Neoplasia: Check List

Dr. Roy

1) Head and Neck

Oral cavity
- benign tumors Fibroma, Leukoplakia,
- malignant tumors Squamous cell carcinoma, Lymphomas
(tonsils),
Nasopharynx Nasopharyngeal Carcinoma (EBV)
Larynx
- benign tumors Laryngeal Papilloma (HPV)
- malignant tumor Squamous cell carcinoma. (larynx smoking,
vodka)
Salivary glands
- benign tumors Pleomorphic Adenoma divergent
differentiation from single cell line
- malignant tumors Sjorgens (MALT Lymphoma)
2) Lungs
-

benign tumors Bronchial adenoma, Hamartomas

(developmental)
malignant tumors Bronchogenic (small cell carcinoma) ,high growth fraction, paraneoplastic (ACTH cushings,
SIADH, Lambert Eaton) pancost tumors (could be other
histological types),
squamous cell carcinoma both related to smoking
(hypercalcemia), RB somatic mut- small cell ca.

3) Pleura Mesothelioma. (Pleura, pericardium, peritoneum)

4) Heart
-

benign tumors Rhabdomyoma (tumor arising from striated

muscle)
malignant tumors - rhabdomyosarcoma

5) Diseases of WBC,
Leukemias Acute Lymphoblastic Leukemia (Blood Brain
Barrier/CSF)
Acute Myologenous Leukemia second malignancy with
chemotherapy. (Cyclophosphamide)

CML Non receptor tyrosine kinase: t9:22 (BCR-ABL)

Lymph nodes - Mantle cell t(11,16), Cyclin D1.
MALToma salivary gland with Sjorgen (marginal), Stomach with
H. Pylori.
6) GIT
Esophagus
Benign tumorsmalignant tumors- GIST (c-MYC transc. Factor), CDKN2A,
Barrets (metaplasia -> dysplasia -> sq. cell ca. AND
adenocarcinoma), sq cell ca d/t somatic mut in E-cadherin
Stomach
- benign tumors- Krukenberg, choristoma
- malignant tumors- atrophic gastritis (TGFb-SMAD4), germline
loss of E-cadherin, TGF-beta
Small and large intestine
- benign tumors- polyp adenoma- FAP (APC loss),
- malignant tumors- HNPCC (mismatch repair), (RAS, TGFbSMAD4), cholangiocarcinoma (RAS)
Peritoneal cavity
6) Liver and Gall bladder
- benign tumors- malignant tumors-HCC, angiosarcoma (PVC),
hepatoblastoma/HCC (d/t APC loss)
-

7) Pancreas
benign tumors- Perineural invasion
malignant tumors- RAS mut (GF-R), Loss of fxn in CDKN2A
(somatic), SMAD4 inactivation

8) Kidney
- benign tumors
- malignant tumors- RCC (VHL), neuroblastoma, Wilms tumor
(WT1)
-

9) Lower urinary tract: Bladder

benign tumors
malignant tumors- RB somatic mut, sporadic mut in CDKN2A

10) Male genital system

benign tumors
malignant tumors

11) Female genital tract

Vagina
- benign tumors
- malignant tumors
-

Cervix
benign tumors
malignant tumors

Endometrium
benign tumors
malignant tumors- Cowden (PTEN), PI3K, RAS, TGF-beta

Ovary
benign tumors
malignant tumors

Gestational and placental

benign tumors
malignant tumors

12) Breast
- benign tumors
- malignant tumors
13) Endocrine tumors
- benign tumors
- malignant tumors
-

14) Skin
benign tumors
malignant tumors

15) Bones and joints

benign tumors
malignant tumors

16) Soft tissue

benign tumors

malignant tumors

17) Peripheral nerves and skeletal muscle

benign tumors
malignant tumors

18) Central Nervous System

benign tumors
malignant tumors

19) Eye
benign tumors
malignant tumors