DREW-3 СИ

DREW-D3
SERVICE MANUAL
REF : D3-SM-000 Rev 01
The Americas
Drew Scientific Inc.
Rest of the World

Drew Scientific Co. Limited
Dallas, TX, USA
Barrow-in-Furness, Cumbria, UK
Tel : +1 214 210 4900
Tel: +44 (0)1229 432089
Fax : +1 214 210 4949

Email: productsusa@drew-scientific.com
http: // www.drew-scientific.com
Email:products@drew-scientific.com
Fax: +44 (0)1229 432096

REVISIONS
Revision Nb
Date
Author
Software
Comments
01
28/10/06
CM/JR
>= V 1.0.2
First Release
CONTACT ADDRESS
AUTHORIZED REPRESENTATIVE
The Americas
Rest of World
DREW-Scientific
DREW-Scientific Co. Limited
4230 Shilling Way
Barrow-in-Furness, Cumbria
Dallas, TX 75237, USA
United Kingdom
Tel : +1 214 210 4900
Tel: +44 (0)1229 432-089
Fax : +1 214 210 4949
Fax: +44 (0)1229 432-096
Email: productsusa@drew-scientific.com
Email: products@drew-scientific.com
LOCAL REPRESENTATIVE
DREW D3
Copyright Drew Scientific. All Rights Reserved.
Page 1/58
IMPORTANT SAFETY INSTRUCTIONS

RISK OF DANGER ! Indicates a procedure to be strictly followed in order to avoid
any risks for the operator (user or technician) or damages to the instrument, or
quality of results.
Indicates that wearing gloves is mandatory before performing the described

operation due to risk of contact with materials that may be infectious.
NOTE : Indicates important additional information.
BEFORE INSTALLING OR
MAINTAINING THE D3, YOU HAVE
TO READ AND REFER TO THE
USERS MANUAL.
OPERATORS MUST HAVE RECEIVED
ADEQUATE TRAINING.
BE CAREFUL WITH THE EDGES OF THE FRAMEWORK AFTER
HAVING DISMANTLED THE COVERS.
Page 2/58
DREW D3
This equipment needs special precautions with regard to EMC, and needs to be installed
and put into service according to the EMC information listed below
Guidance and manufacturers declaration Electromagnetic immunity

The D3 is intended for use in the electromagnetic environment specified below. The customer or the user of
the D3 should assure that it is used in such environment.
Immunity test
IEC 60601 test level
Compliance
level
Electromagnetic environment - guidance

Portable and mobile RF communications equipment should
be used no closer to any part of the D3 including cables,

than the recommended separation distance calculated
from the equation applicable to the frequency of the
transmitter.
Recommended separation distance
Conducted RF
IEC 61000-4-6
3 Vrms
150Khz to 80Mhz
3 Vrms
d = 1,2P
Radiated RF
IEC 61000-4-3
3 Vrms
80Mhz to 2,5Ghz
3 Vrms
d = 1,2P 80MHz to 800MHz

d = 2,3P 800MHz to 2,5GHz
Where P is the maximum output power rating of the
transmitter in watts (W) according to the transmitter
manufacturer and d is the recommended separation
distance in meters (m).
Field strengths from fixed RF transmitters, as
determined by an electromagnetic site survey,a should be
less than the compliance level in each frequency range.b
Interference may occur in the vicinity of equipment
marked with the following symbol:
NOTE 1 At 80Mhz and 800MHz, the higher frequency range applies.

NOTE 2 Theses guidelines may not apply in all situations. Electromagnetic propagation is affected by absorption and reflection from
structures, objects and people.
a
Field strenghts from fixed transmitters, such as base stations for radio (cellular/cordless) telephones and land mobile radios,
amateur radio, AM an FM radio broadcast and TV broadcast cannot be predicted theoretically with accuracy. To assess the
electromagnetic environment due to fixed RF transmitters, an electromagnetic site survey should considered. If the measured field
strenght in the location in which the D3 is used exceeds the applicable RF compliance level above, the D3 should be observed to verify
normal operation. If abnormal performance is observed, additional measures may be necessary, such as re-orienting or relocating the
D3.
b
Over the frequency range 150KHz to 80MHz, field strengths should be less than 3V/m.
DREW D3
Page 3/58
TABLE OF CONTENTS
1.
2.
3.
4.
5.
6.
7.
8.
INTRODUCTION
FLUIDICS
6
7
2.1.
2.2.
2.3.
2.4.
2.4.1.
2.4.2.
2.4.3.
2.5.
2.5.1.
2.5.2.
2.6.
INTRODUCTION ......................................................................................................................................................................... 7
FLUIDICS SEQUENCES DESCRIPTION :..................................................................................................................................... 7
FLUIDICS VIEW ......................................................................................................................................................................... 9
FLUIDICS PARTS DESCRIPTION............................................................................................................................................... 10
Sampling module................................................................................................................................................................. 10
Counting bath module........................................................................................................................................................ 10
Syringes module ................................................................................................................................................................. 10
FLUIDICS DIAGRAM ..................................................................................................................................................................11
General Diagram..................................................................................................................................................................11
Manifold tubing and valves position .............................................................................................................................. 12
SIZE & LENGTH TUBING .......................................................................................................................................................... 15
3.1.
3.2.
3.2.1.
3.2.2.
3.2.3.
3.3.
3.4.
3.4.1.
INTRODUCTION ....................................................................................................................................................................... 16
ELECTRONICS PARTS VIEW ..................................................................................................................................................... 16
Main board........................................................................................................................................................................... 16
IHM board........................................................................................................................................................................... 17
Preamplifier board ............................................................................................................................................................ 17
ELECTRONIC DIAGRAM ............................................................................................................................................................ 18
WIRING DIAGRAM ................................................................................................................................................................... 19
General view ........................................................................................................................................................................ 19
4.1.
4.2.
4.3.
4.4.
4.5.
GENERAL FLAGS.......................................................................................................................................................................20
LEUKOCYTE FLAGS ...................................................................................................................................................................20
ERYTHROCYTE AND HGB FLAGS ............................................................................................................................................. 21
PLATELET FLAGS ...................................................................................................................................................................... 21
FUNCTIONAL FLAGS ................................................................................................................................................................ 21
ELECTRONICS
16
FLAGS
20
OUTPUT FORMAT
22
5.1.
DREW FORMAT .......................................................................................................................................................................22
5.1.1. Short Format......................................................................................................................................................................22
5.1.2. Extended Format...............................................................................................................................................................23
5.1.3. CHECKSUM..........................................................................................................................................................................24
PARTS LIST & BLOW UP VIEW
26
6.1.
6.1.1.
6.1.2.
6.1.3.
6.1.4.
6.2.
6.2.1.
6.2.2.
6.2.3.
6.2.4.
6.2.5.
PARTS LIST ..............................................................................................................................................................................26

Two years spare parts kit ...............................................................................................................................................26
Tubing kit.............................................................................................................................................................................26
O-rings kit ...........................................................................................................................................................................27
Other spare parts .............................................................................................................................................................27
BLOW UP VIEW .........................................................................................................................................................................29
Counting Module .................................................................................................................................................................29
Sampling Module ................................................................................................................................................................30
Syringe Module................................................................................................................................................................... 31
CPU-PREAMPLIFIER Module..........................................................................................................................................34
Front cover Module ...........................................................................................................................................................35
7.1.
7.2.
7.2.1.
7.2.2.
7.3.
INTRODUCTION .......................................................................................................................................................................36
SPECIFIC TECHNICIAN DISPLAY .............................................................................................................................................36
Technician password .........................................................................................................................................................36
Technician display..............................................................................................................................................................36
SOFTWARE FLOW CHARTS .....................................................................................................................................................39
8.1.
MAINTENANCE TABLE .............................................................................................................................................................40
SOFTWARE
36
MAINTENANCE
Page 4/58
40
DREW D3
9.
10.
8.2.
8.3.
CONCENTRATED CLEANING ..................................................................................................................................................... 41

