What Is Antisense Therapy?

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What Is Antisense Therapy?

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Antisense therapy is an approach to fighting various forms of
cancer using oligonucleotides as part of the basic strategy. The
aim of antisense oligonucleotide therapy is to control, and in some
cases prevent, the absorption or translation of proteins that are
believed to be playing a role in the development of the malignancy.
By effectively using this type of therapy to remove essential
building blocks used by the cancer, there is an increased chance
that various treatments currently used to kill cancer cells will be
effective.
Antisense therapies of this type work by locking onto the proteins
and essentially encasing them. Once encased, the proteins cannot
be absorbed and thus cannot feed the cancer. The encased
proteins pass through the body without ever contributing to the
strength or the further development of the malignant tumor.
There are several benefits to using antisense therapy as a front
line treatment or as a stand alone therapy. One advantage has to
do with the fact that the necessary oligonucleotides can be
manufactured very quickly. Currently, it is possible to accomplish
the task within a single week. As long as the gene sequence
relevant to the patient is identified, the creation of the
oligonucleotides can proceed without delay.
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Another advantage associated with antisense therapy is the ease

with which healthcare providers can assess the degree of
sensitivity to the therapy. This makes it much easier to adjust the
treatment series as needed, allowing the patient to progress as a
pace that is in his or her best interests.

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Antisense gene therapy also has great potential to lead to

responses that last longer than other treatment methods. This is
important not only in containing the spread of the cancer, but also
in weakening the malignancy and inhibiting the chances of long
term damage to vital organs.
There is also evidence that the use of antisense therapy is much
easier to focus than many other traditional approaches to cancer
treatment. The binding action can be controlled, measured for
reactions or responses and then redirected as necessary. An
approach of this type helps to eliminate some of the guesswork
involved with other methods that can also damage healthy cells
while attempting to kill off cancer cells.

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is every indication that the strategy will be refined over time,

making it even more valuable in the fight to overcome cancer.

Already utilized in a number of countries, more research into the
potential of this type of treatment is taking place around the world.
The research includes the investigation into potential long-term
side effects as well as the efficacy of the treatment itself.
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