1

SUPPOSITORIES
-solid dosage forms intended for
insertion into body orifices ->
melt, soften & dissolve

2.) COMPRESSION-most
preferred
method
elegant)
3.) HAND
ROLLING
SHAPING

(most
AND

TYPES
1.) RECTAL SUPPOSITORIES
Cylindrical or bullet
shape
32 mm (1 in) in
length
2 g- adults
1 g- children
Either
local
or
systemic effect
2.) URETHRAL SUPPOSITORIES
Bougies
Slender or pencil shape
Male: 4g, 140 mm long,
3-6 mm diameter
Female: 70 mm long,
1g
Used for: Dilation of
uterus (female), antiinfective agent, erectile
dysfunction (male)
3.) VAGINAL SUPPOSITORIES
Globular,
Oviform,
Coned-shaped
Weighs 5g
Uses: Antifungal, Antiinfective, Contraceptive
**AURAL
cones

SUPPOSITORIES-

ear

**NASAL SUPPOSITORIES- nose;

pencil-shaped

METHODS
1.) MOLDING
MELT/FUSION

FROM

SUPPOSITORY BASES
-it affects the melting point of a
suppository
1.) COCOA BUTTER/THEOBRAMA
OIL
Fatty oleaginous base
Most widely used
2.) WITEPOOL BASES
Natural saturated fatty
acid between C12 & C18
3.) WATER
SOLUBLE/MISCIBLE
BASES
Glycerinated
gelatin,
PEG
4.) WEECOBEE BASE
Derived from coconut
oil
5.) MISCELLANOUS
Polyoxyl 40 stearate
Combination
of
Miscible
&
Oleaginous bases

EXPERIMENT PROPER
Name: Glycerin Suppositories
Category: Rectal Suppository
Synonym: Suppositoria Glycerin
Ingredients:
Glycerin
24.4 g

Abigail Beatrice H. Lumbao|2DPH|PHAR3- Suppositories&Creams

Density: 1.249 g/mL (19.5

mL)
Hygroscopic (75%-90%
w/w)
-Sodium
Carbonate..0.5
4g
-Stearic
Acid..
2.48 g
Used as a solidifier
Water
1.67 g
Use: serve as a base for other API;
laxative
Label: RED (External Label)
Container: Suppository Bottle

CREAMS
or

-ointments- used for wet wounds

-creams- used for dry wounds
-Why is it better than ointments?
Easier to spread
Easier to remove
Lighter, less viscous
Impart pseudo-plastic flow
when applied

TYPES

Name: Cold Cream

Category: Water-in-Oil

semi-solid

-Dispersed either in oil-in-water

or water-in-oil

EXPERIMENT PROPER

Synonym: Petrolatum Rose Water

Ointment/Galens
Cerate
Ungentum Aquae

-made of emulsions
-viscous liquid
emulsions

1.) OIL-IN-WATER
o Tends to vanish upon
applying
to
the
skin
(vanishing creams)
o i.e. Shaving cream, Hand
cream, foundation cream
2.) WATER-IN-OIL
o Imparts oily feeling on
skin
o Tend to retain the
moisture
o Emollient
o i.e. Emollient Cream,
Cold
Cream/Petrolatum
Rose
Water
Ointment/Galens
Cerate
Ungentum
Aquae

Ingredients:

Cetyl Alcohol
White Wax
Mineral Oil (density=0.8498)
Sodium Borate
Purified Water

Use: Systemic Modifier

Label: RED (External Label)
Container:
**Why was Spermaceti not used?

Abigail Beatrice H. Lumbao|2DPH|PHAR3- Suppositories&Creams

Came from the sperm whale

(Physeter macrocephalus, a waxlike substance that is found on its
head

Abigail Beatrice H. Lumbao|2DPH|PHAR3- Suppositories&Creams