PREPERATION FOR SHIPPING OR STORAGE...................................................................... ERROR! BOOKMARK NOT DEFINED.
9.1.
9.2.
9.2.1.
9.2.2.
9.3.
9.3.1.
9.3.2.
9.3.3.
9.3.4.
9.4.
9.4.1.
9.4.2.
9.4.3.
9.5.
9.5.1.
9.5.2.
9.5.3.
9.5.4.
EMERGENCY STOP ....................................................................................................................................................................43

SAMPLING MODULE.................................................................................................................................................................43
Needle replacement ..........................................................................................................................................................43
Complete rocker module replacement ..........................................................................................................................43
COUNTING BATHS MODULE ...................................................................................................................................................45
Baths dismantling...............................................................................................................................................................45
Baths o-ring replacement ................................................................................................................................................45
Aperture block replacement...........................................................................................................................................45
Complete baths module replacement............................................................................................................................45
SYRINGE MODULE ...................................................................................................................................................................46
Piston greasing....................................................................................................................................................................46
O-ring or piston replacement .........................................................................................................................................46
Complete syringe module replacement .........................................................................................................................47
BOARDS REPLACEMENT ............................................................................................................................................................48
IHM board replacement ..................................................................................................................................................48
Main board replacement ..................................................................................................................................................50
Main board...........................................................................................................................................................................52
Preamplifier board replacement ....................................................................................................................................54
10.1.
10.2.
10.3.
ANALYTICAL PROBLEMS...........................................................................................................................................................55
OTHER PROBLEMS ....................................................................................................................................................................55
TROUBLESHOOTING MESSAGE ................................................................................................................................................56
REPAIRING
43
TROUBLESHOOTING
DREW D3
55
Page 5/58
1. INTRODUCTION
1.
INTRODUCTION
BEFORE INSTALLING OR
MAINTAINING A D3, YOU HAVE TO
READ AND REFER TO THE USERS
MANUAL
The following chapters describe the different technical parts of the D3

- Fluidic
- Electronics
- Technical specification
- Output format
- Spare parts list and blowup view
- Maintenance procedure
Page 6/58
Copyright Drew Scientific Inc. All Rights Reserved.
DREW D3
2. FLUIDICS
2.
FLUIDICS
2.1.
INTRODUCTION
The D3 is a fully automated analyzer performing hematological analysis of whole blood.

The human blood venous sample should be collected in an EDTA K3 (Ethylene Diamine Tetracetic Acid, tri
potassic) tube in sufficient quantity. The 3 Part Differential (Lymphocyte, Mid Cells, Granulocytes) results
are available for six hours after the blood draw. The use of EDTA K2 is not recommended. The sample must
be correctly homogenized before analysis.
The volume of blood must be in correct proportion to the quantity of anticoagulant otherwise
the dilution will affect the result.
Two dilution rates are performed :
~1/237 to 1/257 for WBC/HB (dependant on the lyse volume)
~1/15000 for RBC/PLT
2.2.
FLUIDICS SEQUENCES DESCRIPTION :
SAMPLING SEQUENCE :
1- Syringes down : (no valve)
~9,8 l of blood sample is aspirated inside the sampling needle
Diluent prime
Vacuum prime
2- Needle up and syringe up (valve 3+4)
Needle exterior cleaned with diluent and waste vacuum
3-Rocker moves above the WBC bath
Syringes up to drain the waste (valve 7)
4- Needle down to the rinsing position
5- Syringe down
WBC bath drain (valve 1)
6- Syringe up
Second exterior needle cleaning (valve 4)
Waste syringe drain (valve 7)
7- Syringe down
8- Syringe up
WBC DILUTION :
9- Needle down to the dilution position
Syringes down to prime the diluent (valve 8)
10- Syringe up for the WBC dilution (~2 ml)
Diluent dispensed from outside of the needle (valve 4)
Diluent dispensed from inside the needle (valve 4+5)
Bubble to mix the dilution (valve 1)
RBC DILUTION AND LYSING :
11- Syringe down (no valve)
Aspirating sample of the first dilution (~20l)
DREW D3
Page 7/58
2. FLUIDICS
Diluent prime
Vacuum prime
12- Needle up and syringe up
Rocker moves above the RBC bath
Needle exterior cleaned with diluent and waste vacuum (valve 3+4)
13- Needle down to the rinsing position
14 Syringe up
Second outside needle cleaning (valve 4+8)
Lyse in the WBC bath (0,3 to 0,5ml) (valve 9) (Species dependant)
Bubble to mix the dilution (valve 1)
15 Syringe down
RBC bath drain (valve 2)
16- Needle down to the dilution position
17- Syringe up for the RBC dilution (~1,5ml)
Diluent dispensed from outside of the needle (valve 4+8)
Diluent dispensed from inside the needle (valve 5)
Bubble to mix the dilution and diluent to rinse the counting head (valve 6+10+2)
MEASUREMENTS :
18- Syringe down to establish the counting vacuum (valve 10)
19- First measurement sequences (valve 10)
20- Syringe up
Diluent back pressure (valve 4+6)
21- Syringe down to establish the counting vacuum (valve 10)
22- Second measurement sequences (valve 10)
DRAIN AND RINSE BATH :
22- Syringe down
Cleaning the apertures (valve 11)
RBC bath drain (valve 2)
23- Syringe up
RBC bath rinse diluent (valve 4)
24- Needle up and syringes up for back flush (valve 4+6)
25- Rocker move above the WBC bath
26- Syringe up
WBC bath rinse diluent (valve 4)
NEEDLE BACK AND WASTE DRAIN :
27- Syringe down
Dry the exterior of the needle (valve 3)
28- Rocker moves into the sampling position
26- Syringe up
30- Needle moves down into sampling position
The D3 is ready to perform a new analysis.
Page 8/58
DREW D3
2. FLUIDICS
2.3.
FLUIDICS VIEW
All the fluidics parts are on the right side of the instrument and consist of only three modules :
- Sampling module :
o Rocker (patent pending) : Manages the Sample Needle positioning.
- Syringe module (patent pending) consists of one block :
o Reagent syringes (Diluent, lyse), sampling and air syringes.
o Liquid valve manifold assembly and tubing.
- Counting module :
o WBC and RBC counting chambers and hemoglobin measurement.
o Liquid valve manifold assembly and tubing.
Sampling module
Syringe Module
Counting module
DREW D3
Page 9/58
2. FLUIDICS
2.4.
FLUIDICS PARTS DESCRIPTION
The hydraulic section of the D3 is very simple and made up of only three modules :
- Sampling module.
- Counting module.
- Syringes module.
The modules are connected together by semi rigid tubing.
2.4.1.
Sampling module
This module (patented) is responsible for aspirating the sample and performing the WBC and RBC/Plt
dilutions.
It is assembled with a rocker assembly which moves the sample needle from the Aspiration position into the
diluting position for performing the WBC/Hgb and RBC/PLT dilutions.
A very reliable system of rack-gear moves the rocker.
The cleaning system of the sampling needle can be removed without tools (see section 9 in the user manual).
The needle o-ring can be removed without tools (see section 9 in the user manual).
2.4.2.
Counting bath module
This module is responsible for counting the WBC and RBC/Plt and measuring the HGB.
It is made with a manifold which contains the reagent valves and the counting bath block including the
apertures.
The counting bath block assembly and apertures can be removed without tools (see section 9 in the user
manual).
2.4.3.
Syringes module
This module (patent pending) performs the following tasks :

