9/5/2016

DermatologicManifestationsofMiliariaMedication:TopicalTherapies

DermatologicManifestationsofMiliariaMedication
Author:NikkiALevin,MD,PhDChiefEditor:DirkMElston,MDmore...
Updated:Feb09,2016

MedicationSummary
Thegoaloftreatingmiliariarubraandmiliariaprofundaistoprovidesymptomatic
reliefandpreventhyperpyrexiaandheatexhaustion.Theauthorsknowofnostrong
evidenceindicatingefficacywithsystemicmedicationstherefore,topical
medicationsarepreferred.However,casereportsofsuccessfultreatmentof
miliariaprofundawithoralisotretinoinexist. [25]

TopicalTherapies
ClassSummary
Anhydrouslanolinisbelievedtopreventductalblockage,allowingsweattoflowto
theskinsurface.Calaminelotionprovidescoolingsymptomaticreliefaftermiliaria
develops.
Viewfulldruginformation

Lanolin
Lanolinisthoughttopreventductalblockage,allowingsweattoflowtotheskin
surface.

Calaminelotion(Caladryl)
Calaminelotionprovidescoolingsymptomaticreliefaftermiliariadevelops.
Followup

ContributorInformationandDisclosures
Author
NikkiALevin,MD,PhDAssociateProfessorofMedicine,DivisionofDermatology,UniversityofMassachusetts
MedicalSchool
NikkiALevin,MD,PhDisamemberofthefollowingmedicalsocieties:AlphaOmegaAlpha,American
AcademyofDermatology,PhiBetaKappa,SigmaXi
Disclosure:Nothingtodisclose.
SpecialtyEditorBoard
MichaelJWells,MD,FAADAssociateProfessor,DepartmentofDermatology,TexasTechUniversityHealth
SciencesCenter,PaulLFosterSchoolofMedicine
MichaelJWells,MD,FAADisamemberofthefollowingmedicalsocieties:AlphaOmegaAlpha,American
AcademyofDermatology,AmericanMedicalAssociation,TexasMedicalAssociation
Disclosure:Nothingtodisclose.
RosalieElenitsas,MDHermanBeermanProfessorofDermatology,UniversityofPennsylvaniaSchoolof
MedicineDirector,PennCutaneousPathologyServices,DepartmentofDermatology,UniversityofPennsylvania
HealthSystem
RosalieElenitsas,MDisamemberofthefollowingmedicalsocieties:AmericanAcademyofDermatology,
AmericanMedicalAssociation,AmericanSocietyofDermatopathology,PennsylvaniaAcademyofDermatology
Disclosure:ReceivedroyaltyfromLippincottWilliamsWilkinsfortextbookeditor.
ChiefEditor
DirkMElston,MDProfessorandChairman,DepartmentofDermatologyandDermatologicSurgery,Medical
UniversityofSouthCarolinaCollegeofMedicine
DirkMElston,MDisamemberofthefollowingmedicalsocieties:AmericanAcademyofDermatology
Disclosure:Nothingtodisclose.
AdditionalContributors
JanetFairley,MDProfessorandHead,DepartmentofDermatology,UniversityofIowa,RoyJandLucilleA
CarverCollegeofMedicine
JanetFairley,MDisamemberofthefollowingmedicalsocieties:AmericanAcademyofDermatology,American
FederationforMedicalResearch,SocietyforInvestigativeDermatology
Disclosure:Nothingtodisclose.

References
1.ChampionRH.Disordersofsweatglands.ChampionRH,BurtonJL,BurnsDA,BreathnachSM,eds.
TextbookofDermatology.6thed.Malden,Mass:BlackwellScientificPublications1998.19979.

