is amino acids .The protein molecules are composed of the
union of a large number of amino acids. There are over 10,000 proteins in the human body. They all
composed of different arrangements of the main 20 fundamental amino acids. The sequence of
amino acids in each protein is specific and is genetically controlled by the DNA of the cell.
Chemical Structure
The synthesis of protein molecule takes place by the union of the-NH2 group of one amino acid with
the-COOH group of another. Elimination of water is known as condensation and the linkage (bond)
formed is a covalent carbon-nitrogen bond, called a peptide bond. The remaining part of amino acid
is known as R group or side chain. In this way dipeptide or polypeptide is formed.
HN CH C NH CH C NH CH C ---R1
R2
R3
Classification of Proteins
Proteins may be classified in the following ways According to Structure
1. Fibrous type with elongate molecule e.g., keratin
2. Pounded type with globular molecule
3. Intermediate type.
According to Composition
1. Simple proteins -e.g., albumins, globulins, histones etc.
Properties of Proteins
Optically active.
They differ from one another in chemical structure, physical and physiological properties.
Function of Proteins
As structural cables - provide mechanical support both within cells and outside.
As hormone receptors and transporters-determine what a cell reacts to and what types of
*substance enter or leave the cell.
Others - act as the defense against infections by protein antibodies, service as toxins, form
blood clots through thrombin, fibrinogen and other protein factors, absorb or refract light and
transport substances from one part of the body to another.
Constitute about half of the dry weight of most organisms and maintain growth.
Most fibrous protein plays structural roles in skin, connective tissue of fibers such as hair, silk
or wool.
Abdominal enlargement, excessive loss in urine and disease to lower urinary tracts-
Vomiting
Diarrhea
Nephrosis
Lassitude
Oedema
Marasmic - Kwashiorkor
Vitamins
Vitamins may be defined as organic compounds occurring in small quantities in different natural
foods and necessary for the growth and maintenance of good health in human beings and certain
experimental animals.
They cannot be synthesized in the body but supplied by the diet to the human body. Plants produce
all vitamins but animal (human) stores them. Some are produced in the body e.g. Provitamin
carotene is converted into vitain A in the body and Vit. D is produced in the body in presence of
ultraviolet radiation.
Classification of Vitamins
Vitamins are classified into two groups.
1. Fat - soluble vitamins
Fat-soluble vitamins are soluble in fats and fat solvents. They are insoluble in water. So these are
utilized only if there is enough fat in the body e.g., vitamin A, D, E and K.
Vitamin A (Ratinol)
Properties
Source of Vitamin A
Liver, heart, kidney, milk, codliver oils, fishliver-oils, butter, eggs, carrots, cabbage, vegetables, green
leaves, mangoes, potatoes tomatoes, spinach, papaya etc.
Functions
Required for bone and teeth formation, influence genetic expression, reproduction to
manufacture R.B.C etc.
Maintain the health and activity of epithelial tissues, and glands prevent infection, maintains
nutrition and function of the nervous tissue.
Controls the action of bone cells and formation, helps in normal fertility and glucose
synthesis.
Acts as antioxidant.
Retardation of growth in children, defective growth of bone and teeth, skin lesions, Bitot's,
sports etc.
Vitamins D (Cholecalciferol)
Properties
Heat stable
Source Fish liver oils e.g., cod liver oil, halibut - liver oil etc. Butter, milk, eggs, liver. In sub
coetaneous tissue, 7 dihydrocholesterol is conveted to vitamin D by UV light.
Functions
Control calcium and phosphorus absorption from the small intestine, concerned with calcium
metabolism, helps in the bone and teeth formation.
Minimize the losses of calcium and increases phoshate excretion by the kidneys, affects
insulin secretion in pancreases.
Deficiency Disease
Causes Rickets (directive bone growth) in childless, osteomalacia in adults, disturbs calcium and
phosphorous absorption.
Sources
Guava, amla, green chilli, amaranth leaves, citrus fruits, green vegetables, potatoes, tomatoes,
cheese, milk etc.
Functions
Acts as antioxidant.
Helps to reduce the ferric iron (Fe3+) to ferrous iron (Fe2+) and is absorbed only in this form.