Aspirate the sample.
Dispense the reagents.
Drain the baths.
Establish the counting vacuum.
Push the waste to the waste container.
The manifold consists of the fluid valves and the five syringes, syringe block including:
Sample syringe
Lyse syringe
Two waste and vacuum/pressure syringes
Diluent syringe.
One motor drives the five syringes.
The diluent intake and the waste output are also included in this manifold.
Page 10/58
DREW D3
2. FLUIDICS
2.5.
2.5.1.
DREW D3
FLUIDICS DIAGRAM
General Diagram
Page 11/58
2. FLUIDICS
2.5.2.
Manifold tubing and valves position
Each figure corresponds to a tubing or a valve number (see the Fluidic diagram section 2.5.1)
Counting manifold tubing position
Counting manifold valve positions
Page 12/58
DREW D3
2. FLUIDICS
Syringe manifold tubing position
Syringe body tubing position
DREW D3
Page 13/58
2. FLUIDICS
Syringe manifold valves position
Page 14/58
DREW D3
2. FLUIDICS
2.6.
SIZE & LENGTH TUBING
**To ensure quality of results, it is mandatory to adhere to the size and the length of the tubing.**
Tygon
Tygon
Tygon
tubing
tubing
tubing
0,8x2,4mm 1,3x3mm 1,6x3,2mm
Bulk Tubing Part
Number
FRU-9318-082
FRU-9318-066
FRU-9318-083
FRU-9318-067
FRU-9318-067
FRU-9318-067
FRU-9318-066
FRU-9318-066
Designation
Tubing 1 - Lyse
Tubing 2
Tubing 3 - Diluent
Tubing 4
Tubing 5
Tubing 6
Tubing 7
Tubing 8
FRU-9318-065
FRU-9318-064
FRU-9318-067
Tubing 9
Tubing 10
Tubing 11
FRU-9318-066
FRU-9318-066
FRU-9318-066
FRU-9318-084
FRU-9318-066
FRU-9318-066
FRU-9318-066
FRU-9318-066
FRU-9318-066
FRU-9318-066
FRU-9318-065
FRU-9318-058
FRU-9318-070
Tubing 12
Tubing 13
Tubing 14
Tubing 15 - Cleaner
Tubing 16
Tubing 17
Tubing 18
Tubing 19
Tubing 20
Tubing 21
Tubing 22
Tubing 24 - Waste
Tubing 61
DREW D3
Tygon
tubing
2x4mm
Tygon
tubing
3x6mm
Tygon
tubing
2.8x5mm
1000mm
250mm
150mm
225mm
210mm
170mm
810mm
220mm
80mm
425mm
370mm
10mm
90mm
60mm
250mm
250mm
1000mm
130mm
80mm
80mm
80mm
130mm
600mm
200mm
1500mm
80mm
Page 15/58
3. ELECTRONICS
3.
ELECTRONICS
3.1.
INTRODUCTION
Three boards compose the D3:

- the Main board
- the Preamplifier board
- and the IHM board
- Ensure correct protection is used when replacing the main board or preamplifier board, as
these are sensitive to electro static discharge (ESD).
- Before operating check the earth connection and use the antistatic bag supply with the
board. Please contact your authorized Drew distributor for more information.
- Be careful with the edges of the frame after having removed the covers.
3.2.
3.2.1.
ELECTRONICS PARTS VIEW

Main board
The Main board is located between the hydraulic compartment and the reagent tray.
The board, driven by a 32-bit processor, controls the following modules:
- Sample needle, rocker, syringe block motors.
- Display and keyboard.
- External communications (RS232, Ethernet, ).
- Printer.
- Measurement (Counting, hemoglobin measurement).
- Data processing.
- External barcode reader.
Page 16/58
DREW D3
3. ELECTRONICS
3.2.2.
IHM board
3.2.3.
Preamplifier board
3.2.4 Power supply Module
(D3 is supplied with an external power supply module)
- The D3 has been certified with the power supply provided. The use of another external
power supply box may affect performance and will invalidate the Warranty. Please contact
Drew Scientific or authorized Drew Distributor.
DREW D3
Page 17/58
3. ELECTRONICS
3.3.
Page 18/58
ELECTRONIC BLOCK DIAGRAM
Copyright Drew Scientific All Rights Reserved.
DREW D3
3. ELECTRONICS
3.4.
3.4.1.
DREW D3
WIRING DIAGRAM
General view
Page 19/58
4. FLAGS
4.
FLAGS
D3 manages different Flags and Alarms. These Flags allow the user to be alerted if there is a situation which
can affect the quality of results. All of these Flags appear to the right of the result.
In presence of one or more Flags, it is recommended to check the result by manual methods
such as a blood smear.
NOTE : Most of these Flags can be modified by the user (see section 3 of the Users Manual).
4.1.
GENERAL FLAGS
The following alarms are common for all parameters.

* : Counting or measure rejection . Can appear with WBC, RBC, PLT and HGB.
XXXD : Higher than linearity limits but lower than the reportable limits. WBC, RBC, PLT, HCT, HGB.
+++D : Higher than the reportable limits. WBC, RBC, PLT, HCT, HGB.
---- : Rejected value.
+ : results higher than normal value.
- : results lower than normal value.
H : results higher than action value.
B : results lower than action value.
4.2.
CL1
LEUKOCYTE FLAGS
CL1-2
CL2-2
CL2
CL2-3
CL4
CL5
FLAG CHANNELS
L1
CL1 to CL1-2
# VALUE
Number of cells in the
zone.
L2

zone.
L3
L4
L5
MEANING
% VALUE
Possible Platelet aggregate Percentage of cells in the
or erythroblast
zone in reference to the
number of lymphocytes.
CL2 to CL2-2 Possible presence of
Percentage of cells in the
Myelocytes, lymphoblast or zone in reference to the total
basophiles
number of leukocytes.
CL2 to CL2-3 Possible presence of
eosinophils, myelocytes
zone in reference to the total
number of leukocytes.
CL4
Granulocyte volume too low Not Available
CL5 to the end Possible presence of large Percentage of cells in the
size cells
number of granulocytes.
Page 20/58

zone.
Channel value
zone.
DREW D3
4. FLAGS
4.3.
ERYTHROCYTE AND HGB FLAGS
CR1
CR2
FLAG CHANNELS
MEANING
R1
0 to CR1
Abnormal quantity of
microcytes at the left side of
the histogram
R2
CR2 to the Abnormal quantity of
end
macrocytes at the right side
of the histogram
Appear
Abnormal measurement of the
*
with HGB
HGB blank.
result.
4.4.
% VALUE
number of erythrocytes.
number of erythrocytes.
Not Available
# VALUE
zone.
zone.
Not Available
PLATELET FLAGS
CP3-2
P2
CP1
CP2
FLAG CHANNELS
FP1
0 to CP1
P CP3
FP2
P to CP2
MEANING
Presence of abnormal
quantity of debris or small
cells
Presence of schizocytes
FP3
CP3 to CP3-2
Presence of microcytes
4.5.
% VALUE
number of platelets until P.
# VALUE
zone.
zone.
zone.
FUNCTIONAL ALARMS
INS_T = Means that the working temperature is lower than 17C or higher than 33C and the result could
be affected.
INS_P = Means that the counting vacuum is out of range. If the flag appears at each cycle, please contact
your local representative.
W-CL or R-CL = Means that the difference between the Count 1 raw data Count 2 raw data exceeds
expectations which indicate a disruption in the sample flow.
DREW D3
Page 21/58
5. OUTPUT FORMAT
5.
OUTPUT FORMAT
The choice of the setting (format, speed ) is explained in page N 24 of the Users Manual.
5.1.
DREW FORMAT
5.1.1.
Byte
location
1
2-7
8-22
23-37
38-67
68 - 77
78- 88
89
109
110
111
112
113
114
115 - 124
125 - 146
147 151
152 156
157 161
162 166
167 171
172 176
177 181
182 186
187 191
192 196
197 201
202 206
207 211
212 216
217 221
222 226
227 231
232 236
237
Format
Size
B1
A6
A15
A15
A30
A10
A11
A20
A1
A1
A1
A1
A1
A1
A10
A22
A5
A5
A5
A5
A5
A5
A5
A5
A5
A5
A5
A5
A5
A5
A5
A5
A5
A5
A1
238
239 - 248
249 250
251
A1
A10
A2
B1
Short Format
Description
STX(02h)
Sequence Number
Id Number
Patient Id
Last Name
Date(DD/MM/YYYY)
Time(HH:MM:SS AM/PM)
Reserved for future parameter expansion
1=WBC Clog
1=RBC Clog
1=Vacuum Failure
1=Hgb Sensor
1=Uncontrolled
1=Uncalibrated
Alarmes : L1L2L3L4L5R1R2P1P2P3
Reserved for future parameter expansion
WBC
LYM N
LYM P
MID N
MID P
GRA N
GRA P
RBC
HGB
HCT
MCV
MCH
MCHC
RDW
PLT
MPV
PCT
PDW
Sample Type: 1=Patient 2=Background,
3=Calibration 4=Low Control
5=Normal Control 6=High Control
Sample Mode : 1=Direct, 2=Prediluted
Blood Type name
Very Simple Checksum
ETX(03h)
Notes
Sample ID, sample N *Note1

PID *Note1
ID, patient name *Note1
1 if alarm else space

1 if errors else space
Not available
*Note2
*Note2
*Note2
*Note2
*Note2
*Note2
*Note2
*Note2
*Note2
*Note2
*Note2
*Note2
*Note2
*Note2
*Note2
*Note2
*Note2
*Note2
Always 1 : Patient results only are
sent
*Note1
*Note3
A: Alphanumeric ASCII Format

B: Binary Format
Page 22/58
DREW D3
5. OUTPUT FORMAT
Note 1 : alphanumeric field, coded in UTF8, Truncated if too long.