http://emedicine.medscape.com/article/1070840medication

1/2

9/5/2016

DermatologicManifestationsofMiliariaMedication:TopicalTherapies

2.WenzelFG,HornTD.Nonneoplasticdisordersoftheeccrineglands.JAmAcadDermatol.1998Jan.
38(1):117quiz1820.[Medline].
3.AleI,LachapelleJM,MaibachHI.Skintolerabilityassociatedwithtransdermaldrugdeliverysystems:an
overview.AdvTher.2009Oct.26(10):92035.[Medline].
4.HolzleE,KligmanAM.Thepathogenesisofmiliariarubra.Roleoftheresidentmicroflora.BrJDermatol.
1978Aug.99(2):11737.[Medline].
5.MowadCM,McGinleyKJ,FogliaA,LeydenJJ.Theroleofextracellularpolysaccharidesubstance
producedbyStaphylococcusepidermidisinmiliaria.JAmAcadDermatol.1995Nov.33(5Pt1):72933.
[Medline].
6.HidanoA,PurwokoR,JitsukawaK.StatisticalsurveyofskinchangesinJapaneseneonates.Pediatr
Dermatol.1986Feb.3(2):1404.[Medline].
7.MoosaviZ,HosseiniT.Oneyearsurveyofcutaneouslesionsin1000consecutiveIraniannewborns.
PediatrDermatol.2006JanFeb.23(1):613.[Medline].
8.HudaM,SahaP.Patternofdermatosisamongpediatricpatientsattendingamedicalcollegehospitalin
northeasternregionofIndia.IndianJDermatol.2009.49:189.
9.ArpeyCJ,NagashimaWhalenLS,ChrenMM,ZaimMT.Congenitalmiliariacrystallina:casereportand
literaturereview.PediatrDermatol.1992Sep.9(3):2837.[Medline].
10.StrakaBF,CooperPH,GreerKE.Congenitalmiliariacrystallina.Cutis.1991Feb.47(2):1036.[Medline].
11.HaasN,HenzBM,WeigelH.Congenitalmiliariacrystallina.JAmAcadDermatol.2002Nov.47(5
Suppl):S2702.[Medline].
12.DoshiBR,MahajanS,KharkarV,KhopkarUS.GranulomatousVariantofGiantCentrifugalMiliaria
Profunda.PediatrDermatol.2012Jan26.[Medline].
13.AlHilo,MaythamM,AlSaedySJ,AlwanAI.AtypicalPresentationofMiliariainIraqiPatientsAttending
AlKindyTeachingHospitalinBaghdad:AClinicalDescriptiveStudy.AmericanJournalofDermatologyand
Venereology.2012.416.
14.CarterR3rd,GarciaAM,SouhanBE.Patientspresentingwithmiliariawhilewearingflameresistant
clothinginhighambienttemperatures:acaseseries.JMedCaseReports.2011.5(1):474.[Medline].
15.ArgoubiH,FitchnerC,RichardO,LavocatMP,CambazardF,StephanJL.[Pustularmiliariarubraand
systemictype1bpseudohypoaldosteronisminanewborn].AnnDermatolVenereol.2007Mar.134(3Pt
1):2536.[Medline].
16.UrbatschA,PallerAS.Pustularmiliariarubra:aspecificcutaneousfindingoftypeI
pseudohypoaldosteronism.PediatrDermatol.2002JulAug.19(4):3179.[Medline].
17.AkcakusM,KokluE,PoyrazogluH,KurtogluS.Newbornwithpseudohypoaldosteronismandmiliaria
rubra.IntJDermatol.2006Dec.45(12):14324.[Medline].
18.TabanelliM,PassariniB,LiguoriR,BalestriR,GaspariV,GiacominiF,etal.Erythematouspapulesonthe
parasternalregionina76yearoldman.ClinExpDermatol.2008May.33(3):36970.[Medline].
19.HaasN,MartensF,HenzBM.Miliariacrystallinainanintensivecaresetting.ClinExpDermatol.2004Jan.
29(1):324.[Medline].
20.GuptaAK,EllisCN,MadisonKC,VoorheesJJ.Miliariacrystallinaoccurringinapatienttreatedwith
isotretinoin.Cutis.1986Oct.38(4):2756.[Medline].
21.GodkarD,RazaqM,FernandezG.Rareskindisordercomplicatingdoxorubicintherapy:miliariacrystallina.
AmJTher.2005MayJun.12(3):2756.[Medline].
22.KumarS,MahajanBB,KaurS,SinghA.Erythropoietininducedmiliariacrystallina:Apossiblenew
adverseeffectoferythropoietin.IntJCaseRepImages.2014.5(9):634637.[FullText].
23.ShusterS.Ductdisruption,anewexplanationofmiliaria.ActaDermVenereol.1997Jan.77(1):13.
[Medline].
24.MohananS,BeheraB,ChandrashekarL,KarR,ThappaDM.Bull'seyepatterninmiliariarubra.Australas
JDermatol.2013Jun28.[Medline].
25.TeyHL,TayEY,CaoT.Invivoimagingofmiliariaprofundausinghighdefinitionopticalcoherence
tomography:diagnosis,pathogenesis,andtreatment.JAMADermatol.2015Mar.151(3):3468.[Medline].
26.KirkJF,WilsonBB,ChunW,CooperPH.Miliariaprofunda.JAmAcadDermatol.1996Nov.35(5Pt
2):8546.[Medline].
27.HaqueMS,HailuT,PritchettE,CusackCA,AllenHB.Theoldestnewfindinginatopicdermatitis:
subclinicalmiliariaasanorigin.JAMADermatol.2013Apr.149(4):4368.[Medline].
MedscapeReference2011WebMD,LLC

http://emedicine.medscape.com/article/1070840medication

2/2