Deficiency Diseases
Scurvy, a disease characterized by sore, spongy gums, loose teeth, fragile blood vessels,
swollen joints, and anemia.
Pain in bones.
Vitamin B1 (Thiamine)
Properties
Water-soluble
Heat labile
Sources
Rice polishing, dried yeast and wheat germ are rich sources of vit. B1. Whole cereals like wheat,
oats, legumes, oil seeds and nuts are good sources. Milled cereals, vegetables, fruits, meat and fish
are poor sources. On milling, vit. B1 is lost from cereals.
Functions
Deficiency Diseases
Beriberi - nervous, system affected, muscles become weak and painful paralysis can occur.
Heart failure, wet beriberi, dry beriberi, infantile beriberi, oedemia, children's growth is
impaired, keto acids accumulate in the blood, wernickes-korsakoffs syndrome etc.
VitaminB2 (Riboflavin)
Properties
Yellow crystals
Soluble in water
Destroy by light.
Sources
Milk, liver, kidney, muscle, butter, chicken, fish, yeast, cheese, raw egg, white grains, green
vegetable such as spinach, peanuts, fruits such as apple, orange etc. Functions
Essential for growth, essential for tissue oxidation related to carbohydrate, fat and protein
metabolism.
Deficiency Diseases
Symptoms
Arrest of growth.
Dermatitis around nose and lips, inflammation of tongue, angular stomatitis and cheilosis,
photophobia, cataract etc.
Minerals
Minerals are inorganic substances that serve a variety of functions such as cofactors in enzymecatalyzed reactions, in the regulation of acid-base balance, in nerve conduction and muscle
irritability, and as structural elements in the body. Each mineral is required in specific amounts
ranging from y to gm per day. Some of the more important of these are calcium, phosphorus,
sodium, potassium and iron.
Kinds of Minerals
Minerals may be divided arbitrarily into 2 groups.
1. Macro minerals: The minerals, which are required in amounts greater than 100 mg/ day.
2. Micro minerals: The minerals, which are required in amounts less than 100 mg/ day.
Calcium: Milk, egg, leafy green vegetable, fish, meat soybeans etc. Formation of bones and
teeth structure. Activates ATP during muscular contraction, helps in blood clotting and capillary
permeability.
Phosphorus: Milk, peas, meat, fish, eggs, cottage, cheese, almonds, wheat germ, soybeans,
black beans etc. Synthesis of nucleic acid, ATP and some protein. Helps in calcification of
bones, maintain buffer system in body and bone formation.
Potassium: Spinach, butter, beans, oranges, milk, peas, meat, fruits nuts, and vegetables.
Involves transmission of nervous impulses chemical reactions and acid base balance in the
body.
Sodium: Table salt, eggs. meat, milk, cheese, butter, margarine, bacon etc. Form part of
tissue fluids inducing blood, involves kidney functioning and transmission of nervous impulses,
acid-base balance in body.
Synthesis of proteins e.g., Keratin and many other organic confounds e.g., coenzymes A.
Constituent of bones and tooth structure, co-factor for many enzymes e.g., ATP-ase.
Micro minerals
Source and Functions
Iron: Liver, eggs, meat, dark and green vegetables, lentis, potatoes, soybeans, chick peas,
black beans, spinach, etc. Forms part of haemoglobin, helps in electron transport in biochemical
reactions.
Fluorine: Water, milk etc. Needed for strong enamel on teeth, as calcium deposit in bone
Nitrogen: Protein e.g., meat, fish and milk,Synthesis of protein NA and many other organic
compounds, e.g., coenzymes and chlorophyll
Manganese: Vegetables and most other foods; Bone development (a growth factor)
Boron: Most foods; Reduction of nitrate to nitrite during amino acid synthesis in plants.
Iodine: Seafoods, such as fish, shellfish and fish oil. Vegetables, spinach, fruits, and cereals.
Nitrogen-kwashiorkor
Sodium-muscular cramps, giddiness, anorexia, scanty urine, dry mouth, inelastic skin and
disorientation.
Cobalt-pernicious anemia,
Fluorine-dental caries