Note 2 : Same numeric value as displayed on screen (same unit and decimal part).
In case of no validity, the Numeric value is replaced by 5 dots (2eh)
In case of overflow, the Numeric value is replaced by 5 Plus (2bh)
Note 3 : Checksum is the LSB of the sum from byte2 to 248 include. It is on two hexadecimal ASCII
characters.
5.1.2.
Extended Format
In Extended Format, each packet should be acknowledged by the LIS.
LIS
D3 automaton
Waiting for ACK,
adjustable Time out
Send header packet , type T

LIS acknowledgement ACK (06h)
Send result packet ,
LIS acknowledgement
The packet
contents a
checksum
type N
ACK (06h)
Send WBC histogram packet , type H

LIS acknowledgement ACK (06h)
Send RBC histogram packet ,
LIS acknowledgement
ACK (06h)
Send PLT histogram packet ,

LIS acknowledgement
End of transmission
type H
type H
ACK (06h)
EOT (06h)
Communication Protocol
If timeout occurs when waiting for ACK, EOT is sent and the transmission stops.
DREW D3
Page 23/58
5. OUTPUT FORMAT
5.1.2.1.
Packets
header packet description : type T

Byte
format
description
notes
location
size
1-6
A6
$$TXMB
Header pattern
7-8
B2
AA
AA = packet type N number, 2 bytes in binary. MSB then LSB.
9 - 10
B2
BB
BB = packet type N size, 2 bytes in binary. MSB then LSB.
11 12
B2
CC
CC = packet type H number, 2 bytes in binary. MSB then LSB.
13 - 14
B2
DD
DD = packet type H size, 2 bytes in binary. MSB then LSB.
15 - 16
B2
EE
checksum = LSB sum from 1 to 14 includes bytes. 2 bytes in binary.
TOTAL size = 16 bytes
result packet description : type N

Byte
size
description
location
1-251
251
Light Format packet
notes
Matches exactly with light format described previously
histogram packet description : type H, size = 261 bytes

Byte location size
description
notes
1
1
STX (02h)
Binary
2
1
type
ASCII, R = RBC histogram, W = WBC histogram
P = PLT histogram
3 - 258
256
128 channels
Binary, 2 bytes for each channel, MSB then LSB
259 - 260
2
checksum
Binary, LSB sum of bytes from 1 to 258 included
261
1
ETX (03h)
TOTAL = Header + result + 3 * histograms + EOT = 16 + 251 + 261 +261 + 261 + 1 = 1051 bytes
5.1.3.
CHECKSUM
For frames with few numbers of lines, the block is finished with an end line containing a checksum. This
checksum is calculated from the beginning of the headline to the end of the line finishing the block.
The algorithm of the calculation for the checksum is :
CRC = 0xFFFF
For each byte
Work on high order byte:
Index = byte XOR CRC

Index = Index AND 000F
CRC = Table(Index) XOR (CRC divided by 16)
Work on low order byte:

Index
Index
Index
CRC =
Page 24/58
= byte divided by 16
= Index XOR CRC
= Index AND 000F
Table(Index) XOR (CRC divided by 16)
DREW D3
5. OUTPUT FORMAT

Example in C language:
/*Hash table :*/
static const unsigned short ausCrcTab1[] =
{
0x0000, 0xCC01,0xD801,0x1400,0xF001,0x3C00,0x2800,0xE401,
0xA001,0x6C00,0x7800,0xB401,0x5000,0x9C01,0x8801,0x4400,
};
/* CRC computing */
unsigned short calc_crc(unsigned char *pucData, long lSize)
{
unsigned short usAcc1 = 0xFFFF;
while ( lSize > 0 )

{
/* gestion par quartet du calcul */
usAcc1 = ausCrcTab1[(*pucData ^ usAcc1) & 15] ^ (usAcc1 >> 4);
usAcc1 = ausCrcTab1[((*pucData >> 4) ^ usAcc1) & 15] ^ (usAcc1 >> 4);
pucData++;
lSize--;
}
return(usAcc1);
}
^ : XOR.
>> : Logical shift right.
& : logical AND.
DREW D3
Page 25/58
6. PARTS LIST & BLOW UP VIEW
6.
PARTS LIST & BLOW UP VIEW

6.1.
PARTS LIST
6.1.1.
Two years spare parts kit
Part Number :
FRU-9318-069
Designation :
D3 (2 years) spare parts kit
QTY Part Number
Description
FRU-9318-034
O-Rings kit
1
2
FRU-9318-068
FRU-9318-051
Piston 22 Waste
D3 Tubing kit
FRU-9318-033
Sampling needle
FRU-9318-052
Piston 6.5 - Syringes module - Lyse
FRU-9318-049
Piston 16 - Syringes module - Diluent
6.1.2.
Tubing kit
Part Number :
FRU-9318-068
Designation :
D3 Tubing kit
QTY Designation
1
Tubing 1 - Lyse
1
1
Tubing 2
Tubing 3 - Diluent
Tubing 4
1
1
Tubing 5
Tubing 6
1
1
Tubing 7
Tubing 8
Tubing 9
1
1
Tubing 10
Tubing 11
Tubing 12
1
1
Tubing 13
Tubing 14
Tubing 15 - Cleaner
Tubing 16
1
1
Tubing 17
Tubing 18
Tubing 19
1
1
Tubing 20
Tubing 21
Tubing 22
Tubing 24 - Waste
Tubing 61
Page 26/58
DREW D3
6.1.3.
O-rings kit
Part Number :
FRU-9318-034
Designation :
D3 O-Rings kit
QTY Part Number

1
2
FRU-9318-038
FRU-9318-041
Designation
O-ring 15.54x2.62 Silicone 60SH Diluent Piston
O-ring 21.89x2.62 Silicone 60SH Waste Piston
FRU-9318-045
O-ring 6.3x2.4 Silicone 60SH Lyse Piston
2
3
FRU-9318-037
FRU-9318-036
O-ring 13.1x1.6 Fluocarbon 80SH Counting Chambers

O-ring 1.4x1.25 Fluocarbon 80SH Sampling Needle
FRU-9318-043
O-ring 5x1 Fluocarbon 80SH - Apertures
6.1.4.
Other spare parts

D3 Spare Parts
Designation
Part Number
Rev 1
Qty/Pkg
Unit
D3-Cleaner Straw
FRU-9318-084
UNIT
D3-Lyse Straw
FRU-9318-082
UNIT
Flexible Flat Cable

70W switching adapter
FRU-9318-003
FRU-9318-001
1
1
UNIT
UNIT
Bottle cap filter
FRU-9318-062
10
UNIT
Counting Chambers
Counting Manifold
FRU-9318-013
FRU-9318-014
1
1
UNIT
UNIT
Counting Valves Cable
FRU-9318-004
UNIT
Electrovalve 2/2
Electrovalve 3/2
FRU-9318-007
FRU-9318-008
1
1
UNIT
UNIT
Electrovalve 3/2 - 1.6mm
FRU-9318-009
UNIT
Fluidic Door Switch

D3-Front cover
FRU-9318-011
FRU-9318-002
1
1
UNIT
UNIT
Lubriplate DS-ES
FRU-9000-033
UNIT
Lyse Spring
FRU-9318-047
UNIT
D3 (2 years) spare part kit

