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26 Jan 20 16
Braz il
Anti-infe ctive s
BMI View: As well as a number of smaller developers looking to carve a niche for themselves, we would expect the most prominent vaccine developers to focus on Zika
vaccine research. The travel vaccine market would provide an element of protability, but regional brand establishment will be a more signicant draw. The lack of
prophylactic options should not immediately impact Brazil's tourist industry, but this year's big events will act as a test case, guiding future travel advice.
Whils t his torically thoug ht of as a relatively ins ig nicant virus , Z ika's g rowing links with microcephaly in neonates and the elicitation of autoimmune
conditions in certain populations has focus ed the s potlig ht on what is now emerg ing as a s erious public health threat, particularly in Brazil. Vaccination
repres ents a key way of eradicating the increas ing ly devas tating virus and GeneOne Life Science has announced the initiation of a collaborative res earch
prog ramme with Inovio Pharmaceuticals to tes t and advance a DNA-bas ed vaccine for preventing and treating Z ika virus infection.
Inovio and its collaborators are leverag ing their pas t experience in des ig ning and tes ting novel DNA-bas ed vaccines for related virus es including the Wes t
Nile, deng ue, and chikung unya virus es . The Z ika virus vaccine candidate is currently underg oing preclinical s tudies to evaluate its immunog enicity. There is
currently no vaccine and no cours e of treatment for the Z ika virus .
Fast Spread Intensifying Focus
According to the Pan Americas Health Org anization (PAHO) and the World Health Org anization (WHO), the Z ika virus is likely to s pread to all reg ions of the
Americas . Between May 2015 and January 23, it has s pread to 21 countries and territories of the Americas . Thes e include: Barbados , Bolivia, Brazil, Colombia,
the Dominican Republic, Ecuador, El Salvador, French Guiana, Guatemala, Guadeloupe, Guyana, Haiti, Honduras , Martinique, Mexico, Panama, Parag uay,
Puerto Rico, Saint Martin, Suriname and Venezuela. Anywhere the Aedes aegypti mos quitoes are found can provide an environment for local s pread of Z ika. In
the US, Z ika virus infections have been reported in returning travellers . The mag nitude of the epidemic in Latin America s ug g es ts that traveller cas es will
pers is t, increas ing the potential for local trans mis s ion in the US.
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