D3 CPU Board
D3 IHM Board
FRU-9318-069
UNIT
FRU-9318-019
UNIT
FRU-9318-021
UNIT
O-Rings kit
FRU-9318-034
UNIT
Preamplifier Board
FRU-9318-018
UNIT
D3 Tubing kit
Needle Belt
FRU-9318-068
FRU-9318-025
1
1
UNIT
UNIT
Needle carriage
Needle Motor
FRU-9318-026
FRU-9318-027
1
1
UNIT
UNIT
Needle Optical Sensor
FRU-9318-028
UNIT
O-ring 1.4x1.25 Fluocarbon 80SH, Sampling Needle

O-ring 13.1x1.6 Fluocarbon 80SH, Counting Chambers
FRU-9318-036
FRU-9318-037
10
10
UNIT
UNIT
O-ring 15.54x2.62 Silicone 60SH, Diluent Piston
FRU-9318-038
10
UNIT
O-ring 21.89x2.62 Silicone 60SH, Waste Piston
FRU-9318-041
10
UNIT
O-ring 5x1 Fluocarbon 80SH, Apertures

O-ring 6.3x2.4 Silicone 60SH, Lyse Piston
FRU-9318-043
FRU-9318-045
10
10
UNIT
UNIT
O-Ring spacer
FRU-9318-035
UNIT
Piston Carriage
FRU-9318-048
UNIT
DREW D3
Page 27/58

Designation
Piston 16, Diluent

Part Number
FRU-9318-049
Qty/Pkg
1
Unit
UNIT
Piston 22, Waste
FRU-9318-051
UNIT
Piston 6.5, Lyse
FRU-9318-052
UNIT
Plastic grease SPG35

RBC Counting Head
FRU-9000-035
FRU-9318-015
1
1
UNIT
UNIT
Rinsing head
FRU-9318-032
UNIT
Rocker Motor
Rocker Optical Sensor
FRU-9318-029
FRU-9318-031
1
1
UNIT
UNIT
Sampling module
FRU-9318-024
UNIT
Sampling needle
Syringe Body Seal plate
FRU-9318-033
FRU-9318-060
1
1
UNIT
UNIT
Screw Kit
FRU-9318-081
Unit
Short Arm TORX T10 Tool

Short Arm TORX T20 Tool
FRU-9000-031
FRU-9000-032
1
1
UNIT
UNIT
Start key Switch
FRU-9318-01
UNIT
Stepper motor cable

Syringe Body
FRU-9318-006
FRU-9318-053
1
1
UNIT
UNIT
UNIT
Syringe Motor
FRU-9318-054
Syringe Motor Holder
FRU-9318-055
UNIT
Syringe Optical Sensor

Syringe Piston 1.6
FRU-9318-056
FRU-9318-057
1
1
UNIT
UNIT
Syringe Valves Cable
FRU-9318-005
UNIT
Temperature Sensor
D3-Tubing 3 - DILUENT
FRU-9318-017
FRU-9318-061
1
1
UNIT
UNIT
D3-Tubing 24 - WASTE
FRU-9318-058
UNIT
Tubing Ground Cable

Tygon tubing 0,8x2,4mm
FRU-9318-063
FRU-9318-064
1
1000
UNIT
mm
Tygon tubing 1,3x3mm
FRU-9318-065
1000
mm
Tygon tubing 1,6x3,2mm

Tygon tubing 2x4mm
FRU-9318-066
FRU-9318-067
5000
5000
mm
mm
WBC Counting Head
FRU-9318-016
UNIT
Page 28/58
DREW D3
6.2.
6.2.1.
BLOW UP VIEW
Counting Module
Rep
1
2
3
4
5
6
7
DREW D3
Part Number
FRU-9318-013
FRU-9318-014
FRU-9318-016
FRU-9318-015
FRU-9318-043
FRU-9318-081
FRU-9318-037
Designation
Counting chambers
Counting manifold
WBC Counting Head
RBC Counting Head
O-ring 5x1 Silicone 80SH
Screw CZX M3 x 6
O-ring 13.1x1.6 Fluocarbon 80SH
Page 29/58

6.2.2.
Sampling Module
Rep
1
2
3
4
5
6
7
8
9
10
11
12
13
14
Page 30/58
Part Number
FRU-9318-024
FRU-9318-029
FRU-9318-027
FRU-9318-032
FRU-9318-033
FRU-9318-036
FRU-9318-026
FRU-9318-025
FRU-9318-028
FRU-9318-081
FRU-9318-081
FRU-9318-081
FRU-9318-031
FRU-9318-081
Designation
Sampling module
Rocker Motor
Needle Motor
Rinsing head
Sampling Needle
O-ring 1.4x1.25 Fluocarbon 80SH
Needle carriage
Belt pitch 2.032 (l=4.763-L=243.84)
Needle Optical Sensor
Screw K 30 x 8
Screw RLX M3 x 6
Screw CZX M3 x 8
Rocker Optical Sensor
Lock washer 3 x 1
DREW D3
6.2.3.
Syringe Module
Rep
1
2
3
4
5
6
7
8
9
10
11
12
DREW D3
Part Number
FRU-9318-053
FRU-9318-060
FRU-9318-049
FRU-9318-051
FRU-9318-052
FRU-9318-057
FRU-9318-038
FRU-9318-041
FRU-9318-045
FRU-9318-036
FRU-9318-035
FRU-9318-081
Designation
Syringes body
Syringe Body Seal plate
Piston 16, Diluent
Piston 22, Waste
Piston 6.5, Lyse
Syringe Piston 1.6, Sampling
O-ring 15.54x2.62 Silicone 60SH, Diluent
O-ring 21.89x2.62 Silicone 60SH, Waste
O-ring 6.3x2.4 Silicone 60SH, Lyse
O-ring 1.4x1.25 Fluocarbon 80SH, Sampling
O-ring spacer
Screw K 30 x 10
Page 31/58
Rep Part Number

1 FRU-9318-054
2 FRU-9318-081
3
4
6
7
Page 32/58
FRU-9318-081
FRU-9318-081
FRU-9318-056
FRU-9318-081
Designation
Syringes Motor
Screw CZX M3 x 8
Screw K 30 x 10
Screw CZX M4 x 20
Syringe Optical Sensor
Screw K 30 x 8
DREW D3
Rep
1
2
3
4
5
DREW D3
Part Number
FRU-9318-055
FRU-9318-053
FRU-9318-081
FRU-9318-081
Purchase Locally
Designation
Syringes motor holder
Syringes body
Plain washer 3
Screw CZX M3 x 8
Tubing 26, 5mm x 8mm
Page 33/58

6.2.4.
CPU-PREAMPLIFIER Module
Rep
2
3
4
5
6
8
Page 34/58
Part Number
FRU-9318-019
FRU-9318-018
FRU-9318-081
FRU-9318-081
Purchase Locally
FRU-9318-081
Designation
D3 CPU board
D3 Preamplifier board
Screw CZX M3 x 6
Screw CZX M4 x 6
Hexagonal spacer FF M4 x 60
Screw RLX M4 x 8
DREW D3
6.2.5.
Front cover Module
Rep Part Number
DREW D3
Designation
FRU-9318-002
Front cover
FRU-9318-012
Start key Switch
Page 35/58
7. SOFTWARE
7.
SOFTWARE
7.1.
INTRODUCTION
Please refer to the Users Manuel for an explanation of the software operation.
7.2.
SPECIFIC TECHNICIAN DISPLAY
The following section describes the software operation which is only accessible to the technician and super
technician passwords.
7.2.1.
Technician password
Contact Drew Scientific for Password List
- It is strictly forbidden to disclose the technician password to the End User

- In such cases, the D3 warranty becomes invalid.
7.2.2.
Technician display
The technician display is accessible from MAIN SCREEN, MAINTENANCE then SERVICE.
7.2.2.1.
Service
System error log.

For an access to the gain adjustment and HGB blank adjustment
Sets D3 Gain settings and Thresholds.
Not Available at this time.
Generates a Service Intervention Entry in the Maintenance Log.
Page 36/58
DREW D3
7. SOFTWARE
7.2.2.2.
Counting parameters
- The modification of one of these parameters must be done in compliance with Drew
Scientific after receiving notice to do so.
- In the case of modification without authorization, Drew Scientific warranty will
not be valid.
- The access of this display is available with the super technician

password only
- The twenty types of blood can be changed and selected from the
drop-down menu:
- This display enables modification of the HGB, WBC, RBC and PLT gain
located in the upper window and the counting pulse parameters in the
lower window.
7.2.2.3.
Gain adjustments
- The modification of one of these parameters must be done in compliance with Drew
Scientific and only after specific training.
- In the case of modification without authorization, Drew Scientific warranty
becomes invalid.
Not available : manufacturing parameters.
Allows adjustment of the HGB blank level.
Allows adjustment of the WBC gain with the use

of special latex particles.
Allows adjustment of the RBC and PLT gain with
the use of special latex particles.
: Tick means that the adjustments are automatically done.
The columns to the right of the gain setting signify the Mean Channel of Sample run and Peak Channel of
Sample run.
Preparing for adjustment:
Ensure the ; AUTO Tickbox is selected to allow D3 to automatically perform adjustment.
Latex Preparation. (Use only Latex supplied by Drew-Scientific)
DREW D3
Page 37/58
7. SOFTWARE
RBC/PLT Latex: Add 4 drops of vigorously mixed 3um latex particles and 6 drops of
vigorously mixed 5um latex particles into a small sample tube.
WBC Latex: Add 10 drops of vigorously mixed 7.0um latex particles into a small
sample tube.
From the Main Menu, go to Maintenance > Service > Prod Adjust.
Start the <<ADJUST HGB>>> cycle by pressing the soft key. (make sure that the system has been
properly primed and the service door is closed) The system will perform an HGB Blank measurement.
Vortex the WBC Latex for 10 seconds.

Present the WBC Latex to the Sample Probe and press the LATEX WBC soft key to start the
Gain Adjustment cycle.
Vortex the RBC/PLT Latex mixture for 10 seconds.
Present the RBC/PLT Latex mixture to the Sample Probe and press the LATEX RBC/PLT soft key
to start the Gain Adjustment cycle.
Verify results meet the criteria below.
Use the SAVE key and EXIT to validate results.
Gain Limites:
HGB
150 < Gain < 250

870 < Value < 930
WBC
210 < Gain < 242

66 < Value 1 < 72
71 < Value 2 < 73
RBC
210 < Gain < 250

40 < Value 1 < 44
42 < Value 2 < 46
PLT
215 < Gain < 250

51 < Value 1 < 55
54 < Value 2 < 57
Page 38/58
DREW D3
7. SOFTWARE
7.3.
DREW D3
SOFTWARE FLOW CHART
Page 39/58
8.
8. MAINTENANCE
MAINTENANCE
The quality and reliability of the results of the D3 are directly linked to the strict adherence to the
maintenance described hereafter.
To perform the maintenance and repair described in this section, it is mandatory to wear
rubber gloves and wash hands with a disinfectant after completion of work.
8.1.
MAINTENANCE TABLE
NOTE : This table is valid for an average number of 50 samples per day. For more, please increase the
maintenance proportionally.
MAINTENANCE
DAILY
User
Reagents level
Start Up
Automatic cleaning
Concentrate cleaning
Shut down
Cover cleaning
WEEKLY
Tech
User
Tech
MONTHLY
SEMI ANNUAL
ANNUALLY
User
User
User
Tech
Tech
Tech
X
X
X
X
X
X
Piston greasing
Needle o-ring replacement

Syringes o-ring replacement
Motor screw greasing
X
X
X
X
- Reagents level control : see Users Manual.

- Start up : see Users Manual.
- Automatic Cleaning : see Users Manual.
- Concentrated cleaning : see Users Manual.
- Shut down : see Users Manual.
- Cover cleaning : see Users Manual.
- Piston greasing : see Users Manual.
- Needle o-ring replacement : see section 9 of Operators Manual
- Syringes o-ring replacement : see section 9 of Operators Manual
- Motor screw greasing : This operation is described during training.
Page 40/58
DREW D3
8. MAINTENANCE
8.2.
CONCENTRATED CLEANING
This cleaning may be necessary when the D3 has a permanent alarm for one or more measured parameters.
Prepare a Sodium Hypochlorite solution at 25% in Distilled Water.
- Return to the main menu by pressing

.
- Then press
- Press
- Press
counting chamber).
DREW D3
to start the cycle (drain the
Page 41/58
8. MAINTENANCE
- Wait for the information window.

- Open the door on the right side.
- Put 2 ml of sodium hypochlorite solution in each counting
chamber.
- Press the button in the window located in the middle of the
screen.
- D3 performs a maintenance cycle of the apertures followed by
a stand by mode of 2 minutes.
- After 2 minutes the D3 rinses all of the elements. Operator
should then perform a background test.
Wear rubber gloves and wash hands
disinfectant after completion of work.
8.3.
with
PREPERATION FOR SHIPPING OR STORAGE
This procedure has to be used when the D3 must be transported for a long distance by car, train or plane.
This procedure consists of cleaning the D3 with sodium hypochloride, then rinsing it with distilled water and
drying it before the transportation.
---
Page 42/58
The
cleaning
is
accessible
from
MAIN
SCREEN,
, then
.
Follow the screen prompts to Bleach the baths, flush the
D3 with Distilled Water, and Drain all fluid from the
D3.
*** Ensure all steps are followed to avoid reagents
drying in the lines or fluid spills occurring during
shipments ***
DREW D3
9. REPAIRING
9.
REPAIRING
For all the following operations wear rubber gloves and wash hands with a disinfectant after
completion of work.
Be careful with the edges of the frame after removing the covers.
9.1.
EMERGENCY STOP
In case of mechanical or hydraulic problem, immediately press
, the D3 will make an emergency stop.
- After having identified the problem, it is necessary to perform a Reset cycle.

- This option is accessible from the MAIN MENU,
,
then
- The Reset Cycle will initialise all motors and fluidics into the Stand-by position.
9.2.
9.2.1.
SAMPLING MODULE
Needle replacement
Perform needle replacement as is describe in the Users Manual.
9.2.2.
Complete rocker module replacement
- Before replacing the complete Sampling Module, drain all the tubing :
x Remove the diluent, lyse and cleaner tubes from their bottle
x Perform a PRIME PACK (MAIN MENU / MAINTENANCE / REAGENT PACK)
- Switch the D3 OFF, and disconnect the power supply.
- Remove the Reagent Pack bottle from its location
- Remove the upper cover (three screws) from the D3.
DREW D3
Page 43/58
9. REPAIRING
- Unscrew the rocker fixation screw but DO NOT remove it.

- Unscrew and remove the screw which holds the Needle Home
Position Sensor.
- Disconnect the three tubing and cut the Tie-wraps.

- Loosen the two guide screws One Turn and DO NOT remove
them.
- Push down the guide
- Pull to remove the complete rocker module.
REASSEMBLY PROCEDURE :
To reassemble the unit, carry out the various operations in reverse order.
*Warning*
Do Not overtighten fasteners. The Threads are plastic and will be
damaged from overtightening.
Page 44/58
DREW D3
9. REPAIRING
9.3.
9.3.1.
COUNTING BATHS MODULE

Baths dismantling
Perform baths dismantling as described in Chapter 9 of the Users Manual.
9.3.2.
Baths o-ring replacement
Perform baths o-ring replacement as described in Chapter 9 of the Users Manual.
9.3.3.
Aperture block replacement
Perform aperture block replacement as described in Chapter 9 of the Users Manual.
9.3.4.
Complete baths module replacement
- Before replacing the complete baths module, drain all the

tubing : **The Cuvettes MUST BE DRAINED **
x Remove the diluent, lyse and cleaner tubes from their
bottle
x Perform a PRIME PACK (MAIN MENU /
MAINTENANCE / REAGENT PACK / PRIME PACK)
- Switch the D3 OFF and disconnect the power supply.
- Remove the Pack from its location
- Place the D3 on its left side.
Remove the baths connection (HGB, WBC coaxial, RBC coaxial

and thermal coupler).
Loosen (but DO NOT remove) the three screws which hold
the baths module (the third screw is located behind the over
flow tubing).
Cut the tie wraps off the tubing.
Disconnect the tubing from the manifold and the bath.
Slide up and remove the baths module.
Disconnect the ground wire from the chassis.
NOTE : Be careful with the tubing reconnection, if necessary, cut few millimeters (2 to 3mm) of tubing or
exchange them, ensuring a snug fit.
DREW D3
Page 45/58
9. REPAIRING
9.4.
9.4.1.
SYRINGE MODULE
Piston greasing
Perform the piston greasing as described in Chapter 9 of the Users Manual.
9.4.2.
O-ring or piston replacement
- Before replacing the complete syringe module, drain all the

tubing :
x Remove the diluent, lyse and cleaner straw from their
bottle
x Perform a PRIME PACK (MAIN MENU / MAINTENACE
/ REAGENT PACK / PRIME PACK)
- Put the syringe in lubrication position (MAIN MENU /
SERVICE / MECHANICS / LUBRICATE POS.)
- Switch the D3 OFF and disconnect the power supply.
- Remove the Pack from its location
- Place the D3 on its left side.
** THE CUVETTES MUST BE DRAINED **
- Loosen (but DO NOT remove) the four screws which hold the
syringe module.
- Pull the Block forward and rotate to gain access to the pistons.
Remove the syringe pistons from the piston carriage.
- Replace the pistons if needed. Replace O-rings.
Page 46/58
DREW D3
9. REPAIRING
To Replace O-Rings-.Unscrew and remove the eight screws which maintain the o-ring
plate.
- Remove the o-ring plate and exchange the o-rings.
-Lubricate O-rings with Dow Corning 101 silicone o-ring grease.
9.4.3.
Complete syringe module replacement
Before exchanging the complete syringe module, put the D3 on its left side as describe above (section 9.4.2).
- Disconnect all the valves connection.
- Loosen (but DO NOT remove) the four screws which hold the
syringe module.
- Remove the waste tubing.
- Cut the tie wraps off the tubing.
--Unscrew and remove the screws which maintain the ground
fitting.
- Disconnect the tubing.
- Remove the complete syringe module.
NOTE : Before reattaching the tubing, cut a few millimeters (2 to 4mm) off the end of the tubing to ensure
a snug fit.
DREW D3
Page 47/58
9. REPAIRING
9.5.
BOARDS REPLACEMENT
THE THREE D3 BOARDS ARE VERY
SENSITIVE TO ELECTROSTATIC
DISCHARGE. YOU MUST GROUND
YOURSELF USING AN BODY EARTH
GROUNDING STRAP TO HANDLE THE
BOARDS FOR THEIR REPLACEMENT OR
REMOVAL.
9.5.1.
IHM board replacement
Loosen (but DO NOT remove) the

two upper screws which hold the
front panel.
Loosen (but DO NOT remove) the

lower screw which holds the front
panel.
Page 48/58
DREW D3
9. REPAIRING
Lift the front panel and then pull it toward the front of the
instrument.
Disconnect the flat cable from the IHM connector
Push out on the ends of the connector in order

to extract the flat cable.
DREW D3
Page 49/58
9. REPAIRING
9.5.2.
Main board replacement
NOTE : Before removing the main board, remove the IHM board.
Push the flat cable through the window.
Remove the nine connectors located at the

top of the board. Label each connector and
record its position.
Unplug the baths connection (HGB, WBC coaxial, RBC coaxial and
temperature sensor).
Page 50/58
DREW D3
9. REPAIRING
Remove these three screws at the back of the instrument.
Remove the two screws located on the hydraulics side.
Disconnect the vacuum tubing, then carefully lift the

board up and out of the Analyser.
NOTE : Remember to reconnect the vacuum tubing after replacing the board.
DREW D3
Page 51/58
9. REPAIRING
9.5.3.
9.5.3.1.
Main board
Fuse replacement
- This fuse protects the 24v circuit.

- Remove the fuse with a thin pliers and replace it by a new one.
- Use a Littelfuse NANO Slo-Blo fuse model 0454
004 to replace the old one.
- Its strictly forbidden to use an another type of fuse
and will void warranty.
9.5.3.2.
Battery replacement
- This battery is only used to supply the real time clock.

- With a plastic screwdriver, lift the clips holding the battery in
place.
- Slide down the battery to remove it and replace it.
- Use a Maxell battery model CR2016 to replace
the old one.
- Its strictly forbidden to use an another type of
battery and will void warranty.
Page 52/58
DREW D3
9. REPAIRING
READ CAREFULLY THE FOLLOWING RECOMMENDATIONS.

Handling/storage
Never expose the battery to ultrasonic sound.
Exposing the battery to ultrasonic sound may cause short-circuiting because the inside material is broken
into pieces, leading to distortion, leakage, overheating, explosion, or fire.
Never subject the battery to severe shock.
Dropping, throwing or stomping on the battery may cause distortion, leakage, overheating, explosion, or fire.
Never short-circuit the battery while installing into equipment.
Please be careful when installing the battery not to short-circuit it with metal portions of the equipment.
Use the correct battery suitable for the equipment.
The battery may not be suitable for the specific equipment due to the using conditions or type of equipment.
Please select the suitable battery according to the handling instructions of the equipment.
Never use or leave the battery in a hot place such as under the direct rays of the sun or in a car in
hot weather.
If you do, this may cause distortion, leakage, overheating, explosion, or fire.
Never allow the battery to come in contact with water.
If it does, this may cause the battery to rust or lead to distortion, leakage, overheating, explosion, or fire.
Never store the battery in a hot and highly humid environment.
Doing so may cause the performance of the battery to deteriorate. In certain environments, this may lead to
distortion, leakage, overheating, explosion, or fire.
Disposal
The battery may be regulated by national or local regulation. Please follow the instructions of proper
regulation. As electric capacity is left in a discarded battery and it comes into contact with other metals, it
could lead to distortion, leakage, overheating, or explosion, so make sure to cover the (+) and (-) terminals
with friction tape or some other insulator before disposal.
DREW D3
Page 53/58
9. REPAIRING
9.5.4.
Preamplifier board replacement
NOTE : Before removing the preamplifier board, remove the Main board.
Remove the two screws located on the copper side.
Gently lift the preamplifier box from the main

board while ensuring the finger connection is not
bent.
To reassemble the part, carry out the various operations in reverse order.
Page 54/58
DREW D3
10. TROUBLESHOOTING
10. TROUBLESHOOTING
In the case of any problem not being solved, call the Drew Scientific distributor.
10.1.
ANALYTICAL PROBLEMS
PARAMETERS
WBC
PROBLEMS
No results
SYMPTOM
No HGB
HGB OK
Bad
reproducibility
RBC
HGB
10.2.
ORIGIN
D3
Printer
No results
No HCT & PLT
Bad
reproducibility
HCT & PLT too
No results
Bad
reproducibility
OTHER PROBLEMS
PROBLEMS
Diluent leaks around the
needle during the run cycle
No starting
All results bad
No display
No printing
Bad printing
DREW D3
SOLUTIONS
Check the cuvette wires
Check the lyse and diluent levels
Check the right lyse tubing connection to the WBC
bath.
Perform a Cleaning Cycle and then a Bleach cycle if
unsuccessful.
Perform a Back flush and a Cleaning Cycle and then a
Bleach cycle if unsuccessful
Check the presence of large bubbles during mixing in
the WBC bath during the run cycle.
Perform a Cleaning Cycle and then a Bleach cycle if
unsuccessful
Perform a Back flush and a Cleaning Cycle and then a
Bleach cycle if unsuccessful
the RBC bath during the run cycle.
the WBC bath during the first dilution.
Check the led light on
Check if no bubble in the lyse tubing.
Check the level bubble flow in the WBC bath during
the run cycle.
SOLUTIONS
Check the rinsing needle block (presence of clots) and clean
it if necessary see section 9 of the Operators Manual.
Check the power supply connection wires
Check the level diluent and if the tubing is pinched.
Check the flat cable between the IHM and Main pcb.
Check the paper.
Check the electrical connection.
Check the black ribbon or toner cartridge.
Page 55/58
10. TROUBLESHOOTING
10.3.
TROUBLESHOOTING MESSAGE
This section give guidance as to know what to do when a troubleshooting message appears on the screen.
MESSAGE
ACTION
***
N/A
SYSTEM: FATAL ERROR
Re-start the Analyser.
SYSTEM : INTERNAL TIME OUT
CYCLE : BUSY
Wait before performing a cycle.
CYCLE STOPPED BY USER
Emergency stop, please perform a reset cycle.
CYCLE : EMERGENCY STOP
Perform a reset cycle.
CYCLE: BAD CYCLE MODULE
CYCLE : CMD VALVE FAILED
Change the valve
CYCLE : VALVE 1 FAILED
Change the valve
Change the valve
Change the valve
Change the valve
Change the valve
Change the valve
Change the valve
Change the valve
Change the valve
Change the valve
Change the valve
CYCLE : INIT NOT DONE
Perform an initialization or a reset cycle.
OUT OF RANGE
Modify the value
MECA: MOTOR NEEDLE BUSY
MECA: MOTOR SYRINGE BUSY
MECA: MOTOR ROCKER BUSY
MECA : HOME NEEDLE NOT FOUND
MECA : HOME SYRINGE NOT FOUND
MECA : HOME ROCKER NOT FOUND
MECA : MOTOR NEEDLE GAP
Nothing.
MECA : MOTOR SYRINGE GAP
Nothing.
MECA : MOTOR ROCKER GAP
Nothing.
MECA : NEEDLE NOT IN TOP POSITION
CONTROL CYCLE NOT DONE
BACKGROUND NOT DONE
Perform a background cycle.
RINSE NOT DONE
Perform a clean cycle.
CLEAN NOT DONE
Perform a rinse cycle.
BACKGROUND FAILED
Perform a new background cycle
CYCLE: DOOR OPENED
Close the door and perform an reset cycle
INTERN : COUNT ERROR
RUNNING AUTO CLEANING ,
Press OK.
REAGENT:PACK ALMOST EMPTY
Replace the pack and perform a prime all
Page 56/58
DREW D3
10. TROUBLESHOOTING

MESSAGE
ACTION
THE REAGENT PACK IS OUT OF DATE
Replace the container and perform a prime all
SYSTEM : EEPROM COM ERROR
INIT PRINTER
Switch on the printer or invalidate the printings.
NO PRINTER RESPONSE
NO PRINTER SELECTED
PRINTER IS OFF
NO PRINTER RESPONSE
PRINTER ERROR

Wait before performing a cycle. If persisting, re-start
the Analyser.
INTERN: RESULT AREA IS LOCKED

BACKUP: SYSTEM ERROR
HARDWARE: SYSTEM ERROR
BACKUP : MEMORY FULL. OLDEST RESULTS HAVE BEEN
DELETED.
BACKUP : MEMORY IS ALMOST FULL. PLEASE ARCHIVE
RESULTS
BACKUP : BAD FOLDER DUPLICATION
BACKUP : CALIBRATION HISTORY IS FULL
Delete the calibration results.
Delete the stored results.

NO PROBLEM. Information Only.
BACKUP : REPEATABILITY HISTORY IS FULL
Delete the repeatability results.
BACKUP : QC HISTORY IS FULL
Delete the Q.C. results of the ongoing lot.
INTERN: NO MEMORY AVAILABLE
INTERN: MEMORY CORRUPTED
COM: CRC CONTROL ERROR
Communication error retry
RS232: TIME OUT
RS232: INTERNAL ERROR
RS232: SYNCHRO ERROR
RS232: ACK ERROR

ID AND/OR PID MANDATORY ( CHECK SETUP). SID
ALWAYS MANDATORY
CYCLE: PRESSURE DEFAULT ERROR
BACKUP : FOLDER NOT FOUND
BACKUP: LAST SETUP RESTORED.
Indicate that your SETUP has been restored
BACKUP: SETUP UPDATED WITH DEFAULT VALUES.
Indicate that your SETUP has been released
DREW D3
Enter an ID and/or PID and SID

Perform reset cycle
Page 57/58
10. TROUBLESHOOTING
MESSAGE
ACTION
BACKUP: PARTIAL NUM DELETED.
A bad Result storage happened
BACKUP: PARTIAL CALI. RES. DELETED.
BACKUP: PARTIAL REPET. RES. DELETED.
BACKUP: PARTIAL QC RES. DELETED.
BACKUP: LAST RESULTS RESTORED.
File has been restored to previous state
BACKUP: LAST QC RESTORED.
File has been restored to previous state
BACKUP: FILE SYSTEM FAILED
BACKUP: SECTOR FAILED
hardware failure on memory
COM: BAD CYCLE MODULE
Rebuild cycles with good options
COM: SIZE ERROR

SYSTEM : DOWNLOADING NEW VERSION PLEASE
WAIT
USB:UNABLE TO OPEN FILE
Send File again
USB:THUMB DRIVE IS FULL
Insert new key or delete some files.
USB:EMPTY FILE
The item was not found on the key.
USB:THUMB DRIVE IS NOT PRESENT
Connecter une cle USB au Analyser.
System is resetting after internal modifications

Read error. Try again. The key might have a problem.
USB:WRITE PROTECTED FILE
Modify the file's properties (security).
USB:TOO MANY FILES OPENED
Please close files.
SETUP: MODIFICATION NOT ALLOWED.
The access path need higher privilege to proceed.
REAGENT:DILUENT EMPTY.
Change Pack
REAGENT:LYSE EMPTY.
Change Pack
REAGENT:CLEANER EMPTY.
Change Pack
BACKUP: FIFO MODIFIED
End of document.
Page 58/58
DREW D3

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DREW-D3

Rest of the World

Dallas, TX, USA

Tel : +1 214 210 4900

Tel: +44 (0)1229 432089

Fax : +1 214 210 4949

Fax: +44 (0)1229 432096

DREW-Scientific Co. Limited

4230 Shilling Way

Dallas, TX 75237, USA

Tel : +1 214 210 4900

Tel: +44 (0)1229 432-089

Fax : +1 214 210 4949

Fax: +44 (0)1229 432-096

Copyright Drew Scientific. All Rights Reserved.

REF : D3-SM-000 Rev 01

IMPORTANT SAFETY INSTRUCTIONS

Indicates that wearing gloves is mandatory before performing the described

Copyright Drew Scientific. All Rights Reserved.

REF : D3-SM-000 Rev 01

Guidance and manufacturers declaration Electromagnetic immunity

IEC 60601 test level

Electromagnetic environment - guidance

be used no closer to any part of the D3 including cables,

d = 1,2P 80MHz to 800MHz

NOTE 1 At 80Mhz and 800MHz, the higher frequency range applies.

Copyright Drew Scientific. All Rights Reserved.

REF : D3-SM-000 Rev 01

PARTS LIST & BLOW UP VIEW

PARTS LIST ..............................................................................................................................................................................26

MAINTENANCE TABLE .............................................................................................................................................................40

Copyright Drew Scientific. All Rights Reserved.

REF : D3-SM-000 Rev 01

CONCENTRATED CLEANING ..................................................................................................................................................... 41

EMERGENCY STOP ....................................................................................................................................................................43

Copyright Drew Scientific. All Rights Reserved.

REF : D3-SM-000 Rev 01

The following chapters describe the different technical parts of the D3

Copyright Drew Scientific Inc. All Rights Reserved.

REF : D3-SM-000 Rev 01

The D3 is a fully automated analyzer performing hematological analysis of whole blood.

FLUIDICS SEQUENCES DESCRIPTION :

Copyright Drew Scientific Inc. All Rights Reserved.

REF : D3-SM-000 Rev 01

Copyright Drew Scientific Inc. All Rights Reserved.

REF : D3-SM-000 Rev 01

Copyright Drew Scientific. All Rights Reserved.

REF : D3-SM-000 Rev 01

FLUIDICS PARTS DESCRIPTION

Counting bath module

This module (patent pending) performs the following tasks :

Copyright Drew Scientific Inc. All Rights Reserved.

REF : D3-SM-000 Rev 01

Copyright Drew Scientific. All Rights Reserved.

REF : D3-SM-000 Rev 01

Manifold tubing and valves position

Counting manifold tubing position

Counting manifold valve positions

Copyright Drew Scientific Inc. All Rights Reserved.

REF : D3-SM-000 Rev 01

Syringe manifold tubing position

Syringe body tubing position

Copyright Drew Scientific. All Rights Reserved.

REF : D3-SM-000 Rev 01